Micro-MR imaging-based computational biomechanics demonstrates reduction in cortical and trabecular bone strength after renal transplantation

Radiology

Volumn 262, Issue 3, 2012, Pages 912-920

  Rajapakse, Chamith S ^a   Leonard, Mary B ^b   Bhagat, Yusuf A ^a   Sun, Wenli ^a   Magland, Jeremy F ^a   Wehrli, Felix W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE RADIOGRAPHY; BONE STRENGTH; BONE STRUCTURE; CLINICAL ARTICLE; CORTICAL BONE; FEMALE; FINITE ELEMENT ANALYSIS; HUMAN; IMAGE ANALYSIS; IMAGE QUALITY; KIDNEY TRANSPLANTATION; MALE; MICROANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; THREE DIMENSIONAL IMAGING; TRABECULAR BONE;

ABSORPTIOMETRY, PHOTON; ADULT; BIOMECHANICS; BONE DENSITY; FEMALE; FINITE ELEMENT ANALYSIS; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; KIDNEY TRANSPLANTATION; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RENAL OSTEODYSTROPHY; TIBIA; WHOLE BODY IMAGING;

EID: 84858712278     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.11111044     Document Type: Article

References (58)

1. Hruska KA, Teitelbaum SL. Renal osteodystrophy. N Engl J Med 1995;333(3):166-174.
2. Amling M, Grote HJ, Vogel M, Hahn M, Delling G. Three-dimensional analysis of the spine in autopsy cases with renal osteodystrophy. Kidney Int 1994;46(3):733-743. (Pubitemid 24272031)
3. Parfitt AM. A structural approach to renal bone disease. J Bone Miner Res 1998;13(8):1213-1220. (Pubitemid 28373321)
4. Alem AM, Sherrard DJ, Gillen DL, et al. Increased risk of hip fracture among patients with end-stage renal disease. Kidney Int 2000;58(1):396-399. (Pubitemid 30429887)
5. Hariharan S, McBride MA, Cherikh WS, Tolleris CB, Bresnahan BA, Johnson CP. Post-transplant renal function in the first year predicts long-term kidney transplant survival. Kidney Int 2002;62(1):311-318. (Pubitemid 34754077)
6. Bia M. Evaluation and management of bone disease and fractures post transplant. Transplant Rev (Orlando) 2008;22(1):52-61. (Pubitemid 350131579)
7. Ball AM, Gillen DL, Sherrard D, et al. Risk of hip fracture among dialysis and renal transplant recipients. JAMA 2002;288(23):3014-3018. (Pubitemid 35471163)
8. Durieux S, Mercadal L, Orcel P, et al. Bone mineral density and fracture prevalence in long-term kidney graft recipients. Transplantation 2002;74(4):496-500. (Pubitemid 34977678)
9. Grotz WH, Mundinger FA, Gugel B, Exner V, Kirste G, Schollmeyer PJ. Bone fracture and osteodensitometry with dual energy x-ray absorptiometry in kidney transplant recipients. Transplantation 1994;58(8):912-915. (Pubitemid 24333282)
10. Ramsey-Goldman R, Dunn JE, Dunlop DD, et al. Increased risk of fracture in patients receiving solid organ transplants. J Bone Miner Res 1999;14(3):456-463. (Pubitemid 29106723)
11. Jamal SA, Gilbert J, Gordon C, Bauer DC. Cortical pQCT measures are associated with fractures in dialysis patients. J Bone Miner Res 2006;21(4):543-548.
12. Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int Suppl 2009;(113):S1-S130.
13. Negri AL, Lombas C, Cuevas C, Schiavelli R, Bogado CE, Zanchetta JR. Evaluation of cortical bone by peripheral quantitative computed tomography in renal transplant recipients. Transplant Proc 2005;37(2):1020-1022. (Pubitemid 40590779)
14. Krug R, Han ET, Banerjee S, Majumdar S. Fully balanced steady-state 3D-spin-echo (bSSSE) imaging at 3 Tesla. Magn Reson Med 2006;56(5):1033-1040. (Pubitemid 44691345)
15. Magland JF, Rajapakse CS, Wright AC, Acciavatti R, Wehrli FW. 3D fast spin echo with out-of-slab cancellation: a technique for high-resolution structural imaging of trabecular bone at 7 Tesla. Magn Reson Med 2010;63(3):719-727.
16. Boutroy S, Bouxsein ML, Munoz F, Delmas PD. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 2005;90(12):6508-6515. (Pubitemid 41759306)
17. Laib A, Hammerle S, Koller B. A new 100 μm resolution scanner for in vivo 3D-CT of the human forearm and lower leg. Presented at the 16th International Bone Densitometry Workshop, Annecy, France, June 20-24, 2004.
18. Link TM, Saborowski, Kisters K, et al. Changes in calcaneal trabecular bone structure assessed with high-resolution MR imaging in patients with kidney transplantation. Osteoporos Int 2002;13(2):119-129.
19. Macneil JA, Boyd SK. Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method. Bone 2008;42(6):1203-1213.
20. Rajapakse CS, Magland JF, Wald MJ, et al. Computational biomechanics of the distal tibia from high-resolution MR and micro-CT images. Bone 2010;47(3):556-563.
21. Wehrli FW, Rajapakse CS, Magland JF, Snyder PJ. Mechanical implications of estrogen supplementation in early postmenopausal women. J Bone Miner Res 2010;25(6):1406-1414.
22. Zhang XH, Liu XS, Vasilic B, et al. In vivo microMRI-based finite element and morphological analyses of tibial trabecular bone in eugonadal and hypogonadal men before and after testosterone treatment. J Bone Miner Res 2008;23(9):1426-1434.
23. Almond MK, Kwan JT, Evans K, Cunningham J. Loss of regional bone mineral density in the first 12 months following renal transplantation. Nephron 1994;66(1):52-57. (Pubitemid 23355576)
24. Kodras K, Haas M. Effect of kidney transplantation on bone. Eur J Clin Invest 2006;36(Suppl 2):63-75. (Pubitemid 44050611)
25. Nickolas TL, Leonard MB, Shane E. Chronic kidney disease and bone fracture: a growing concern. Kidney Int 2008;74(6):721-731.
26. Julian BA, Laskow DA, Dubovsky J, Dubovsky EV, Curtis JJ, Quarles LD. Rapid loss of vertebral mineral density after renal transplantation. N Engl J Med 1991;325(8):544-550.
27. Patel S, Kwan JT, McCloskey E, et al. Prevalence and causes of low bone density and fractures in kidney transplant patients. J Bone Miner Res 2001;16(10):1863-1870. (Pubitemid 32911493)
28. Rajapakse CS, Magland JF, Wehrli FW. Fast prospective registration of in vivo MR images of trabecular bone microstructure in longitudinal studies. Magn Reson Med 2008;59(5):1120-1126. (Pubitemid 351590526)
29. Magland JF, Wald MJ, Wehrli FW. Spinecho micro-MRI of trabecular bone using improved 3D fast large-angle spin-echo (FLASE). Magn Reson Med 2009;61(5):1114-1121.
30. Song HK, Wehrli FW. In vivo micro-imaging using alternating navigator echoes with applications to cancellous bone structural analysis. Magn Reson Med 1999;41(5):947-953. (Pubitemid 29211138)
31. Lin W, Ladinsky GA, Wehrli FW, Song HK. Image metric-based correction (autofocusing) of motion artifacts in high-resolution trabecular bone imaging. J Magn Reson Imaging 2007;26(1):191-197. (Pubitemid 47235250)
32. Bhagat YA, Rajapakse CS, Magland JF, et al. On the significance of motion degradation in high-resolution 3D μMRI of trabecular bone. Acad Radiol 2011;18(10):1205-1216.
33. Vasilic B, Wehrli FW. A novel local thresholding algorithm for trabecular bone volume fraction mapping in the limited spatial resolution regime of in vivo MRI. IEEE Trans Med Imaging 2005;24(12):1574-1585. (Pubitemid 41812025)
34. Magland JF, Jones CE, Leonard MB, Wehrli FW. Retrospective 3D registration of trabecular bone MR images for longitudinal studies. J Magn Reson Imaging 2009;29(1):118-126.
35. Rajapakse CS, Magland JF, Wald MJ, et al. Estimation of relative stiffness contributions of cortical and trabecular compartments by MRI-based finite element analysis [abstr]. J Bone Miner Res 2008;23(Suppl):S366.
36. Zysset PK, Guo XE, Hoffler CE, Moore KE, Goldstein SA. Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur. J Biomech 1999;32(10):1005-1012. (Pubitemid 29356039)
37. Pistoia W, van Rietbergen B, Lochmüller EM, Lill CA, Eckstein F, Rüegsegger P. Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone 2002;30(6):842-848. (Pubitemid 34616011)
38. Niebur GL, Feldstein MJ, Yuen JC, Chen TJ, Keaveny TM. High-resolution finite element models with tissue strength asymmetry accurately predict failure of trabecular bone. J Biomech 2000;33(12):1575-1583.
39. van Rietbergen B, Pistoia W, Ulrich D, Huiskes R, Ruegsegger P. Prediction of trabecular bone failure parameters using a tissue failure criterion and mFE analysis. Comput Simul & Model in Med 2000;1:98-101. http://www.mate.tue.nl/mate/showabstract.php/913.
40. Saha PK, Wehrli FW. Measurement of trabecular bone thickness in the limited resolution regime of in vivo MRI by fuzzy distance transform. IEEE Trans Med Imaging 2004;23(1):53-62.
41. Aroldi A, Tarantino A, Montagnino G, Cesana B, Cocucci C, Ponticelli C. Effects of three immunosuppressive regimens on vertebral bone density in renal transplant recipients: a prospective study. Transplantation 1997;63(3):380-386. (Pubitemid 27086029)
42. Coco M, Glicklich D, Faugere MC, et al. Prevention of bone loss in renal transplant recipients: a prospective, randomized trial of intravenous pamidronate. J Am Soc Nephrol 2003;14(10):2669-2676. (Pubitemid 37169355)
43. Kwan JT, Almond MK, Evans K, Cunningham J. Changes in total body bone mineral content and regional bone mineral density in renal patients following renal transplantation. Miner Electrolyte Metab 1992;18(2-5):166-168.
44. McIntyre HD, Menzies B, Rigby R, Perry- Keene DA, Hawley CM, Hardie IR. Long-term bone loss after renal transplantation: comparison of immunosuppressive regimens. Clin Transplant 1995;9(1):20-24.
45. Mikuls TR, Julian BA, Bartolucci A, Saag KG. Bone mineral density changes within six months of renal transplantation. Transplantation 2003;75(1):49-54. (Pubitemid 36139694)
46. van den Ham EC, Kooman JP, Christiaans ML, van Hooff JP. The influence of early steroid withdrawal on body composition and bone mineral density in renal transplantation patients. Transpl Int 2003;16(2):82-87. (Pubitemid 36682203)
47. Grotz WH, Mundinger FA, Müller CB, et al. Trabecular bone architecture in female renal allograft recipients: assessed by computed tomography. Nephrol Dial Transplant 1997;12(3):564-569. (Pubitemid 27105636)
48. Cruz EA, Lugon JR, Jorgetti V, Draibe SA, Carvalho AB. Histologic evolution of bone disease 6 months after successful kidney transplantation. Am J Kidney Dis 2004;44(4):747-756. (Pubitemid 39237620)
49. Haas M, Leko-Mohr Z, Roschger P, et al. Zoledronic acid to prevent bone loss in the first 6 months after renal transplantation. Kidney Int 2003;63(3):1130-1136. (Pubitemid 36315593)
50. MacNeil JA, Boyd SK. Load distribution and the predictive power of morphological indices in the distal radius and tibia by high resolution peripheral quantitative computed tomography. Bone 2007;41(1):129-137. (Pubitemid 46891896)
51. Liu XS, Zhang XH, Rajapakse CS, et al. Accuracy of high-resolution in vivo micro magnetic resonance imaging for measurements of microstructural and mechanical properties of human distal tibial bone. J Bone Miner Res 2010;25(9):2039-2050.
52. Bevill G, Keaveny TM. Trabecular bone strength predictions using finite element analysis of micro-scale images at limited spatial resolution. Bone 2009;44(4):579-584.
53. Lam SC, Wald MJ, Rajapakse CS, Liu Y, Saha PK, Wehrli FW. Performance of the MRI-based virtual bone biopsy in the distal radius: serial reproducibility and reliability of structural and mechanical parameters in women representative of osteoporosis study populations. Bone 2011;49(4):895-903.
54. Wald MJ, Magland JF, Rajapakse CS, Wehrli FW. Structural and mechanical parameters of trabecular bone estimated from in vivo high-resolution magnetic resonance images at 3 tesla field strength. J Magn Reson Imaging 2010;31(5):1157-1168.
55. Krug R, Burghardt AJ, Majumdar S, Link TM. High-resolution imaging techniques for the assessment of osteoporosis. Radiol Clin North Am 2010;48(3):601-621.
56. Ladinsky GA, Vasilic B, Popescu AM, et al. Trabecular structure quantified with the MRI-based virtual bone biopsy in postmenopausal women contributes to vertebral deformity burden independent of areal vertebral BMD. J Bone Miner Res 2008;23(1):64-74.
57. Link TM, Bauer J, Kollstedt A, et al. Trabecular bone structure of the distal radius, the calcaneus, and the spine: which site predicts fracture status of the spine best? Invest Radiol 2004;39(8):487-497. (Pubitemid 38982152)
58. Lochmüller EM, Lill CA, Kuhn V, Schneider E, Eckstein F. Radius bone strength in bending, compression, and falling and its correlation with clinical densitometry at multiple sites. J Bone Miner Res 2002;17(9):1629-1638.