Tumor necrosis factor alpha disrupts tight junction assembly

Journal of Surgical Research

Volumn 116, Issue 1, 2004, Pages 14-18

  Poritz, Lisa S ^a   Garver, Kristian I ^a   Tilberg, Anna F ^a   Koltun, Walter A ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Claudin; Crohn's disease; Occludin; Tight junction; Tumor necrosis factor alpha; ZO 1

Indexed keywords

CLAUDIN 1; MONOCLONAL ANTIBODY; OCCLUDIN; PROTEIN ZO1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL MEMBRANE PERMEABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOLYSIS; FRAGMENTATION REACTION; IMMUNOFLUORESCENCE; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; QUALITATIVE ANALYSIS; STAINING; TIGHT JUNCTION; WESTERN BLOTTING;

EID: 0347721125     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-4804(03)00311-1     Document Type: Article

References (19)

1. Stevenson B.R., Silicano J.D., Mooseker M., Goodenough D.A. Identification of ZO-1 a high molecular weight polypeptide associated with the tight junction (zona occludens) in a variety of epithelia . J.Cell. Biol. 103:1986;755.
2. Anderson J.M. Molecular structure of tight junctions and their role in epithelial transport. News Physiol. Sci. 16:2001;126.
3. Schmitz H., Barmeyer C., Fromm M., et al. Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology. 116:1999;301.
4. Gassler N., Rohr C., Schneider A., et al. Inflammatory bowel disease is associated with changes of enterocytic junctions. Am.J. Physiol. Gastrointest. Liver Physio. 281:2001;G216.
5. Poritz L.S., Lynch C.J., Tilberg A.F., Page M.J., Koltun W.A. Decreased Expression of Occludin in the Intestine of Patients With Inflammatory Bowel Disease. FASEB J. 11:1997;A310.
6. Koltun W.A., Tilberg A.F., Page M.J., Poritz L.S. Bowel Permeability is Improved in Crohn's Disease After Ileocolectomy. Dis. Colon Rectum. 41:1998;687.
7. Targan S.R., Hanauer S.B., van Deventer S.J.H., et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor (alpha) for Crohn's disease. N.Engl. J. Med. 337:1997;1029.
8. Present D.H., Rutgeerts P., Targan S., et al. Infliximab for the treatment of fistulas in patients with Crohn's Disease. N.Engl. J. Med. 340:1999;1398.
9. Schmitz H., Fromm M., Bentzel C.J., Scholz P., Detjen K., Mankertz J., Bode H., Epple H., Riecken E., Schulzke J. Tumor necrosis factor-alpha (TNFα) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. Journal of Cell Science. 112:1999;137.
10. Mullin J.M., Snock K.V. Effect of Tumor Necrosis Factor on Epithelial Tight Junctions and Transepithelial Permeability. Cancer Res. 50:1990;2172.
11. Marano C.W., Lewis S.A., Garulacan L.A., Soler A.P., Mullin J.M. Tumor necrosis factor-alpha increases sodium and chloride conductance across the tight junction of CACO-2 BBE, a human intestinal epithelial cell line. J. Membr. Biol. 161:1998;263.
12. Blum M.S., Toninelli E., Anderson J.M., Balda M.S., Zhou A., Odonnell L., Pardi R., Bender J.R. Cytoskeletal rearrangement mediates human microvascular endothelial tight junction modulation by cytokines. Am.J. Physiol. 273:1997;H286.
13. Furuse M., Hirase T., Itoh M., Nagafuchi A., Yonemura S., Tsukita S., Tsukita S. Occludin a novel integral membrane protein localizing at tight junctions . J.Cell. Biol. 123:1993;1777.
14. Fanning A.S., Mitic L.L., Anderson J.M. Transmembrane proteins in the tight junction barrier. J. AM. Soc. Nephrol. 10:1999;1337.
15. Furuse M., Fujita K., Hiiragi T., Fujimoto K., Tsukita S. Claudin-1 and -2 novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin . J.Cell. Biol. 141:1998;1539.
16. Tsukita S., Furuse M. The structure and function of claudins, cell adhesion molecules at tight junctions. Annals New York Academy of Sciences. 915:2000;129.
17. Ozaki H., Ishii K., Horiuchi H., Arai H., Kawamoto T., Okawa K., Iwamatsu A., Kita T. Cutting edge combined treatment of TNF-α and IFN-γ causes redistribution of junctional adhesion molecule in human endothelial cells . J.Immunol. 163:1999;553.
18. Hollander D., Vadheim C.M., Brettholz E., et al. Increased intestinal permeability in patients with Crohn's disease and their relatives a possible etiologic factor. Ann. Intern. Med. 105:1986;883.
19. Siegel S.A., Shealy D.J., Nakada M.T., et al. The mouse human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo. Cytokine. 7:1995;15.