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Volumn 3, Issue 1, 2012, Pages 35-46

Statins and their interactions with other lipid-modifying medications: Safety issues in the elderly

Author keywords

adverse effects; bile acid sequestrants; drug drug interactions; elderly; ezetimibe; fibrates; fish oil; nicotinic acid; statins

Indexed keywords

ACETYLSALICYLIC ACID; ATORVASTATIN; BILE ACID SEQUESTRANT; DOCOSAHEXAENOIC ACID; EZETIMIBE; FENOFIBRATE; FIBRIC ACID DERIVATIVE; FLUINDOSTATIN; GEMFIBROZIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ICOSAPENTAENOIC ACID; LAROPIPRANT; MEVALONIC ACID; MEVINOLIN; NICOTINIC ACID; OMEGA 3 FATTY ACID ESTER; PITAVASTATIN; PLACEBO; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN;

EID: 84859055200     PISSN: 20420986     EISSN: 20420994     Source Type: Journal    
DOI: 10.1177/2042098611428486     Document Type: Review
Times cited : (18)

References (75)
  • 3
    • 77951944375 scopus 로고    scopus 로고
    • The myth of statin-induced hepatotoxicity
    • Bader T. (2010) The myth of statin-induced hepatotoxicity. Am J Gastroenterol 105: 978–980.
    • (2010) Am J Gastroenterol , vol.105 , pp. 978-980
    • Bader, T.1
  • 4
    • 50949133756 scopus 로고    scopus 로고
    • Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs simvastatin monotherapy in patients with increased non-HDL cholesterol (from the SEACOAST I study)
    • Ballantyne C.M. Davidson M.H. McKenney J. Keller L.H. Bajorunas D.R. Karas R.H. (2008) Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs simvastatin monotherapy in patients with increased non-HDL cholesterol (from the SEACOAST I study). Am J Cardiol 101: 1428–1436.
    • (2008) Am J Cardiol , vol.101 , pp. 1428-1436
    • Ballantyne, C.M.1    Davidson, M.H.2    McKenney, J.3    Keller, L.H.4    Bajorunas, D.R.5    Karas, R.H.6
  • 5
    • 75749115919 scopus 로고    scopus 로고
    • Effects of prescription omega-3-acid ethyl esters on non–high-density lipoprotein cholesterol when coadministered with escalating doses of atorvastatin
    • Bays H.E. McKenney J. Maki K.C. Doyle R.T. Carter R.N. Stein E. (2010) Effects of prescription omega-3-acid ethyl esters on non–high-density lipoprotein cholesterol when coadministered with escalating doses of atorvastatin. Mayo Clin Proc 85: 122–128.
    • (2010) Mayo Clin Proc , vol.85 , pp. 122-128
    • Bays, H.E.1    McKenney, J.2    Maki, K.C.3    Doyle, R.T.4    Carter, R.N.5    Stein, E.6
  • 6
    • 2942705774 scopus 로고    scopus 로고
    • Safety of statins: focus on clinical pharmacokinetics and drug interactions
    • Bellosta S. Paoletti R. Corsini A. (2004) Safety of statins: focus on clinical pharmacokinetics and drug interactions. Circulation 109(23 Suppl. 1): III50–III57.
    • (2004) Circulation , vol.109 , Issue.23 , pp. III50-III57
    • Bellosta, S.1    Paoletti, R.2    Corsini, A.3
  • 7
    • 16244384606 scopus 로고    scopus 로고
    • Statins and hepatotoxicity: focus on patients with fatty liver
    • Chalasani N. (2005) Statins and hepatotoxicity: focus on patients with fatty liver. Hepatology 41: 690–695.
    • (2005) Hepatology , vol.41 , pp. 690-695
    • Chalasani, N.1
  • 8
    • 0035192078 scopus 로고    scopus 로고
    • Hepatic and intestinal cytochrome P450 3A activity in cirrhosis: effects of transjugular intrahepatic portosystemic shunts
    • Chalasani N. Gorski J.C. Patel N.H. Hall S.D. Galinsky R.E. (2001) Hepatic and intestinal cytochrome P450 3A activity in cirrhosis: effects of transjugular intrahepatic portosystemic shunts. Hepatology 34: 1103–1108.
    • (2001) Hepatology , vol.34 , pp. 1103-1108
    • Chalasani, N.1    Gorski, J.C.2    Patel, N.H.3    Hall, S.D.4    Galinsky, R.E.5
  • 9
    • 33645888317 scopus 로고    scopus 로고
    • An assessment of statin safety by hepatologists
    • Cohen D.E. Anania F.A. Chalasani N. (2006) An assessment of statin safety by hepatologists. Am J Cardiol 97(8A): 77C–81C.
    • (2006) Am J Cardiol , vol.97 , Issue.8A , pp. 77C-81C
    • Cohen, D.E.1    Anania, F.A.2    Chalasani, N.3
  • 11
    • 34548319692 scopus 로고    scopus 로고
    • Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study
    • Davidson M.H. Stein E.A. Bays H.E. Maki K.C. Doyle R.T. Shalwitz R.A. (2007) Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study. Clin Ther 29: 1354–1367.
    • (2007) Clin Ther , vol.29 , pp. 1354-1367
    • Davidson, M.H.1    Stein, E.A.2    Bays, H.E.3    Maki, K.C.4    Doyle, R.T.5    Shalwitz, R.A.6
  • 12
    • 33847171482 scopus 로고    scopus 로고
    • Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: results of the Study Assessing Goals in the Elderly (SAGE)
    • Deedwania P. Stone P.H. Bairey Merz C.N. Cosin-Aguilar J. Koylan N. Luo D. (2007) Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: results of the Study Assessing Goals in the Elderly (SAGE). Circulation 115: 700–707.
    • (2007) Circulation , vol.115 , pp. 700-707
    • Deedwania, P.1    Stone, P.H.2    Bairey Merz, C.N.3    Cosin-Aguilar, J.4    Koylan, N.5    Luo, D.6
  • 13
    • 62149146834 scopus 로고    scopus 로고
    • The relationship between reduction in low-density lipoprotein cholesterol by statins and reduction in risk of cardiovascular outcomes: an updated meta-analysis
    • Delahoy P. Magliano D.J. Webb K. Grobler M. Liew D. (2009) The relationship between reduction in low-density lipoprotein cholesterol by statins and reduction in risk of cardiovascular outcomes: an updated meta-analysis. Clin Therapeut 31: 236–244.
    • (2009) Clin Therapeut , vol.31 , pp. 236-244
    • Delahoy, P.1    Magliano, D.J.2    Webb, K.3    Grobler, M.4    Liew, D.5
  • 14
    • 0037381782 scopus 로고    scopus 로고
    • Evolution of statin prescribing 1994–2001: a case of agism but not of sexism?
    • DeWilde S. Carey I.M. Bremner S.A. Richards N. Hilton S.R. Cook D.G. (2003) Evolution of statin prescribing 1994–2001: a case of agism but not of sexism? Heart 89: 417–421.
    • (2003) Heart , vol.89 , pp. 417-421
    • DeWilde, S.1    Carey, I.M.2    Bremner, S.A.3    Richards, N.4    Hilton, S.R.5    Cook, D.G.6
  • 15
    • 57549108116 scopus 로고    scopus 로고
    • Effect of omega-3-acid ethyl esters on steady-state plasma pharmacokinetics of atorvastatin in healthy adults
    • Di Spirito M. Morelli G. Doyle R.T. Johnson J. McKenney J. (2008) Effect of omega-3-acid ethyl esters on steady-state plasma pharmacokinetics of atorvastatin in healthy adults. Expert Opin Pharmacother 9: 2939–2945.
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 2939-2945
    • Di Spirito, M.1    Morelli, G.2    Doyle, R.T.3    Johnson, J.4    McKenney, J.5
  • 16
    • 0034762548 scopus 로고    scopus 로고
    • An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia
    • Durrington P.N. Bhatnagar D. Mackness M.I. Morgan J. Julier K. Khan M.A. (2001) An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. Heart 85: 544–548.
    • (2001) Heart , vol.85 , pp. 544-548
    • Durrington, P.N.1    Bhatnagar, D.2    Mackness, M.I.3    Morgan, J.4    Julier, K.5    Khan, M.A.6
  • 17
    • 77952760040 scopus 로고    scopus 로고
    • Approach to the patient who is intolerant of statin therapy
    • Eckel R.H. (2010) Approach to the patient who is intolerant of statin therapy. J Clin Endocrinol Metab 95: 2015–2022.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2015-2022
    • Eckel, R.H.1
  • 18
    • 34249795153 scopus 로고    scopus 로고
    • Prevalence of thyroid disease in an older Australian population
    • Empson M. Flood V. Ma G. Eastman C.J. Mitchell P. (2007) Prevalence of thyroid disease in an older Australian population. Intern Med J 37: 448–455.
    • (2007) Intern Med J , vol.37 , pp. 448-455
    • Empson, M.1    Flood, V.2    Ma, G.3    Eastman, C.J.4    Mitchell, P.5
  • 19
    • 41649098889 scopus 로고    scopus 로고
    • Management of mixed dyslipidemia in patients with or at risk for cardiovascular disease: a role for combination fibrate therapy
    • Fazio S. (2008) Management of mixed dyslipidemia in patients with or at risk for cardiovascular disease: a role for combination fibrate therapy. Clin Ther 30: 294–306.
    • (2008) Clin Ther , vol.30 , pp. 294-306
    • Fazio, S.1
  • 20
    • 80054699298 scopus 로고    scopus 로고
    • FDA Drug Safety Communication: New restrictions, contraindications, and dose limitations for Zocor (simvastatin) to reduce the risk of muscle injury
    • Available at
    • Food and Drug Administration (2011) FDA Drug Safety Communication: New restrictions, contraindications, and dose limitations for Zocor (simvastatin) to reduce the risk of muscle injury. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm256581.htm.
    • (2011)
  • 21
    • 0029128788 scopus 로고
    • Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver
    • George J. Byth K. Farrell G.C. (1995) Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver. Biochem Pharmacol 50: 727–730.
    • (1995) Biochem Pharmacol , vol.50 , pp. 727-730
    • George, J.1    Byth, K.2    Farrell, G.C.3
  • 22
    • 59549089180 scopus 로고    scopus 로고
    • Statin adverse effects: a review of the literature and evidence for a mitochondrial mechanism
    • Golomb B.A. Evans M.A. (2008) Statin adverse effects: a review of the literature and evidence for a mitochondrial mechanism. Am J Cardiovasc Drugs 8: 373–418.
    • (2008) Am J Cardiovasc Drugs , vol.8 , pp. 373-418
    • Golomb, B.A.1    Evans, M.A.2
  • 23
    • 57549087184 scopus 로고    scopus 로고
    • Effect of omega-3-acid ethyl esters on the steady-state plasma pharmacokinetics of rosuvastatin in healthy adults
    • Gosai P. Liu J. Doyle R.T. Johnson J. Carter R. Sica D. (2008) Effect of omega-3-acid ethyl esters on the steady-state plasma pharmacokinetics of rosuvastatin in healthy adults. Expert Opin Pharmacother 9: 2947–2953.
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 2947-2953
    • Gosai, P.1    Liu, J.2    Doyle, R.T.3    Johnson, J.4    Carter, R.5    Sica, D.6
  • 24
    • 33847112869 scopus 로고    scopus 로고
    • Statin therapy and the elderly: SAGE advice?
    • Gotto A.M. Jr (2007) Statin therapy and the elderly: SAGE advice? Circulation 115: 681–683.
    • (2007) Circulation , vol.115 , pp. 681-683
    • Gotto, A.M.1
  • 25
    • 9644252909 scopus 로고    scopus 로고
    • Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs
    • Graham D.J. Staffa J.A. Shatin D. Andrade S.E. Schech S.D. La Grenade L. (2004) Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. Jama 292: 2585–2590.
    • (2004) Jama , vol.292 , pp. 2585-2590
    • Graham, D.J.1    Staffa, J.A.2    Shatin, D.3    Andrade, S.E.4    Schech, S.D.5    La Grenade, L.6
  • 26
    • 0037158150 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial
    • Grundy S.M. Vega G.L. McGovern M.E. Tulloch B.R. Kendall D.M. Fitz-Patrick D. (2002) Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial. Arch Intern Med 162: 1568–1576.
    • (2002) Arch Intern Med , vol.162 , pp. 1568-1576
    • Grundy, S.M.1    Vega, G.L.2    McGovern, M.E.3    Tulloch, B.R.4    Kendall, D.M.5    Fitz-Patrick, D.6
  • 27
    • 0032530770 scopus 로고    scopus 로고
    • Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia
    • Guyton J.R. Goldberg A.C. Kreisberg R.A. Sprecher D.L. Superko H.R. O–Connor C.M. (1998) Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia. Am J Cardiol 82: 737–743.
    • (1998) Am J Cardiol , vol.82 , pp. 737-743
    • Guyton, J.R.1    Goldberg, A.C.2    Kreisberg, R.A.3    Sprecher, D.L.4    Superko, H.R.5    O–Connor, C.M.6
  • 29
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group (2002) MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360: 7–22.
    • (2002) Lancet , vol.360 , pp. 7-22
  • 30
    • 0035873251 scopus 로고    scopus 로고
    • Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: Results from the LIPID trial
    • Hunt D. Young P. Simes J. Hague W. Mann S. Owensby D. (2001) Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: Results from the LIPID trial. Ann Intern Med 134: 931–940.
    • (2001) Ann Intern Med , vol.134 , pp. 931-940
    • Hunt, D.1    Young, P.2    Simes, J.3    Hague, W.4    Mann, S.5    Owensby, D.6
  • 31
    • 33646725076 scopus 로고    scopus 로고
    • Overcoming ‘ageism– bias in the treatment of hypercholesterolaemia: a review of safety issues with statins in the elderly
    • Jacobson T.A. (2006) Overcoming ‘ageism– bias in the treatment of hypercholesterolaemia: a review of safety issues with statins in the elderly. Drug Saf 29: 421–448.
    • (2006) Drug Saf , vol.29 , pp. 421-448
    • Jacobson, T.A.1
  • 32
    • 11144239674 scopus 로고    scopus 로고
    • Reporting rate of rhabdomyolysis with fenofibrate + statin versus gemfibrozil + any statin
    • Jones P.H. Davidson M.H. (2005) Reporting rate of rhabdomyolysis with fenofibrate + statin versus gemfibrozil + any statin. Am J Cardiol 95: 120–122.
    • (2005) Am J Cardiol , vol.95 , pp. 120-122
    • Jones, P.H.1    Davidson, M.H.2
  • 33
    • 67249111853 scopus 로고    scopus 로고
    • Narrative review: statin-related myopathy
    • Joy T.R. Hegele R.A. (2009) Narrative review: statin-related myopathy. Ann Intern Med 150: 858–868.
    • (2009) Ann Intern Med , vol.150 , pp. 858-868
    • Joy, T.R.1    Hegele, R.A.2
  • 34
    • 41049092899 scopus 로고    scopus 로고
    • Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: the OCEANS study
    • Karas R.H. Kashyap M.L. Knopp R.H. Keller L.H. Bajorunas D.R. Davidson M.H. (2008) Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: the OCEANS study. Am J Cardiovasc Drugs 8: 69–81.
    • (2008) Am J Cardiovasc Drugs , vol.8 , pp. 69-81
    • Karas, R.H.1    Kashyap, M.L.2    Knopp, R.H.3    Keller, L.H.4    Bajorunas, D.R.5    Davidson, M.H.6
  • 36
    • 2442425776 scopus 로고    scopus 로고
    • Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia
    • Knopp R.H. Alagona P. Davidson M. Goldberg A.C. Kafonek S.D. Kashyap M. (1998) Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia. Metabolism 47: 1097–1104.
    • (1998) Metabolism , vol.47 , pp. 1097-1104
    • Knopp, R.H.1    Alagona, P.2    Davidson, M.3    Goldberg, A.C.4    Kafonek, S.D.5    Kashyap, M.6
  • 37
    • 1942542443 scopus 로고    scopus 로고
    • Lipid-lowering therapy with statins in high-risk elderly patients: the treatment-risk paradox
    • Ko D.T. Mamdani M. Alter D.A. (2004) Lipid-lowering therapy with statins in high-risk elderly patients: the treatment-risk paradox. Jama 291: 1864–1870.
    • (2004) Jama , vol.291 , pp. 1864-1870
    • Ko, D.T.1    Mamdani, M.2    Alter, D.A.3
  • 39
    • 0035337643 scopus 로고    scopus 로고
    • Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate
    • Kyrklund C. Backman J.T. Kivisto K.T. Neuvonen M. Laitila J. Neuvonen P.J. (2001) Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate. Clin Pharmacol Ther 69: 340–345.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 340-345
    • Kyrklund, C.1    Backman, J.T.2    Kivisto, K.T.3    Neuvonen, M.4    Laitila, J.5    Neuvonen, P.J.6
  • 40
    • 0037534010 scopus 로고    scopus 로고
    • Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance
    • Kyrklund C. Backman J.T. Neuvonen M. Neuvonen P.J. (2003) Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance. Clin Pharmacol Ther 73: 538–544.
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 538-544
    • Kyrklund, C.1    Backman, J.T.2    Neuvonen, M.3    Neuvonen, P.J.4
  • 41
    • 14444271787 scopus 로고    scopus 로고
    • Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range. Results of the Cholesterol and Recurrent Events (CARE) trial
    • Lewis S.J. Moye L.A. Sacks F.M. Johnstone D.E. Timmis G. Mitchell J. (1998) Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range. Results of the Cholesterol and Recurrent Events (CARE) trial. Ann Intern Med 129: 681–689.
    • (1998) Ann Intern Med , vol.129 , pp. 681-689
    • Lewis, S.J.1    Moye, L.A.2    Sacks, F.M.3    Johnstone, D.E.4    Timmis, G.5    Mitchell, J.6
  • 42
    • 0021910427 scopus 로고
    • Longitudinal studies on the rate of decline in renal function with age
    • Lindeman R.D. Tobin J. Shock N.W. (1985) Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 33: 278–285.
    • (1985) J Am Geriatr Soc , vol.33 , pp. 278-285
    • Lindeman, R.D.1    Tobin, J.2    Shock, N.W.3
  • 43
    • 11344285421 scopus 로고    scopus 로고
    • Efficacy and safety of coadministration of ezetimibe and statins in elderly patients with primary hypercholesterolaemia
    • Lipka L. Sager P. Strony J. Yang B. Suresh R. Veltri E. (2004) Efficacy and safety of coadministration of ezetimibe and statins in elderly patients with primary hypercholesterolaemia. Drugs Aging 21: 1025–1032.
    • (2004) Drugs Aging , vol.21 , pp. 1025-1032
    • Lipka, L.1    Sager, P.2    Strony, J.3    Yang, B.4    Suresh, R.5    Veltri, E.6
  • 44
    • 0344664550 scopus 로고    scopus 로고
    • Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteers
    • Martin P.D. Warwick M.J. Dane A.L. Hill S.J. Giles P.B. Phillips P.J. (2003) Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteers. Clin Ther 25: 2822–2835.
    • (2003) Clin Ther , vol.25 , pp. 2822-2835
    • Martin, P.D.1    Warwick, M.J.2    Dane, A.L.3    Hill, S.J.4    Giles, P.B.5    Phillips, P.J.6
  • 45
    • 30144445801 scopus 로고    scopus 로고
    • Prolonged-release nicotinic acid: a review of its use in the treatment of dyslipidaemia
    • McCormack P.L. Keating G.M. (2005) Prolonged-release nicotinic acid: a review of its use in the treatment of dyslipidaemia. Drugs 65: 2719–2740.
    • (2005) Drugs , vol.65 , pp. 2719-2740
    • McCormack, P.L.1    Keating, G.M.2
  • 46
    • 0038630864 scopus 로고    scopus 로고
    • Niacin for dyslipidemia: considerations in product selection
    • McKenney J. (2003) Niacin for dyslipidemia: considerations in product selection. Am J Health Syst Pharm 60: 995–1005.
    • (2003) Am J Health Syst Pharm , vol.60 , pp. 995-1005
    • McKenney, J.1
  • 48
    • 34248150891 scopus 로고    scopus 로고
    • Comparative effects on lipid levels of combination therapy with a statin and extended-release niacin or ezetimibe versus a statin alone (the COMPELL study)
    • McKenney J.M. Jones P.H. Bays H.E. Knopp R.H. Kashyap M.L. Ruoff G.E. (2007) Comparative effects on lipid levels of combination therapy with a statin and extended-release niacin or ezetimibe versus a statin alone (the COMPELL study). Atherosclerosis 192: 432–437.
    • (2007) Atherosclerosis , vol.192 , pp. 432-437
    • McKenney, J.M.1    Jones, P.H.2    Bays, H.E.3    Knopp, R.H.4    Kashyap, M.L.5    Ruoff, G.E.6
  • 49
    • 33745063941 scopus 로고    scopus 로고
    • Study of the pharmacokinetic interaction between simvastatin and prescription omega-3-acid ethyl esters
    • McKenney J.M. Swearingen D. Di Spirito M. Doyle R. Pantaleon C. Kling D. (2006) Study of the pharmacokinetic interaction between simvastatin and prescription omega-3-acid ethyl esters. J Clin Pharmacol 46: 785–791.
    • (2006) J Clin Pharmacol , vol.46 , pp. 785-791
    • McKenney, J.M.1    Swearingen, D.2    Di Spirito, M.3    Doyle, R.4    Pantaleon, C.5    Kling, D.6
  • 50
    • 2642572647 scopus 로고    scopus 로고
    • Aging biology and geriatric clinical pharmacology
    • McLean A.J. Le Couteur D.G. (2004) Aging biology and geriatric clinical pharmacology. Pharmacol Rev 56: 163–184.
    • (2004) Pharmacol Rev , vol.56 , pp. 163-184
    • McLean, A.J.1    Le Couteur, D.G.2
  • 51
    • 79951835528 scopus 로고    scopus 로고
    • Simvastatin: increased risk of myopathy at high dose (80 mg)
    • Medicines and Healthcare Products Regulatory Agency (2010) Simvastatin: increased risk of myopathy at high dose (80 mg). Drug Safety Update 3(10): 7–8.
    • (2010) Drug Safety Update , vol.3 , Issue.10 , pp. 7-8
  • 52
    • 0344653659 scopus 로고    scopus 로고
    • Cholesterol-lowering therapy in women and elderly patients with myocardial infarction or angina pectoris: findings from the Scandinavian Simvastatin Survival Study (4S)
    • Miettinen T.A. Pyorala K. Olsson A.G. Musliner T.A. Cook T.J. Faergeman O. (1997) Cholesterol-lowering therapy in women and elderly patients with myocardial infarction or angina pectoris: findings from the Scandinavian Simvastatin Survival Study (4S). Circulation 96: 4211–4218.
    • (1997) Circulation , vol.96 , pp. 4211-4218
    • Miettinen, T.A.1    Pyorala, K.2    Olsson, A.G.3    Musliner, T.A.4    Cook, T.J.5    Faergeman, O.6
  • 53
    • 0031909536 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of fibric acid derivatives (fibrates)
    • Miller D.B. Spence J.D. (1998) Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet 34: 155–162.
    • (1998) Clin Pharmacokinet , vol.34 , pp. 155-162
    • Miller, D.B.1    Spence, J.D.2
  • 54
    • 20544440861 scopus 로고    scopus 로고
    • Aging muscle
    • Nair K. (2005) Aging muscle. Am J Clin Nutr 81: 953–963.
    • (2005) Am J Clin Nutr , vol.81 , pp. 953-963
    • Nair, K.1
  • 55
    • 84857881695 scopus 로고    scopus 로고
    • Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease
    • NICE clinical guideline 67, National Institute for Health and Clinical Excellence.
    • National Institute for Health and Clinical Excellence (2010) Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease. NICE clinical guideline 67, National Institute for Health and Clinical Excellence.
    • (2010)
  • 56
    • 29244483080 scopus 로고    scopus 로고
    • Comparative safety of atorvastatin 80 mg versus 10 mg derived from analysis of 49 completed trials in 14,236 patients
    • Newman C. Tsai J. Szarek M. Luo D. Gibson E. (2006) Comparative safety of atorvastatin 80 mg versus 10 mg derived from analysis of 49 completed trials in 14,236 patients. Am J Cardiol 97: 61–67.
    • (2006) Am J Cardiol , vol.97 , pp. 61-67
    • Newman, C.1    Tsai, J.2    Szarek, M.3    Luo, D.4    Gibson, E.5
  • 57
    • 4444278991 scopus 로고    scopus 로고
    • The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes
    • Parkinson A. Mudra D.R. Johnson C. Dwyer A. Carroll K.M. (2004) The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes. Toxicol Appl Pharmacol 199: 193–209.
    • (2004) Toxicol Appl Pharmacol , vol.199 , pp. 193-209
    • Parkinson, A.1    Mudra, D.R.2    Johnson, C.3    Dwyer, A.4    Carroll, K.M.5
  • 59
    • 18344380806 scopus 로고    scopus 로고
    • Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects
    • Patrick J.E. Kosoglou T. Stauber K.L. Alton K.B. Maxwell S.E. Zhu Y. (2002) Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects. Drug Metab Dispos 30: 430–437.
    • (2002) Drug Metab Dispos , vol.30 , pp. 430-437
    • Patrick, J.E.1    Kosoglou, T.2    Stauber, K.L.3    Alton, K.B.4    Maxwell, S.E.5    Zhu, Y.6
  • 60
    • 68949083513 scopus 로고    scopus 로고
    • Extended-release niacin (nicotinic acid)/laropiprant
    • Perry C.M. (2009) Extended-release niacin (nicotinic acid)/laropiprant. Drugs 69: 1665–1679.
    • (2009) Drugs , vol.69 , pp. 1665-1679
    • Perry, C.M.1
  • 62
    • 0036082036 scopus 로고    scopus 로고
    • Use of statins in the secondary prevention of coronary heart disease: is treatment equitable?
    • Reid F.D. Cook D.G. Whincup P.H. (2002) Use of statins in the secondary prevention of coronary heart disease: is treatment equitable? Heart 88: 15–19.
    • (2002) Heart , vol.88 , pp. 15-19
    • Reid, F.D.1    Cook, D.G.2    Whincup, P.H.3
  • 63
    • 56749130484 scopus 로고    scopus 로고
    • Statin induced myopathy
    • Sathasivam S. Lecky B. (2008) Statin induced myopathy. Bmj 337: a2286.
    • (2008) Bmj , vol.337 , pp. a2286
    • Sathasivam, S.1    Lecky, B.2
  • 64
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
    • Shepherd J. Blauw G.J. Murphy M.B. Bollen E.L. Buckley B.M. Cobbe S.M. (2002) Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 360: 1623–1630.
    • (2002) Lancet , vol.360 , pp. 1623-1630
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3    Bollen, E.L.4    Buckley, B.M.5    Cobbe, S.M.6
  • 66
    • 0017105491 scopus 로고
    • The age-dependent decrease in creatine kinase and aldolase activities in human striated muscle is not caused by an accumulation of faulty proteins
    • Steinhagen-Thiessen E. Hilz H. (1976) The age-dependent decrease in creatine kinase and aldolase activities in human striated muscle is not caused by an accumulation of faulty proteins. Mech Ageing Dev 5: 447–457.
    • (1976) Mech Ageing Dev , vol.5 , pp. 447-457
    • Steinhagen-Thiessen, E.1    Hilz, H.2
  • 68
    • 53049110571 scopus 로고    scopus 로고
    • Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial
    • Tavazzi L. Maggioni A.P. Marchioli R. Barlera S. Franzosi M.G. Latini R. (2008) Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet 372: 1223–1230.
    • (2008) Lancet , vol.372 , pp. 1223-1230
    • Tavazzi, L.1    Maggioni, A.P.2    Marchioli, R.3    Barlera, S.4    Franzosi, M.G.5    Latini, R.6
  • 69
    • 10044281651 scopus 로고    scopus 로고
    • Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double- blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins
    • Taylor A.J. Sullenberger L.E. Lee H.J. Lee J.K. Grace K.A. (2004) Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double- blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation 110: 3512–3517.
    • (2004) Circulation , vol.110 , pp. 3512-3517
    • Taylor, A.J.1    Sullenberger, L.E.2    Lee, H.J.3    Lee, J.K.4    Grace, K.A.5
  • 70
    • 0037414218 scopus 로고    scopus 로고
    • Statin-associated myopathy
    • Thompson P.D. Clarkson P. Karas R.H. (2003) Statin-associated myopathy. Jama 289: 1681–1690.
    • (2003) Jama , vol.289 , pp. 1681-1690
    • Thompson, P.D.1    Clarkson, P.2    Karas, R.H.3
  • 71
    • 0037097465 scopus 로고    scopus 로고
    • The liver and lovastatin
    • Tolman K.G. (2002) The liver and lovastatin. Am J Cardiol 89: 1374–1380.
    • (2002) Am J Cardiol , vol.89 , pp. 1374-1380
    • Tolman, K.G.1
  • 72
    • 0031962151 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis
    • Weltman M.D. Farrell G.C. Hall P. Ingelman-Sundberg M. Liddle C. (1998) Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 27: 128–133.
    • (1998) Hepatology , vol.27 , pp. 128-133
    • Weltman, M.D.1    Farrell, G.C.2    Hall, P.3    Ingelman-Sundberg, M.4    Liddle, C.5
  • 73
    • 0036708020 scopus 로고    scopus 로고
    • A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin
    • White C.M. (2002) A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin. J Clin Pharmacol 42: 963–970.
    • (2002) J Clin Pharmacol , vol.42 , pp. 963-970
    • White, C.M.1
  • 74
    • 0036291921 scopus 로고    scopus 로고
    • Pharmacokinetic–pharmacodynamic drug interactions with HMG-CoA reducatsae inhibitors
    • Williams D. Feely J. (2002) Pharmacokinetic–pharmacodynamic drug interactions with HMG-CoA reducatsae inhibitors. Clin Pharmacokinet 41: 343–370.
    • (2002) Clin Pharmacokinet , vol.41 , pp. 343-370
    • Williams, D.1    Feely, J.2
  • 75
    • 0037146190 scopus 로고    scopus 로고
    • Combination therapy for combined dyslipidemia
    • Xydakis A.M. Ballantyne C.M. (2002) Combination therapy for combined dyslipidemia. Am J Cardiol 90(10B): 21K–29K.
    • (2002) Am J Cardiol , vol.90 , Issue.10B , pp. 21K-29K
    • Xydakis, A.M.1    Ballantyne, C.M.2


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