Ozone as Janus: This controversial gas can be either toxic or medically useful

Mediators of Inflammation

Volumn 13, Issue 1, 2004, Pages 3-11

  Bocci, Velio ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

Antioxidants; Cytokines; Nitric oxide; Oxidative stress; Ozone; Ozone tolerance

Indexed keywords

AUTACOID; OZONE; TOXIC GAS;

ACUTE DISEASE; ACUTE TOXICITY; ATHEROSCLEROSIS; BACTERIAL INFECTION; BONE DISEASE; CARDIOVASCULAR SYSTEM; CELL ACTIVATION; CHRONIC DISEASE; CHRONIC TOXICITY; ENDOTHELIUM CELL; ERYTHROCYTE; HEMATOLOGIC DISEASE; HUMAN; INFLAMMATION; ISCHEMIA; KIDNEY DISEASE; LEUKOCYTE; LEUKOCYTE ACTIVATION; LUNG DISEASE; MYCOSIS; NERVE DEGENERATION; PARENCHYMA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; SKIN DISEASE; THROMBOCYTE ACTIVATION; TREATMENT INDICATION; VIRUS INFECTION;

ANIMALS; BLOOD PLATELETS; CARDIOVASCULAR SYSTEM; DENTAL CARIES; ENDOTHELIAL CELLS; HUMANS; INFECTION; INTERVERTEBRAL DISK DISPLACEMENT; ISCHEMIA; LEUKOCYTES; MACULAR DEGENERATION; METAPHOR; OSTEOARTHRITIS; OZONE;

BACTERIA (MICROORGANISMS); JANUS;

EID: 2442440009     PISSN: 09629351     EISSN: None     Source Type: Journal    
DOI: 10.1080/0962935062000197083     Document Type: Review

References (76)

1. Wehrli F, Steinbart H. Erfahrungen mit der Haematogenen Oxydations-Therapie (HOT). Ars Medici 1954; 10: 44-51.
2. Wolff HH. Die Behandlung peripherer Durchblutungsstörungen mit Ozon. Erfahr Hk 1974; 23: 181-184.
3. Bocci V. Oxygen-ozone Therapy. A Critical Evaluation, Dordrect: Kluwer Academic Publishers, 2002.
4. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991; 11: 81-128.
5. 2 gradients across biomembranes. FEBS Lett 2000; 475: 121-126.
6. Stone JR, Collins T. The role of hydrogen peroxide in endothelial proliferative responses. Endothelium 2002; 9: 231-238.
7. Miller NJ, Rice-Evans C, Davies MJ, Gopinathan V, Milner A. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci 1993; 84: 407-412.
8. May JM, Qu Z-C, Whitesell RR, Cobb CE. Ascorbate recycling in human erythrocytes: role of GSH in reducing dehydroascorbate. Free Radic Biol Med 1996; 20: 543-551.
9. Mendiratta S, Qu ZC, May JM. Erythrocyte ascorbate recycling: antioxidant effects in blood. Free Radic Biol Med 1998; 24: 789-797.
10. Buege JA, Aust SD. Microsomal lipid peroxidation. Meth Enzymol 1978; 52: 302-310.
11. Hu ML. Measurement of protein thiol groups and glutathione in plasma. Meth Enzymol 1994; 233: 380-385.
12. Goldstein BD, Balchum OJ. Effect of ozone on lipid peroxidation in the red blood cell. Proc Soc Exp Biol Med 1967; 126: 356-358.
13. Freeman BA, Miller BE, Mudd JB. Reaction of ozone with human erythrocytes. In: Lee SD, Mudd JB, eds. Assessing Toxic Effects of Environmental Pollutants, Ann Arbor, MI: Ann Arbor Science Publishers, 1979: 151-171.
14. Uppu RM, Cueto R, Squadrito GL, Pryor WA. What does ozone react with at the air/lung interface? Model studies using human red blood cell membranes. Arch Biochem Biophys 1995; 319: 257-266.
15. Gòrnicki A, Gutsze A. In vitro effects of ozone on human erythrocyte membranes: an EPR study. Acta Biochim Pol 2000; 47: 963-971.
16. Shinriki N, Suzuki T, Takama K, Fukunaga K, Ohgiya S, Kubota K, Miura T. Susceptibilities of plasma antioxidants and erythrocyte constituents to low levels of ozone. Haematologia (Budap) 1998; 29: 229-239.
17. Bocci V, Luzzi E, Corradeschi F, Paulesu L, Rossi R, Cardaioli E, Di Simplicio P. Studies on the biological effects of ozone: 4. Cytokine production and glutathione levels in human erythrocytes. J Biol Regulat Homeost Agents 1993; 7: 133-138.
18. Bocci V, Valacchi G, Corradeschi F, Aldinucci C, Silvestri S, Paccagnini E, Gerli R. Studies on the biological effects of ozone: 7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone. J Biol Regulat Homeost Agents 1998; 12: 67-75.
19. Clemens MR, Waller HD. Lipid peroxidation in erythrocytes. Chem Phys Lipids 1987; 45: 251-268.
20. Machlin LJ, Bendich A. Free radical tissue damage: protective role of antioxidant nutrients. FASEB J 1987; 1: 441-445.
21. Galleano M, Puntarulo S. Role of antioxidants on the erythrocytes resistance to lipid peroxidation after acute iron overload in rats. Biochim Biophys Acta 1995; 1271: 321-326.
22. Mudd JB, Dawson PJ, Santrock J. Ozone does not react with human erythrocyte membrane lipids. Arch Biochem Biophys 1997; 341: 251-258.
23. Zimran A, Wasser G, Forman L, Gelbart T, Beutler E. Effect of ozone on red blood cell enzymes and intermediates. Acta Haematol 1999; 102: 148-151.
24. Cross CE, Motchnik PA, Bruener BA, Jones DA, Kaur H, Ames BN, Halliwell B. Oxidative damage to plasma constituents by ozone. FEBS Lett 1992; 298: 269-272.
25. Bocci V, Larini A, Micheli V. A constant restoration of normoxia may control neoplastic growth. A reappraisal of an old approach. Cancer Invest 2004; in press.
26. Diadori A, Bocci V, Carraro F, et al. Ozonetherapy and age-related macular degeneration: a pilot study. In: Ceccherelli F, Giron F, eds. L'Ozonoterapia nel 2000, Torino: Edizioni Libreria Cortina, 2000: 33-45.
27. Viebahn R. The Use of Ozone in Medicine, Iffezheim: ODREI Publishers, 1999: 1-148.
28. Akioka K, Shiratori R, Kaneko Y, Ogawa S. Mechanisms of action of ozone in maintaining energy metabolism in hemorrhagic shock. Nihon Univ J Med 2002; 44: 123-133.
29. Bocci V, Paulesu L. Studies on the biological effects of ozone 1. Induction of interferon gamma on human leucocytes. Haematologica 1990; 75: 510-515.
30. Bocci V, Luzzi E, Corradeschi F, Paulesu L, Di Stefano A. Studies on the biological effects of ozone: 3. An attempt to define conditions for optimal induction of cytokines. Lymphokine Cytokine Res 1993; 12: 121-126.
31. Bocci V, Valacchi G, Corradeschi F, Fanetti G. Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production. Mediat Inflamm 1998; 7: 313-317.
32. Arsalane K, Gosset P, Vanhee D, Voisin C, Hamid Q, Tonnel AB, Wallaert B. Ozone stimulates synthesis of inflammatory cytokines by alveolar macrophages in vitro. Am J Respir Cell Mol Biol 1995; 13: 60-68.
33. Van Hoof HJM, Zijlstra FJ, Voss H-P, Garrelds IM, Dormans JAMA, Van Bree L, Bast A. The effect of ozone exposure on the release of eicosanoids in guinea-pig BAL fluid in relation to cellular damage and inflammation. Mediat Inflamm 1997; 6: 355-361.
34. Bayram H, Sapsford RJ, Abdelaziz MM, Khair OA. Effect of ozone and nitrogen dioxide on the release of proinflammatory mediators from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients in vitro. J Allergy Clin Immunol 2001; 107: 287-294.
35. Cho HY, Zhang LY, Kleeberger SR. Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-alpha receptors. Am J Physiol Lung Cell Mol Physiol 2001; 280: L537-L546.
36. Reth M. Hydrogen peroxide as second messenger in lymphocyte activation. Nat Immunol 2002; 3: 1129-1134.
37. Verma IM, Stevenson J. IkappaB kinase: beginning, not the end. Proc Natl Acad Sci USA 1997; 94: 11758-11760.
38. Soberman RJ. The expanding network of redox signaling: new observations, complexities, and perspectives. J Clin Invest 2003; 111: 571-574.
39. Bocci V, Luzzi E, Corradeschi F, Paulesu L. Studies on the biological effects of ozone: 5. Evaluation of immunological parameters and tolerability in normal volunteers receiving ambulatory autohaemotherapy. Biotherapy 1994; 7: 83-90.
40. Hernandez F, Menendez S, Wong R. Decrease of blood cholesterol and stimulation of antioxidative response in cardiopathy patients treated with endovenous ozone therapy. Free Radic Biol Med 1995; 19: 115-119.
41. Bocci V. Does ozone therapy normalize the cellular redox balance? Med Hypotheses 1996; 46: 150-154.
42. Sharma YK, Davis KR. The effects of ozone on antioxidant responses in plants. Free Radic Biol Med 1997; 23: 480-488.
43. León OS, Menéndez S, Merino N, et al. Ozone oxidative preconditioning: a protection against cellular damage by free radicals. Mediat Inflamm 1998; 7: 289-294.
44. Csonka C, Pataki T, Kovacs P, Muller SL, Schroeter ML, Tosaki A, Blasig IE. Effects of oxidative stress on the expression of antioxidative defense enzymes in spontaneously hypertensive rat hearts. Free Radic Biol Med 2000; 29: 612-619.
45. Maresca M, Colao C, Leoncini G. Generation of hydrogen peroxide in resting and activated platelets. Cell Biochem Funct 1992; 10: 79-85.
46. Iuliano L, Colavita AR, Leo R, Praticò D, Violi F. Oxygen free radicals and platelet activation. Free Radic Biol Med 1997; 22: 999-1006.
47. Bocci V, Valacchi G, Rossi R, Giustarini D, Paccagnini E, Pucci AM, Di Simplicio P. Studies on the biological effects of ozone: 9. Effects of ozone on human platelets. Platelets 1999; 10: 110-116.
48. Valacchi G, Bocci V. Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets. Mediat Inflamm 1999; 8: 205-209.
49. Rokitansky O, Rokitansky A, Steiner J, Trubel W, Viebahn R, Washüttl J. Die Ozontherapie bei peripheren, arteriellen Durchblutungs-störungen; klinik, biochemische und blutgasanalytische Untersuchungen. In: Wasser IOA, Berlin: Ozon-Weltkongress, 1981: 53-75.
50. Werkmeister H. Dekubitalgeschwüre und die Behandlung mit der Ozon-Unterdruckbegasung. In: Beck EG, Viebahn-Hänsler R, eds. Ozon-Handbuch. Grundlagen. Prävention. Therapie, Landsberg: Ecomed, 1995: V-7.1 1-V-7.1 22.
51. Valacchi G, Bocci V. Studies on the biological effects of ozone: 11. Release of factors from human endothelial cells. Mediat Inflamm 2000; 9: 271-276.
52. Wink DA, Grisham MB, Mitchell JB, Ford PC. Direct and indirect effects of nitric oxide in chemical reactions relevant to biology. Methods Enzymol 1996; 268: 12-31.
53. Jia L, Bonaventura C, Bonaventura J, Stamler JS. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature 1996; 380: 221-226.
54. Pawloski JR, Hess DT, Stamler JS. Export by red blood cells of nitric oxide bioactivity. Nature 2001; 409: 622-626.
55. Benson H, Friedman R. Harnessing the power of the placebo effect and renaming it 'remembered wellness'. Annu Rev Med 1996; 47: 193-199.
56. Snyder SH, Baranano DE. Heme oxygenase: a font of multiple messengers. Neuropsychopharmacology 2001; 25: 294-298.
57. Lee TS, Chau LY. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med 2002; 8: 240-246.
58. Hamilton KL, Staib JL, Phillips T, Hess A, Lennon SL, Powers SK. Exercise, antioxidants, and HSP72: protection against myiocardial ischemia/reperfusion. Free Radic Biol Med 2003; 34: 800-809.
59. Wagner M, Cadetg P, Ruf R, Mazzucchelli L, Ferrari P, Redaelli CA. Heme oxygenase-1 attenuates ischemia/reperfusion-induced apoptosis and improves survival in rat renal allografts. Kidney Int 2003; 63: 1564-1573.
60. Babior BM, Takeuchi C, Ruedi J, Gutierrez A, Wentworth P. Investigating antibody-catlyzed ozone generation by human neutrophils. Proc Natl Acad Sci USA 2003; 100: 3031-3034.
61. Bocci V. Biological and clinical effects of ozone. Has ozonetherapy a future in medicine? Br J Biomed Sci 1999; 56: 270-279.
62. Menéndez S, Falcon L, Simon DR, Landa N. Efficacy of ozonized sunflower oil in the treatment of tinea pedis. Mycoses 2002; 45: 329-332.
63. Giunta R, Coppola C, Luongo C, et al. Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissues in patients with peripheral occlusive arterial disease. Ann Hematol 2001; 80: 745-748.
64. Mattassi R, D'Angelo F, Bisetti P, Colombo R, Vaghi M. Terapia con ozono per via parenterale nelle arteriopatie obliteranti periferiche: meccanismo biochimico e risultati clinici. Il Giornale Di Chirurgia 1987; VIII: 109-111.
65. Tylicki L, Niewglowski T, Biedunkiewicz B, Burakoski S, Rutkows B. Beneficial clinical effects of ozonated autohemotherapy in chronically dialysed patients with atherosclerotic ischemia of the lower limbs-pilot study. Int J Artif Organs 2001; 24: 79-82.
66. Di Paolo N, Bocci V, Garosi G, et al. Extracorporeal blood oxigenation and ozonation (EBOO) in man. Preliminary report. Int J Artif Organs 2000; 23: 131-141.
67. Lippman M. Health effects of ozone, a critical review. J Am Air Pollut Control Assoc 1989; 39: 672-695.
68. Andreula CF, Simonetti L, De Santis F, Agati R, Ricci R, Leonardi M. Minimally invasive oxygen-ozone therapy for lumbar disk hernation. Am J Neuroradiol 2003; 24: 996-1000.
69. Siemsen CH. Ozon-Anwendung bei akuten und chronischen Gelenkerkrankungen. In: Beck EG, Viebahn-Hänsler R, eds. Ȯzon-Handbuch. Grundlagen. Prävention. Therapie, Landsberg: Ecomed, 1995: V-9.2 1-V-9.2 14.
70. Goldman M. Cancer risk of low-level exposure. Science 1996; 271: 1821-1822.
71. Tracey KJ. The inflammatory reflex. Nature 2002; 420: 853-859.
72. Baysan A, Whiley RA, Lynch E. Antimicrobial effect of a novel ozone-generating device on micro-organisms associated with primary root carious lesions in vitro. Caries Res 2000; 34: 498-501.
73. Bocci V. Ozonetherapy as a possible biological response modifier in cancer. Forsch Komplementärmed 1998; 5: 54-60.
74. Leist M, Raab B, Maurer S, Brigelius-Flohé R. Conventional cell culture media do not adequately supply cells with antioxidants and thus facilitate peroxide-induced genotoxicity. Free Radic Biol Med 1996; 21: 297-306.
75. Dìaz-Llera S, Gonzàlez-Hernàndez Y, Prieto-Gonzàlez EA, Azoy A. Genotoxic effect of ozone in human peripheral blood leukocytes. Mutat Res 2002; 517: 13-20.
76. Jacobs M-T. Untersuchung uber Zwischenfalle und typische Komplikationen in der Ozon-Sauerstoff-Therapie. OzoNachrichten 1982; 1: 5.