Mesh biocompatibility: Effects of cellular inflammation and tissue remodelling

Langenbeck's Archives of Surgery

Volumn 397, Issue 2, 2012, Pages 255-270

  Junge, Karsten ^a   Binnebösel, Marcel ^a   Von Trotha, Klaus T ^a   Rosch, Raphael ^a   Klinge, Uwe ^a   Neumann, Ulf P ^a   Jansen, Petra Lynen ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Foreign body reaction; Inflammation; Mesh biocompatability

Indexed keywords

BIOMATERIAL; CEFAMANDOLE; DOXYCYCLINE; GENTAMICIN; INFLIXIMAB; MATRIX METALLOPROTEINASE; POLYMER; REAGENT;

ABSORPTION; BIOCOMPATIBILITY; CELL ACTIVITY; CELL MIGRATION; CELL TYPE; CELLULAR INFLAMMATION; CHEMICAL COMPOSITION; CHEMICAL MODIFICATION; CHRONIC INFLAMMATION; DEVICE INFECTION; DISEASE COURSE; ELASTICITY; EXTRACELLULAR MATRIX; FIBROSIS; FOREIGN BODY GRANULOMA; FOREIGN BODY REACTION; GIANT CELL; HERNIA; HERNIOPLASTY; HUMAN; IMMUNOMODULATION; IMPLANT; IMPLANTATION; INFECTION PREVENTION; INFLAMMATION; LAPAROSCOPIC SURGERY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PATHOPHYSIOLOGY; PHYSICAL CHEMISTRY; POROSITY; PRIORITY JOURNAL; PROTEIN ABSORPTION; REVIEW; SCAR FORMATION; SURGICAL EQUIPMENT; SURGICAL TECHNIQUE; TISSUE DIFFERENTIATION; TISSUE INTERACTION; TISSUE STRUCTURE; TREATMENT INDICATION; WOUND HEALING;

ANIMALS; BIOCOMPATIBLE MATERIALS; EXTRACELLULAR MATRIX; FEMALE; FOREIGN-BODY REACTION; GIANT CELLS, FOREIGN-BODY; GRANULOMA, FOREIGN-BODY; HUMANS; IMMUNITY, CELLULAR; INFLAMMATION; MALE; MATERIALS TESTING; POLYMERS; PROSTHESES AND IMPLANTS; PROSTHESIS-RELATED INFECTIONS; REGENERATION; RISK ASSESSMENT; SURGICAL MESH; SURGICAL PROCEDURES, OPERATIVE;

EID: 84858859785     PISSN: 14352443     EISSN: 14352451     Source Type: Journal    
DOI: 10.1007/s00423-011-0780-0     Document Type: Review

References (196)

1. Williams DF (2008) On the mechanisms of biocompatibility. Biomaterials 29:2941-2953
2. Brown CN, Finch JG (2010) Which mesh for hernia repair? Ann R Coll Surg Engl 92:272-278
3. Welty G, Klinge U, Klosterhalfen B, Kasperk R, Schumpelick V (2001) Functional impairment and complaints following incisional hernia repair with different polypropylene meshes. Hernia 5:142-147 (Pubitemid 33039809)
4. Lange B, Langer C, Markus PM, Becker H (2003) Mesh penetration of the sigmoid colon following a transabdominal preperitoneal hernia repair. Surg Endosc 17:157
5. Conze J, Rosch R, Klinge U, Weiss C, Anurov M, Titkowa S, Oettinger A, Schumpelick V (2004) Polypropylene in the intra-abdominal position: influence of pore size and surface area. Hernia 8:365-372 (Pubitemid 39530577)
6. Conze J, Klinge U, Schumpelick V (2006) Evidenzbasierte laparoskopische Chirurgie - Narbenhernie. Viszeralchirurgie 41:246-252 (Pubitemid 44306229)
7. Leber GE, Garb JL, Alexander AI, Reed WP (1998) Long-term complications associated with prosthetic repair of incisional hernias. Arch Surg 133:378-382 (Pubitemid 28193521)
8. Robinson TN, Clarke JH, Schoen J,WalshMD (2005) Major mesh-related complications following hernia repair: events reported to the food and drug administration. Surg Endosc 19:1556-1560 (Pubitemid 41719519)
9. Simons MP, Aufenacker T, Bay-Nielsen M, Bouillot JL, Campanelli G, Conze J, de Lange D, Fortelny R, Heikkinen T, Kingsnorth A, Kukleta J, Morales-Conde S, Nordin P, Schumpelick V, Smedberg S, Smietanski M, Weber G, Miserez M (2009) European Hernia society guidelines on the treatment of inguinal hernia in adult patients. Hernia 13:343-403
10. Klinge U (2008) Mesh for hernia repair. Br J Surg 95:539-540
11. Usher F, JL O, Tuttle LJ (1958) Use of Marlex mesh in the repair of incisional hernias. Am Surg 24:969-974
12. Klinge U, Junge K, Stumpf M, AP AP, Klosterhalfen B (2002) Functional and morphological evaluation of a low-weight, monofilament polypropylene mesh for hernia repair. J Biomed Mater Res 63:129-136 (Pubitemid 34263856)
13. Klinge U, Klosterhalfen B, Birkenhauer V, Junge K, Conze J, Schumpelick V (2002) Impact of polymer pore size on the interface scar formation in a rat model. J Surg Res 103:208-214 (Pubitemid 34948503)
14. Klinge U, Klosterhalfen B, Conze J, Limberg W, Obolenski B, Ottinger AP, Schumpelick V (1998) Modified mesh for hernia repair that is adapted to the physiology of the abdominal wall. Eur J Surg 164:951-960 (Pubitemid 29057879)
15. Horstmann R, Hellwig M, Classen C, Rottgermann S, Palmes D (2006) Impact of polypropylene amount on functional outcome and quality of life after inguinal hernia repair by the TAPP procedure using pure, mixed, and titanium-coated meshes. World J Surg 30:1742-1749 (Pubitemid 44411233)
16. O'dwyer PJ, Kingsnorth AN, Molloy RG, Small PK, Lammers B, Horeyseck G (2005) Randomized clinical trial assessing impact of a lightweight or heavyweight mesh on chronic pain after inguinal hernia repair. Br J Surg 92:166-170
17. Bringman S, Wollert S, Osterberg J, Smedberg S, Granlund H, Heikkinen TJ (2006) Three-year results of a randomized clinical trial of lightweight or standard polypropylene mesh in Lichtenstein repair of primary inguinal hernia. Br J Surg 93:1056-1059 (Pubitemid 44343501)
18. Nienhuijs S, Staal E, Strobbe L, Rosman C, Groenewoud H, Bleichrodt R (2007) Chronic pain after mesh repair of inguinal hernia: a systematic review. Am J Surg 194:394-400 (Pubitemid 47212052)
19. Conze J, Krones CJ, Schumpelick V, Klinge U (2007) Incisional hernia: challenge of re-operations after mesh repair. Langenbecks Arch Surg 392:453-457 (Pubitemid 46911417)
20. Conze J, Binnebosel M, Junge K, Schumpelick V (2010) Incisional hernia-how do I do it? Standard surgical approach. Chirurg 81:192-200
21. Klinge U, Junge K, Mertens PR (2004) Herniosis: a biological approach. Hernia 8:300-301 (Pubitemid 39530565)
22. Klinge U, Krones CJ (2005) Can we be sure that the meshes do improve the recurrence rates? Hernia 9:1-2 (Pubitemid 40403496)
23. Nilsson B, Korsgren O, Lambris JD, Ekdahl KN (2010) Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition? Trends Immunol 31:32-38
24. Morais JM, Papadimitrakopoulos F, Burgess DJ (2010) Biomaterials/tissue interactions: possible solutions to overcome foreign body response. AAPS J 12:188-196
25. Junge K, Rosch R, Klinge U, Krones C, Klosterhalfen B, Mertens PR, Lynen P, Kunz D, Preiss A, Peltroche-Llacsahuanga H, Schumpelick V (2005) Gentamicin supplementation of polyvinylidenfluoride mesh materials for infection prophylaxis. Biomaterials 26:787-793 (Pubitemid 39179963)
26. Franz MG, Kuhn MA, Nguyen K, Wang X, Ko F, Wright TE, Robson MC (2001) Transforming growth factor beta(2) lowers the incidence of incisional hernias. J Surg Res 97:109-116 (Pubitemid 34948478)
27. Anderson JM, Rodriguez A, Chang DT (2008) Foreign body reaction to biomaterials. Semin Immunol 20:86-100
28. Wilson CJ, Clegg RE, Leavesley DI, Pearcy MJ (2005) Mediation of biomaterial-cell interactions by adsorbed proteins: a review. Tissue Eng 11:1-18 (Pubitemid 40515171)
29. Jenney CR, Anderson JM (2000) Adsorbed IgG: a potent adhesive substrate for humanmacrophages. J Biomed Mater Res 50:281-290 (Pubitemid 30180720)
30. Jenney CR, Anderson JM (2000) Adsorbed serum proteins responsible for surface dependent human macrophage behavior. J Biomed Mater Res 49:435-447 (Pubitemid 30030463)
31. Andersson J, Ekdahl KN, Larsson R, Nilsson UR, Nilsson B (2002) C3 adsorbed to a polymer surface can form an initiating alternative pathway convertase. J Immunol 168:5786-5791 (Pubitemid 34556164)
32. Tengvall P, Askendal A, Lundstrom I (2001) I Ellipsometric in vitro studies on the activation of complement by human immunoglobulins M and G after adsorption to methylated silicon. Colloids Surf B Biointerfaces 20:51-62 (Pubitemid 33646415)
33. Vroman L, Adams AL, Klings M (1971) Interactions among human blood proteins at interfaces. Fed Proc 30:1494-1502
34. Xu LC, Siedlecki CA (2007) Effects of surface wettability and contact time on protein adhesion to biomaterial surfaces. Biomaterials 28:3273-3283
35. Brash JL, Lyman DJ (1969) Adsorption of plasma proteins in solution to uncharged, hydrophobic polymer surfaces. J Biomed Mater Res 3:175-189
36. Krishnan A, Cha P, Liu YH, Allara D, Vogler EA (2006) Interfacial energetics of blood plasma and serum adsorption to a hydrophobic self-assembled monolayer surface. Biomaterials 27:3187-3194 (Pubitemid 43344332)
37. Nilsson B, Ekdahl KN, Mollnes TE, Lambris JD (2007) The role of complement in biomaterial-induced inflammation. Mol Immunol 44:82-94 (Pubitemid 44647107)
38. Gorbet MB, Sefton MV (2004) Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes. Biomaterials 25:5681-5703 (Pubitemid 38624449)
39. Broughton G, Janis JE, Attinger CE (2006) The basic science of wound healing. Plast Reconstr Surg 117:12S-34S (Pubitemid 44317769)
40. Rhodes NP, Hunt JA, Williams DF (1997) Macrophage subpopulation differentiation by stimulation with biomaterials. J Biomed Mater Res 37:481-8 (Pubitemid 27514855)
41. Charo IF, Ransohoff RM (2006) The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354:610-621 (Pubitemid 43209108)
42. Kyriakides TR, Foster MJ, Keeney GE, Tsai A, Giachelli CM, Clark-Lewis I, Rollins BJ, Bornstein P (2004) The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation. Am J Pathol 165:2157-2166 (Pubitemid 39578392)
43. Jones JA, Chang DT, Meyerson H, Colton E, Kwon IK, Matsuda T, Anderson JM (2007) Proteomic analysis and quantification of cytokines and chemokines from biomaterial surface-adherent macrophages and foreign body giant cells. J Biomed Mater Res A 83:585-596 (Pubitemid 350086284)
44. Esche C, Stellato C, Beck LA (2005) Chemokines: key players in innate and adaptive immunity. J Invest Dermatol 125:615-628
45. Brodbeck WG, Colton E, Anderson JM (2003) Effects of adsorbed heat labile serum proteins and fibrinogen on adhesion and apoptosis of monocytes/ macrophages on biomaterials. J Mater Sci Mater Med 14:671-675 (Pubitemid 36976213)
46. McNally AK, Anderson JM (1994) Complement C3 participation in monocyte adhesion to different surfaces. Proc Natl Acad Sci USA 91:10119-10123
47. Gallant ND, Garcia AJ (2007) Model of integrin-mediated cell adhesion strengthening. J Biomech 40:1301-1309 (Pubitemid 46505142)
48. Delon I, Brown NH (2007) Integrins and the actin cytoskeleton. Curr Opin Cell Biol 19:43-50 (Pubitemid 46123977)
49. Giancotti FG, Ruoslahti E (1999) Integrin signaling. Science 285:1028-1032
50. McNally AK, Anderson JM (2002) Beta1 and beta2 integrins mediate adhesion during macrophage fusion and multinucleated foreign body giant cell formation. Am J Pathol 160:621-630 (Pubitemid 34160340)
51. Rose DM, Alon R, Ginsberg MH (2007) Integrin modulation and signaling in leukocyte adhesion and migration. Immunol Rev 218:126-134 (Pubitemid 47052306)
52. Damsky CH, Ilic D (2002) Integrin signaling: it's where the action is. Curr Opin Cell Biol 14:594-602 (Pubitemid 35247743)
53. Frisch SM, Screaton RA (2001) Anoikis mechanisms. Curr Opin Cell Biol 13:555-562 (Pubitemid 32817013)
54. Brodbeck WG, Patel J, Voskerician G, Christenson E, Shive MS, Nakayama Y, Matsuda T, Ziats NP, Anderson JM (2002) Biomaterial adherent macrophage apoptosis is increased by hydrophilic and anionic substrates in vivo. Proc Natl Acad Sci USA 99:10287-10292
55. DeFife KM, Jenney CR, McNally AK, Colton E, Anderson JM (1997) Interleukin-13 induces human monocyte/macrophage fusion and macrophage mannose receptor expression. J Immunol 158:3385-3390 (Pubitemid 127484058)
56. Helming L, Gordon S (2007) Macrophage fusion induced by IL-4 alternative activation is a multistage process involving multiple target molecules. Eur J Immunol 37:33-42 (Pubitemid 46128784)
57. Jones JA, Dadsetan M, Collier TO, Ebert M, Stokes KS, Ward RS, Hiltner PA, Anderson JM (2004) Macrophage behavior on surface-modified polyurethanes. J Biomater Sci Polym Ed 15:567-584 (Pubitemid 38832581)
58. Helming L, Gordon S (2009) Molecular mediators of macrophage fusion. Trends Cell Biol 19:514-522
59. Henson PM (1971) The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles. J Immunol 107:1535-1546
60. Henson PM (1971) The immunologic release of constituents from neutrophil leukocytes. II. Mechanisms of release during phagocytosis, and adherence to nonphagocytosable surfaces. J Immunol 107:1547-1557
61. Cozad MJ, Grant DA, Bachman SL, Grant DN, Ramshaw BJ, Grant SA (2010) Materials characterization of explanted polypropylene, polyethylene terephthalate, and expanded polytetrafluoroethylene composites: spectral and thermal analysis. J Biomed Mater Res B Appl Biomater 94:455-462
62. Martin P, Leibovich SJ (2005) Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol 15:599-607 (Pubitemid 41619424)
63. Li AG, Quinn MJ, Siddiqui Y, Wood MD, Federiuk IF, Duman HM, Ward WK (2007) Elevation of transforming growth factor beta (TGFbeta) and its downstream mediators in subcutaneous foreign body capsule tissue. J Biomed Mater Res A 82:498-508 (Pubitemid 47051682)
64. Higgins DM, Basaraba RJ, Hohnbaum AC, Lee EJ, Grainger DW, Gonzalez-Juarrero M (2009) Localized immunosuppressive environment in the foreign body response to implanted biomaterials. Am J Pathol 175:161-170
65. Ward WK, Li AG, Siddiqui Y, Federiuk IF, Wang XJ (2008) Increased expression of Interleukin-13 and connective tissue growth factor, and their potential roles during foreign body encapsulation of subcutaneous implants. J Biomater Sci Polym Ed 19:1065-1072 (Pubitemid 351957391)
66. Yu Q, Stamenkovic I (2000) Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 14:163-176 (Pubitemid 30070982)
67. Xue M, Le NT, Jackson CJ (2006) Targeting matrix metalloproteases to improve cutaneous wound healing. Expert Opin Ther Targets 10:143-155 (Pubitemid 43263272)
68. Le NT, Xue M, Castelnoble LA, Jackson CJ (2007) The dual personalities of matrix metalloproteinases in inflammation. Front Biosci 12:1475-1487 (Pubitemid 46846846)
69. Ravi A, Garg P, Sitaraman SV (2007) Matrix metalloproteinases in inflammatory bowel disease: boon or a bane? Inflamm Bowel Dis 13:97-107 (Pubitemid 46080015)
70. Visse R, Nagase H (2003) Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 92:827-839 (Pubitemid 36542523)
71. Jansen PL, Kever M, Rosch R, Krott E, Jansen M, Alfonso-Jaume A, Dooley S, Klinge U, Lovett DH, Mertens PR (2007) Polymeric meshes induce zonal regulation of matrix metalloproteinase-2 gene expression by macrophages and fibroblasts. FASEB J 21:1047-1057 (Pubitemid 46495694)
72. Luttikhuizen DT, Harmsen MC, Van Luyn MJ (2006) Cellular and molecular dynamics in the foreign body reaction. Tissue Eng 12:1955-1970 (Pubitemid 44162854)
73. Miller KM, Anderson JM (1989) In vitro stimulation of fibroblast activity by factors generated from human monocytes activated by biomedical polymers. J Biomed Mater Res 23:911-930 (Pubitemid 19192257)
74. Miller KM, Rose-Caprara V, Anderson JM (1989) Generation of IL-1-like activity in response to biomedical polymer implants: a comparison of in vitro and in vivo models. J Biomed Mater Res 23:1007-1026 (Pubitemid 19211882)
75. Junge K, Klinge U, Prescher A, Giboni P, Niewiera M, Schumpelick V (2001) Elasticity of the anterior abdominal wall and impact for reparation of incisional hernias using mesh implants. Hernia 5:113-118 (Pubitemid 33039803)
76. Liebert TC, Chartoff RP, Cosgrove SL, McCuskey RS (1976) Subcutaneous implants of polypropylene filaments. J Biomed Mater Res 10:939-951
77. Mary C, Marois Y, King MW, Laroche G, Douville Y, Martin L, Guidoin R (1998) Comparison of the in vivo behavior of polyvinylidene fluoride and polypropylene sutures used in vascular surgery. ASAIO J 44:199-206 (Pubitemid 28224368)
78. Vinard E, Eloy R, Descotes J, Brudon JR, Guidicelli H, Magne JL, Patra P, Berruet R, Huc A, Chauchard J (1988) Stability of performances of vascular prostheses retrospective study of 22 cases of human implanted prostheses. J Biomed Mater Res 22:633-648
79. Maarek JM, Guidoin R, Aubin M, Prud'homme RE (1984) Molecular weight characterization of virgin and explanted polyester arterial prostheses. J Biomed Mater Res 18:881-894 (Pubitemid 14013161)
80. Berger K, Suavage L (1980) Late fiber deterioration in Dacron arterial grafts. Ann Surg 193:477-491
81. Riepe G, Loos J, Imig H, Schroder A, Schneider E, Petermann J, Rogge A, Ludwig M, Schenke A, Nassutt R, Chakfe N, Morlock M (1997) Long-term in vivo alterations of polyester vascular grafts in humans. Eur J Vasc Endovasc Surg 13:540-548 (Pubitemid 27332188)
82. van der Lei B, Simmermacher RKJ, van Schilfgaarde R (1989) Expanded polytetrafluorethylene patch for the repair of large abdominal wall defects. Br J Surg 76:803-5 (Pubitemid 19200940)
83. Bellon JM, Contreras LA, Bujan J (2000) Ultrastructural alterations of polytetrafluoroethylene prostheses implanted in abdominal wall provoked by infection: clinical and experimental study. World J Surg 24:528-531
84. Bellon JM, Contreras LA, Bujan J, Pascual G, Carrera-San Martin A (1999) Effect of relaparotomy through previously integrated polypropylene and polytetrafluoroethylene experimental implants in the abdominal wall. J Am Coll Surg 188:466-472 (Pubitemid 29214358)
85. Klinge U, Klosterhalfen B, Ottinger AP, Junge K, Schumpelick V (2002) PVDF as a new polymer for the construction of surgical meshes. Biomaterials 23:3487-3493 (Pubitemid 34615656)
86. Urban E, King MW, Guidoin R, Laroche G, Marois Y, Martin L, Cardou A, Douville Y (1994) Why make monofilament sutures out of polyvinylidene fluoride? ASAIO J 40:145-156 (Pubitemid 24130768)
87. Conze J, Junge K, Weiss C, Anurov M, Oettinger A, Klinge U, Schumpelick V (2008) New polymer for intra-abdominal meshes-PVDF copolymer. J Biomed Mater Res B Appl Biomater 87:321-328
88. Junge K, Binnebosel M, Rosch R, Jansen M, Kammer D, Otto J, Schumpelick V, Klinge U (2009) Adhesion formation of a polyvinylidenfluoride/polypropylene mesh for intra-abdominal placement in a rodent animal model. Surg Endosc 23:327-333
89. Klosterhalfen B, Junge K, Klinge U (2005) The lightweight and large porous mesh concept for hernia repair. Expert Rev Med Devices 2:103-117 (Pubitemid 40124905)
90. Weyhe D, Schmitz I, Belyaev O, Grabs R, Muller KM, Uhl W, Zumtobel V (2006) Experimental comparison of monofile light and heavy polypropylene meshes: less weight does not mean less biological response. World J Surg 30:1586-1591 (Pubitemid 44421265)
91. Weyhe D, Belyaev O, Muller C, Meurer K, Bauer KH, Papapostolou G, Uhl W (2007) Improving outcomes in hernia repair by the use of light meshes-a comparison of different implant constructions based on a critical appraisal of the literature. World J Surg 31:234-244 (Pubitemid 46089571)
92. Bellon JM, Jurado F, Garcia-Honduvilla N, Lopez R, Carrera-San Martin A, Bujan J (2002) The structure of a biomaterial rather than its chemical composition modulates the repair process at the peritoneal level. Am J Surg 184:154-159 (Pubitemid 34880222)
93. Muhl T, Binnebosel M, Klinge U, Goedderz T (2008) New objective measurement to characterize the porosity of textile implants. J Biomed Mater Res B Appl Biomater 84:176-183
94. Eichhorn SJ, Sampson WW (2005) Statistical geometry of pores and statistics of porous nanofibrous assemblies. J R Soc Interface 2:309-318
95. Clowes AW, Zacharias RK, Kirkman TR (1987) Early endothelial coverage of synthetic arterial grafts: porosity revisited. Am J Surg 153:501-504 (Pubitemid 17102221)
96. Tsukada H, Osada H (2004) Experimental study of a new tracheal prosthesis: pored Dacron tube. J Thorac Cardiovasc Surg 127:877-884 (Pubitemid 38316197)
97. Frosch KH, Barvencik F, Lohmann CH, Viereck V, Siggelkow H, Breme J, Dresing K, Sturmer KM (2002) Migration, matrix production and lamellar bone formation of human osteoblast-like cells in porous titanium implants. Cells Tissues Organs 170:214-227 (Pubitemid 34264162)
98. Zhang Y, Xu HH, Takagi S, Chow LC (2006) In-situ hardening hydroxyapatite-based scaffold for bone repair. J Mater Sci Mater Med 17:437-445 (Pubitemid 43827973)
99. Karageorgiou V, Kaplan D (2005) Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 26:5474-5491 (Pubitemid 40592136)
100. Cooper JA, Lu HH, Ko FK, Freeman JW, Laurencin CT (2005) Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation. Biomaterials 26:1523-1532 (Pubitemid 39441385)
101. Bobyn JD, Stackpool GJ, Hacking SA, Tanzer M, Krygier JJ (1999) Characteristics of bone ingrowth and interface mechanics of a new porous tantalum biomaterial. J Bone Joint Surg Br 81:907-914 (Pubitemid 29438375)
102. Ayers RA, Simske SJ, Nunes CR, Wolford LM (1998) Longterm bone ingrowth and residual microhardness of porous block hydroxyapatite implants in humans. J Oral Maxillofac Surg 56:1297-1301
103. Eggli PS, Muller W, Schenk RK (1988) Porous hydroxyapatite and tricalcium phosphate cylinders with two different pore size ranges implanted in the cancellous bone of rabbits. A comparative histomorphometric and histologic study of bony ingrowth and implant substitution. Clin Orthop Relat Res 127-138
104. Deng X, Guidoin R (2000) Alternative blood conduits: assessment of whether the porosity of synthetic prostheses is the key to long-term biofunctionality. Med Biol Eng Comput 38:219-225 (Pubitemid 30192998)
105. Bragdon CR, Burke D, Lowenstein JD, O'Connor DO, Ramamurti B, Jasty M, Harris WH (1996) Differences in stiffness of the interface between a cementless porous implant and cancellous bone in vivo in dogs due to varying amounts of implant motion. J Arthroplasty 11:945-951 (Pubitemid 27014857)
106. Zellin G, Linde A (1996) Effects of different osteopromotive membrane porosities on experimental bone neogenesis in rats. Biomaterials 17:695-702 (Pubitemid 26091220)
107. Bertheville B (2006) Porous single-phase NiTi processed under Ca reducing vapor for use as a bone graft substitute. Biomaterials 27:1246-1250
108. Martakos P, Karwoski T (1995) Healing characteristics of hybrid and conventional polytetrafluoroethylene vascular grafts. ASAIO J 41:M735-M741
109. Akers DL, Du YH, Kempczinski RF (1993) The effect of carbon coating and porosity on early patency of expanded polytetrafluoroethylene grafts: an experimental study. J Vasc Surg 18: 10-15 (Pubitemid 23228312)
110. Saberski ER, Orenstein SB, Novitsky YW (2010) Anisotropic evaluation of synthetic surgical meshes. Hernia
111. Binnebosel M, Rosch R, Junge K, Flanagan TC, Schwab R, Schumpelick V, Klinge U (2007) Biomechanical analyses of overlap and mesh dislocation in an incisional hernia model in vitro. Surgery 142:365-371 (Pubitemid 47302040)
112. Klinge U, Junge K, Spellerberg B, Piroth C, Klosterhalfen B, Schumpelick V (2002) Do multifilament alloplastic meshes increase the infection rate? Analysis of the polymeric surface, the bacteria adherence, and the in vivo consequences in a rat model. J Biomed Mater Res 63:765-771 (Pubitemid 35375424)
113. Engelsman AF, van Dam GM, van der Mei HC, Busscher HJ, Ploeg RJ (2010) In vivo evaluation of bacterial infection involving morphologically different surgical meshes. Ann Surg 251:133-137
114. Junge K, Klinge U, Rosch R, Klosterhalfen B, Schumpelick V (2002) Functional and morphologic properties of a modified mesh for Inguinal hernia repair. World J Surg 26:1472-1480 (Pubitemid 36920208)
115. Rosch R, Junge K, Quester R, Klinge U, Klosterhalfen B, Schumpelick V (2003) Vypro II mesh in hernia repair: impact of polyglactin on long-term incorporation in rats. Eur Surg Res 35:445-450 (Pubitemid 37034396)
116. Bellon JM, Rodriguez M, Garcia-Honduvilla N, Gomez-Gil V, Pascual G, Bujan J (2008) Postimplant behavior of lightweight polypropylene meshes in an experimental model of abdominal hernia. J Invest Surg 21:280-287
117. Bellon JM, Rodriguez M, Garcia-Honduvilla N, Pascual G, Bujan J (2007) Partially absorbable meshes for hernia repair offer advantages over nonabsorbable meshes. Am J Surg 194:68-74 (Pubitemid 46874345)
118. Weyhe D, Belyaev O, Buettner G, Mros K, Mueller C, Meurer K, Papapostolou G, Uhl W (2008) In vitro comparison of three different mesh constructions. ANZ J Surg 78:55-60
119. Junge K, Rosch R, Krones CJ, Klinge U, Mertens PR, Lynen P, Schumpelick V, Klosterhalfen B (2005) Influence of polyglecaprone 25 (Monocryl) supplementation on the biocompatibility of a polypropylene mesh for hernia repair. Hernia 9:212-217 (Pubitemid 43192937)
120. Otto J, BinneboselM, Pietsch S,AnurovM, Titkova S, Ottinger AP, Jansen M, Rosch R, Kammer D, Klinge U (2010) Large-pore PDS mesh compared to small-pore PG mesh. J Invest Surg 23:190-196
121. Gruber-Blum S, Petter-Puchner AH, Brand J, Fortelny RH, Walder N, Oehlinger W, Koenig F, Redl H (2010) Comparison of three separate antiadhesive barriers for intraperitoneal onlay mesh hernia repair in an experimental model. Br J Surg
122. Loury JN, Chevrel JP (1983) Treatment of ventral hernias. Simultaneous use of polyglactin 910 and dacron mesh (letter). Presse Méd 12(2116 issn):0755-4982
123. Vries Reilingh TS, van Goor H, Koppe MJ, Bodegom ME, Hendriks T, Bleichrodt RP (2007) Interposition of polyglactin mesh does not prevent adhesion formation between viscera and polypropylene mesh. J Surg Res 140:27-30 (Pubitemid 46669537)
124. Conze J, Junge K, Klinge U, Weiss C, Polivoda M, Oettinger AP, Schumpelick V (2005) Intraabdominal adhesion formation of polypropylene mesh. Influence of coverage of omentum and polyglactin. Surg Endosc 19:798-803 (Pubitemid 41215982)
125. Bellon JM, Rodriguez M, Garcia-Honduvilla N, Pascual G, Gomez GV, Bujan J (2007) Peritoneal effects of prosthetic meshes used to repair abdominal wall defects: monitoring adhesions by sequential laparoscopy. J Laparoendosc Adv Surg Tech A 1:160-166 (Pubitemid 46685129)
126. Jacob BP, Hogle NJ, Durak E, Kim T, Fowler DL (2007) Tissue ingrowth and bowel adhesion formation in an animal comparative study: polypropylene versus proceed versus parietex composite. Surg Endosc 21:629-633 (Pubitemid 46439383)
127. Judge TW, Parker DM, Dinsmore RC (2007) Abdominal wall hernia repair: a comparison of sepramesh and parietex composite mesh in a rabbit hernia model. J Am Coll Surg 204:276-281 (Pubitemid 46124049)
128. Emans PJ, Schreinemacher MH, Gijbels MJ, Beets GL, Greve JW, Koole LH, Bouvy ND (2009) Polypropylene meshes to prevent abdominal herniation. Can stable coatings prevent adhesions in the long term? Ann Biomed Eng 37:410-418
129. Schreinemacher MH, Emans PJ, Gijbels MJ, Greve JW, Beets GL, Bouvy ND (2009) Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model. Br J Surg 96:305-313
130. van't RM, de Vos van Steenwijk PJ, Bonthuis F, Marquet RL, Steyerberg EW, Jeekel J, Bonjer HJ (2003) Prevention of adhesion to prosthetic mesh: comparison of different barriers using an incisional hernia model. Ann Surg 237:123-128
131. Vrijland WW, Bonthuis F, Steyerberg EW, Marquet RL, Jeekel J, Bonjer HJ (2000) Peritoneal adhesions to prosthetic materials: choice of mesh for incisional hernia repair. Surg Endosc 14: 960-963
132. Burger JW, Halm JA, Wijsmuller AR, ten Raa S, Jeekel J (2006) Evaluation of new prosthetic meshes for ventral hernia repair. Surg Endosc 20:1320-1325 (Pubitemid 44259064)
133. Chelala E, Debardemaeker Y, Elias B, Charara F, Dessily M, Alle JL (2010) Eighty-five redo surgeries after 733 laparoscopic treatments for ventral and incisional hernia: adhesion and recurrence analysis. Hernia 14:123-129
134. Wassenaar EB, Schoenmaeckers EJ, Raymakers JT, Rakic S (2010) Subsequent abdominal surgery after laparoscopic ventral and incisional hernia repair with an expanded polytetrafluoroethylene mesh: a single institution experience with 72 reoperations. Hernia 14:137-142
135. Zinther NB, Zeuten A, Marinovskij E, Haislund M, Friis-Andersen H (2010) Functional cine MRI and transabdominal ultrasonography for the assessment of adhesions to implanted synthetic mesh 5-7 years after laparoscopic ventral hernia repair. Hernia 14:499-504
136. Jenkins ED, Yom V, Melman L, Brunt LM, Eagon JC, Frisella MM, Matthews BD (2010) Prospective evaluation of adhesion characteristics to intraperitoneal mesh and adhesiolysis-related complications during laparoscopic re-exploration after prior ventral hernia repair. Surg Endosc 24:3002-3007
137. Shastri VP (2003) Non-degradable biocompatible polymers in medicine: past, present and future. Curr Pharm Biotechnol 4:331-337
138. Wisniewski N, Reichert M (2000) Methods for reducing biosensor membrane biofouling. Colloids Surf B Biointerfaces 18:197-219 (Pubitemid 30479863)
139. Shen M, Horbett TA (2001) The effects of surface chemistry and adsorbed proteins on monocyte/macrophage adhesion to chemically modified polystyrene surfaces. J Biomed Mater Res 57:336-345 (Pubitemid 32885265)
140. de Vos P, van Hoogmoed CG, de Haan BJ, Busscher HJ (2002) Tissue responses against immunoisolating alginate-PLL capsules in the immediate posttransplant period. J Biomed Mater Res 62:430-437
141. de Vos P, Hoogmoed CG, Busscher HJ (2002) Chemistry and biocompatibility of alginate-PLL capsules for immunoprotection of mammalian cells. J Biomed Mater Res 60:252-259 (Pubitemid 34194586)
142. Vercruysse KP, Prestwich GD (1998) Hyaluronate derivatives in drug delivery. Crit Rev Ther Drug Carrier Syst 15:513-555 (Pubitemid 28512541)
143. Uchegbu IF, Schatzlein AG, Tetley L, Gray AI, Sludden J, Siddique S, Mosha E (1998) Polymeric chitosan-based vesicles for drug delivery. J Pharm Pharmacol 50:453-458 (Pubitemid 28241130)
144. Borchard G, Junginger HE (2001) Modern drug delivery applications of chitosan. Adv Drug Deliv Rev 52:103 (Pubitemid 33079165)
145. Sano A, Hojo T, Maeda M, Fujioka K (1998) Protein release from collagen matrices. Adv Drug Deliv Rev 31:247-266 (Pubitemid 28191868)
146. Geiger M, Li RH, Friess W (2003) Collagen sponges for bone regeneration with rhBMP-2. Adv Drug Deliv Rev 55:1613-1629 (Pubitemid 37420006)
147. Draye JP, Delaey B, Van de Voorde A, Van Den Bulcke A, De Reu B, Schacht E (1998) In vitro and in vivo biocompatibility of dextran dialdehyde cross-linked gelatin hydrogel films. Biomaterials 19:1677-1687 (Pubitemid 28512848)
148. Draye JP, Delaey B, Van de Voorde A, Van Den Bulcke A, Bogdanov B, Schacht E (1998) In vitro release characteristics of bioactive molecules from dextran dialdehyde cross-linked gelatin hydrogel films. Biomaterials 19:99-107 (Pubitemid 28239472)
149. Athanasiou KA, Niederauer GG, Agrawal CM(1996) Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers. Biomaterials 17:93-102 (Pubitemid 26031365)
150. Athanasiou KA, Niederauer GG, Agrawal CM, Landsman AS (1995) Applications of biodegradable lactides and glycolides in podiatry. Clin Podiatr Med Surg 12:475-95
151. Shive MS, Anderson JM (1997) Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 28:5-24 (Pubitemid 27497671)
152. Espadas-Torre C, Meyerhoff ME (1995) Thrombogenic properties of untreated and poly(ethylene oxide)-modified polymeric matrices useful for preparing intraarterial ion-selective electrodes. Anal Chem 67:3108-3114
153. Paradossi G, Cavalieri F, Chiessi E, Spagnoli C, Cowman MK (2003) Poly(vinyl alcohol) as versatile biomaterial for potential biomedical applications. J Mater Sci Mater Med 14:687-691 (Pubitemid 36976216)
154. Maruoka S, Matsuura T, Kawasaki K, Okamoto M, Yoshiaki H, Kodama M, Sugiyama M, Annaka M (2006) Biocompatibility of polyvinylalcohol gel as a vitreous substitute. Curr Eye Res 31:599-606 (Pubitemid 44179986)
155. Voskerician G, Jin J, White MF, Williams CP, Rosen MJ (2010) Effect of biomaterial design criteria on the performance of surgical meshes for abdominal hernia repair: a pre-clinical evaluation in a chronic rat model. J Mater Sci Mater Med 21:1989-1995
156. Schug-Pass C, Sommerer F, Tannapfel A, Lippert H, Kockerling F (2009) The use of composite meshes in laparoscopic repair of abdominal wall hernias: are there differences in biocompatibily?: experimental results obtained in a laparoscopic porcine model. Surg Endosc 23:487-495
157. Murphy JL, Vollenweider L, Xu F, Lee BP (2010) Adhesive performance of biomimetic adhesive-coated biologic scaffolds. Biomacromolecules
158. Junge K, Rosch R, Anurov M, Titkova S, Ottinger A, Klinge U, Schumpelick V (2006) Modification of collagen formation using supplemented mesh materials. Hernia 10:492-497 (Pubitemid 44834991)
159. Leber GE, Garb JL, Alexander AI, Reed WP (1998) Long-term complications associated with prosthetic repair of incisional hernias. Arch Surg 133:378-82 (Pubitemid 28193521)
160. Kumar S (1999) Chronic groin sepsis following tension-free inguinal hernioplasty [letter; comment]. Br J Surg 86:1482
161. White TJ, SantosMC, Thompson JS (1998) Factors affecting wound complications in repair of ventral hernias. Am Surg 64:276-80 (Pubitemid 28246489)
162. Deysine M (1998) Pathophysiology, prevention, and management of prosthetic infections in hernia surgery. Surg Clin North Am 78:1105-15
163. Taylor EW, Byrne DJ, Leaper DJ, Karran SJ, Browne MK, Mitchell KJ (1997) Antibiotic prophylaxis and open groin hernia repair. World J Surg 21:811-814
164. Rios A, Rodriguez JM, Munitiz V, Alcaraz P, Perez FD, Parrilla P (2001) Antibiotic prophylaxis in incisional hernia repair using a prosthesis. Hernia 5:148-152 (Pubitemid 33039810)
165. Lazorthes F, Chiotasso P, Massip P, Materre JP, Sarkissian M (1992) Local antibiotic prophylaxis in inguinal hernia repair. Surg Gynecol Obstet 175:569-570
166. Musella M, Guido A, Musella S (2001) Collagen tampons as aminoglycoside carriers to reduce postoperative infection rate in prosthetic repair of groin hernias. Eur J Surg 167:130-132 (Pubitemid 32198121)
167. Bandyk DF (2002) Antibiotics-why so many and when should we use them? Semin Vasc Surg 15:268-274
168. Pratesi C, Russo D, Dorigo W, Chiti E (2001) Antibiotic prophylaxis in clean surgery: vascular surgery. J Chemother 13 (Spec No 1):123-128 (Pubitemid 34183606)
169. Murray WR (1984) Use of antibiotic-containing bone cement. Clin Orthop 89-95
170. McQueen MM, Hughes SP, May P, Verity L (1990) Cefuroxime in total joint arthroplasty. Intravenous or in bone cement. J Arthroplasty 5:169-172 (Pubitemid 20317078)
171. Gilbert AI, Felton LL (1993) Infection in inguinal hernia repair considering biomaterials and antibiotics [published erratum appears in Surg Gynecol Obstet 1993 Nov;177(5):528]. Surg Gynecol Obstet 177:126-130 (Pubitemid 23232688)
172. Deysine M (2004) Infections associated with surgical implants. N Engl J Med 351:193-195
173. Badiou W, Lavigne JP, Bousquet PJ, O'Callaghan D, Mares P, de Tayrac R (2010) In vitro and in vivo assessment of silver-coated polypropylene mesh to prevent infection in a rat model. Int Urogynecol J Pelvic Floor Dysfunct
174. Franklin ME Jr, Gonzalez JJ Jr, Michaelson RP, Glass JL, Chock DA (2002) Preliminary experience with new bioactive prosthetic material for repair of hernias in infected fields. Hernia 6:171-174 (Pubitemid 36007833)
175. Dubay DA, Wang X, Kuhn MA, Robson MC, Franz MG (2004) The prevention of incisional hernia formation using a delayed-release polymer of basic fibroblast growth factor. Ann Surg 240:179-186 (Pubitemid 38808250)
176. Robson MC, Dubay DA, Wang X, Franz MG (2004) Effect of cytokine growth factors on the prevention of acute wound failure. Wound Repair Regen 12:38-43 (Pubitemid 38249134)
177. Korenkov M, Yuecel N, Koebke J, Schierholz J, Morsczeck C, Tasci I, Neugebauer EA, Nagelschmidt M (2005) Local administration of TGF-beta1 to reinforce the anterior abdominal wall in a rat model of incisional hernia. Hernia
178. Orenstein SB, Saberski ER, Klueh U, Kreutzer DL, Novitsky YW (2010) Effects of mast cell modulation on early host response to implanted synthetic meshes. Hernia 14:511-516
179. Tang L, Jennings TA, Eaton JW (1998) Mast cells mediate acute inflammatory responses to implanted biomaterials. Proc Natl Acad Sci USA 95:8841-8846 (Pubitemid 28350576)
180. Lopez-Neblina F, Toledo AH, Toledo-Pereyra LH (2005) Molecular biology of apoptosis in ischemia and reperfusion. J Invest Surg 18:335-350 (Pubitemid 43123614)
181. Mullonkal CJ, Toledo-Pereyra LH (2007) Akt in ischemia and reperfusion. J Invest Surg 20:195-203 (Pubitemid 47050383)
182. Schaffer M, Bongartz M, Hoffmann W, Viebahn R (2006) Regulation of nitric oxide synthesis in wounds by IFN-gamma depends on TNF-alpha. J Invest Surg 19:371-379 (Pubitemid 44768479)
183. Bradley JR (2008) TNF-mediated inflammatory disease. J Pathol 214:149-160
184. Park JY, Pillinger MH (2007) Interleukin-6 in the pathogenesis of rheumatoid arthritis. Bull NYU Hosp Jt Dis 65(Suppl 1):S4-10
185. Mudter J, Neurath MF (2007) Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance. Inflamm Bowel Dis 13:1016-1023 (Pubitemid 47309974)
186. Di Vita G, D'Agostino P, Patti R, Arcara M, Caruso G, Davi V, Cillari E (2005) Acute inflammatory response after inguinal and incisional hernia repair with implantation of polypropylene mesh of different size. Langenbecks Arch Surg 390: 306-311 (Pubitemid 41110974)
187. Junge K, Binnebosel M, Rosch R, Otto J, Kammer D, Schumpelick V, Klinge U (2009) Impact of proinflammatory cytokine knockout on mesh integration. J Invest Surg 22:256-262
188. Junge K, Klinge U, Rosch R, Lynen P, Binnebosel M, Conze J, Mertens PR, Schwab R, Schumpelick, V (2007) Improved collagen type I/III ratio at the interface of gentamicin-supplemented polyvinylidenfluoride mesh materials. Langenbecks Arch Surg
189. Binnebosel M, Ricken C, Klink CD, Junge K, Jansen M, Schumpelick V, Lynen JP (2010) Impact of gentamicin-supplemented polyvinylidenfluoride mesh materials on MMP-2 expression and tissue integration in a transgenic mice model. Langenbecks Arch Surg 395:413-420
190. Tekos A, Prodromaki E, Papadimou E, Pavlidou D, Tsambaos D, Drainas D (2003) Aminoglycosides suppress tRNA processing in human epidermal keratinocytes in vitro. Skin Pharmacol Appl Skin Physiol 16:252-258 (Pubitemid 36649415)
191. Sacha PT, Zaremba ML, Jakoniuk P (1999) The influence of antibiotics on phagocytic and bacteriocidal activity of rabbit peritoneal macrophages stimulated by filtrates of cultured t-lymphocytes. Med Dosw Mikrobiol 51:399-412 (Pubitemid 30050860)
192. Keeling KM, Bedwell DM (2002) Clinically relevant aminoglycosides can suppress disease-associated premature stop mutations in the IDUA and P53 cDNAs in a mammalian translation system. J Mol Med 80:367-376 (Pubitemid 34775375)
193. Wilschanski M, Yahav Y, Yaacov Y, Blau H, Bentur L, Rivlin J, Aviram M, Bdolah-Abram T, Bebok Z, Shushi L, Kerem B, Kerem E (2003) Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations. N Engl J Med 349:1433-1441 (Pubitemid 37211058)
194. Clancy JP, Bebok Z, Ruiz F, King C, Jones J, Walker L, Greer H, Hong J, Wing L, Macaluso M, Lyrene R, Sorscher EJ, Bedwell DM (2001) Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis. Am J Respir Crit Care Med 163:1683-1692 (Pubitemid 32578776)
195. Wrzesniok D, Buszman E, Karna E, Nawrat P, Palka J (2002) Melanin potentiates gentamicin-induced inhibition of collagen biosynthesis in human skin fibroblasts. Eur J Pharmacol 446:7-13 (Pubitemid 34722552)
196. Asch HL, Farnham PJ (1978) Effects of gentamicin on trypsin, chymotrypsin, and collagenase. J Infect Dis 138:257-259 (Pubitemid 9005536)