메뉴 건너뛰기




Volumn 4, Issue , 2011, Pages 169-183

Targeted treatment for chronic lymphocytic leukemia

Author keywords

Akt inhibitors; Bcl 2 inhibitors; CLL; Cyclin d kinase inhibitors; Heat shock protein inhibitors; Immunomodulatory drugs; Monoclonal antibodies

Indexed keywords

ALEMTUZUMAB; ANTINEOPLASTIC AGENT; BENDAMUSTINE; BREAKPOINT CLUSTER REGION PROTEIN; CD19 ANTIGEN; CD20 ANTIGEN; CD23 ANTIGEN; CD40 ANTIGEN; CD52 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR; DACETUZUMAB; DEATH RECEPTOR; DENILEUKIN DIFTITOX; FLUDARABINE; FOSTAMATINIB; IMMUNOMODULATING AGENT; INTERLEUKIN 2 RECEPTOR ALPHA; LENALIDOMIDE; LUMILIXIMAB; MAPATUMUMAB; MONOCLONAL ANTIBODY; OBINUTUZUMAB; OFATUMUMAB; PROTEIN KINASE B INHIBITOR; RITUXIMAB; THALIDOMIDE; TRU 016; UNCLASSIFIED DRUG; UNINDEXED DRUG; VELTUZUMAB; XMAB 5574;

EID: 84858807412     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S7173     Document Type: Review
Times cited : (6)

References (114)
  • 1
    • 30144443996 scopus 로고    scopus 로고
    • Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001
    • Morton LM, Wang SS, Devesa SS, et al. Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001. Blood. 2006;107: 265-276.
    • (2006) Blood , vol.107 , pp. 265-276
    • Morton, L.M.1    Wang, S.S.2    Devesa, S.S.3
  • 2
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111:5446-5456.
    • (2008) Blood , vol.111 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 3
    • 34447530283 scopus 로고    scopus 로고
    • Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): A randomised controlled trial
    • Catovsky D, Richards S, Matutes E, et al. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial. Lancet. 2007;370: 230-239.
    • (2007) Lancet , vol.370 , pp. 230-239
    • Catovsky, D.1    Richards, S.2    Matutes, E.3
  • 4
    • 31544434508 scopus 로고    scopus 로고
    • Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia
    • Eichhorst BF, Busch R, Hopfinger G, et al. Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia. Blood. 2006;107:885-891.
    • (2006) Blood , vol.107 , pp. 885-891
    • Eichhorst, B.F.1    Busch, R.2    Hopfinger, G.3
  • 5
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating MJ, O'Brien S, Albitar M, et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol. 2005;23: 4079-4088.
    • (2005) J Clin Oncol , vol.23 , pp. 4079-4088
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3
  • 6
    • 4544332737 scopus 로고    scopus 로고
    • The leukemic presentation of mantle-cell lymphoma: Disease features and prognostic factors in 58 patients
    • Matutes E, Parry-Jones N, Brito-Babapulle V, et al. The leukemic presentation of mantle-cell lymphoma: disease features and prognostic factors in 58 patients. Leuk Lymphoma. 2004;45:2007-2015.
    • (2004) Leuk Lymphoma , vol.45 , pp. 2007-2015
    • Matutes, E.1    Parry-Jones, N.2    Brito-Babapulle, V.3
  • 7
    • 0032079746 scopus 로고    scopus 로고
    • Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with in vitro and in vivo chemoresponses
    • Kitada S, Andersen J, Akar S, et al. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses. Blood. 1998;91:3379-3389.
    • (1998) Blood , vol.91 , pp. 3379-3389
    • Kitada, S.1    Andersen, J.2    Akar, S.3
  • 8
    • 79951498701 scopus 로고    scopus 로고
    • Cellular origin(s) of chronic lymphocytic leukemia: Cautionary notes and additional considerations and possibilities
    • Chiorazzi N FM: Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood. 2011;117:1781-1791.
    • (2011) Blood , vol.117 , pp. 1781-1791
    • Chiorazzi, N.F.M.1
  • 9
    • 65549151712 scopus 로고    scopus 로고
    • E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction
    • Gorgun G, Ramsay AG, Holderried TA, et al. E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction. Proc Natl Acad Sci U S A. 2009;106:6250-6255.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 6250-6255
    • Gorgun, G.1    Ramsay, A.G.2    Holderried, T.A.3
  • 10
    • 70349562920 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of CLL: Novel therapeutic approaches
    • Pleyer L, Egle A, Hartmann TN, et al. Molecular and cellular mechanisms of CLL: novel therapeutic approaches. Nat Rev Clin Oncol. 2009;6:405-418.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 405-418
    • Pleyer, L.1    Egle, A.2    Hartmann, T.N.3
  • 11
    • 17144430972 scopus 로고    scopus 로고
    • Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells
    • Farahani M, Treweeke AT, Toh CH, et al. Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells. Leukemia. 2005;19:524-530.
    • (2005) Leukemia , vol.19 , pp. 524-530
    • Farahani, M.1    Treweeke, A.T.2    Toh, C.H.3
  • 12
    • 33748616265 scopus 로고    scopus 로고
    • Molecular pathogenesis of chronic lymphocytic leukemia
    • Danilov AV, Danilova OV, Klein AK, et al. Molecular pathogenesis of chronic lymphocytic leukemia. Curr Mol Med. 2006;6:665-675.
    • (2006) Curr Mol Med , vol.6 , pp. 665-675
    • Danilov, A.V.1    Danilova, O.V.2    Klein, A.K.3
  • 13
    • 0242298176 scopus 로고    scopus 로고
    • Role of the microenvironment in chronic lymphocytic leukemia
    • Caligris-Cappio F: Role of the microenvironment in chronic lymphocytic leukemia. Br J Hematol. 2003;123:380-388.
    • (2003) Br J Hematol , vol.123 , pp. 380-388
    • Caligris-Cappio, F.1
  • 14
    • 83455196326 scopus 로고    scopus 로고
    • A pilot study of genasense (R) (oblimersen sodium, Bcl-2 antisense oligonucleotide), fludarabine and rituximab in previously treated and untreated subjects with chronic lymphocytic leukemia
    • Chanan-Khan AA, Mavromatis B, Rai KR, et al. A pilot study of genasense (R) (oblimersen sodium, Bcl-2 antisense oligonucleotide), fludarabine and rituximab in previously treated and untreated subjects with chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. 2004;104:4827.
    • (2004) ASH Annual Meeting Abstracts , vol.104 , pp. 4827
    • Chanan-Khan, A.A.1    Mavromatis, B.2    Rai, K.R.3
  • 15
    • 58849164097 scopus 로고    scopus 로고
    • Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
    • O'Brien SM, Claxton DF, Crump M, et al. Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood. 2009;113:299-305.
    • (2009) Blood , vol.113 , pp. 299-305
    • O'Brien, S.M.1    Claxton, D.F.2    Crump, M.3
  • 16
    • 33750834023 scopus 로고    scopus 로고
    • The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
    • van Delft MF, Wei AH, Mason KD, et al. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell. 2006;10:389-399.
    • (2006) Cancer Cell , vol.10 , pp. 389-399
    • van Delft, M.F.1    Wei, A.H.2    Mason, K.D.3
  • 17
    • 33645123690 scopus 로고    scopus 로고
    • Novel approaches to immunotherapy for B-cell malignancies
    • Brentjens RJ: Novel approaches to immunotherapy for B-cell malignancies. Curr Hematol Rep. 2005;4:64-72.
    • (2005) Curr Hematol Rep , vol.4 , pp. 64-72
    • Brentjens, R.J.1
  • 18
    • 0035999150 scopus 로고    scopus 로고
    • Chronic B cell malignancies and bone marrow microenvironment
    • Ghia P, Granziero L, Chilosi M, et al. Chronic B cell malignancies and bone marrow microenvironment. Semin Cancer Biol. 2002;12:149-155.
    • (2002) Semin Cancer Biol , vol.12 , pp. 149-155
    • Ghia, P.1    Granziero, L.2    Chilosi, M.3
  • 19
    • 84873563141 scopus 로고    scopus 로고
    • Treatment with lenalidomide (Revlimid(R)) upregulates CD40 expression on CLL Cells and increases their sensitivity to CD40-mediated cytotoxicity in vitro
    • Glezer E, Ferrajoli A, Reuben JM, et al. Treatment with lenalidomide (Revlimid(R)) upregulates CD40 expression on CLL Cells and increases their sensitivity to CD40-mediated cytotoxicity in vitro. ASH Annual Meeting Abstracts. 2008;112:3168.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 3168
    • Glezer, E.1    Ferrajoli, A.2    Reuben, J.M.3
  • 20
    • 70449477828 scopus 로고    scopus 로고
    • The role of the microenvironment for CLL proliferation and survival: Gene expression profiling of leukemic cells derived from blood, bone marrow and lymph nodes reveals the B-cell receptor and NF {kappa}B as dominant signaling pathways
    • Herishanu Y, Vire B, Liu D, et al. The role of the microenvironment for CLL proliferation and survival: gene expression profiling of leukemic cells derived from blood, bone marrow and lymph nodes reveals the B-cell receptor and NF {kappa}B as dominant signaling pathways. ASH Annual Meeting Abstracts. 2008;112:356.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 356
    • Herishanu, Y.1    Vire, B.2    Liu, D.3
  • 21
    • 67649272030 scopus 로고    scopus 로고
    • Ofatumumab (HuMax-CD20), a Novel CD20 monoclonal antibody, is an active treatment for patients with CLL refractory to both fludarabine and alemtuzumab or bulky fludarabine-refractory disease: Results from the planned interim analysis of an international pivotal trial
    • Osterborg A, Kipps TJ, Mayer J, et al. Ofatumumab (HuMax-CD20), a Novel CD20 monoclonal antibody, is an active treatment for patients with CLL refractory to both fludarabine and alemtuzumab or bulky fludarabine-refractory disease: Results from the planned interim analysis of an international pivotal trial. ASH Annual Meeting Abstracts. 2008;112:328.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 328
    • Osterborg, A.1    Kipps, T.J.2    Mayer, J.3
  • 22
    • 41149168649 scopus 로고    scopus 로고
    • Lenalidomide for the treatment of B-cell malignancies
    • Chanan-Khan AA, Cheson BD. Lenalidomide for the treatment of B-cell malignancies. J Clin Oncol. 2008;26:1544-1552.
    • (2008) J Clin Oncol , vol.26 , pp. 1544-1552
    • Chanan-Khan, A.A.1    Cheson, B.D.2
  • 23
    • 84873533627 scopus 로고    scopus 로고
    • In vivo evaluation of immunomodulating effects of lenalidomide (L) on tumor cell microenvironment as a possible underlying mechanism of the antitumor effects observed in patients (pts) with chronic lymphocytic leukemia (CLL)
    • Chanan-Khan AA, Padmanabhan S, Miller KC, et al. In vivo evaluation of immunomodulating effects of lenalidomide (L) on tumor cell microenvironment as a possible underlying mechanism of the antitumor effects observed in patients (pts) with chronic lymphocytic leukemia (CLL). ASH Annual Meeting Abstracts. 2005;106:2975.
    • (2975) ASH Annual Meeting Abstracts , vol.2005 , pp. 106
    • Chanan-Khan, A.A.1    Padmanabhan, S.2    Miller, K.C.3
  • 24
    • 27744597929 scopus 로고    scopus 로고
    • Results of a phase 1 clinical trial of thalidomide in combination with fludarabine as initial therapy for patients with treatment-requiring chronic lymphocytic leukemia (CLL)
    • Chanan-Khan A, Miller KC, Takeshita K, et al. Results of a phase 1 clinical trial of thalidomide in combination with fludarabine as initial therapy for patients with treatment-requiring chronic lymphocytic leukemia (CLL). Blood. 2005;106:3348-3352.
    • (2005) Blood , vol.106 , pp. 3348-3352
    • Chanan-Khan, A.1    Miller, K.C.2    Takeshita, K.3
  • 25
    • 70350123882 scopus 로고    scopus 로고
    • Thalidomide exerts distinct molecular antileukemic effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia
    • Giannopoulos K, Dmoszynska A, Kowal M, et al. Thalidomide exerts distinct molecular antileukemic effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia. Leukemia 2009;23:1771-1778.
    • (2009) Leukemia , vol.23 , pp. 1771-1778
    • Giannopoulos, K.1    Dmoszynska, A.2    Kowal, M.3
  • 26
    • 68449101813 scopus 로고    scopus 로고
    • N9986: A phase II trial of thalidomide in patients with relapsed chronic lymphocytic leukemia
    • Kay NE, Shanafelt TD, Call TG, et al. N9986: a phase II trial of thalidomide in patients with relapsed chronic lymphocytic leukemia. Leuk Lymphoma. 2009;50:588-592.
    • (2009) Leuk Lymphoma , vol.50 , pp. 588-592
    • Kay, N.E.1    Shanafelt, T.D.2    Call, T.G.3
  • 27
    • 33947243663 scopus 로고    scopus 로고
    • Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase II study
    • Chanan-Khan A, Miller KC, Musial L, et al. Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study. J Clin Oncol. 2006;24: 5343-5349.
    • (2006) J Clin Oncol , vol.24 , pp. 5343-5349
    • Chanan-Khan, A.1    Miller, K.C.2    Musial, L.3
  • 28
    • 74949083498 scopus 로고    scopus 로고
    • Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics
    • Sher T, Miller KC, Lawrence D, et al. Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics. Leuk Lymphoma. 2010;51:85-88.
    • (2010) Leuk Lymphoma , vol.51 , pp. 85-88
    • Sher, T.1    Miller, K.C.2    Lawrence, D.3
  • 29
    • 80054995804 scopus 로고    scopus 로고
    • Low-dose prednisone decreases the severity but not the frequency of lenalidomide associated tumor flare reaction (TFR) in chronic lymphocytic leukemia (CLL) patients
    • Musial L, Miller KC, Tonelli A, et al. Low-dose prednisone decreases the severity but not the frequency of lenalidomide associated tumor flare reaction (TFR) in chronic lymphocytic leukemia (CLL) patients. ASH Annual Meeting Abstracts. 2006;108:4987.
    • (2006) ASH Annual Meeting Abstracts , vol.108 , pp. 4987
    • Musial, L.1    Miller, K.C.2    Tonelli, A.3
  • 30
    • 79955515528 scopus 로고    scopus 로고
    • Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response
    • Chanan-Khan A, Miller KC, Lawrence D, et al. Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response. Cancer. 2011;117:2127-2135.
    • (2011) Cancer , vol.117 , pp. 2127-2135
    • Chanan-Khan, A.1    Miller, K.C.2    Lawrence, D.3
  • 31
    • 70449483516 scopus 로고    scopus 로고
    • Clinical efficacy of lenalidomide in fludarabine-refractory chronic lymphocytic leukemia patients
    • Chanan-Khan AA, Czuczman MS, Padmanabhan S, et al. Clinical efficacy of lenalidomide in fludarabine-refractory chronic lymphocytic leukemia patients. ASH Annual Meeting Abstracts. 2007;110:3108.
    • (2007) ASH Annual Meeting Abstracts , vol.110 , pp. 3108
    • Chanan-Khan, A.A.1    Czuczman, M.S.2    Padmanabhan, S.3
  • 32
    • 45949100928 scopus 로고    scopus 로고
    • Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
    • Ferrajoli A, Lee BN, Schlette EJ, et al. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood. 2008;111:5291-5297.
    • (2008) Blood , vol.111 , pp. 5291-5297
    • Ferrajoli, A.1    Lee, B.N.2    Schlette, E.J.3
  • 33
    • 34248159539 scopus 로고    scopus 로고
    • Lenalidomide induces complete and partial responses in patients with relapsed and treatmentrefractory chronic lymphocytic leukemia (CLL)
    • Ferrajoli A, O'Brien SM, Faderl SH, et al. Lenalidomide induces complete and partial responses in patients with relapsed and treatmentrefractory chronic lymphocytic leukemia (CLL). ASH Annual Meeting Abstracts. 2006;108:305.
    • (2006) ASH Annual Meeting Abstracts , vol.108 , pp. 305
    • Ferrajoli, A.1    O'Brien, S.M.2    Faderl, S.H.3
  • 34
    • 66749113746 scopus 로고    scopus 로고
    • A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL)
    • Chen C, Paul H, Xu W, et al. A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL). ASH Annual Meeting Abstracts. 2008;112:44.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 44
    • Chen, C.1    Paul, H.2    Xu, W.3
  • 35
    • 76149124676 scopus 로고    scopus 로고
    • Combination therapy with lenalidomide and rituximab in patients with relapsed chronic lymphocytic leukemia (CLL)
    • Ferrajoli A, Badoux XC, O'Brien S, et al. Combination therapy with lenalidomide and rituximab in patients with relapsed chronic lymphocytic leukemia (CLL). ASH Annual Meeting Abstracts. 2009; 114:206.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 206
    • Ferrajoli, A.1    Badoux, X.C.2    O'Brien, S.3
  • 36
    • 84873539533 scopus 로고    scopus 로고
    • A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL)
    • Chen CI, Paul H, Mariela P, et al. A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL). ASH Annual Meeting Abstracts. 2007;110:2042.
    • (2042) ASH Annual Meeting Abstracts , vol.2007 , pp. 110
    • Chen, C.I.1    Paul, H.2    Mariela, P.3
  • 37
    • 83255183478 scopus 로고    scopus 로고
    • Combination of ofatumumab and lenalidomide in patients with relapsed chronic lymphocytic leukemia: Initial results of a phase II trial
    • Badoux X, O'Brien S, Wierda WG, et al. Combination of ofatumumab and lenalidomide in patients with relapsed chronic lymphocytic leukemia: initial results of a phase II trial. ASH Annual Meeting Abstracts. 2010;116:2464.
    • (2464) ASH Annual Meeting Abstracts , vol.2010 , pp. 116
    • Badoux, X.1    O'Brien, S.2    Wierda, W.G.3
  • 38
    • 76949104717 scopus 로고    scopus 로고
    • Ofatumumab, a human CD20 monoclonal antibody
    • Osterborg A. Ofatumumab, a human CD20 monoclonal antibody. Expert Opin Biol Ther. 2010;10:439-449.
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 439-449
    • Osterborg, A.1
  • 39
    • 0035469851 scopus 로고    scopus 로고
    • Rituximab therapy of patients with B-cell chronic lymphocytic leukemia
    • Huhn D, von Schilling C, Wilhelm M, et al. Rituximab therapy of patients with B-cell chronic lymphocytic leukemia. Blood. 2001;98: 1326-1331.
    • (2001) Blood , vol.98 , pp. 1326-1331
    • Huhn, D.1    von Schilling, C.2    Wilhelm, M.3
  • 40
    • 0035871441 scopus 로고    scopus 로고
    • Rituximab doseescalation trial in chronic lymphocytic leukemia
    • O'Brien SM, Kantarjian H, Thomas DA, et al. Rituximab doseescalation trial in chronic lymphocytic leukemia. J Clin Oncol. 2001;19: 2165-2170.
    • (2001) J Clin Oncol , vol.19 , pp. 2165-2170
    • O'Brien, S.M.1    Kantarjian, H.2    Thomas, D.A.3
  • 41
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712)
    • Byrd JC, Peterson BL, Morrison VA, et al. Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood. 2003;101:6-14.
    • (2003) Blood , vol.101 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3
  • 42
    • 23044501404 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia
    • Wierda W, O'Brien S, Wen S, et al. Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia. J Clin Oncol. 2005;23:4070-4078.
    • (2005) J Clin Oncol , vol.23 , pp. 4070-4078
    • Wierda, W.1    O'Brien, S.2    Wen, S.3
  • 43
    • 51649093353 scopus 로고    scopus 로고
    • Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia
    • Tam CS, O'Brien S, Wierda W, et al. Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia. Blood. 2008;112:975-980.
    • (2008) Blood , vol.112 , pp. 975-980
    • Tam, C.S.1    O'Brien, S.2    Wierda, W.3
  • 44
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek MFK, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet. 2010;376: 1164-1174.
    • (2010) Lancet , vol.376 , pp. 1164-1174
    • Hallek, M.F.K.1    Fingerle-Rowson, G.2
  • 45
    • 79952278698 scopus 로고    scopus 로고
    • Ofatumumab: A new CD20 monoclonal antibody therapy for B-cell chronic lymphocytic leukemia
    • O'Brien S, Osterborg A. Ofatumumab: a new CD20 monoclonal antibody therapy for B-cell chronic lymphocytic leukemia. Clin Lymphoma Myeloma Leuk. 2010;10(5):361-368.
    • (2010) Clin Lymphoma Myeloma Leuk , vol.10 , Issue.5 , pp. 361-368
    • O'Brien, S.1    Osterborg, A.2
  • 46
    • 38949185742 scopus 로고    scopus 로고
    • Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: A phase 1-2 study
    • Coiffier B, Lepretre S, Pedersen LM, et al. Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study. Blood. 2008;111:1094-1100.
    • (2008) Blood , vol.111 , pp. 1094-1100
    • Coiffier, B.1    Lepretre, S.2    Pedersen, L.M.3
  • 47
    • 79955870406 scopus 로고    scopus 로고
    • Final analysis from the international trial of single-agent ofatumumab in patients with fludarabine-refractory chronic lymphocytic leukemia
    • Wierda WG, Kipps TJ, Mayer J, et al. Final analysis from the international trial of single-agent ofatumumab in patients with fludarabine-refractory chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. 2010; 116:921.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , pp. 921
    • Wierda, W.G.1    Kipps, T.J.2    Mayer, J.3
  • 48
    • 77950502126 scopus 로고    scopus 로고
    • Ofatumumab as single-agent CD20 immunotherapy in fludarabinerefractory chronic lymphocytic leukemia
    • Hx-CD20-406 Study Investigators
    • Wierda WG-KT, Mayer J, et al; Hx-CD20-406 Study Investigators. Ofatumumab as single-agent CD20 immunotherapy in fludarabinerefractory chronic lymphocytic leukemia. J Clin Oncol. 2010 28: 1749-1755.
    • (2010) J Clin Oncol , vol.28 , pp. 1749-1755
    • Wierda, W.G.-K.T.1    Mayer, J.2
  • 49
    • 76149128849 scopus 로고    scopus 로고
    • Ofatumumab combined with fludarabine and cyclophosphamide (O-FC) shows high activity in patients with previously untreated chronic lymphocytic leukemia (CLL): Results from a randomized, multicenter, international, two-dose, parallel group, phase II trial
    • Wierda WG, Kipps TJ, Durig J, et al. Ofatumumab combined with fludarabine and cyclophosphamide (O-FC) shows high activity in patients with previously untreated chronic lymphocytic leukemia (CLL): results from a randomized, multicenter, international, two-dose, parallel group, phase II trial. ASH Annual Meeting Abstracts. 2009;114:207.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 207
    • Wierda, W.G.1    Kipps, T.J.2    Durig, J.3
  • 50
    • 67650657179 scopus 로고    scopus 로고
    • GA-101, a third-generation, humanized and glyco-engineered anti-CD20 mAb for the treatment of B-cell lymphoid malignancies
    • Robak T. GA-101, a third-generation, humanized and glyco-engineered anti-CD20 mAb for the treatment of B-cell lymphoid malignancies. Curr Opin Investig Drugs. 2009;10:588-596.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 588-596
    • Robak, T.1
  • 51
    • 76949107685 scopus 로고    scopus 로고
    • Phase I study of RO5072759 (GA101) in relapsed/refractory chronic lymphocytic leukemia
    • Morschhauser F, Cartron G, Lamy T, et al. Phase I study of RO5072759 (GA101) in relapsed/refractory chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. 2009;114:884.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 884
    • Morschhauser, F.1    Cartron, G.2    Lamy, T.3
  • 52
    • 63849169216 scopus 로고    scopus 로고
    • Veltuzumab, an anti-CD20 mAb for the t{stroke}reatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura
    • Milani C, Castillo J: Veltuzumab, an anti-CD20 mAb for the t{stroke}reatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura. Curr Opin Mol Ther. 2009;11: 200-207.
    • (2009) Curr Opin Mol Ther , vol.11 , pp. 200-207
    • Milani, C.1    Castillo, J.2
  • 53
    • 70249106098 scopus 로고    scopus 로고
    • Humanized antiCD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: Phase I/II results
    • Morschhauser F, Leonard JP, Fayad L, et al. Humanized antiCD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: phase I/II results. J Clin Oncol. 2009;27:3346-3353.
    • (2009) J Clin Oncol , vol.27 , pp. 3346-3353
    • Morschhauser, F.1    Leonard, J.P.2    Fayad, L.3
  • 54
    • 60849089338 scopus 로고    scopus 로고
    • Properties and structurefunction relationships of veltuzumab (hA20), a humanized antiCD20 monoclonal antibody
    • Goldenberg DM, Rossi EA, Stein R, et al. Properties and structurefunction relationships of veltuzumab (hA20), a humanized antiCD20 monoclonal antibody. Blood. 2009;113:1062-1070.
    • (2009) Blood , vol.113 , pp. 1062-1070
    • Goldenberg, D.M.1    Rossi, E.A.2    Stein, R.3
  • 55
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
    • Keating MJ, Flinn I, Jain V, et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study. Blood. 2002;99:3554-3561.
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3
  • 56
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia
    • Osterborg A, Dyer MJ, Bunjes D, et al. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol. 1997;15: 1567-1574.
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3
  • 57
    • 8644274039 scopus 로고    scopus 로고
    • A pilot trial of rituximab and alemtuzumab combination therapy in patients with relapsed and/or refractory chronic lymphocytic leukemia (CLL)
    • Nabhan C, Patton D, Gordon LI, et al. A pilot trial of rituximab and alemtuzumab combination therapy in patients with relapsed and/or refractory chronic lymphocytic leukemia (CLL). Leuk Lymphoma. 2004;45:2269-2273.
    • (2004) Leuk Lymphoma , vol.45 , pp. 2269-2273
    • Nabhan, C.1    Patton, D.2    Gordon, L.I.3
  • 58
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • Hillmen P, Skotnicki AB, Robak T, et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol. 2007;25:5616-5623.
    • (2007) J Clin Oncol , vol.25 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.B.2    Robak, T.3
  • 59
    • 11144357657 scopus 로고    scopus 로고
    • Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
    • Lozanski G, Heerema NA, Flinn IW, et al. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood. 2004;103:3278-3281.
    • (2004) Blood , vol.103 , pp. 3278-3281
    • Lozanski, G.1    Heerema, N.A.2    Flinn, I.W.3
  • 60
    • 77949499778 scopus 로고    scopus 로고
    • CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody
    • Awan FT, Lapalombella R, Trotta R, et al. CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody. Blood. 2010;115:1204-1213.
    • (2010) Blood , vol.115 , pp. 1204-1213
    • Awan, F.T.1    Lapalombella, R.2    Trotta, R.3
  • 61
    • 80051744286 scopus 로고    scopus 로고
    • Phase 1 dose escalation study of TRU-016, an anti-CD37 SMIPTM protein in relapsed and refractory CLL
    • Furman RR, Andritsos L, Flinn IW, et al. Phase 1 dose escalation study of TRU-016, an anti-CD37 SMIPTM protein in relapsed and refractory CLL. ASH Annual Meeting Abstracts. 2010;116:56.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , pp. 56
    • Furman, R.R.1    Andritsos, L.2    Flinn, I.W.3
  • 62
    • 77955176357 scopus 로고    scopus 로고
    • A Phase 1 Trial of TRU-016, An Anti-CD37 small modular immunopharmaceutical (SMIPTM) protein in relapsed and refractory CLL: Early promising clinical activity
    • Andritsos L, Furman RR, Flinn IW, et al. A Phase 1 Trial of TRU-016, An Anti-CD37 small modular immunopharmaceutical (SMIPTM) protein in relapsed and refractory CLL: early promising clinical activity. ASH Annual Meeting Abstracts. 2009;114:3424.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 3424
    • Andritsos, L.1    Furman, R.R.2    Flinn, I.W.3
  • 63
    • 70349334508 scopus 로고    scopus 로고
    • Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma
    • Advani R, Forero-Torres A, Furman RR, et al. Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. J Clin Oncol. 2009;27: 4371-4377.
    • (2009) J Clin Oncol , vol.27 , pp. 4371-4377
    • Advani, R.1    Forero-Torres, A.2    Furman, R.R.3
  • 64
    • 76349120845 scopus 로고    scopus 로고
    • A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia
    • Furman RR, Forero-Torres A, Shustov A, et al. A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2010; 51:228-235.
    • (2010) Leuk Lymphoma , vol.51 , pp. 228-235
    • Furman, R.R.1    Forero-Torres, A.2    Shustov, A.3
  • 65
    • 40449108219 scopus 로고    scopus 로고
    • Novel monoclonal antibodies for the treatment of chronic lymphocytic leukemia
    • Robak T. Novel monoclonal antibodies for the treatment of chronic lymphocytic leukemia. Curr Cancer Drug Targets. 2008;8(2):156-171.
    • (2008) Curr Cancer Drug Targets , vol.8 , Issue.2 , pp. 156-171
    • Robak, T.1
  • 66
    • 84873553218 scopus 로고    scopus 로고
    • Pharmacokinetics of Single-Agent Lumiliximab (Anti-CD23 Antibody) in Patients with Chronic Lymphocytic Leukemia
    • Woodworth J, Leigh BR, O'Brien S, et al. Pharmacokinetics of Single-Agent Lumiliximab (Anti-CD23 Antibody) in Patients with Chronic Lymphocytic Leukemia. ASH Annual Meeting Abstracts. 2004;104:4831.
    • (2004) ASH Annual Meeting Abstracts , vol.104 , pp. 4831
    • Woodworth, J.1    Leigh, B.R.2    O'Brien, S.3
  • 67
    • 38949216227 scopus 로고    scopus 로고
    • Comparison of results from a phase 1/2 study of lumiliximab (Anti-CD23) in combination with FCR for patients with relapsed CLL with published FCR results
    • Byrd JC, Castro J, O'Brien S, et al. Comparison of results from a phase 1/2 study of lumiliximab (Anti-CD23) in combination with FCR for patients with relapsed CLL with published FCR results. ASH Annual Meeting Abstracts. 2006;108:32.
    • (2006) ASH Annual Meeting Abstracts , vol.108 , pp. 32
    • Byrd, J.C.1    Castro, J.2    O'Brien, S.3
  • 68
    • 32744456968 scopus 로고    scopus 로고
    • Safety and efficacy results from a phase I trial of single-agent lumiliximab (anti-CD23 antibody) for chronic lymphocytic leukemia
    • Byrd JC, O'Brien S, Flinn I, et al. Safety and efficacy results from a phase I trial of single-agent lumiliximab (anti-CD23 antibody) for chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. 2004; 104:2503.
    • (2503) ASH Annual Meeting Abstracts , vol.2004 , pp. 104
    • Byrd, J.C.1    O'Brien, S.2    Flinn, I.3
  • 69
    • 77449133613 scopus 로고    scopus 로고
    • Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia
    • Byrd JC, Kipps TJ, Flinn IW, et al. Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia. Blood. 2010;115:489-495.
    • (2010) Blood , vol.115 , pp. 489-495
    • Byrd, J.C.1    Kipps, T.J.2    Flinn, I.W.3
  • 70
    • 17744401939 scopus 로고    scopus 로고
    • Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2
    • LeMaistre CF, Saleh MN, Kuzel TM, et al. Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2. Blood. 1998;91:399-405.
    • (1998) Blood , vol.91 , pp. 399-405
    • Lemaistre, C.F.1    Saleh, M.N.2    Kuzel, T.M.3
  • 71
    • 0037322572 scopus 로고    scopus 로고
    • DAB389IL2 (ONTAK) fusion protein therapy of chronic lymphocytic leukaemia
    • Frankel AE, Fleming DR, Powell BL, et al. DAB389IL2 (ONTAK) fusion protein therapy of chronic lymphocytic leukaemia. Expert Opin Biol Ther. 2003;3:179-186.
    • (2003) Expert Opin Biol Ther , vol.3 , pp. 179-186
    • Frankel, A.E.1    Fleming, D.R.2    Powell, B.L.3
  • 72
    • 2542472359 scopus 로고    scopus 로고
    • Confirmation of the activity of the interleukin-2 fusion toxin denileukin diftitox against chemorefractory chronic lymphocytic leukemia, including cases with chromosome 17p deletions and without detectable CD25 expression
    • Morgan SJ, Seymour JF, Prince HM, et al. Confirmation of the activity of the interleukin-2 fusion toxin denileukin diftitox against chemorefractory chronic lymphocytic leukemia, including cases with chromosome 17p deletions and without detectable CD25 expression. Clin Cancer Res. 2004;10:3572-3575.
    • (2004) Clin Cancer Res , vol.10 , pp. 3572-3575
    • Morgan, S.J.1    Seymour, J.F.2    Prince, H.M.3
  • 73
    • 77956170550 scopus 로고    scopus 로고
    • New insights into apoptosis signaling by Apo2L/ TRAIL
    • Gonzalvez F AA: New insights into apoptosis signaling by Apo2L/ TRAIL. Oncogene. 2010;29:4752-65.
    • (2010) Oncogene , vol.29 , pp. 4752-4765
    • Gonzalvez, F.A.A.1
  • 74
    • 12744261484 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies
    • Inoue S, MacFarlane M, Harper N, et al. Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies. Cell Death Differ. 2004 (11 Suppl 2):S193-S206.
    • (2004) Cell Death Differ , Issue.11 SUPPL. 2
    • Inoue, S.1    Macfarlane, M.2    Harper, N.3
  • 75
    • 0032523201 scopus 로고    scopus 로고
    • Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis
    • Plumas J, Jacob MC, Chaperot L, et al. Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis. Blood. 1998;91:2875-2885.
    • (1998) Blood , vol.91 , pp. 2875-2885
    • Plumas, J.1    Jacob, M.C.2    Chaperot, L.3
  • 76
    • 0037015675 scopus 로고    scopus 로고
    • Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia
    • MacFarlane M, Harper N, Snowden RT, et al. Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia. Oncogene. 2002;21:6809-6818.
    • (2002) Oncogene , vol.21 , pp. 6809-6818
    • Macfarlane, M.1    Harper, N.2    Snowden, R.T.3
  • 77
    • 84873554276 scopus 로고    scopus 로고
    • In vitro synergistic antitumor activity by targeting TRAIL-R1 and CD20 antigen by combining HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) and rituximab monoclonal antibody against non-Hodgkin's lymphoma cells (NHL)
    • Czuczman MS, Maddipatla S, Knight J, et al. In vitro synergistic antitumor activity by targeting TRAIL-R1 and CD20 antigen by combining HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) and rituximab monoclonal antibody against non-Hodgkin's lymphoma cells (NHL). ASH Annual Meeting Abstracts. 2005;106:1475.
    • (2005) ASH Annual Meeting Abstracts , vol.106 , pp. 1475
    • Czuczman, M.S.1    Maddipatla, S.2    Knight, J.3
  • 78
    • 84873543361 scopus 로고    scopus 로고
    • Mapatumumab, a TRAIL receptor 1 agonist antibody, induces apoptosis in bortezomib resistant multiple myeloma
    • Ghoshal P, Chitta K, Vujcic S, et al. Mapatumumab, a TRAIL receptor 1 agonist antibody, induces apoptosis in bortezomib resistant multiple myeloma. ASH Annual Meeting Abstracts. 2009;114:2832.
    • (2832) ASH Annual Meeting Abstracts , vol.2009 , pp. 114
    • Ghoshal, P.1    Chitta, K.2    Vujcic, S.3
  • 79
    • 33646390886 scopus 로고    scopus 로고
    • Results of a phase 2 Trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed/refractory non-Hodgkin's lymphoma (NHL)
    • Younes A, Vose JM, Zelenetz AD, et al. Results of a phase 2 Trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed/refractory non-Hodgkin's lymphoma (NHL). ASH Annual Meeting Abstracts. 2005;106:489.
    • (2005) ASH Annual Meeting Abstracts , vol.106 , pp. 489
    • Younes, A.1    Vose, J.M.2    Zelenetz, A.D.3
  • 80
    • 35748975398 scopus 로고    scopus 로고
    • TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2
    • Natoni A, MacFarlane M, Inoue S, et al. TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2. Br J Haematol. 2007;139:568-577.
    • (2007) Br J Haematol , vol.139 , pp. 568-577
    • Natoni, A.1    Macfarlane, M.2    Inoue, S.3
  • 81
    • 2942724589 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Development as cancer therapy
    • discussion 281-288
    • Marks PA, Richon VM, Kelly WK, et al. Histone deacetylase inhibitors: development as cancer therapy. Novartis Found Symp. 2004;259: 269-281; discussion 281-288.
    • (2004) Novartis Found Symp , vol.259 , pp. 269-281
    • Marks, P.A.1    Richon, V.M.2    Kelly, W.K.3
  • 82
    • 28544439923 scopus 로고    scopus 로고
    • On the TRAIL of a new therapy for leukemia
    • Kaufmann SH, Steensma DP. On the TRAIL of a new therapy for leukemia. Leukemia. 2005;19:2195-21202.
    • (2005) Leukemia , vol.19 , pp. 2195-21202
    • Kaufmann, S.H.1    Steensma, D.P.2
  • 83
    • 13844309711 scopus 로고    scopus 로고
    • Clinical development of histone deacetylase inhibitors as anticancer agents
    • Drummond DC, Noble CO, Kirpotin DB, et al. Clinical development of histone deacetylase inhibitors as anticancer agents. Annu Rev Pharmacol Toxicol. 2005;45:495-528.
    • (2005) Annu Rev Pharmacol Toxicol , vol.45 , pp. 495-528
    • Drummond, D.C.1    Noble, C.O.2    Kirpotin, D.B.3
  • 84
    • 78751549662 scopus 로고    scopus 로고
    • The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
    • Herishanu Y P-GP, Liu D et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood. 2011;117: 563-574.
    • (2011) Blood , vol.117 , pp. 563-574
    • Herishanu, Y.P.-G.P.1    Liu, D.2
  • 85
    • 77951002653 scopus 로고    scopus 로고
    • Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin's lymphoma and chronic lymphocytic leukemia
    • Friedberg JW SJ, Sweetenham J, et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Blood. 2010;115:2578-2585.
    • (2010) Blood , vol.115 , pp. 2578-2585
    • Friedberg, J.W.S.J.1    Sweetenham, J.2
  • 87
    • 70349923269 scopus 로고    scopus 로고
    • Dasatinib has activity in relapsed/refractory chronic lymphocytic leukemia (CLL/SLL), a phase II trial
    • Amrein PC, Attar E, Takvorian T, et al. Dasatinib has activity in relapsed/refractory chronic lymphocytic leukemia (CLL/SLL), a phase II trial. ASH Annual Meeting Abstracts. 2008;112:3162.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 3162
    • Amrein, P.C.1    Attar, E.2    Takvorian, T.3
  • 88
    • 0242721548 scopus 로고    scopus 로고
    • Targeting Bcl-2 and Bcl-XL with non peptidic small-molecule antagonists
    • Wang S, Yang D, Lippman ME: Targeting Bcl-2 and Bcl-XL with non peptidic small-molecule antagonists. Semin Oncol. 2003;30:133-142.
    • (2003) Semin Oncol , vol.30 , pp. 133-142
    • Wang, S.1    Yang, D.2    Lippman, M.E.3
  • 89
    • 4544340539 scopus 로고    scopus 로고
    • Antiapoptotic BCL-2 is required for maintenance of a model leukemia
    • Letai A, Sorcinelli MD, Beard C, et al. Antiapoptotic BCL-2 is required for maintenance of a model leukemia. Cancer Cell. 2004;6:241-249.
    • (2004) Cancer Cell , vol.6 , pp. 241-249
    • Letai, A.1    Sorcinelli, M.D.2    Beard, C.3
  • 91
    • 70449723145 scopus 로고    scopus 로고
    • 5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen
    • O'Brien S, Moore JO, Boyd TE, et al. 5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen. J Clin Oncol. 2009;27:5208-5212.
    • (2009) J Clin Oncol , vol.27 , pp. 5208-5212
    • O'Brien, S.1    Moore, J.O.2    Boyd, T.E.3
  • 92
    • 37649023004 scopus 로고    scopus 로고
    • Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
    • Nguyen M, Marcellus RC, Roulston A, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007;104: 19512-19517.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19512-19517
    • Nguyen, M.1    Marcellus, R.C.2    Roulston, A.3
  • 93
    • 34249321391 scopus 로고    scopus 로고
    • A phase I trial of the small molecule pan-Bcl-2 family inhibitor obatoclax mesylate (GX15-070) administered by 24 hour infusion every 2 weeks to patients with myeloid malignancies and chronic lymphocytic leukemia (CLL)
    • Borthakur G, O'Brien S, Ravandi-Kashani F, et al. A phase I trial of the small molecule pan-Bcl-2 family inhibitor obatoclax mesylate (GX15-070) administered by 24 hour infusion every 2 weeks to patients with myeloid malignancies and chronic lymphocytic leukemia (CLL). ASH Annual Meeting Abstracts. 2006;108:2654.
    • (2006) ASH Annual Meeting Abstracts , vol.2654 , pp. 108
    • Borthakur, G.1    O'Brien, S.2    Ravandi-Kashani, F.3
  • 94
    • 59449095496 scopus 로고    scopus 로고
    • AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance
    • Balakrishnan K, Burger JA, Wierda WG, et al. AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood. 2009;113:149-153.
    • (2009) Blood , vol.113 , pp. 149-153
    • Balakrishnan, K.1    Burger, J.A.2    Wierda, W.G.3
  • 95
    • 37049007709 scopus 로고    scopus 로고
    • AT-101, a small molecule Bcl-2 antagonist, in treatment naïve CLL patients (pts) with high risk features; Preliminary results from an ongoing phase I trial
    • James D, Castro JE, Loria O, Prada CE, Aguillon RA, Kipps TJ. AT-101, a small molecule Bcl-2 antagonist, in treatment naïve CLL patients (pts) with high risk features; Preliminary results from an ongoing phase I trial. J Clin Oncol. 2006;24:6605.
    • (2006) J Clin Oncol , vol.24 , pp. 6605
    • James, D.1    Castro, J.E.2    Loria, O.3    Prada, C.E.4    Aguillon, R.A.5    Kipps, T.J.6
  • 96
    • 57049108617 scopus 로고    scopus 로고
    • A Phase II, Open Label Study of AT-101 in combination with rituximab in patients with relapsed or refractory chronic lymphocytic leukemia
    • Castro JE, Olivier LJ, Robier AA, et al. A Phase II, Open Label Study of AT-101 in combination with rituximab in patients with relapsed or refractory chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. 2006;108:2838.
    • (2006) ASH Annual Meeting Abstracts , vol.2838 , pp. 108
    • Castro, J.E.1    Olivier, L.J.2    Robier, A.A.3
  • 97
    • 54049111866 scopus 로고    scopus 로고
    • Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis
    • Stolz C, Hess G, Hahnel PS, et al. Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis. Blood. 2008;112:3312-3321.
    • (2008) Blood , vol.112 , pp. 3312-3321
    • Stolz, C.1    Hess, G.2    Hahnel, P.S.3
  • 98
    • 67650648386 scopus 로고    scopus 로고
    • ABT-263 activity in patients with relapsed or refractory lymphoid malignancies in particular chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
    • Wilson W, O'Conner O, Roberts AW, et al. ABT-263 activity in patients with relapsed or refractory lymphoid malignancies in particular chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). J Clin Oncol. 2009;27:15s.
    • (2009) J Clin Oncol , vol.15 s , pp. 27
    • Wilson, W.1    O'Conner, O.2    Roberts, A.W.3
  • 99
    • 4344664011 scopus 로고    scopus 로고
    • A sustained activation of PI3 K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells
    • Cuni S, Perez-Aciego P, Perez-Chacon G, et al. A sustained activation of PI3 K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells. Leukemia. 2004;18:1391-1400.
    • (2004) Leukemia , vol.18 , pp. 1391-1400
    • Cuni, S.1    Perez-Aciego, P.2    Perez-Chacon, G.3
  • 100
    • 73149092535 scopus 로고    scopus 로고
    • Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells
    • De Frias M, Iglesias-Serret D, Cosialls AM, et al. Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells. Haematologica. 2009; 94(12):1698-1707.
    • (2009) Haematologica , vol.94 , Issue.12 , pp. 1698-1707
    • de Frias, M.1    Iglesias-Serret, D.2    Cosialls, A.M.3
  • 101
    • 77957201023 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
    • Herman SE, Gordon AL, Wagner AJ, et al. Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116:2078-2088.
    • (2010) Blood , vol.116 , pp. 2078-2088
    • Herman, S.E.1    Gordon, A.L.2    Wagner, A.J.3
  • 102
    • 79953655788 scopus 로고    scopus 로고
    • CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110{delta}, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia
    • Furman RR, Byrd JC, Brown JR, et al. CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110{delta}, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. 2010;116:55.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , pp. 55
    • Furman, R.R.1    Byrd, J.C.2    Brown, J.R.3
  • 104
    • 77954945333 scopus 로고    scopus 로고
    • Targeting the dynamic HSP90 complex in cancer
    • Trepel J, Mollapour M, Giaccone G, et al. Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer. 2010;10:537-549.
    • (2010) Nat Rev Cancer , vol.10 , pp. 537-549
    • Trepel, J.1    Mollapour, M.2    Giaccone, G.3
  • 105
    • 79960337453 scopus 로고    scopus 로고
    • Heat shock proteins in oncology: Diagnostic biomarkers or therapeutic targets?
    • Epub ahead of print
    • Khalil AA, Kabapy NF, Deraz SF, Smith C. Heat shock proteins in oncology: diagnostic biomarkers or therapeutic targets? Biochim Biophys Acta. 2011;1816(2):89-104. Epub ahead of print.
    • (2011) Biochim Biophys Acta , vol.1816 , Issue.2 , pp. 89-104
    • Khalil, A.A.1    Kabapy, N.F.2    Deraz, S.F.3    Smith, C.4
  • 106
    • 1442356824 scopus 로고    scopus 로고
    • Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs
    • Jones DT, Addison E, North JM, et al. Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. Blood. 2004; 103:1855-1861.
    • (2004) Blood , vol.103 , pp. 1855-1861
    • Jones, D.T.1    Addison, E.2    North, J.M.3
  • 107
    • 42049109174 scopus 로고    scopus 로고
    • Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells
    • Lin K, Rockliffe N, Johnson GG, et al. Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells. Oncogene. 2008;27:2445-2455.
    • (2008) Oncogene , vol.27 , pp. 2445-2455
    • Lin, K.1    Rockliffe, N.2    Johnson, G.G.3
  • 108
    • 27144434812 scopus 로고    scopus 로고
    • Transcription inhibition by flavopiridol: Mechanism of chronic lymphocytic leukemia cell death
    • Chen R, Keating MJ, Gandhi V, et al. Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death. Blood. 2005;106:2513-2519.
    • (2005) Blood , vol.106 , pp. 2513-2519
    • Chen, R.1    Keating, M.J.2    Gandhi, V.3
  • 109
    • 33846219417 scopus 로고    scopus 로고
    • Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
    • Byrd JC, Lin TS, Dalton JT, et al. Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood. 2007;109:399-404.
    • (2007) Blood , vol.109 , pp. 399-404
    • Byrd, J.C.1    Lin, T.S.2    Dalton, J.T.3
  • 110
    • 80052566316 scopus 로고    scopus 로고
    • Interim analysis of EFC6663, a multicenter phase 2 study of alvocidib (flavopiridol), demonstrates clinical responses among patients with fludarabine refractory CLL
    • Lanasa MC, Andritsos L, Brown JR, et al. Interim analysis of EFC6663, a multicenter phase 2 study of alvocidib (flavopiridol), demonstrates clinical responses among patients with fludarabine refractory CLL. ASH Annual Meeting Abstracts. 2010;116:58.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , pp. 58
    • Lanasa, M.C.1    Andritsos, L.2    Brown, J.R.3
  • 111
    • 77954611291 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma
    • Tong WG, Chen R, Plunkett W, et al. Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma. J Clin Oncol. 2010;28(18):3015-3022.
    • (2010) J Clin Oncol , vol.28 , Issue.18 , pp. 3015-3022
    • Tong, W.G.1    Chen, R.2    Plunkett, W.3
  • 112
    • 70349330220 scopus 로고    scopus 로고
    • Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia
    • Knauf WU, Lissichkov T, Aldaoud A, et al. Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol. 2009;27:4378-4384.
    • (2009) J Clin Oncol , vol.27 , pp. 4378-4384
    • Knauf, W.U.1    Lissichkov, T.2    Aldaoud, A.3
  • 113
    • 84873550794 scopus 로고    scopus 로고
    • Bendamustine versus chlorambucil in treatment-naive patients with B-cell chronic lymphocytic leukemia (B-CLL): Results of an international phase III study
    • 2007
    • Knauf WU, Lissichkov T, Aldaoud A, et al. Bendamustine versus chlorambucil in treatment-naive patients with B-cell chronic lymphocytic leukemia (B-CLL): results of an international phase III study. ASH Annual Meeting Abstracts. 2007;110:2043.
    • (2043) ASH Annual Meeting Abstracts , pp. 110
    • Knauf, W.U.1    Lissichkov, T.2    Aldaoud, A.3
  • 114
    • 77950321929 scopus 로고    scopus 로고
    • Bendamustine combined with rituximab (BR) in first-line therapy of advanced CLL: A multicenter phase II trial of the German CLL Study Group (GCLLSG)
    • Fischer K, Cramer P, Stilgenbauer S, et al. Bendamustine combined with rituximab (BR) in first-line therapy of advanced CLL: a multicenter phase II trial of the German CLL Study Group (GCLLSG). ASH Annual Meeting Abstracts. 2009;114:205.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 205
    • Fischer, K.1    Cramer, P.2    Stilgenbauer, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.