Ionic and substrate mechanisms of atrial fibrillation: Rotors and the excitation frequency approach;Mecanismos iónicos y sustratos en la fibrilación auricular; Rotores y su relación con la frecuencia de excitación

Archivos de Cardiologia de Mexico

Volumn 80, Issue 4, 2010, Pages 301-314

  Berenfeld, Omer ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Atrial fibrillation; Dominant frequency; Fibrosis; Potassium currents; Rotors; USA

Indexed keywords

ACETYLCHOLINE; ADENOSINE; ION; POTASSIUM;

CELL CULTURE; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART SURGERY; HUMAN; NONHUMAN; PATCH CLAMP; PATHOGENESIS; REVIEW; SHEEP; ANIMAL; ELECTROPHYSIOLOGY; FIBROSIS; HEART FUNCTION TEST; HEART MUSCLE; PATHOLOGY; PATHOPHYSIOLOGY; POSTOPERATIVE COMPLICATION;

ANIMALS; ATRIAL FIBRILLATION; CARDIAC SURGICAL PROCEDURES; CELLS, CULTURED; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; ELECTROPHYSIOLOGICAL PROCESSES; FIBROSIS; HUMANS; MYOCARDIUM; POSTOPERATIVE COMPLICATIONS; SHEEP;

EID: 84858755741     PISSN: 14059940     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (107)

1. Chen LY, Shen WK. Epidemiology of atrial fibrillation: a current perspective. Heart Rhythm 2007;4:S1-S6.
2. Haissaguerre M, Jais P, Shah DC, et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med 1998;339:659-666.
3. Haissaguerre M, Shah DC, Jais P, et al. Mapping-guided ablation of pulmonary veins to cure atrial fibrillation. American Journal of Cardiology 2000;86:9K-19K.
4. Moe GK, Abildskov JA. Atrial fibrillation as a self-sustaining arrhythmia independent of focal discharges. American Heart Journal 1959;58:59-70.
5. Oral H, Pappone C, Chugh A, et al. Circumferential pulmonary-vein ablation for chronic atrial fibrillation. N Engl J Med 2006;354:934-941.
6. Moe GK. On the multiple wavelet hypothesis of atrial fibrillation. Archives Internationales de Pharmacodynamie et de Therapie 1962;CXL:183-188.
7. Allessie MA, Lammers WJEP, Bonke FIM, et al. Experimental evaluation of Moe's wavelet hypothesis of atrial fibrillation. In: Zipes DP, Jalife J, editors. Cardiac Electrophysiology and Arrhythmias. Orlando: Grune & Stratton, 1985: 265-275.
8. Lewis T. The mechanism and graphic registration of the heart beat. 3 ed. London: Shaw & Sons, 1925.
9. Krinskii VI. Excitation propagation in nonhomogenous medium (actions analogous to heart fibrillation). Biofizika 1966;11:676-683.
10. Winfree AT. Suppressing drosophila circadian rhythm with dim light. Science 1974;183:970-972.
11. Allessie MA, Bonke FI, Schopman FJ. Circus movement in rabbit atrial muscle as a mechanism of tachycardia. III. The «leading circle» concept: a new model of circus movement in cardiac tissue without the involvement of an anatomical obstacle. Circ Res 1977;41:9-18.
12. Jalife J, Berenfeld O, Skanes A, et al. Mechanisms of atrial fibrillation: mother rotors or multiple daughter wavelets, or both? J Cardiovasc Electrophysiol 1998;9:S2-S12.
13. Morillo CA, Klein GJ, Jones DL, et al. Chronic rapid atrial pacing: Structural, functional, and electrophysiological characteristics of a new model of sustained atrial fibrillation. Circulation 1995;91:1588-1595.
14. Harada A, Sasaki K, Fukushima T, et al. Atrial activation during chronic atrial fibrillation in patients with isolated mitral valve disease. Ann Thorac Surg. 1996;61:104-112.
15. Skanes AC, Mandapati R, Berenfeld O, et al. Spatiotemporal periodicity during atrial fibrillation in the isolated sheep heart. Circulation 1998;98:1236-1248.
16. Berenfeld O, Mandapati R, Dixit S, et al. Spatially distributed dominant excitation frequencies reveal hidden organization in atrial fibrillation in the Langendorff-perfused sheep heart. J Cardiovasc Electrophysiol 2000;11:869-879.
17. Mandapati R, Skanes A, Chen J, Berenfeld O, Jalife J. Stable microreentrant sources as a mechanism of atrial fibrillation in the isolated sheep heart. Circulation 2000;101:194-199.
18. Mansour M, Mandapati R, Berenfeld O, et al. Left-to-right gradient of atrial frequencies during acute atrial fibrillation in the isolated sheep heart. Circulation 2001;103:2631-2636.
19. Pappone C, Rosanio S. Pulmonary Vein Isolation for Atrial Fibrillation. In: Zipes DP, Jalife J, editors. Cardiac Electrophysiology -From Cell to Bedside. Philadelphia: Saunders, 2004: 1039-1052.
20. Haissaguerre M, Sanders P, Hocini M, et al. Changes in atrial fibrillation cycle length and inducibility during catheter ablation and their relation to outcome. Circulation 2004;109:3007-3013.
21. Berenfeld O. Quantifying activation frequency in atrial fibrillation to establish underlying mechanisms and ablation guidance. Heart Rhythm. 2007;4:1225-1234.
22. Schuessler RB, Kay MW, Melby SJ, et al. Spatial and temporal stability of the dominant frequency of activation in human atrial fibrillation. J Electrocardiol. 2006.
23. Berenfeld O, Zaitsev AV, Mironov SF, et al. Frequency-dependent breakdown of wave propagation into fibrillatory conduction across the pectinate muscle network in the isolated sheep right atrium. Circ Res 2002;90:1173-1180.
24. Scherf D. Studies on auricular tachycardia caused by aconitine administration. Proc Soc Exp Biol Med 1947;64:233-239.
25. Kumagai K, Khrestian C, Waldo AL. Simultaneous multisite mapping studies during induced atrial fibrillation in the sterile pericarditis model. Insights into the mechanisms of its maintenance. Circulation 1997;95:511-521.
26. Kumagai K, Uno K, Khrestian C, et al. Single site radiofrequency catheter ablation of atrial fibrillation: Studies guided by simultaneous multisite mapping in the canine sterile pericarditis model. Journal of the American College of Cardiology. 2000;36:917-923.
27. Jais P, Haissaguerre M, Shah DC, et al. A focal source of atrial fibrillation treated by discrete radiofrequency ablation. Circulation 1997;95:572-576.
28. Schuessler RB, Grayson TM, Bromberg BI, et al. Cholinergically mediated tachyarrhythmias induced by a single extrastimulus in the isolated canine right atrium. Circ Res 1992;71:1254-1267.
29. Sarmast F, Kolli A, Zaitsev A, et al. Cholinergic atrial fibrillation: I-K,I-ACh gradients determine unequal left/right atrial frequencies and rotor dynamics. Cardiovascular Research. 2003;59:863-873.
30. Kneller J, Zou R, Vigmond EJ, et al. Cholinergic atrial fibrillation in a computer model of a two-dimensional sheet of canine atrial cells with realistic ionic properties. Circ Res 2002;90:E73-E87.
31. Samie FH, Berenfeld O, Anumonwo J, et al. Rectification of the Background Potassium Current: A Determinant of Rotor Dynamics in Ventricular Fibrillation. Circ Res 2001;89:1216-1223.
32. Atienza F, Almendral J, Moreno J, et al. Activation of inward rectifier potassium channels accelerates atrial fibrillation in humans: evidence for a reentrant mechanism. Circulation 2006;114:2434-2442.
33. Courtemanche M, Ramirez RJ, Nattel S. Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. American Journal of Physiology-Heart and Circulatory Physiology 1998;44:H301-H321.
34. Li D, Zhang L, Kneller J, et al. Potential ionic mechanism for repolarization differences between canine right and left atrium. Circ Res 2001;88:1168-1175.
35. Beaumont J, Jalife J. Rotors and spiral waves in two dimensions. In: Zipes DP, Jalife J, editors. Cardiac Electrophysiology From Cell to Bedside. Philadelphia, PA: W.B. Saunders, 2000:327-335.
36. Lubitz SA, Benjamin EJ, Ellinor PT. Atrial fibrillation in congestive heart failure. Heart Fail Clin 2010;6:187-200.
37. Shelton RJ, Clark AL, Kaye GC, et al. The atrial fibrillation paradox of heart failure. Congest Heart Fail 2010;16:3-9.
38. Nattel S. Driver regions in atrial fibrillation associated with congestive heart failure: where are they, and what are they telling us? J Cardiovasc Electrophysiol 2005;16:1359-1361.
39. Manabe I, Shindo T, Nagai R. Gene expression in fibroblasts and fibrosis: involvement in cardiac hypertrophy. Circ Res 2002;91:1103-1113.
40. Brown RD, Ambler SK, Mitchell MD, et al. The cardiac fibroblast: therapeutic target in myocardial remodeling and failure. Annu Rev Pharmacol Toxicol 2005;45:657-687.
41. Basso C, Ronco F, Marcus F, et al. Quantitative assessment of endomyocardial biopsy in arrhythmogenic right ventricular cardiomyopathy/dysplasia: an in vitro validation of diagnostic criteria. Eur Heart J 2008;29:2760-2771.
42. Rohr S. Myofibroblasts in diseased hearts: new players in cardiac arrhythmias? Heart Rhythm 2009;6:848-856.
43. de Bakker JM, van Capelle FJ, Janse MJ, et al. Slow conduction in the infarcted human heart. 'Zigzag' course of activation. Circulation 1993;88:915-926.
44. Bian W, Tung L. Structure-related initiation of reentry by rapid pacing in monolayers of cardiac cells. Circ Res 2006;98:e29-e38.
45. Spach MS, Boineau JP. Microfibrosis produces electrical load variations due to loss of side-to-side cell connections: a major mechanism of structural heart disease arrhythmias. Pacing Clin Electrophysiol 1997;20:397-413.
46. de Bakker JM, Stein M, van Rijen HV. Three-dimensional anatomic structure as substrate for ventricular tachycardia/ventricular fibrillation. Heart Rhythm. 2005;2:777-779.
47. Valderrabano M, Kim YH, Yashima M, et al. Obstacle-induced transition from ventricular fibrillation to tachycardia in isolated swine right ventricles: insights into the transition dynamics and implications for the critical mass. J Am Coll Cardiol 2000;36:2000-2008.
48. Jacquemet V, Henriquez CS. Genesis of complex fractionated atrial electrograms in zones of slow conduction: a computer model of microfibrosis. Heart Rhythm 2009;6:803-810.
49. Jacquemet V, Henriquez CS. Modulation of conduction velocity by nonmyocytes in the low coupling regime. IEEE Trans Biomed Eng 2009;56:893-896.
50. Camelliti P, Green CR, LeGrice I, et al. Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling. Circ Res 2004;94:828-835.
51. Weber KT. The Dead Sea lives! Someone's rockin' my dreamboat. Cardiovasc Res 1995;29:604-610.
52. Camelliti P, Borg TK, Kohl P. Structural and functional characterization of cardiac fibroblasts. Cardiovasc Res 2005;65:40-51.
53. Gaudesius G, Miragoli M, Thomas SP, et al. Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin. Circ Res 2003;93:421-428.
54. Miragoli M, Gaudesius G, Rohr S. Electrotonic modulation of cardiac impulse conduction by myofibroblasts. Circ Res 2006;98:801-810.
55. Rook MB, van Ginneken AC, de Jonge B, et al. Differences in gap junction channels between cardiac myocytes, fibroblasts, and heterologous pairs. Am J Physiol 1992;263:C959-C977.
56. Goshima K. Formation of nexuses and electrotonic transmission between myocardial and FL cells in monolayer culture. Exp Cell Res 1970;63:124-130.
57. Kamkin A, Kiseleva I, Wagner KD, et al. Mechanically induced potentials in fibroblasts from human right atrium. Exp Physiol 1999;84:347-356.
58. Kohl P, Kamkin AG, Kiseleva IS, et al. Mechanosensitive fibroblasts in the sino-atrial node region of rat heart: interaction with cardiomyocytes and possible role. Exp Physiol 1994;79:943-956.
59. Kohl P, Camelliti P, Burton FL, et al. Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. J Electrocardiol. 2005;38:45-50.
60. Tanaka K, Zlochiver S, Vikstrom KL, et al. Spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure. Circ Res 2007;101:839-847.
61. Fenelon G, Shepard RK, Stambler BS. Focal origin of atrial tachycardia in dogs with rapid ventricular pacing-induced heart failure. J Cardiovasc Electrophysiol 2003;14:1093-1102.
62. Ryu K, Shroff SC, Sahadevan J, et al. Mapping of atrial activation during sustained atrial fibrillation in dogs with rapid ventricular pacing induced heart failure: evidence for a role of driver regions. J Cardiovasc Electrophysiol 2005;16:1348-1358.
63. Okuyama Y, Miyauchi Y, Park AM, et al. High resolution mapping of the pulmonary vein and the vein of Marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure. J Am Coll Cardiol 2003;42:348-260.
64. Stambler BS, Fenelon G, Shepard RK, et al. Characterization of sustained atrial tachycardia in dogs with rapid ventricular pacing-induced heart failure. J Cardiovasc Electrophysiol 2003;14:499-507.
65. Rudolph V, Andrie RP, Rudolph TK, et al. Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation. Nat Med 2010;16:470-474.
66. Kalifa J, Tanaka K, Zaitsev AV, et al. Mechanisms of wave fractionation at boundaries of high-frequency excitation in the posterior left atrium of the isolated sheep heart during atrial fibrillation. Circulation 2006;113:626-633.
67. Burstein B, Nattel S. Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation. J Am Coll Cardiol 2008;51:802-809.
68. Zlochiver S, Munoz V, Vikstrom KL, et al. Electrotonic myofibroblast-to-myocyte coupling increases propensity to reentrant arrhythmias in two-dimensional cardiac monolayers. Biophys J 2008;95:4469-4480.
69. Gray RA, Pertsov AM, Jalife J. Spatial and temporal organization during cardiac fibrillation. Nature 1998;392:75-78.
70. Li D, Melnyk P, Feng J, et al. Effects of experimental heart failure on atrial cellular and ionic electrophysiology. Circulation 2000;101:2631-2638.
71. Lazar S, Dixit S, Marchlinski FE, et al. Presence of left-to-right atrial frequency gradient in paroxysmal but not persistent atrial fibrillation in humans. Circulation 2004;110:3181-3186.
72. Sahadevan J, Ryu K, Peltz L, et al. Epicardial Mapping of Chronic Atrial Fibrillation in Patients: Preliminary Observations. Circulation 2004;110:3293-3299.
73. Sanders P, Berenfeld O, Hocini M, et al. Spectral analysis identifies sites of high-frequency activity maintaining atrial fibrillation in humans. Circulation 2005;112:789-797.
74. Botteron GW, Smith JM. Quantitative assessment of the spatial organization of atrial fibrillation in the intact human heart. Circulation 1996;93:513-518.
75. Fischer G, Stuhlinger MC, Nowak CN, et al. On computing dominant frequency from bipolar intracardiac electrograms. IEEE Trans Biomed Eng 2007;54:165-169.
76. Wu TJ, Doshi RN, Huang HLA, et al. Simultaneous biatrial computerized mapping during permanent atrial fibrillation in patients with organic heart disease. J Cardiovasc Electrophysiol 2002;13:571-577.
77. Sih HJ, Zipes DP, Berbari EJ, et al. Differences in organization between acute and chronic atrial fibrillation in dogs. Journal of the American College of Cardiology 2000;36:924-931.
78. Wu TJ, Ong JJC, Chang CM, et al. Pulmonary veins and ligament of Marshall as sources of rapid activations in a canine model of sustained atrial fibrillation. Circulation 2001;103:1157-1163.
79. Arora R, Verheule S, Scott L, et al. Arrhythmogenic substrate of the pulmonary veins assessed by high-resolution optical mapping. Circulation 2003;107:1816-1821.
80. Kalifa J, Jalife J, Zaitsev AV, et al. Intra-atrial pressure increases rate and organization of waves emanating from the superior pulmonary veins during atrial fibrillation. Circulation 2003;108:668-671.
81. Vigmond EJ, Tsoi V, Kuo S, et al. The effect of vagally induced dispersion of action potential duration on atrial arrhythmogenesis. Heart Rhythm 2004;1:334-344.
82. Kumagai K, Yasuda T, Tojo H, et al. Role of rapid focal activation in the maintenance of atrial fibrillation originating from the pulmonary veins. Pacing Clin Electrophysiol 2000;23:1823-1827.
83. O'Donnell D, Furniss SS, Bourke JP. Paroxysmal cycle length shortening in the pulmonary veins during atrial fibrillation correlates with arrhythmogenic triggering foci in sinus rhythm. J Cardiovasc Electrophysiol 2002;13:124-128.
84. Oral H, Ozaydin M, Tada H, et al. Mechanistic significance of intermittent pulmonary vein tachycardia in patients with atrial fibrillation. J Cardiovasc Electrophysiol 2002;13:645-650.
85. Atienza F, Almendral J, Jalife J, et al. Real-time dominant frequency mapping and ablation of dominant frequency sites in atrial fibrillation with left-to-right frequency gradients predicts long-term maintenance of sinus rhythm. Heart Rhythm. 2009;6:33-40.
86. Yoshida K, Chugh A, Ulfarsson M, et al. Relationship between the spectral characteristics of atrial fibrillation and atrial tachycardias that occur after catheter ablation of atrial fibrillation. Heart Rhythm 2009;6:11-17.
87. Lazar S, Dixit S, Callans DJ, et al. Effect of pulmonary vein isolation on the left-to-right atrial dominant frequency gradient in human atrial fibrillation. Heart Rhythm 2006;3:889-895.
88. Sanders P, Hocini M, Jais P, et al. Characterization of focal atrial tachycardia using high-density mapping. J Am Coll Cardiol 2005;46:2088-2099.
89. Hsu LF, Jais P, Hocini M, et al. High-density circumferential pulmonary vein mapping with a 20-pole expandable circular mapping catheter. Pacing Clin Electrophysiol 2005;28 Suppl 1:S94-S98.
90. Kabell G, Buchanan LV, Gibson JK, et al. Effects of adenosine on atrial refractoriness and arrhythmias. Cardiovasc Res 1994;28:1385-1389.
91. Belardinelli L, Shryock JC, Song Y, et al. Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes. FASEB Journal 1995;9:359-365.
92. Khositseth A, Clapham DE, Ackerman MJ. Intracellular signaling and regulation of cardiac ion channels. In: Zipes DP, Jalife J, editors. Cardiac Electrophysiology -From Cell to Bedside. Philadelphia, PA: W.B. Saunders, 2004: 33-41.
93. McKeown PP, Gutterman D. Executive summary: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery. Chest 2005;128:1S-5S.
94. Mathew JP, Parks R, Savino JS, et al. Atrial fibrillation following coronary artery bypass graft surgery: predictors, outcomes, and resource utilization. MultiCenter Study of Perioperative Ischemia Research Group. JAMA 1996;276:300-306.
95. Nakai T, Chandy J, Nakai K, et al. Histologic assessment of right atrial appendage myocardium in patients with atrial fibrillation after coronary artery bypass graft surgery. Cardiology 2007;108:90-96.
96. Cosgrave J, Foley JB, Flavin R, et al. Preoperative atrial histological changes are not associated with postoperative atrial fibrillation. Cardiovasc Pathol. 2006;15:213-217.
97. Workman AJ, Kane KA, Rankin AC. Cellular bases for human atrial fibrillation. Heart Rhythm 2008;5:S1-S6.
98. Swartz MF, Fink GW, Lutz CJ, et al. Left versus right atrial difference in dominant frequency, K(+) channel transcripts, and fibrosis in patients developing atrial fibrillation after cardiac surgery. Heart Rhythm 2009;6:1415-1422.
99. Weber KT, Pick R, Jalil JE, et al. Patterns of myocardial fibrosis. J Mol Cell Cardiol. 1989;21 Suppl 5:121-131.
100. Anyukhovsky EP, Sosunov EA, Plotnikov A, et al. Cellular electrophysiologic properties of old canine atria provide a substrate for arrhythmogenesis. Cardiovasc Res 2002;54:462-469.
101. Voigt N, Trausch A, Knaut M, et al. Left-to-Right Atrial Inward-Rectifier Potassium Current Gradients in Patients with Paroxysmal Versus Chronic Atrial Fibrillation. Circ Arrhythm Electrophysiol 2010.
102. Pandit SV, Berenfeld O, Anumonwo J, et al. Ionic Determinants of Functional Reentry in a 2-D Model of Human Atrial Cells During Simulated Chronic Atrial Fibrillation. Biophys J 2005.
103. Nademanee K, McKenzie J, Kosar E, et al. A new approach for catheter ablation of atrial fibrillation: Mapping of the electrophysiologic substrate. Journal of the American College of Cardiology 2004;43:2044-2053.
104. Zlochiver S, Yamazaki M, Kalifa J, et al. Rotor meandering contributes to irregularity in electrograms during atrial fibrillation. Heart Rhythm 2008;5:846-854.
105. Yoshida K, Chugh A, Good E, et al. A critical decrease in dominant frequency and clinical outcome after catheter ablation of persistent atrial fibrillation. Heart Rhythm 2010;7:295-302.
106. Bertaglia E, Zoppo F, Tondo C, et al. Early complications of pulmonary vein catheter ablation for atrial fibrillation: A multicenter prospective registry on procedural safety. Heart Rhythm 2007;4:1265-1271.
107. Cappato R, Calkins H, Chen SA, et al. Worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation. Circulation 2005;111:1100-1105.