Metadherin: An emerging key regulator of the malignant progression of multiple cancers

Thoracic Cancer

Volumn 2, Issue 4, 2011, Pages 143-148

  Liang, Yajun ^a   Fu, Da ^a   Hu, Guohong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Astrocyte elevated gene 1; Chemoresistance; Metadherin; Metastasis; Multifunctional gene; Tumor progression

Indexed keywords

METADHERIN; TUMOR MARKER; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANGIOGENESIS; CANCER CELL; CANCER GROWTH; CANCER RESISTANCE; CANCER SURVIVAL; CARCINOGENESIS; CELL PROLIFERATION; HUMAN; METASTASIS; MOLECULARLY TARGETED THERAPY; MULTIPLE CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW;

EID: 84858779006     PISSN: 17597706     EISSN: 17597714     Source Type: Journal    
DOI: 10.1111/j.1759-7714.2011.00064.x     Document Type: Review

References (34)

1. Su ZZ, Kang DC, Chen Y etal. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH. Oncogene 2002; 21: 3592-602.
2. Britt DE, Yang DF, Yang DQ etal. Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Exp Cell Res 2004; 300: 134-48.
3. Brown DM, Ruoslahti E. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 2004; 5: 365-74.
4. Kang DC, Su ZZ, Sarkar D, Emdad L, Volsky DJ, Fisher PB. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 2005; 353: 8-15.
5. Sutherland HG, Lam YW, Briers S, Lamond AI, Bickmore WA. 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Exp Cell Res 2004; 294: 94-105.
6. Thirkettle HJ, Girling J, Warren AY etal. LYRIC/AEG-1 Is Targeted to Different Subcellular Compartments by Ubiquitinylation and Intrinsic Nuclear Localization Signals. Clin Cancer Res 2009; 15: 3003-13.
7. Hu G, Chong RA, Yang Q etal. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 2009; 15: 9-20.
8. Liu H, Song X, Liu C, Xie L, Wei L, Sun R. Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells. J Exp Clin Cancer Res 2009; 28: 19.
9. Li J, Zhang N, Song LB etal. Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 2008; 14: 3319-26.
10. Kikuno N, Shiina H, Urakami S etal. Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene 2007; 26: 7647-55.
11. Yoo BK, Emdad L, Su ZZ etal. Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest 2009; 119: 465-77.
12. Lee SG, Jeon HY, Su ZZ etal. Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene 2009; 28: 2476-84.
13. Liu L, Wu J, Ying Z etal. Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion. Cancer Res 2010; 70: 3750-9.
14. Yu C, Chen K, Zheng H etal. Overexpression of Astrocyte Elevated Gene-1 (AEG-1) Is Associated with Esophageal Squamous Cell Carcinoma (ESCC) Progression and Pathogenesis. Carcinogenesis 2009; 30: 894-901.
15. Song L, Li W, Zhang H etal. Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. J Pathol 2009; 219: 317-26.
16. Meng F, Luo C, Ma L, Hu Y, Lou G. Clinical significance of astrocyte elevated gene-1 expression in human epithelial ovarian carcinoma. Int J Gynecol Pathol 2011; 30: 145-50.
17. Jian-Bo X, Hui W, Yu-Long H etal. Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol 2011; 28: 455-62.
18. Song H, Li C, Li R, Geng J. Prognostic significance of AEG-1 expression in colorectal carcinoma. Int J Colorectal Dis 2010; 25: 1201-9.
19. Chen W, Ke Z, Shi H, Yang S, Wang L. Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression. Neoplasma 2010; 57: 522-9.
20. Song H, Li C, Lu R, Zhang Y, Geng J. Expression of astrocyte elevated gene-1: a novel marker of the pathogenesis, progression, and poor prognosis for endometrial cancer. Int J Gynecol Cancer 2010; 20: 1188-96.
21. Emdad L, Lee SG, Su ZZ etal. Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc Natl Acad Sci USA 2009; 106: 21300-5.
22. Li J, Yang L, Song L etal. Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene 2009; 28: 3188-96.
23. Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ, Fisher PB. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 2008; 68: 1478-84.
24. Zhang B, Liu XX, He JR etal. Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. Carcinogenesis 2009; 32: 2-9.
25. Emdad L, Sarkar D, Su ZZ etal. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res 2006; 66: 1509-16.
26. Xia Z, Zhang N, Jin H, Yu Z, Xu G, Huang Z. Clinical significance of astrocyte elevated gene-1 expression in human oligodendrogliomas. Clin Neurol Neurosurg 2010; 112: 413-19.
27. Yoo BK, Chen D, Su ZZ etal. Molecular mechanism of chemoresistance by astrocyte elevated gene-1. Cancer Res 2010; 70: 3249-58.
28. Yoo BK, Santhekadur PK, Gredler R etal. Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma. Hepatology (Baltimore. Md 2011; 53: 1538-48.
29. Blanco MA, Aleckovic M, Hua Y etal. Identification of Staphylococcal Nuclease Domain-containing 1 (SND1) as a Metadherin-interacting Protein with Metastasis-promoting Functions. J Biol Chem 2011; 286: 19982-92.
30. Lee SG, Su ZZ, Emdad L, Sarkar D, Fisher PB. Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proc Natl Acad Sci USA 2006; 103: 17390-5.
31. Lee SG, Su ZZ, Emdad L, Sarkar D, Franke TF, Fisher PB. Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 2007; 27: 1114-21.
32. Ash SC, Yang DQ, Britt DE. LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. Biochem Biophys Res Commun 2008; 371: 333-8.
33. Liu J, Yuan Y, Huan J, Shen Z. Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. Oncogene 2001; 20: 336-45.
34. Thirkettle HJ, Mills IG, Whitaker HC, Neal DE. Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression. Oncogene 2009; 28: 3663-70.