Genesis of complex fractionated atrial electrograms in zones of slow conduction: A computer model of microfibrosis

Heart Rhythm

Volumn 6, Issue 6, 2009, Pages 803-810

  Jacquemet, Vincent ^a   Henriquez, Craig S ^a  

^a Duke University   (United States)

Author keywords

Atrial electrogram; Computer modeling; Electrogram fractionation; Fibrosis; Slow conduction; Substrate mapping

Indexed keywords

AMPLITUDE MODULATION; ARTICLE; CHANNEL GATING; COMPLEX FRACTIONATED ATRIUM ELECTROGRAM; COMPUTER MODEL; ELECTRODE; ELECTROGRAPHY; HEART ATRIUM CONDUCTION; HEART MUSCLE FIBROSIS; HEART PACING; HEART RHYTHM; PRIORITY JOURNAL; VELOCITY;

BODY SURFACE POTENTIAL MAPPING; COMPUTER SIMULATION; ELECTROCARDIOGRAPHY; ENDOMYOCARDIAL FIBROSIS; HEART CONDUCTION SYSTEM; HUMANS;

EID: 65649103735     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2009.02.026     Document Type: Article

References (19)

1. Nademanee K., McKenzie J., Kosar E., et al. A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrate. J Am Coll Cardiol 43 (2004) 2044-2053
2. Konings K.T., Smeets J.L., Penn O.C., et al. Configuration of unipolar atrial electrograms during electrically induced atrial fibrillation in humans. Circulation 95 (1997) 1231-1241
3. Centurión O.A., Isomoto S., Shimizu A., et al. The effects of aging on atrial endocardial electrograms in patients with paroxysmal atrial fibrillation. Clin Cardiol 26 (2003) 435-438
4. Spach M.S., Heidlage J.F., Dolber P.C., et al. Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study. Heart Rhythm 4 (2007) 175-185
5. Ellis W.S., Auslander D.M., and Lesh M.D. Fractionated electrograms from a computer model of heterogeneously uncoupled anisotropic ventricular myocardium. Circulation 92 (1995) 1619-1626
6. Jacquemet V., Virag N., Ihara Z., et al. Study of unipolar electrogram morphology in a computer model of atrial fibrillation. J Cardiovasc Electrophysiol 14 Suppl 10 (2003) S172-S179
7. Turner I., Huang C.L.H., and Saumarez R.C. Numerical simulation of paced electrogram fractionation: relating clinical observations to changes in fibrosis and action potential duration. J Cardiovasc Electrophysiol 16 (2005) 151-161
8. Lellouche N., Buch E., Celigoj A., et al. Functional characterization of atrial electrograms in sinus rhythm delineates sites of parasympathetic innervation in patients with paroxysmal atrial fibrillation. J Am Coll Cardiol 50 (2007) 1324-1331
9. Tanaka K., Zlochiver S., Vikstrom K.L., et al. Spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure. Circ Res 101 (2007) 839-847
10. Jacquemet V., and Henriquez C.S. Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model. Am J Physiol Heart Circ Physiol 294 (2008) H2040-H2052
11. Ramirez R.J., Nattel S., and Courtemanche M. Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodeling. Am J Physiol Heart Circ Physiol 279 (2000) H1767-H1785
12. Geselowitz D.B., Barr R.C., Spach M.S., et al. The impact of adjacent isotropic fluids on electrograms from anisotropic cardiac muscle. A modeling study. Circ Res 51 (1982) 602-613
13. Plonsey R. Dependence of scalar potential measurements on electrode geometry. Rev Sci Instrum 36 (1965) 1034-1036
14. van Oosterom A., and Strackee J. Computing the lead field of electrodes with axial symmetry. Med Biol Eng Comput 21 (1983) 473-481
15. Houben R.P.M., de Groot N.M.S., Smeets J.L.R.M., et al. S-wave predominance of epicardial electrograms during atrial fibrillation in humans: indirect evidence for a role of the thin subepicardial layer. Heart Rhythm 1 (2004) 639-647
16. Hubbard M.L., Ying W., and Henriquez C.S. Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study. Europace 9 Suppl 6 (2007) vi20-vi28
17. Scherr D., Dalal D., Cheema A., et al. Automated detection and characterization of complex fractionated atrial electrograms in human left atrium during atrial fibrillation. Heart Rhythm 4 (2007) 1013-1020
18. Spach M.S., and Dolber P.C. Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle. Evidence for electrical uncoupling of side-to-side fiber connections with increasing age. Circ Res 58 (1986) 356-371
19. Roberts S.F., Stinstra J.G., and Henriquez C.S. Effect of nonuniform interstitial space properties on impulse propagation: a discrete multidomain model. Biophys J 95 (2008) 3724-3737