Glutamate-induced free radical formation in rat brain synaptosomes is not dependent on intrasynaptosomal mitochondria membrane potential

Neuroscience Letters

Volumn 513, Issue 2, 2012, Pages 238-242

  Alekseenko, Aleksandra V ^a   Lemeshchenko, Valeriya V ^a   Pekun, Tatyana G ^a   Waseem, Tatyana V ^a   Fedorovich, Sergei V ^a  

^a INSTITUTE OF PHOTOBIOLOGY   (Belarus)

Author keywords

Glutamate; Mitochondria; NADPH oxidase; NMDA; ROS; Synaptosomes

Indexed keywords

DIZOCILPINE; GLUTAMIC ACID; KAINIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; OLIGOMYCIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ROTENONE;

ANIMAL CELL; ARTICLE; BRAIN SYNAPTOSOME; CONTROLLED STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; FREE RADICALS; GLUTAMIC ACID; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEURONS; PROTON IONOPHORES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; ROTENONE; SYNAPTOSOMES; UNCOUPLING AGENTS;

EID: 84858996594     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.02.051     Document Type: Article

References (45)

1. Abramov A.Y., Scorziello A., Duchen M.R. Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J. Neurosci. 2007, 27:1129-1138.
2. Alekseenko A.V., Waseem T.V., Fedorovich S.V. Ferritin, a protein containing iron nanoparticles, induces reactive oxygen species formation and inhibits glutamate uptake in rat brain synaptosomes. Brain Res. 2008, 1241:193-200.
3. Alekseenko A.V., Kolos V.A., Vasim T.V., Fedorovich S.V. Glutamate induces the formation of free radicals in rat brain synaptosomes. Biofizika 2009, 54:876-880. (in Russian).
4. +-ATPase activity in synaptosomes from various brain regions. Neurochem. Res. 1999, 24:1101-1106.
5. Behrens M.M., Ali S.S., Dao D.N., Lucero J., Shekhtman G., Quick K.L., Dugan L.L. Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase. Science 2007, 318:1645-1647.
6. Bedard K., Krause K.-H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol. Rev. 2007, 87:245-313.
7. Brennan A.M., Suh S.W., Won S.J., Narasimhan P., Kauppinen T.M., Lee H., Edling Y., Chan P.H., Swanson R.A. NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nat. Neurosci. 2009, 12:857-863.
8. Breukel A.I.M., Besselsen E., da Silva F.H.L., Ghijsen W.E.J.M. A presynaptic N-methyl-d-aspartate autoreceptor in rat hippocampus modulating amino acid release from a cytoplasmic pool. Eur. J. Neurosci. 1998, 10:106-114.
9. 2+ overload than nonsynaptic mitochondria. J. Biol. Chem. 2006, 281:11658-11668.
10. 2+ rises and consequent oxygen radical production. J. Neurosci. 1998, 18:7727-7738.
11. 2+ overload and ROS generation in spinal motor neurons in vitro. J. Neurosci. 2000, 20:240-250.
12. Choi D.W. Ionic dependence of glutamate neurotoxicity. J. Neurosci. 1987, 7:369-379.
13. DeKosky S.T., Scheff S.W., Styren S.D. Structural correlates of cognition in dementia: quantification and assessment of synaptic changes. Neurodegenaration 1996, 5:417-421.
14. Deliconstantinos G., Villiotou V. NO synthase and xanthine oxidase activities of rabbit brain synaptosomes: peroxynitrite formation as a causative factor of neurotoxicity. Neurochem. Res. 1996, 21:51-56.
15. Dingledine R., Borges K., Bowie D., Traynelis S.F. The glutamate receptor ion channels. Pharm. Rev. 1999, 51:7-61.
16. Dugan L.L., Ali S.S., Shekhtman G., Roberts A.J., Lucero J., Quick K.L., Behrens M.M. IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase. PLoS ONE 2009, 4:e5518.
17. Gunasekar P.G., Kanthasamy A.G., Borowitz J.L., Isom G.E. NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: implication for cell death. J. Neurochem. 1995, 65:2016-2021.
18. Hajos F. An improved method for the preparation of synaptosomal fractions in high purity. Brain Res. 1975, 93:485-489.
19. Halliwell B. Oxidative stress and neurodegeneration: where are we now?. J. Neurochem. 2006, 97:1634-1658.
20. Kumar A., Singh R.L., Babu G.N. Cell death mechanisms in the early stages of acute glutamate neurotoxicity. Neurosci. Res. 2010, 66:271-278.
21. Lafon-Cazal M., Pietri S., Culcasi M., Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature 1993, 364:535-537.
22. Lau A., Tymianski M. Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch. 2010, 460:525-542.
23. LeBel C.P., Bondy S.C. Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes. Neurochem. Int. 1990, 17:435-440.
24. Lipton S.A. Ischemic cell death in brain neurons. Physiol. Rev. 1999, 79:1431-1568.
25. Lipton S.A. Pathologically activated therapeutics for neuroprotection. Nat. Rev. Neurosci. 2007, 8:803-808.
26. Lores-Arnaiz S., Bustamante J. Age-related alterations in mitochondrial physiological parameters and nitric oxide production in synaptic and non-synaptic brain cortex mitochondria. Neuroscience 2011, 188:117-124.
27. Lowry O., Rosenbrough H., Farr H., Randall R. Protein measurements with Folin reagent. J. Biol. Chem. 1951, 193:265-279.
28. McDermott A.B., Role L.W., Siegelbaum S.A. Presynaptic ionotropic receptors and the control of transmitter release. Ann. Rev. Neurosci. 1999, 22:443-485.
29. Mattson M.P., Magnus T. Ageing and neuronal vulnerability. Nat. Rev. Neurosci. 2006, 7:278-294.
30. Perez-De La Cruz V., Konigsberg M., Pedraza-Chaverri J., Herrera-Mundo N., Diaz-Munoz M., Moran J., Fortoul-van der Goes T., Rondan-Zarate A., Maldonado P.D., Ali S.F., Santamaria A. Cytoplasmic calcium mediates oxidative damage in an excitotoxic/energetic deficit synergic model in rats. Eur. J. Neurosci. 2008, 27:1075-1085.
31. Perkinton M.S., Sihra T.S. A high-affinity presynaptic kainate-type glutamate receptor facilitates glutamate exocytosis from cerebral cortex nerve terminals (synaptosomes). Neuroscience 1999, 90:1281-1292.
32. Reynolds I.J., Hastings T.G. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci. 1995, 15:3318-3327.
33. Santamaria A., Galvan-Arzate S., Lisy V., Ali S.F., Duhart H.M., Osorio-Rico L., Rios C., Stastny F. Quinolinic acid induces oxidative stress in rat brain synaptosomes. NeuroReport 2001, 12:871-874.
34. Segueira S.M., Malva J.O., Carvalho A.P., Carvalho C.M. Presynaptic N-methyl-d-aspartate receptor activation inhibits neurotransmitter release through nitric oxide formation in rat hippocampal nerve terminals. Brain Res. Mol. Brain Res. 2001, 89:111-118.
35. Sengpiel B., Preis E., Krieglstein J., Prehn J.H. NMDA-induced superoxide production and neurotoxicity in cultured rat hippocampal neurons: role of mitochondria. Eur. J. Neurosci. 1998, 10:1903-1910.
36. Setsukinai K.-I., Urano Y., Kakinuma K., Majima H.J., Nagano T. Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. J. Biol. Chem. 2003, 278:3170-3175.
37. Tarasenko A., Krupko O., Himmelreich N. Presynaptic kainate and NMDA receptors are implicated in the modulation of GABA release from cortical and hippocampal nerve terminals. Neurochem. Int. 2011, 59:81-89.
38. Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., Hansen L.A., Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 1991, 30:572-580.
39. Tretter L., Chinopoulos C., Adam-Vizi V. Enhanced depolarization-evoked calcium signal and reduced [ATP]/[ADP] ratio are unrelated events induced by oxidative stress in synaptosomes. J. Neurochem. 1997, 69:2529-2537.
40. Vergun O., Keelan J., Khodorov B.I., Duchen M.R. Glutamate-induced mitochondrial depolarization and perturbation of calcium homeostasis in cultured rat hippocampal neurons. J. Physiol. 1999, 519:451-466.
41. Waseem T.V., Konev S.V., Fedorovich S.V. Influence of hypotonic shock on glutamate and GABA uptake in rat brain synaptosomes. Neurochem. Res. 2004, 29:1653-1658.
42. Waseem T.V., Rakovich A.A., Lavrukevich T.V., Konev S.V., Fedorovich S.V. Calcium regulates the mode of exocytosis induced by hypotonic shock in isolated neuronal presynaptic endings. Neurochem. Int. 2005, 46:235-242.
43. Waseem T.V., Kolos V.A., Lapatsina L.P., Fedorovich S.V. Hypertonic shrinking but not hypotonic swelling increases sodium concentration in rat brain synaptosomes. Brain Res. Bull. 2007, 73:135-142.
44. White R.J., Reynolds I.J. Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitation exposure. J. Neurosci. 1996, 16:5688-5697.
45. Wind S., Beuerlein K., Eucker T., Muller H., Scheurer P., Armitage M.E., Ho H., Smidt H.H., Wingler K. Comparative pharmacology of chemically distinct NADPH oxidase. Br. J. Pharmacol. 2010, 161:885-898.