The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury

Environmental Toxicology and Pharmacology

Volumn 34, Issue 1, 2012, Pages 81-86

  Gul, Husamettin ^a   Uysal, Bulent ^a   Cakir, Erdinc ^a   Yaman, Halil ^a   Macit, Enis ^a   Yildirim, Ali Osman ^a   Eyi, Yusuf Emrah ^a   Kaldirim, Umit ^a   Oztas, Emin ^a   Akgul, Emin Ozgur ^a   Cayci, Tuncer ^a   Ozler, Mehmet ^a   Topal, Turgut ^a   Oter, Sukru ^a   Korkmaz, Ahmet ^a   Toygar, Mehmet ^a   Demirbag, Suzi ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

Acetaminophen; Liver injury; Neopterin; Oxidative stress; Ozone therapy

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; NEOPTERIN; OXYGEN; OZONE; PARACETAMOL; SUPEROXIDE DISMUTASE;

ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BLOOD LEVEL; BLOOD SAMPLING; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; HISTOPATHOLOGY; LIVER NECROSIS; LIVER PROTECTION; MALE; NEOPTERIN BLOOD LEVEL; NONHUMAN; OXIDATIVE STRESS; OZONE THERAPY; PRIORITY JOURNAL; RAT; SHAM PROCEDURE; SINGLE DRUG DOSE; TISSUE SECTION; TOXIC HEPATITIS;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; ASPARTATE AMINOTRANSFERASES; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; GLUTATHIONE PEROXIDASE; LIVER; MALE; MALONDIALDEHYDE; NECROSIS; NEOPTERIN; NITRATES; NITRITES; OZONE; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

ANIMALIA; RATTUS;

EID: 84858974683     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2012.02.006     Document Type: Article

References (35)

1. Ajamieh H., Merino N., Candelario-Jalil E., Menendez S., Martinez-Sanchez G., Re L., Giuliani A., Leon O.S. Similar protective effect of ischaemic and ozone oxidative preconditionings in liver ischaemia/reperfusion injury. Pharmacol. Res. 2002, 45:333-339.
2. Alrashed M., Abougoush M., Akgul E., Erbil M., Boyunaga H., Almarafi A., Akman S., Kutluay T. Detection method of serum and urine neopterin levels by high performance liquid chromatography and clinical applications. Gulhane MJ 2002, 44:273-277.
3. Bocci V. A reasonable approach for the treatment of HIV infection in the early phase with ozonetherapy (autohaemotherapy). How 'Inflammatory' cytokines may have A therapeutic role. Mediators Inflamm. 1994, 3:315-321.
4. Bocci V. Does ozone therapy normalize the cellular redox balance? Implications for therapy of human immunodeficiency virus infection and several other diseases. Med. Hypotheses 1996, 46:150-154.
5. Bocci V. Ozone as Janus: this controversial gas can be either toxic or medically useful. Mediators Inflamm. 2004, 13:3-11.
6. Bocci V. Is it true that ozone is always toxic? The end of a dogma. Toxicol. Appl. Pharmacol. 2006, 216:493-504.
7. Bocci V., Luzzi E., Corradeschi F., Paulesu L., Rossi R., Cardaioli E., Di Simplicio P. Studies on the biological effects of ozone. 4. Cytokine production and glutathione levels in human erythrocytes. J. Biol. Regul. Homeost. Agents 1993, 7:133-138.
8. Bocci V., Paulesu L. Studies on the biological effects of ozone. 1. Induction of interferon gamma on human leucocytes. Haematologica 1990, 75:510-515.
9. Bocci V., Valacchi G., Corradeschi F., Fanetti G. Studies on the biological effects of ozone. 8. Effects on the total antioxidant status and on interleukin-8 production. Mediators Inflamm. 1998, 7:313-317.
10. Bocci V., Zanardi I., Travagli V. Has oxygen-ozonetherapy a future in medicine?. J. Exp. Integr. Med. 2011, 1:5-11.
11. Bocci V.A. Scientific and medical aspects of ozone therapy. State of the art. Arch. Med. Res. 2006, 37:425-435.
12. Bruss M., Homann J., Molderings G.J. Dysferlinopathy as an extrahepatic cause for the elevation of serum transaminases. Med. Klin. (Munich) 2004, 99:326-329.
13. Chen H., Xing B., Liu X., Zhan B., Zhou J., Zhu H., Chen Z. Similarities between ozone oxidative preconditioning and ischemic preconditioning in renal ischemia/reperfusion injury. Arch. Med. Res. 2008, 39:169-178.
14. Demirbag S., Uysal B., Guven A., Cayci T., Ozler M., Ozcan A., Kaldirim U., Surer I., Korkmaz A. Effects of medical ozone therapy on acetaminophen-induced nephrotoxicity in rats. Ren. Fail. 2010, 32:493-497.
15. Demirbas S., Cakir E., Akgul E.O., Seyrek M., Cayci T., Kurt Y.G., Uysal B., Aydin I., Kurt B., Yaman H., Erbil M.K. Elevated serum neopterin levels in acetaminophen-induced liver injury. Environ. Toxicol. Pharmacol. 2011, 31:165-170.
16. Durak I., Yurtarslanl Z., Canbolat O., Akyol O. A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction. Clin. Chim. Acta 1993, 214:103-104.
17. Guven A., Gundogdu G., Sadir S., Topal T., Erdogan E., Korkmaz A., Surer I., Ozturk H. The efficacy of ozone therapy in experimental caustic esophageal burn. J. Pediatr. Surg. 2008, 43:1679-1684.
18. Guven A., Gundogdu G., Vurucu S., Uysal B., Oztas E., Ozturk H., Korkmaz A. Medical ozone therapy reduces oxidative stress and intestinal damage in an experimental model of necrotizing enterocolitis in neonatal rats. J. Pediatr. Surg. 2009, 44:1730-1735.
19. Huang L., Heinloth A.N., Zeng Z.B., Paules R.S., Bushel P.R. Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants. BMC Genomics 2008, 9:288.
20. Jollow D.J., Mitchell J.R., Potter W.Z., Davis D.C., Gillette J.R., Brodie B.B. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. 1973, 187:195-202.
21. Kaufmann P., Tilz G.P., Demel U., Wachter H., Kreijs G.J., Fuchs D. Neopterin plasma concentrations predict the course of severe acute pancreatitis. Clin. Chem. Lab. Med. 1998, 36:29-34.
22. Kesik V., Uysal B., Kurt B., Kismet E., Koseoglu V. Ozone ameliorates methotrexate-induced intestinal injury in rats. Cancer Biol. Ther. 2009, 8:1623-1628.
23. Knight T.R., Kurtz A., Bajt M.L., Hinson J.A., Jaeschke H. Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress. Toxicol. Sci. 2001, 62:212-220.
24. Koca K., Yurttas Y., Yildiz C., Cayci T., Uysal B., Korkmaz A. Effect of hyperbaric oxygen and ozone preconditioning on oxidative/nitrosative stress induced by tourniquet ischemia/reperfusion in rat skeletal muscle. Acta Orthop. Traumatol. Turc. 2010, 44:476-483.
25. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
26. Nelson S.D. Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury. Drug Metab. Rev. 1995, 27:147-177.
27. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
28. Pacher P., Beckman J.S., Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol. Rev. 2007, 87:315-424.
29. Pacifici G.M., Back D.J., Orme M.L. Sulphation and glucuronidation of paracetamol in human liver: assay conditions. Biochem. Pharmacol. 1988, 37:4405-4407.
30. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 1967, 70:158-169.
31. Paulesu L., Luzzi E., Bocci V. Studies on the biological effects of ozone. 2. Induction of tumor necrosis factor (TNF-alpha) on human leucocytes. Lymphokine Cytokine Res. 1991, 10:409-412.
32. Re L., Mawsouf M.N., Menendez S., Leon O.S., Sanchez G.M., Hernandez F. Ozone therapy: clinical and basic evidence of its therapeutic potential. Arch. Med. Res. 2008, 39:17-26.
33. Uysal B., Yasar M., Ersoz N., Coskun O., Kilic A., Cayc T., Kurt B., Oter S., Korkmaz A., Guven A. Efficacy of hyperbaric oxygen therapy and medical ozone therapy in experimental acute necrotizing pancreatitis. Pancreas 2010, 39:9-15.
34. Yaman H., Cayci T., Seyrek M., Akgul E., Kurt Y., Aydin I., Yaren H., Cakir E., Ozcan O., Cimen B., Turkozkan N., Erbil M. Effects of vitamin A and C and melatonin on 3-nitrotyrosine formation in guinea pig heart under lipopolysaccharide-induced stress. Turk. J. Med. Sci. 2010, 40:715-721.
35. Yaman H., Isbilir S., Cakir E., Uysal B. Current issues with paracetamol induced toxicity. J. Exp. Integr. Med. 2011, 1:165-166.