Cell quantification: Evolution of compartmentalization and distribution of iron-oxide particles and labeled cells

Contrast Media and Molecular Imaging

Volumn 7, Issue 2, 2012, Pages 195-203

  Kotek, Gyula ^a   van Tiel, Sandra T ^a   Wielopolski, Piotr A ^a   Houston, Gavin C ^b   Krestin, Gabriel P ^a   Bernsen, Monique R ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b General Electric Healthcare   (Netherlands)

Author keywords

Cell fate; Cell labeling; Iron and cell quantification; Iron oxide; MRI; Relaxometry

Indexed keywords

IRON OXIDE; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE;

ARTICLE; CELL COMPARTMENTALIZATION; CELL DEATH; CELL DENSITY; CELL DIVISION; CELL LABELING; CELL MIGRATION; CELL QUANTIFICATION; CELL TRACKING; CELLULAR DISTRIBUTION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROCEDURES CONCERNING CELLS; SPECTROMETRY;

ANIMALS; CELL COMPARTMENTATION; CELL LINE, TUMOR; FERRIC COMPOUNDS; INTRACELLULAR SPACE; IRON; RATS; STAINING AND LABELING;

EID: 84858723228     PISSN: 15554309     EISSN: 15554317     Source Type: Journal    
DOI: 10.1002/cmmi.481     Document Type: Article

References (33)

1. Long CM, van Laarhoven HW, Bulte JW, Levitsky HI. Magnetovaccination as a novel method to assess and quantify dendritic cell tumor antigen capture and delivery to lymph nodes. Cancer Res 2009; 69: 3180-3187.
2. Hauger O, Frost EE, van Heeswijk R, Deminiere C, Xue R, Delmas Y, Combe C, Moonen CT, Grenier N, Bulte JW. MR evaluation of the glomerular homing of magnetically labeled mesenchymal stem cells in a rat model of nephropathy. Radiology 2006; 238: 200-210.
3. Bos C, Delmas Y, Desmouliere A, Solanilla A, Hauger O, Grosset C, Dubus I, Ivanovic Z, Rosenbaum J, Charbord P, Combe C, Bulte JW, Moonen CT, Ripoche J, Grenier N. In vivo MR imaging of intravascularly injected magnetically labeled mesenchymal stem cells in rat kidney and liver. Radiology 2004; 233: 781-789.
4. Flexman JA, Cross DJ, Tran LN, Sasaki T, Kim Y, Minoshima S. Quantitative analysis of neural stem cell migration and tracer clearance in the rat brain by MRI. Mol Imag Biol 2011; 13(1): 104-111.
5. Farrell E, Wielopolski P, Pavljasevic P, van Tiel S, Jahr H, Verhaar J, Weinans H, Krestin G, O'Brien FJ, van Osch G, Bernsen M. Effects of iron oxide incorporation for long term cell tracking on MSC differentiation in vitro and in vivo. Biochem Biophys Res Commun 2008; 369: 1076-1081.
6. Zhang Z, van den Bos EJ, Wielopolski PA, de Jong-Popijus M, Bernsen MR, Duncker DJ, Krestin GP. In vitro imaging of single living human umbilical vein endothelial cells with a clinical 3.0-T MRI scanner. MAGMA 2005; 18: 175-185.
7. de Vries IJ, Lesterhuis WJ, Barentsz JO, Verdijk P, van Krieken JH, Boerman OC, Oyen WJ, Bonenkamp JJ, Boezeman JB, Adema GJ, Bulte JW, Scheenen TW, Punt CJ, Heerschap A, Figdor CG. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat Biotechnol 2005; 23: 1407-1413.
8. Himes N, Min JY, Lee R, Brown C, Shea J, Huang X, Xiao YF, Morgan JP, Burstein D, Oettgen P. In vivo MRI of embryonic stem cells in a mouse model of myocardial infarction. Magn Reson Med 2004; 52: 1214-1219.
9. Terrovitis J, Stuber M, Youssef A, Preece S, Leppo M, Kizana E, Schar M, Gerstenblith G, Weiss RG, Marban E, Abraham MR. Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart. Circulation 2008; 117: 1555-1562.
10. Pawelczyk E, Arbab AS, Chaudhry A, Balakumaran A, Robey PG, Frank JA. In vitro model of bromodeoxyuridine or iron oxide nanoparticle uptake by activated macrophages from labeled stem cells: implications for cellular therapy. Stem Cells 2008; 26: 1366-1375.
11. Boutry S, Forge D, Burtea C, Mahieu I, Murariu O, Laurent S, Vander Elst L, Muller RN. How to quantify iron in an aqueous or biological matrix: a technical note. Contrast Media Mol Imag 2009; 4: 299-304.
12. 2* mapping for sensing cell-bound superparamagnetic nanoparticles: in vitro and murine in vivo testing. Radiology 2007; 245: 449-457.
13. Peldschus K, Schultze A, Nollau P, Kaul M, Schumacher U, Wagener C, Adam G, Ittrich H. Quantitative MR imaging of targeted SPIO particles on the cell surface and comparison to flow cytometry. Magn Reson Imag 2010; 28(4): 599-606.
14. Young IR, Cox IJ, Bryant DJ, Bydder GM. The benefits of increasing spatial resolution as a means of reducing artifacts due to field inhomogeneities. Magn Reson Imag 1988; 6: 585-590.
15. Frahm J, Merboldt KD, Hanicke W. Direct FLASH MR imaging of magnetic field inhomogeneities by gradient compensation. Magn Reson Med 1988; 6: 474-480.
16. Bowen CV, Zhang X, Saab G, Gareau PJ, Rutt BK. Application of the static dephasing regime theory to superparamagnetic iron-oxide loaded cells. Magn Reson Med 2002; 48: 52-61.
17. Rad AM, Arbab AS, Iskander AS, Jiang Q, Soltanian-Zadeh H. Quantification of superparamagnetic iron oxide (SPIO)-labeled cells using MRI. J Magn Reson Imag 2007; 26: 366-374.
18. Politi LS, Bacigaluppi M, Brambilla E, Cadioli M, Falini A, Comi G, Scotti G, Martino G, Pluchino S. Magnetic-resonance-based tracking and quantification of intravenously injected neural stem cell accumulation in the brains of mice with experimental multiple sclerosis. Stem Cells 2007; 25: 2583-2592.
19. Cheng YC, Haacke EM, Yu YJ. An exact form for the magnetic field density of states for a dipole. Magn Reson Imag 2001; 19: 1017-1023.
20. Muller RN, Gillis P, Moiny F, Roch A. Transverse relaxivity of particulate MRI contrast media: from theories to experiments. Magn Reson Med 1991; 22: 178-182;discussion 195-176.
21. Bulte JW, Miller GF, Vymazal J, Brooks RA, Frank JA. Hepatic hemosiderosis in non-human primates: quantification of liver iron using different field strengths. Magn Reson Med 1997; 37: 530-536.
22. Gossuin Y, Gillis P, Muller RN, Hocq A. Relaxation by clustered ferritin: a model for ferritin-induced relaxation in vivo. NMR Biomed 2007; 20: 749-756.
23. St Pierre TG, Clark PR, Chua-Anusorn W. Single spin-echo proton transverse relaxometry of iron-loaded liver. NMR Biomed 2004; 17: 446-458.
24. Walczak P, Kedziorek DA, Gilad AA, Barnett BP, Bulte JW. Applicability and limitations of MR tracking of neural stem cells with asymmetric cell division and rapid turnover: the case of the shiverer dysmyelinated mouse brain. Magn Reson Med 2007; 58: 261-269.
25. Liu W, Frank JA. Detection and quantification of magnetically labeled cells by cellular MRI. Eur J Radiol 2009; 70: 258-264.
26. Jensen JH, Chandra R. Strong field behavior of the NMR signal from magnetically heterogeneous tissues. Magn Reson Med 2000; 43: 226-236.
27. Brown R. Distribution of fields from randomly placed dipoles: free precession signal-decay as result of magnetic grains. Phys Rev 1961; 121: 1379-1382.
28. Yablonskiy DA, Haacke EM. Theory of NMR signal behavior in magnetically inhomogeneous tissues: the static dephasing regime. Magn Reson Med 1994; 32: 749-763.
29. 2-shortening by weakly magnetized particles: the chemical exchange model. Magn Reson Med 2001; 45: 1014-1020.
30. Winter EM, Hogers B, van der Graaf LM, Gittenberger-de Groot AC, Poelmann RE, van der Weerd L. Cell tracking using iron oxide fails to distinguish dead from living transplanted cells in the infarcted heart. Magn Reson Med 2010; 63(3): 817-821.
31. Kotek G, Berente Z, Schwarcz A, Vajda Z, Hadjiev J, Horvath I, Repa I, Miseta A, Bogner P. Effects of intra- and extracellular space properties on diffusion and T(2) relaxation in a tissue model. Magn Reson Imag 2009; 27: 279-284.
32. 2 during focal cerebral ischemia in the rat studied at 8.5 T. Magn Reson Med 1999; 41: 479-485.
33. Van Dorsten FA, Olah L, Schwindt W, Grune M, Uhlenkuken U, Pillekamp F, Hossmann KA, Hoehn M. Dynamic changes of ADC, perfusion, and NMR relaxation parameters in transient focal ischemia of rat brain. Magn Reson Med 2002; 47: 97-104.