The immunoregulatory effects of CMV-infection in human fibroblasts and the impact on cellular senescence

Immunity and Ageing

Volumn 9, Issue , 2012, Pages

  Wolf, Juliane ^a   Weinberger, Birgit ^a   Grubeck Loebenstein, Beatrix ^a  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

Aging; Cytomegalovirus; Fibroblasts; Replicative senescence

Indexed keywords

ADAPTIVE IMMUNITY; ARTICLE; CELL AGING; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; HUMAN; HUMAN CELL; IMMUNOREGULATION; INNATE IMMUNITY; LUNG FIBROBLAST; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

EID: 84858956028     PISSN: None     EISSN: 17424933     Source Type: Journal    
DOI: 10.1186/1742-4933-9-1     Document Type: Article

References (18)

1. Crough T, Khanna R. Immunobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol Rev 2009, 22:76-98. 10.1128/CMR.00034-08, 2620639, 19136435.
2. Landolfo S, Gariglio M, Gribaudo G, Lembo D. The human cytomegalovirus. Pharmacol Ther 2003, 98:269-297. 10.1016/S0163-7258(03)00034-2, 12782241.
3. Arnold CR, Wolf J, Brunner S, Herndler-Brandstetter D, Grubeck-Loebenstein B. Gain and loss of T cell subsets in old age-age-related reshaping of the T cell repertoire. J Clin Immunol 2011, 31:137-146. 10.1007/s10875-010-9499-x, 21243520.
4. Ibanez CE, Schrier R, Ghazal P, Wiley C, Nelson JA. Human cytomegalovirus productively infects primary differentiated macrophages. J Virol 1991, 65:6581-6588. 250717, 1658363.
5. Myerson D, Hackman RC, Nelson JA, Ward DC, McDougall JK. Widespread presence of histologically occult cytomegalovirus. Hum Pathol 1984, 15:430-439. 10.1016/S0046-8177(84)80076-3, 6327494.
6. Sinzger C, Kahl M, Laib K, Klingel K, Rieger P, Plachter B, Jahn G. Tropism of human cytomegalovirus for endothelial cells is determined by a post-entry step dependent on efficient translocation to the nucleus. J Gen Virol 2000, 81:3021-3035.
7. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997, 88:593-602. 10.1016/S0092-8674(00)81902-9, 9054499.
8. Noris E, Zannetti C, Demurtas A, Sinclair J, De Andrea M, Gariglio M, Landolfo S. Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence. J Virol 2002, 76:12135-12148. 10.1128/JVI.76.23.12135-12148.2002, 136868, 12414954.
9. Zannetti C, Mondini M, De Andrea M, Caposio P, Hara E, Peters G, Gribaudo G, Gariglio M, Landolfo S. The expression of p16INK4a tumor suppressor is upregulated by human cytomegalovirus infection and required for optimal viral replication. Virology 2006, 349:79-86. 10.1016/j.virol.2006.01.042, 16504234.
10. Shelton DN, Chang E, Whittier PS, Choi D, Funk WD. Microarray analysis of replicative senescence. Curr Biol 1999, 9:939-945. 10.1016/S0960-9822(99)80420-5, 10508581.
11. Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000, 908:244-254.
12. Giunta B, Fernandez F, Nikolic WV, Obregon D, Rrapo E, Town T, Tan J. Inflammaging as a prodrome to Alzheimer's disease. J Neuroinflammation 2008, 5:51. 10.1186/1742-2094-5-51, 2615427, 19014446.
13. Campisi J. The role of cellular senescence in skin aging. J Investig Dermatol Symp Proc 1998, 3:1-5. 10.1038/jidsp.1998.2, 9732048.
14. Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008, 6:2853-2868. 2592359, 19053174.
15. Brunner S, Herndler-Brandstetter D, Weinberger B, Grubeck-Loebenstein B. Persistent viral infections and immune aging. Ageing Res Rev 2011, 10:362-369. 10.1016/j.arr.2010.08.003, 20727987.
16. Schmaltz HN, Fried LP, Xue QL, Walston J, Leng SX, Semba RD. Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. J Am Geriatr Soc 2005, 53:747-754. 10.1111/j.1532-5415.2005.53250.x, 15877548.
17. van der Loo B, Fenton MJ, Erusalimsky JD. Cytochemical detection of a senescence-associated beta-galactosidase in endothelial and smooth muscle cells from human and rabbit blood vessels. Exp Cell Res 1998, 241:309-315. 10.1006/excr.1998.4035, 9637772.
18. Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000, 132:365-386.