-
1
-
-
30144443996
-
Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001
-
Morton LM, Wang SS, Devesa SS, et al. Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001. Blood. 2006;107: 265-276.
-
(2006)
Blood
, vol.107
, pp. 265-276
-
-
Morton, L.M.1
Wang, S.S.2
Devesa, S.S.3
-
2
-
-
45149100665
-
Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
-
Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111:5446-5456.
-
(2008)
Blood
, vol.111
, pp. 5446-5456
-
-
Hallek, M.1
Cheson, B.D.2
Catovsky, D.3
-
3
-
-
34447530283
-
Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): A randomised controlled trial
-
Catovsky D, Richards S, Matutes E, et al. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial. Lancet. 2007;370: 230-239.
-
(2007)
Lancet
, vol.370
, pp. 230-239
-
-
Catovsky, D.1
Richards, S.2
Matutes, E.3
-
4
-
-
31544434508
-
Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia
-
Eichhorst BF, Busch R, Hopfinger G, et al. Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia. Blood. 2006;107:885-891.
-
(2006)
Blood
, vol.107
, pp. 885-891
-
-
Eichhorst, B.F.1
Busch, R.2
Hopfinger, G.3
-
5
-
-
23044510136
-
Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
-
Keating MJ, O'Brien S, Albitar M, et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol. 2005;23: 4079-4088.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4079-4088
-
-
Keating, M.J.1
O'Brien, S.2
Albitar, M.3
-
6
-
-
4544332737
-
The leukemic presentation of mantle-cell lymphoma: Disease features and prognostic factors in 58 patients
-
Matutes E, Parry-Jones N, Brito-Babapulle V, et al. The leukemic presentation of mantle-cell lymphoma: disease features and prognostic factors in 58 patients. Leuk Lymphoma. 2004;45:2007-2015.
-
(2004)
Leuk Lymphoma
, vol.45
, pp. 2007-2015
-
-
Matutes, E.1
Parry-Jones, N.2
Brito-Babapulle, V.3
-
7
-
-
0032079746
-
Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with in vitro and in vivo chemoresponses
-
Kitada S, Andersen J, Akar S, et al. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses. Blood. 1998;91:3379-3389.
-
(1998)
Blood
, vol.91
, pp. 3379-3389
-
-
Kitada, S.1
Andersen, J.2
Akar, S.3
-
8
-
-
79951498701
-
Cellular origin(s) of chronic lymphocytic leukemia: Cautionary notes and additional considerations and possibilities
-
Chiorazzi N FM: Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood. 2011;117:1781-1791.
-
(2011)
Blood
, vol.117
, pp. 1781-1791
-
-
Chiorazzi, N.F.M.1
-
9
-
-
65549151712
-
E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction
-
Gorgun G, Ramsay AG, Holderried TA, et al. E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction. Proc Natl Acad Sci U S A. 2009;106:6250-6255.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 6250-6255
-
-
Gorgun, G.1
Ramsay, A.G.2
Holderried, T.A.3
-
10
-
-
70349562920
-
Molecular and cellular mechanisms of CLL: Novel therapeutic approaches
-
Pleyer L, Egle A, Hartmann TN, et al. Molecular and cellular mechanisms of CLL: novel therapeutic approaches. Nat Rev Clin Oncol. 2009;6:405-418.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 405-418
-
-
Pleyer, L.1
Egle, A.2
Hartmann, T.N.3
-
11
-
-
17144430972
-
Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells
-
Farahani M, Treweeke AT, Toh CH, et al. Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells. Leukemia. 2005;19:524-530.
-
(2005)
Leukemia
, vol.19
, pp. 524-530
-
-
Farahani, M.1
Treweeke, A.T.2
Toh, C.H.3
-
12
-
-
33748616265
-
Molecular pathogenesis of chronic lymphocytic leukemia
-
Danilov AV, Danilova OV, Klein AK, et al. Molecular pathogenesis of chronic lymphocytic leukemia. Curr Mol Med. 2006;6:665-675.
-
(2006)
Curr Mol Med
, vol.6
, pp. 665-675
-
-
Danilov, A.V.1
Danilova, O.V.2
Klein, A.K.3
-
13
-
-
0242298176
-
Role of the microenvironment in chronic lymphocytic leukemia
-
Caligris-Cappio F: Role of the microenvironment in chronic lymphocytic leukemia. Br J Hematol. 2003;123:380-388.
-
(2003)
Br J Hematol
, vol.123
, pp. 380-388
-
-
Caligris-Cappio, F.1
-
14
-
-
83455196326
-
A pilot study of genasense (R) (oblimersen sodium, Bcl-2 antisense oligonucleotide), fludarabine and rituximab in previously treated and untreated subjects with chronic lymphocytic leukemia
-
Chanan-Khan AA, Mavromatis B, Rai KR, et al. A pilot study of genasense (R) (oblimersen sodium, Bcl-2 antisense oligonucleotide), fludarabine and rituximab in previously treated and untreated subjects with chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. 2004;104:4827.
-
(2004)
ASH Annual Meeting Abstracts
, vol.104
, pp. 4827
-
-
Chanan-Khan, A.A.1
Mavromatis, B.2
Rai, K.R.3
-
15
-
-
58849164097
-
Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
-
O'Brien SM, Claxton DF, Crump M, et al. Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood. 2009;113:299-305.
-
(2009)
Blood
, vol.113
, pp. 299-305
-
-
O'Brien, S.M.1
Claxton, D.F.2
Crump, M.3
-
16
-
-
33750834023
-
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
-
van Delft MF, Wei AH, Mason KD, et al. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell. 2006;10:389-399.
-
(2006)
Cancer Cell
, vol.10
, pp. 389-399
-
-
van Delft, M.F.1
Wei, A.H.2
Mason, K.D.3
-
17
-
-
33645123690
-
Novel approaches to immunotherapy for B-cell malignancies
-
Brentjens RJ: Novel approaches to immunotherapy for B-cell malignancies. Curr Hematol Rep. 2005;4:64-72.
-
(2005)
Curr Hematol Rep
, vol.4
, pp. 64-72
-
-
Brentjens, R.J.1
-
18
-
-
0035999150
-
Chronic B cell malignancies and bone marrow microenvironment
-
Ghia P, Granziero L, Chilosi M, et al. Chronic B cell malignancies and bone marrow microenvironment. Semin Cancer Biol. 2002;12:149-155.
-
(2002)
Semin Cancer Biol
, vol.12
, pp. 149-155
-
-
Ghia, P.1
Granziero, L.2
Chilosi, M.3
-
19
-
-
84873563141
-
Treatment with lenalidomide (Revlimid(R)) upregulates CD40 expression on CLL Cells and increases their sensitivity to CD40-mediated cytotoxicity in vitro
-
Glezer E, Ferrajoli A, Reuben JM, et al. Treatment with lenalidomide (Revlimid(R)) upregulates CD40 expression on CLL Cells and increases their sensitivity to CD40-mediated cytotoxicity in vitro. ASH Annual Meeting Abstracts. 2008;112:3168.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 3168
-
-
Glezer, E.1
Ferrajoli, A.2
Reuben, J.M.3
-
20
-
-
70449477828
-
The role of the microenvironment for CLL proliferation and survival: Gene expression profiling of leukemic cells derived from blood, bone marrow and lymph nodes reveals the B-cell receptor and NF {kappa}B as dominant signaling pathways
-
Herishanu Y, Vire B, Liu D, et al. The role of the microenvironment for CLL proliferation and survival: gene expression profiling of leukemic cells derived from blood, bone marrow and lymph nodes reveals the B-cell receptor and NF {kappa}B as dominant signaling pathways. ASH Annual Meeting Abstracts. 2008;112:356.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 356
-
-
Herishanu, Y.1
Vire, B.2
Liu, D.3
-
21
-
-
67649272030
-
Ofatumumab (HuMax-CD20), a Novel CD20 monoclonal antibody, is an active treatment for patients with CLL refractory to both fludarabine and alemtuzumab or bulky fludarabine-refractory disease: Results from the planned interim analysis of an international pivotal trial
-
Osterborg A, Kipps TJ, Mayer J, et al. Ofatumumab (HuMax-CD20), a Novel CD20 monoclonal antibody, is an active treatment for patients with CLL refractory to both fludarabine and alemtuzumab or bulky fludarabine-refractory disease: Results from the planned interim analysis of an international pivotal trial. ASH Annual Meeting Abstracts. 2008;112:328.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 328
-
-
Osterborg, A.1
Kipps, T.J.2
Mayer, J.3
-
22
-
-
41149168649
-
Lenalidomide for the treatment of B-cell malignancies
-
Chanan-Khan AA, Cheson BD. Lenalidomide for the treatment of B-cell malignancies. J Clin Oncol. 2008;26:1544-1552.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1544-1552
-
-
Chanan-Khan, A.A.1
Cheson, B.D.2
-
23
-
-
84873533627
-
In vivo evaluation of immunomodulating effects of lenalidomide (L) on tumor cell microenvironment as a possible underlying mechanism of the antitumor effects observed in patients (pts) with chronic lymphocytic leukemia (CLL)
-
Chanan-Khan AA, Padmanabhan S, Miller KC, et al. In vivo evaluation of immunomodulating effects of lenalidomide (L) on tumor cell microenvironment as a possible underlying mechanism of the antitumor effects observed in patients (pts) with chronic lymphocytic leukemia (CLL). ASH Annual Meeting Abstracts. 2005;106:2975.
-
(2975)
ASH Annual Meeting Abstracts
, vol.2005
, pp. 106
-
-
Chanan-Khan, A.A.1
Padmanabhan, S.2
Miller, K.C.3
-
24
-
-
27744597929
-
Results of a phase 1 clinical trial of thalidomide in combination with fludarabine as initial therapy for patients with treatment-requiring chronic lymphocytic leukemia (CLL)
-
Chanan-Khan A, Miller KC, Takeshita K, et al. Results of a phase 1 clinical trial of thalidomide in combination with fludarabine as initial therapy for patients with treatment-requiring chronic lymphocytic leukemia (CLL). Blood. 2005;106:3348-3352.
-
(2005)
Blood
, vol.106
, pp. 3348-3352
-
-
Chanan-Khan, A.1
Miller, K.C.2
Takeshita, K.3
-
25
-
-
70350123882
-
Thalidomide exerts distinct molecular antileukemic effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia
-
Giannopoulos K, Dmoszynska A, Kowal M, et al. Thalidomide exerts distinct molecular antileukemic effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia. Leukemia 2009;23:1771-1778.
-
(2009)
Leukemia
, vol.23
, pp. 1771-1778
-
-
Giannopoulos, K.1
Dmoszynska, A.2
Kowal, M.3
-
26
-
-
68449101813
-
N9986: A phase II trial of thalidomide in patients with relapsed chronic lymphocytic leukemia
-
Kay NE, Shanafelt TD, Call TG, et al. N9986: a phase II trial of thalidomide in patients with relapsed chronic lymphocytic leukemia. Leuk Lymphoma. 2009;50:588-592.
-
(2009)
Leuk Lymphoma
, vol.50
, pp. 588-592
-
-
Kay, N.E.1
Shanafelt, T.D.2
Call, T.G.3
-
27
-
-
33947243663
-
Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase II study
-
Chanan-Khan A, Miller KC, Musial L, et al. Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study. J Clin Oncol. 2006;24: 5343-5349.
-
(2006)
J Clin Oncol
, vol.24
, pp. 5343-5349
-
-
Chanan-Khan, A.1
Miller, K.C.2
Musial, L.3
-
28
-
-
74949083498
-
Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics
-
Sher T, Miller KC, Lawrence D, et al. Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics. Leuk Lymphoma. 2010;51:85-88.
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 85-88
-
-
Sher, T.1
Miller, K.C.2
Lawrence, D.3
-
29
-
-
80054995804
-
Low-dose prednisone decreases the severity but not the frequency of lenalidomide associated tumor flare reaction (TFR) in chronic lymphocytic leukemia (CLL) patients
-
Musial L, Miller KC, Tonelli A, et al. Low-dose prednisone decreases the severity but not the frequency of lenalidomide associated tumor flare reaction (TFR) in chronic lymphocytic leukemia (CLL) patients. ASH Annual Meeting Abstracts. 2006;108:4987.
-
(2006)
ASH Annual Meeting Abstracts
, vol.108
, pp. 4987
-
-
Musial, L.1
Miller, K.C.2
Tonelli, A.3
-
30
-
-
79955515528
-
Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response
-
Chanan-Khan A, Miller KC, Lawrence D, et al. Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response. Cancer. 2011;117:2127-2135.
-
(2011)
Cancer
, vol.117
, pp. 2127-2135
-
-
Chanan-Khan, A.1
Miller, K.C.2
Lawrence, D.3
-
31
-
-
70449483516
-
Clinical efficacy of lenalidomide in fludarabine-refractory chronic lymphocytic leukemia patients
-
Chanan-Khan AA, Czuczman MS, Padmanabhan S, et al. Clinical efficacy of lenalidomide in fludarabine-refractory chronic lymphocytic leukemia patients. ASH Annual Meeting Abstracts. 2007;110:3108.
-
(2007)
ASH Annual Meeting Abstracts
, vol.110
, pp. 3108
-
-
Chanan-Khan, A.A.1
Czuczman, M.S.2
Padmanabhan, S.3
-
32
-
-
45949100928
-
Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
-
Ferrajoli A, Lee BN, Schlette EJ, et al. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood. 2008;111:5291-5297.
-
(2008)
Blood
, vol.111
, pp. 5291-5297
-
-
Ferrajoli, A.1
Lee, B.N.2
Schlette, E.J.3
-
33
-
-
34248159539
-
Lenalidomide induces complete and partial responses in patients with relapsed and treatmentrefractory chronic lymphocytic leukemia (CLL)
-
Ferrajoli A, O'Brien SM, Faderl SH, et al. Lenalidomide induces complete and partial responses in patients with relapsed and treatmentrefractory chronic lymphocytic leukemia (CLL). ASH Annual Meeting Abstracts. 2006;108:305.
-
(2006)
ASH Annual Meeting Abstracts
, vol.108
, pp. 305
-
-
Ferrajoli, A.1
O'Brien, S.M.2
Faderl, S.H.3
-
34
-
-
66749113746
-
A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL)
-
Chen C, Paul H, Xu W, et al. A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL). ASH Annual Meeting Abstracts. 2008;112:44.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 44
-
-
Chen, C.1
Paul, H.2
Xu, W.3
-
35
-
-
76149124676
-
Combination therapy with lenalidomide and rituximab in patients with relapsed chronic lymphocytic leukemia (CLL)
-
Ferrajoli A, Badoux XC, O'Brien S, et al. Combination therapy with lenalidomide and rituximab in patients with relapsed chronic lymphocytic leukemia (CLL). ASH Annual Meeting Abstracts. 2009; 114:206.
-
(2009)
ASH Annual Meeting Abstracts
, vol.114
, pp. 206
-
-
Ferrajoli, A.1
Badoux, X.C.2
O'Brien, S.3
-
36
-
-
84873539533
-
A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL)
-
Chen CI, Paul H, Mariela P, et al. A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL). ASH Annual Meeting Abstracts. 2007;110:2042.
-
(2042)
ASH Annual Meeting Abstracts
, vol.2007
, pp. 110
-
-
Chen, C.I.1
Paul, H.2
Mariela, P.3
-
37
-
-
83255183478
-
Combination of ofatumumab and lenalidomide in patients with relapsed chronic lymphocytic leukemia: Initial results of a phase II trial
-
Badoux X, O'Brien S, Wierda WG, et al. Combination of ofatumumab and lenalidomide in patients with relapsed chronic lymphocytic leukemia: initial results of a phase II trial. ASH Annual Meeting Abstracts. 2010;116:2464.
-
(2464)
ASH Annual Meeting Abstracts
, vol.2010
, pp. 116
-
-
Badoux, X.1
O'Brien, S.2
Wierda, W.G.3
-
38
-
-
76949104717
-
Ofatumumab, a human CD20 monoclonal antibody
-
Osterborg A. Ofatumumab, a human CD20 monoclonal antibody. Expert Opin Biol Ther. 2010;10:439-449.
-
(2010)
Expert Opin Biol Ther
, vol.10
, pp. 439-449
-
-
Osterborg, A.1
-
39
-
-
0035469851
-
Rituximab therapy of patients with B-cell chronic lymphocytic leukemia
-
Huhn D, von Schilling C, Wilhelm M, et al. Rituximab therapy of patients with B-cell chronic lymphocytic leukemia. Blood. 2001;98: 1326-1331.
-
(2001)
Blood
, vol.98
, pp. 1326-1331
-
-
Huhn, D.1
von Schilling, C.2
Wilhelm, M.3
-
40
-
-
0035871441
-
Rituximab doseescalation trial in chronic lymphocytic leukemia
-
O'Brien SM, Kantarjian H, Thomas DA, et al. Rituximab doseescalation trial in chronic lymphocytic leukemia. J Clin Oncol. 2001;19: 2165-2170.
-
(2001)
J Clin Oncol
, vol.19
, pp. 2165-2170
-
-
O'Brien, S.M.1
Kantarjian, H.2
Thomas, D.A.3
-
41
-
-
0037220152
-
Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712)
-
Byrd JC, Peterson BL, Morrison VA, et al. Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood. 2003;101:6-14.
-
(2003)
Blood
, vol.101
, pp. 6-14
-
-
Byrd, J.C.1
Peterson, B.L.2
Morrison, V.A.3
-
42
-
-
23044501404
-
Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia
-
Wierda W, O'Brien S, Wen S, et al. Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia. J Clin Oncol. 2005;23:4070-4078.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4070-4078
-
-
Wierda, W.1
O'Brien, S.2
Wen, S.3
-
43
-
-
51649093353
-
Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia
-
Tam CS, O'Brien S, Wierda W, et al. Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia. Blood. 2008;112:975-980.
-
(2008)
Blood
, vol.112
, pp. 975-980
-
-
Tam, C.S.1
O'Brien, S.2
Wierda, W.3
-
44
-
-
77957664665
-
Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
-
Hallek MFK, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet. 2010;376: 1164-1174.
-
(2010)
Lancet
, vol.376
, pp. 1164-1174
-
-
Hallek, M.F.K.1
Fingerle-Rowson, G.2
-
45
-
-
79952278698
-
Ofatumumab: A new CD20 monoclonal antibody therapy for B-cell chronic lymphocytic leukemia
-
O'Brien S, Osterborg A. Ofatumumab: a new CD20 monoclonal antibody therapy for B-cell chronic lymphocytic leukemia. Clin Lymphoma Myeloma Leuk. 2010;10(5):361-368.
-
(2010)
Clin Lymphoma Myeloma Leuk
, vol.10
, Issue.5
, pp. 361-368
-
-
O'Brien, S.1
Osterborg, A.2
-
46
-
-
38949185742
-
Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: A phase 1-2 study
-
Coiffier B, Lepretre S, Pedersen LM, et al. Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study. Blood. 2008;111:1094-1100.
-
(2008)
Blood
, vol.111
, pp. 1094-1100
-
-
Coiffier, B.1
Lepretre, S.2
Pedersen, L.M.3
-
47
-
-
79955870406
-
Final analysis from the international trial of single-agent ofatumumab in patients with fludarabine-refractory chronic lymphocytic leukemia
-
Wierda WG, Kipps TJ, Mayer J, et al. Final analysis from the international trial of single-agent ofatumumab in patients with fludarabine-refractory chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. 2010; 116:921.
-
(2010)
ASH Annual Meeting Abstracts
, vol.116
, pp. 921
-
-
Wierda, W.G.1
Kipps, T.J.2
Mayer, J.3
-
48
-
-
77950502126
-
Ofatumumab as single-agent CD20 immunotherapy in fludarabinerefractory chronic lymphocytic leukemia
-
Hx-CD20-406 Study Investigators
-
Wierda WG-KT, Mayer J, et al; Hx-CD20-406 Study Investigators. Ofatumumab as single-agent CD20 immunotherapy in fludarabinerefractory chronic lymphocytic leukemia. J Clin Oncol. 2010 28: 1749-1755.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1749-1755
-
-
Wierda, W.G.-K.T.1
Mayer, J.2
-
49
-
-
76149128849
-
Ofatumumab combined with fludarabine and cyclophosphamide (O-FC) shows high activity in patients with previously untreated chronic lymphocytic leukemia (CLL): Results from a randomized, multicenter, international, two-dose, parallel group, phase II trial
-
Wierda WG, Kipps TJ, Durig J, et al. Ofatumumab combined with fludarabine and cyclophosphamide (O-FC) shows high activity in patients with previously untreated chronic lymphocytic leukemia (CLL): results from a randomized, multicenter, international, two-dose, parallel group, phase II trial. ASH Annual Meeting Abstracts. 2009;114:207.
-
(2009)
ASH Annual Meeting Abstracts
, vol.114
, pp. 207
-
-
Wierda, W.G.1
Kipps, T.J.2
Durig, J.3
-
50
-
-
67650657179
-
GA-101, a third-generation, humanized and glyco-engineered anti-CD20 mAb for the treatment of B-cell lymphoid malignancies
-
Robak T. GA-101, a third-generation, humanized and glyco-engineered anti-CD20 mAb for the treatment of B-cell lymphoid malignancies. Curr Opin Investig Drugs. 2009;10:588-596.
-
(2009)
Curr Opin Investig Drugs
, vol.10
, pp. 588-596
-
-
Robak, T.1
-
51
-
-
76949107685
-
Phase I study of RO5072759 (GA101) in relapsed/refractory chronic lymphocytic leukemia
-
Morschhauser F, Cartron G, Lamy T, et al. Phase I study of RO5072759 (GA101) in relapsed/refractory chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. 2009;114:884.
-
(2009)
ASH Annual Meeting Abstracts
, vol.114
, pp. 884
-
-
Morschhauser, F.1
Cartron, G.2
Lamy, T.3
-
52
-
-
63849169216
-
Veltuzumab, an anti-CD20 mAb for the t{stroke}reatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura
-
Milani C, Castillo J: Veltuzumab, an anti-CD20 mAb for the t{stroke}reatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura. Curr Opin Mol Ther. 2009;11: 200-207.
-
(2009)
Curr Opin Mol Ther
, vol.11
, pp. 200-207
-
-
Milani, C.1
Castillo, J.2
-
53
-
-
70249106098
-
Humanized antiCD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: Phase I/II results
-
Morschhauser F, Leonard JP, Fayad L, et al. Humanized antiCD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: phase I/II results. J Clin Oncol. 2009;27:3346-3353.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3346-3353
-
-
Morschhauser, F.1
Leonard, J.P.2
Fayad, L.3
-
54
-
-
60849089338
-
Properties and structurefunction relationships of veltuzumab (hA20), a humanized antiCD20 monoclonal antibody
-
Goldenberg DM, Rossi EA, Stein R, et al. Properties and structurefunction relationships of veltuzumab (hA20), a humanized antiCD20 monoclonal antibody. Blood. 2009;113:1062-1070.
-
(2009)
Blood
, vol.113
, pp. 1062-1070
-
-
Goldenberg, D.M.1
Rossi, E.A.2
Stein, R.3
-
55
-
-
0037092951
-
Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
-
Keating MJ, Flinn I, Jain V, et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study. Blood. 2002;99:3554-3561.
-
(2002)
Blood
, vol.99
, pp. 3554-3561
-
-
Keating, M.J.1
Flinn, I.2
Jain, V.3
-
56
-
-
0030897222
-
Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia
-
Osterborg A, Dyer MJ, Bunjes D, et al. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol. 1997;15: 1567-1574.
-
(1997)
J Clin Oncol
, vol.15
, pp. 1567-1574
-
-
Osterborg, A.1
Dyer, M.J.2
Bunjes, D.3
-
57
-
-
8644274039
-
A pilot trial of rituximab and alemtuzumab combination therapy in patients with relapsed and/or refractory chronic lymphocytic leukemia (CLL)
-
Nabhan C, Patton D, Gordon LI, et al. A pilot trial of rituximab and alemtuzumab combination therapy in patients with relapsed and/or refractory chronic lymphocytic leukemia (CLL). Leuk Lymphoma. 2004;45:2269-2273.
-
(2004)
Leuk Lymphoma
, vol.45
, pp. 2269-2273
-
-
Nabhan, C.1
Patton, D.2
Gordon, L.I.3
-
58
-
-
37649004407
-
Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
-
Hillmen P, Skotnicki AB, Robak T, et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol. 2007;25:5616-5623.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5616-5623
-
-
Hillmen, P.1
Skotnicki, A.B.2
Robak, T.3
-
59
-
-
11144357657
-
Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
-
Lozanski G, Heerema NA, Flinn IW, et al. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood. 2004;103:3278-3281.
-
(2004)
Blood
, vol.103
, pp. 3278-3281
-
-
Lozanski, G.1
Heerema, N.A.2
Flinn, I.W.3
-
60
-
-
77949499778
-
CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody
-
Awan FT, Lapalombella R, Trotta R, et al. CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody. Blood. 2010;115:1204-1213.
-
(2010)
Blood
, vol.115
, pp. 1204-1213
-
-
Awan, F.T.1
Lapalombella, R.2
Trotta, R.3
-
61
-
-
80051744286
-
Phase 1 dose escalation study of TRU-016, an anti-CD37 SMIPTM protein in relapsed and refractory CLL
-
Furman RR, Andritsos L, Flinn IW, et al. Phase 1 dose escalation study of TRU-016, an anti-CD37 SMIPTM protein in relapsed and refractory CLL. ASH Annual Meeting Abstracts. 2010;116:56.
-
(2010)
ASH Annual Meeting Abstracts
, vol.116
, pp. 56
-
-
Furman, R.R.1
Andritsos, L.2
Flinn, I.W.3
-
62
-
-
77955176357
-
A Phase 1 Trial of TRU-016, An Anti-CD37 small modular immunopharmaceutical (SMIPTM) protein in relapsed and refractory CLL: Early promising clinical activity
-
Andritsos L, Furman RR, Flinn IW, et al. A Phase 1 Trial of TRU-016, An Anti-CD37 small modular immunopharmaceutical (SMIPTM) protein in relapsed and refractory CLL: early promising clinical activity. ASH Annual Meeting Abstracts. 2009;114:3424.
-
(2009)
ASH Annual Meeting Abstracts
, vol.114
, pp. 3424
-
-
Andritsos, L.1
Furman, R.R.2
Flinn, I.W.3
-
63
-
-
70349334508
-
Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma
-
Advani R, Forero-Torres A, Furman RR, et al. Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. J Clin Oncol. 2009;27: 4371-4377.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4371-4377
-
-
Advani, R.1
Forero-Torres, A.2
Furman, R.R.3
-
64
-
-
76349120845
-
A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia
-
Furman RR, Forero-Torres A, Shustov A, et al. A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2010; 51:228-235.
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 228-235
-
-
Furman, R.R.1
Forero-Torres, A.2
Shustov, A.3
-
65
-
-
40449108219
-
Novel monoclonal antibodies for the treatment of chronic lymphocytic leukemia
-
Robak T. Novel monoclonal antibodies for the treatment of chronic lymphocytic leukemia. Curr Cancer Drug Targets. 2008;8(2):156-171.
-
(2008)
Curr Cancer Drug Targets
, vol.8
, Issue.2
, pp. 156-171
-
-
Robak, T.1
-
66
-
-
84873553218
-
Pharmacokinetics of Single-Agent Lumiliximab (Anti-CD23 Antibody) in Patients with Chronic Lymphocytic Leukemia
-
Woodworth J, Leigh BR, O'Brien S, et al. Pharmacokinetics of Single-Agent Lumiliximab (Anti-CD23 Antibody) in Patients with Chronic Lymphocytic Leukemia. ASH Annual Meeting Abstracts. 2004;104:4831.
-
(2004)
ASH Annual Meeting Abstracts
, vol.104
, pp. 4831
-
-
Woodworth, J.1
Leigh, B.R.2
O'Brien, S.3
-
67
-
-
38949216227
-
Comparison of results from a phase 1/2 study of lumiliximab (Anti-CD23) in combination with FCR for patients with relapsed CLL with published FCR results
-
Byrd JC, Castro J, O'Brien S, et al. Comparison of results from a phase 1/2 study of lumiliximab (Anti-CD23) in combination with FCR for patients with relapsed CLL with published FCR results. ASH Annual Meeting Abstracts. 2006;108:32.
-
(2006)
ASH Annual Meeting Abstracts
, vol.108
, pp. 32
-
-
Byrd, J.C.1
Castro, J.2
O'Brien, S.3
-
68
-
-
32744456968
-
Safety and efficacy results from a phase I trial of single-agent lumiliximab (anti-CD23 antibody) for chronic lymphocytic leukemia
-
Byrd JC, O'Brien S, Flinn I, et al. Safety and efficacy results from a phase I trial of single-agent lumiliximab (anti-CD23 antibody) for chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. 2004; 104:2503.
-
(2503)
ASH Annual Meeting Abstracts
, vol.2004
, pp. 104
-
-
Byrd, J.C.1
O'Brien, S.2
Flinn, I.3
-
69
-
-
77449133613
-
Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia
-
Byrd JC, Kipps TJ, Flinn IW, et al. Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia. Blood. 2010;115:489-495.
-
(2010)
Blood
, vol.115
, pp. 489-495
-
-
Byrd, J.C.1
Kipps, T.J.2
Flinn, I.W.3
-
70
-
-
17744401939
-
Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2
-
LeMaistre CF, Saleh MN, Kuzel TM, et al. Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2. Blood. 1998;91:399-405.
-
(1998)
Blood
, vol.91
, pp. 399-405
-
-
Lemaistre, C.F.1
Saleh, M.N.2
Kuzel, T.M.3
-
71
-
-
0037322572
-
DAB389IL2 (ONTAK) fusion protein therapy of chronic lymphocytic leukaemia
-
Frankel AE, Fleming DR, Powell BL, et al. DAB389IL2 (ONTAK) fusion protein therapy of chronic lymphocytic leukaemia. Expert Opin Biol Ther. 2003;3:179-186.
-
(2003)
Expert Opin Biol Ther
, vol.3
, pp. 179-186
-
-
Frankel, A.E.1
Fleming, D.R.2
Powell, B.L.3
-
72
-
-
2542472359
-
Confirmation of the activity of the interleukin-2 fusion toxin denileukin diftitox against chemorefractory chronic lymphocytic leukemia, including cases with chromosome 17p deletions and without detectable CD25 expression
-
Morgan SJ, Seymour JF, Prince HM, et al. Confirmation of the activity of the interleukin-2 fusion toxin denileukin diftitox against chemorefractory chronic lymphocytic leukemia, including cases with chromosome 17p deletions and without detectable CD25 expression. Clin Cancer Res. 2004;10:3572-3575.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3572-3575
-
-
Morgan, S.J.1
Seymour, J.F.2
Prince, H.M.3
-
73
-
-
77956170550
-
New insights into apoptosis signaling by Apo2L/ TRAIL
-
Gonzalvez F AA: New insights into apoptosis signaling by Apo2L/ TRAIL. Oncogene. 2010;29:4752-65.
-
(2010)
Oncogene
, vol.29
, pp. 4752-4765
-
-
Gonzalvez, F.A.A.1
-
74
-
-
12744261484
-
Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies
-
Inoue S, MacFarlane M, Harper N, et al. Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies. Cell Death Differ. 2004 (11 Suppl 2):S193-S206.
-
(2004)
Cell Death Differ
, Issue.11 SUPPL. 2
-
-
Inoue, S.1
Macfarlane, M.2
Harper, N.3
-
75
-
-
0032523201
-
Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis
-
Plumas J, Jacob MC, Chaperot L, et al. Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis. Blood. 1998;91:2875-2885.
-
(1998)
Blood
, vol.91
, pp. 2875-2885
-
-
Plumas, J.1
Jacob, M.C.2
Chaperot, L.3
-
76
-
-
0037015675
-
Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia
-
MacFarlane M, Harper N, Snowden RT, et al. Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia. Oncogene. 2002;21:6809-6818.
-
(2002)
Oncogene
, vol.21
, pp. 6809-6818
-
-
Macfarlane, M.1
Harper, N.2
Snowden, R.T.3
-
77
-
-
84873554276
-
In vitro synergistic antitumor activity by targeting TRAIL-R1 and CD20 antigen by combining HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) and rituximab monoclonal antibody against non-Hodgkin's lymphoma cells (NHL)
-
Czuczman MS, Maddipatla S, Knight J, et al. In vitro synergistic antitumor activity by targeting TRAIL-R1 and CD20 antigen by combining HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) and rituximab monoclonal antibody against non-Hodgkin's lymphoma cells (NHL). ASH Annual Meeting Abstracts. 2005;106:1475.
-
(2005)
ASH Annual Meeting Abstracts
, vol.106
, pp. 1475
-
-
Czuczman, M.S.1
Maddipatla, S.2
Knight, J.3
-
78
-
-
84873543361
-
Mapatumumab, a TRAIL receptor 1 agonist antibody, induces apoptosis in bortezomib resistant multiple myeloma
-
Ghoshal P, Chitta K, Vujcic S, et al. Mapatumumab, a TRAIL receptor 1 agonist antibody, induces apoptosis in bortezomib resistant multiple myeloma. ASH Annual Meeting Abstracts. 2009;114:2832.
-
(2832)
ASH Annual Meeting Abstracts
, vol.2009
, pp. 114
-
-
Ghoshal, P.1
Chitta, K.2
Vujcic, S.3
-
79
-
-
33646390886
-
Results of a phase 2 Trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed/refractory non-Hodgkin's lymphoma (NHL)
-
Younes A, Vose JM, Zelenetz AD, et al. Results of a phase 2 Trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed/refractory non-Hodgkin's lymphoma (NHL). ASH Annual Meeting Abstracts. 2005;106:489.
-
(2005)
ASH Annual Meeting Abstracts
, vol.106
, pp. 489
-
-
Younes, A.1
Vose, J.M.2
Zelenetz, A.D.3
-
80
-
-
35748975398
-
TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2
-
Natoni A, MacFarlane M, Inoue S, et al. TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2. Br J Haematol. 2007;139:568-577.
-
(2007)
Br J Haematol
, vol.139
, pp. 568-577
-
-
Natoni, A.1
Macfarlane, M.2
Inoue, S.3
-
81
-
-
2942724589
-
Histone deacetylase inhibitors: Development as cancer therapy
-
discussion 281-288
-
Marks PA, Richon VM, Kelly WK, et al. Histone deacetylase inhibitors: development as cancer therapy. Novartis Found Symp. 2004;259: 269-281; discussion 281-288.
-
(2004)
Novartis Found Symp
, vol.259
, pp. 269-281
-
-
Marks, P.A.1
Richon, V.M.2
Kelly, W.K.3
-
82
-
-
28544439923
-
On the TRAIL of a new therapy for leukemia
-
Kaufmann SH, Steensma DP. On the TRAIL of a new therapy for leukemia. Leukemia. 2005;19:2195-21202.
-
(2005)
Leukemia
, vol.19
, pp. 2195-21202
-
-
Kaufmann, S.H.1
Steensma, D.P.2
-
83
-
-
13844309711
-
Clinical development of histone deacetylase inhibitors as anticancer agents
-
Drummond DC, Noble CO, Kirpotin DB, et al. Clinical development of histone deacetylase inhibitors as anticancer agents. Annu Rev Pharmacol Toxicol. 2005;45:495-528.
-
(2005)
Annu Rev Pharmacol Toxicol
, vol.45
, pp. 495-528
-
-
Drummond, D.C.1
Noble, C.O.2
Kirpotin, D.B.3
-
84
-
-
78751549662
-
The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
-
Herishanu Y P-GP, Liu D et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood. 2011;117: 563-574.
-
(2011)
Blood
, vol.117
, pp. 563-574
-
-
Herishanu, Y.P.-G.P.1
Liu, D.2
-
85
-
-
77951002653
-
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin's lymphoma and chronic lymphocytic leukemia
-
Friedberg JW SJ, Sweetenham J, et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Blood. 2010;115:2578-2585.
-
(2010)
Blood
, vol.115
, pp. 2578-2585
-
-
Friedberg, J.W.S.J.1
Sweetenham, J.2
-
87
-
-
70349923269
-
Dasatinib has activity in relapsed/refractory chronic lymphocytic leukemia (CLL/SLL), a phase II trial
-
Amrein PC, Attar E, Takvorian T, et al. Dasatinib has activity in relapsed/refractory chronic lymphocytic leukemia (CLL/SLL), a phase II trial. ASH Annual Meeting Abstracts. 2008;112:3162.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 3162
-
-
Amrein, P.C.1
Attar, E.2
Takvorian, T.3
-
88
-
-
0242721548
-
Targeting Bcl-2 and Bcl-XL with non peptidic small-molecule antagonists
-
Wang S, Yang D, Lippman ME: Targeting Bcl-2 and Bcl-XL with non peptidic small-molecule antagonists. Semin Oncol. 2003;30:133-142.
-
(2003)
Semin Oncol
, vol.30
, pp. 133-142
-
-
Wang, S.1
Yang, D.2
Lippman, M.E.3
-
89
-
-
4544340539
-
Antiapoptotic BCL-2 is required for maintenance of a model leukemia
-
Letai A, Sorcinelli MD, Beard C, et al. Antiapoptotic BCL-2 is required for maintenance of a model leukemia. Cancer Cell. 2004;6:241-249.
-
(2004)
Cancer Cell
, vol.6
, pp. 241-249
-
-
Letai, A.1
Sorcinelli, M.D.2
Beard, C.3
-
91
-
-
70449723145
-
5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen
-
O'Brien S, Moore JO, Boyd TE, et al. 5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen. J Clin Oncol. 2009;27:5208-5212.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5208-5212
-
-
O'Brien, S.1
Moore, J.O.2
Boyd, T.E.3
-
92
-
-
37649023004
-
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
-
Nguyen M, Marcellus RC, Roulston A, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007;104: 19512-19517.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19512-19517
-
-
Nguyen, M.1
Marcellus, R.C.2
Roulston, A.3
-
93
-
-
34249321391
-
A phase I trial of the small molecule pan-Bcl-2 family inhibitor obatoclax mesylate (GX15-070) administered by 24 hour infusion every 2 weeks to patients with myeloid malignancies and chronic lymphocytic leukemia (CLL)
-
Borthakur G, O'Brien S, Ravandi-Kashani F, et al. A phase I trial of the small molecule pan-Bcl-2 family inhibitor obatoclax mesylate (GX15-070) administered by 24 hour infusion every 2 weeks to patients with myeloid malignancies and chronic lymphocytic leukemia (CLL). ASH Annual Meeting Abstracts. 2006;108:2654.
-
(2006)
ASH Annual Meeting Abstracts
, vol.2654
, pp. 108
-
-
Borthakur, G.1
O'Brien, S.2
Ravandi-Kashani, F.3
-
94
-
-
59449095496
-
AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance
-
Balakrishnan K, Burger JA, Wierda WG, et al. AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood. 2009;113:149-153.
-
(2009)
Blood
, vol.113
, pp. 149-153
-
-
Balakrishnan, K.1
Burger, J.A.2
Wierda, W.G.3
-
95
-
-
37049007709
-
AT-101, a small molecule Bcl-2 antagonist, in treatment naïve CLL patients (pts) with high risk features; Preliminary results from an ongoing phase I trial
-
James D, Castro JE, Loria O, Prada CE, Aguillon RA, Kipps TJ. AT-101, a small molecule Bcl-2 antagonist, in treatment naïve CLL patients (pts) with high risk features; Preliminary results from an ongoing phase I trial. J Clin Oncol. 2006;24:6605.
-
(2006)
J Clin Oncol
, vol.24
, pp. 6605
-
-
James, D.1
Castro, J.E.2
Loria, O.3
Prada, C.E.4
Aguillon, R.A.5
Kipps, T.J.6
-
96
-
-
57049108617
-
A Phase II, Open Label Study of AT-101 in combination with rituximab in patients with relapsed or refractory chronic lymphocytic leukemia
-
Castro JE, Olivier LJ, Robier AA, et al. A Phase II, Open Label Study of AT-101 in combination with rituximab in patients with relapsed or refractory chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. 2006;108:2838.
-
(2006)
ASH Annual Meeting Abstracts
, vol.2838
, pp. 108
-
-
Castro, J.E.1
Olivier, L.J.2
Robier, A.A.3
-
97
-
-
54049111866
-
Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis
-
Stolz C, Hess G, Hahnel PS, et al. Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis. Blood. 2008;112:3312-3321.
-
(2008)
Blood
, vol.112
, pp. 3312-3321
-
-
Stolz, C.1
Hess, G.2
Hahnel, P.S.3
-
98
-
-
67650648386
-
ABT-263 activity in patients with relapsed or refractory lymphoid malignancies in particular chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
-
Wilson W, O'Conner O, Roberts AW, et al. ABT-263 activity in patients with relapsed or refractory lymphoid malignancies in particular chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). J Clin Oncol. 2009;27:15s.
-
(2009)
J Clin Oncol
, vol.15 s
, pp. 27
-
-
Wilson, W.1
O'Conner, O.2
Roberts, A.W.3
-
99
-
-
4344664011
-
A sustained activation of PI3 K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells
-
Cuni S, Perez-Aciego P, Perez-Chacon G, et al. A sustained activation of PI3 K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells. Leukemia. 2004;18:1391-1400.
-
(2004)
Leukemia
, vol.18
, pp. 1391-1400
-
-
Cuni, S.1
Perez-Aciego, P.2
Perez-Chacon, G.3
-
100
-
-
73149092535
-
Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells
-
De Frias M, Iglesias-Serret D, Cosialls AM, et al. Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells. Haematologica. 2009; 94(12):1698-1707.
-
(2009)
Haematologica
, vol.94
, Issue.12
, pp. 1698-1707
-
-
de Frias, M.1
Iglesias-Serret, D.2
Cosialls, A.M.3
-
101
-
-
77957201023
-
Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
-
Herman SE, Gordon AL, Wagner AJ, et al. Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116:2078-2088.
-
(2010)
Blood
, vol.116
, pp. 2078-2088
-
-
Herman, S.E.1
Gordon, A.L.2
Wagner, A.J.3
-
102
-
-
79953655788
-
CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110{delta}, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia
-
Furman RR, Byrd JC, Brown JR, et al. CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110{delta}, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. 2010;116:55.
-
(2010)
ASH Annual Meeting Abstracts
, vol.116
, pp. 55
-
-
Furman, R.R.1
Byrd, J.C.2
Brown, J.R.3
-
104
-
-
77954945333
-
Targeting the dynamic HSP90 complex in cancer
-
Trepel J, Mollapour M, Giaccone G, et al. Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer. 2010;10:537-549.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 537-549
-
-
Trepel, J.1
Mollapour, M.2
Giaccone, G.3
-
105
-
-
79960337453
-
Heat shock proteins in oncology: Diagnostic biomarkers or therapeutic targets?
-
Epub ahead of print
-
Khalil AA, Kabapy NF, Deraz SF, Smith C. Heat shock proteins in oncology: diagnostic biomarkers or therapeutic targets? Biochim Biophys Acta. 2011;1816(2):89-104. Epub ahead of print.
-
(2011)
Biochim Biophys Acta
, vol.1816
, Issue.2
, pp. 89-104
-
-
Khalil, A.A.1
Kabapy, N.F.2
Deraz, S.F.3
Smith, C.4
-
106
-
-
1442356824
-
Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs
-
Jones DT, Addison E, North JM, et al. Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. Blood. 2004; 103:1855-1861.
-
(2004)
Blood
, vol.103
, pp. 1855-1861
-
-
Jones, D.T.1
Addison, E.2
North, J.M.3
-
107
-
-
42049109174
-
Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells
-
Lin K, Rockliffe N, Johnson GG, et al. Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells. Oncogene. 2008;27:2445-2455.
-
(2008)
Oncogene
, vol.27
, pp. 2445-2455
-
-
Lin, K.1
Rockliffe, N.2
Johnson, G.G.3
-
108
-
-
27144434812
-
Transcription inhibition by flavopiridol: Mechanism of chronic lymphocytic leukemia cell death
-
Chen R, Keating MJ, Gandhi V, et al. Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death. Blood. 2005;106:2513-2519.
-
(2005)
Blood
, vol.106
, pp. 2513-2519
-
-
Chen, R.1
Keating, M.J.2
Gandhi, V.3
-
109
-
-
33846219417
-
Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
-
Byrd JC, Lin TS, Dalton JT, et al. Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood. 2007;109:399-404.
-
(2007)
Blood
, vol.109
, pp. 399-404
-
-
Byrd, J.C.1
Lin, T.S.2
Dalton, J.T.3
-
110
-
-
80052566316
-
Interim analysis of EFC6663, a multicenter phase 2 study of alvocidib (flavopiridol), demonstrates clinical responses among patients with fludarabine refractory CLL
-
Lanasa MC, Andritsos L, Brown JR, et al. Interim analysis of EFC6663, a multicenter phase 2 study of alvocidib (flavopiridol), demonstrates clinical responses among patients with fludarabine refractory CLL. ASH Annual Meeting Abstracts. 2010;116:58.
-
(2010)
ASH Annual Meeting Abstracts
, vol.116
, pp. 58
-
-
Lanasa, M.C.1
Andritsos, L.2
Brown, J.R.3
-
111
-
-
77954611291
-
Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma
-
Tong WG, Chen R, Plunkett W, et al. Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma. J Clin Oncol. 2010;28(18):3015-3022.
-
(2010)
J Clin Oncol
, vol.28
, Issue.18
, pp. 3015-3022
-
-
Tong, W.G.1
Chen, R.2
Plunkett, W.3
-
112
-
-
70349330220
-
Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia
-
Knauf WU, Lissichkov T, Aldaoud A, et al. Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol. 2009;27:4378-4384.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4378-4384
-
-
Knauf, W.U.1
Lissichkov, T.2
Aldaoud, A.3
-
113
-
-
84873550794
-
Bendamustine versus chlorambucil in treatment-naive patients with B-cell chronic lymphocytic leukemia (B-CLL): Results of an international phase III study
-
2007
-
Knauf WU, Lissichkov T, Aldaoud A, et al. Bendamustine versus chlorambucil in treatment-naive patients with B-cell chronic lymphocytic leukemia (B-CLL): results of an international phase III study. ASH Annual Meeting Abstracts. 2007;110:2043.
-
(2043)
ASH Annual Meeting Abstracts
, pp. 110
-
-
Knauf, W.U.1
Lissichkov, T.2
Aldaoud, A.3
-
114
-
-
77950321929
-
Bendamustine combined with rituximab (BR) in first-line therapy of advanced CLL: A multicenter phase II trial of the German CLL Study Group (GCLLSG)
-
Fischer K, Cramer P, Stilgenbauer S, et al. Bendamustine combined with rituximab (BR) in first-line therapy of advanced CLL: a multicenter phase II trial of the German CLL Study Group (GCLLSG). ASH Annual Meeting Abstracts. 2009;114:205.
-
(2009)
ASH Annual Meeting Abstracts
, vol.114
, pp. 205
-
-
Fischer, K.1
Cramer, P.2
Stilgenbauer, S.3
|