Epigallocatechin gallate changes mRNA expression level of genes involved in cholesterol metabolism in hepatocytes

British Journal of Nutrition

Volumn 107, Issue 6, 2012, Pages 769-773

  Goto, Tsuyoshi ^a   Saito, Yuuki ^a   Morikawa, Kensei ^a   Kanamaru, Yoshihiro ^a   Nagaoka, Satoshi ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

Cholesterol; Epigallocatechin gallate; HepG2; LDL receptor; Tea catechins

Indexed keywords

APOLIPOPROTEIN B; DNA; EPIGALLOCATECHIN GALLATE; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA;

ARTICLE; CELL STRAIN HEPG2; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; TEA;

ANTICHOLESTEREMIC AGENTS; APOLIPOPROTEINS B; CATECHIN; CHOLESTEROL; DOWN-REGULATION; GENE EXPRESSION REGULATION; HEP G2 CELLS; HEPATOCYTES; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSMOLAR CONCENTRATION; RECEPTORS, LDL; RNA, MESSENGER; UP-REGULATION;

ANIMALIA;

EID: 84858768919     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114511003758     Document Type: Article

References (45)

1. Leinonen M & Saikku P (2002) Evidence for infectious agents in cardiovascular disease and atherosclerosis. Lancet Infect Dis 2, 11-17. (Pubitemid 36109301)
2. Kannel WB, Castelli WP & Gordon T (1979) Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham Study. Ann Intern Med 90, 85-91. (Pubitemid 9096758)
3. Castelli WP (1988) Cholesterol and lipids in the risk of coronary artery disease-the Framingham Heart Study. Can J Cardiol 4, Suppl. A, 5A-10A.
4. Yang CS & Landau JM (2000) Effects of tea consumption on nutrition and health. J Nutr 130, 2409-2412.
5. Mukhtar H & Ahmad N (2000) Tea polyphenols: prevention of cancer and optimizing health. Am J Clin Nutr 71, 1698S-1702S.
6. Zaveri NT (2006) Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications. Life Sci 78, 2073-2080.
7. Rice-Evans CA, Miller NJ & Paganga G (1996) Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 20, 933-956. (Pubitemid 26157509)
8. Shankar S, Ganapathy S & Srivastava RK (2007) Green tea polyphenols: biology and therapeutic implications in cancer. Front Biosci 12, 4881-4899.
9. Matsumoto N, Ishigaki F, Ishigaki A, et al. (1993) Reduction of blood glucose levels by tea catechin. Biosci Biotechnol Biochem 57, 525-527.
10. Miura Y, Chiba T, Tomita I, et al. (2001) Tea catechins prevent the development of atherosclerosis in apoprotein E-deficient mice. J Nutr 131, 27-32. (Pubitemid 32060618)
11. Murase T, Haramizu S, Shimotoyodome A, et al. (2005) Green tea extract improves endurance capacity and increases muscle lipid oxidation in mice. Am J Physiol Regul Integr Comp Physiol 288, R708-R715. (Pubitemid 40250583)
12. Murase T, Nagasawa A, Suzuki J, et al. (2002) Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver. Int J Obes Relat Metab Disord 26, 1459-1464. (Pubitemid 36005776)
13. Imai K & Nakachi K (1995) Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases. Br Med J 310, 693-696.
14. Kono S, Shinchi K, Wakabayashi K, et al. (1996) Relation of green tea consumption to serum lipids and lipoproteins in Japanese men. J Epidemiol 6, 128-133. (Pubitemid 126839365)
15. Muramatsu K, Fukuyo M & Hara Y (1986) Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats. J Nutr Sci Vitaminol 32, 613-622.
16. Matsuda H, Chisaka T, Kubomura Y, et al. (1986) Effects of crude drugs on experimental hypercholesterolemia. I. Tea and its active principles. J Ethnopharmacol 17, 213-224. (Pubitemid 17209184)
17. Chisaka T, Matsuda H, Kubomura Y, et al. (1988) The effect of crude drugs on experimental hypercholesteremia: mode of action of (2)-epigallocatechin gallate in tea leaves. Chem Pharm Bull 36, 227-233. (Pubitemid 18073387)
18. Ando T, Nishimura T, Matsubayashi A, et al. (1989) Effects of tea catechins on cholesterol absorption with exogenously hypercholesterolemic rat (ExHC-Ta). Bull Kanagawa Dent Coll 17, 21-23.
19. Yang TT & Koo MW (1997) Hypocholesterolemic effects of Chinese tea. Pharmacol Res 35, 505-512. (Pubitemid 27420465)
20. Chan PT, Fong WP, Cheung YL, et al. (1999) Jasmine green tea epicatechins are hypolipidemic in hamsters (Mesocricetus auratus) fed a high fat diet. J Nutr 129, 1094-1101. (Pubitemid 29250155)
21. Yang TT & Koo MW (2000) Chinese green tea lowers cholesterol level through an increase in fecal lipid excretion. Life Sci 66, 411-423. (Pubitemid 30025497)
22. Bursill CA & Roach PD (2006) Modulation of cholesterol metabolism by the green tea polyphenol (2)-epigallocatechin gallate in cultured human liver (HepG2) cells. J Agric Food Chem 54, 1621-1626.
23. Lee MS, Park JY, Freake H, et al. (2008) Green tea catechin enhances cholesterol 7alpha-hydroxylase gene expression in HepG2 cells. Br J Nutr 99, 1182-1185.
24. Morikawa K, Kondo I, Kanamaru Y, et al. (2007) A novel regulatory pathway for cholesterol degradation via lactostatin. Biochem Biophys Res Commun 352, 697-702. (Pubitemid 44880310)
25. Snedecor GW & Cochran WG (1967) Statistical Methods, 6th ed. Ames, IA: The Iowa State University Press (Japanese edition; Tokyo: Iwanami Publishers, Inc.).
26. Hayter AJ (1984) A proof of the conjecture that the Tukey-Kramer multiple comparisons procedure is conservative. Ann Statist 12, 61-75.
27. Beglova N & Blacklow SC (2005) The LDL receptor: how acid pulls the trigger. Trends Biochem Sci 30, 309-317. (Pubitemid 40799049)
28. Sniderman AD, Scantlebury T & Cianflone K (2001) Hypertriglyceridemic hyperapoB: the unappreciated atherogenic dyslipoproteinemia in type 2 diabetes mellitus. Ann Intern Med 135, 447-459. (Pubitemid 32845869)
29. Javitt NB (1990) Hep G2 cells as a resource for metabolic studies: lipoprotein, cholesterol, and bile acids. FASEB J 4, 161-168.
30. Izem L, Rassart E, Kamate L, et al. (1998) Effect of reduced low-density lipoprotein receptor level on HepG2 cell cholesterol metabolism. Biochem J 329, 81-89. (Pubitemid 128705710)
31. Wilson GM, Roberts EA & Deeley RG (1997) Modulation of LDL receptor mRNA stability by phorbol esters in human liver cell culture models. J Lipid Res 38, 437-446. (Pubitemid 27166687)
32. Mehta KD, Radominska-Pandya A, Kapoor GS, et al. (2002) Critical role of diacylglycerol-and phospholipid-regulated protein kinase C epsilon in induction of low-density lipoprotein receptor transcription in response to depletion of cholesterol. Mol Cell Biol 22, 3783-3793. (Pubitemid 34525220)
33. Kamps JA & van Berkel TJ (1993) Regulation of low-densitylipoprotein receptors in the human hepatoma cell line Hep G2. Effect of phorbol 12-myristate 13-acetate and lowdensity lipoprotein. Eur J Biochem 213, 989-994. (Pubitemid 23152206)
34. Kumar A, Chambers TC, Cloud-Heflin BA, et al. (1997) Phorbol ester-induced low density lipoprotein receptor gene expression in HepG2 cells involves protein kinase C-mediated p42/44 MAP kinase activation. J Lipid Res 38, 2240-2248. (Pubitemid 27495383)
35. Vargas NB, Brewer BY & Rogers TB (2009) Protein kinase C activation stabilizes LDL receptor mRNA via the JNK pathway in HepG2 cells. J Lipid Res 50, 386-397.
36. Zhao Y, Yu L, Xu S, et al. (2011) Down-regulation of connexin43 gap junction by serum deprivation in human endothelial cells was improved by (2)-epigallocatechin gallate via ERK MAP kinase pathway. Biochem Biophys Res Commun 404, 217-222.
37. Takahashi S, Sakai J, Fujino T, et al. (2004) The very lowdensity lipoprotein (VLDL) receptor: characterization and functions as a peripheral lipoprotein receptor. J Atheroscler Thromb 11, 200-208.
38. Oliver WR Jr, Shenk JL, Snaith MR, et al. (2001) A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci USA 98, 5306-5311. (Pubitemid 32397124)
39. Sakakura Y, Shimano H, Sone H, et al. (2001) Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis. Biochem Biophys Res Commun 286, 176-183. (Pubitemid 32917666)
40. Brown MS & Goldstein JL (1997) The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331-340. (Pubitemid 27220877)
41. Murase T, Misawa K, Haramizu S, et al. (2009) Catechininduced activation of the LKB1/AMP-activated protein kinase pathway. Biochem Pharmacol 78, 78-84.
42. Chen L, Lee MJ, Li H, et al. (1997) Absorption, distribution, elimination of tea polyphenols in rats. Drug Metab Dispos 25, 1045-1050. (Pubitemid 27396491)
43. Nakagawa K & Miyazawa T (1997) Absorption and distribution of tea catechin, (2)-epigallocatechin-3-gallate, in the rat. J Nutr Sci Vitaminol 43, 679-684. (Pubitemid 28045726)
44. Nagaoka S, Kamuro H, Oda H, et al. (1991) Effects of polychlorinated biphenyls on cholesterol and ascorbic acid metabolism in primary cultured rat hepatocytes. Biochem Pharmacol 41, 1259-1261.
45. Soutar AK & Naoumova RP (2007) Mechanisms of disease: genetic causes of familial hypercholesterolemia. Nat Clin Pract Cardiovasc Med 4, 214-225. (Pubitemid 46502094)