The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients

Journal of Hepatology

Volumn 56, Issue 4, 2012, Pages 758-764

  Nischalke, Hans Dieter ^a   Berger, Cordula ^a   Luda, Carolin ^a   Müller, Tobias ^b   Berg, Thomas ^c   Coenen, Martin ^a   Krämer, Benjamin ^a   Körner, Christian ^a   Trebicka, Jonel ^a   Grünhage, Frank ^d   Lammert, Frank ^d   Nattermann, Jacob ^a   Sauerbruch, Tilman ^a   Spengler, Ulrich ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^d SAARLAND UNIVERSITY   (Germany)

Author keywords

Cirrhosis; CXCL1; HCV; Polymorphism; rs4074; TLR2

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; CXCL1 CHEMOKINE; GENOMIC DNA; LIGAND; MESSENGER RNA; TOLL LIKE RECEPTOR 2; TRANSCRIPTION FACTOR; VIRUS PROTEIN;

ADULT; ALCOHOL CONSUMPTION; ALLELE; ANTIBODY DETECTION; ARTICLE; BINDING SITE; BLOOD LEVEL; BODY MASS; CAUCASIAN; CELL STRAIN HEK293; CHRONIC HEPATITIS; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENOTYPE; HEPATITIS B; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LIVER BIOPSY; LIVER CELL; LIVER CIRRHOSIS; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; MICROPARTICLE ENZYME IMMUNOASSAY; NONHUMAN; OBESITY; PRIORITY JOURNAL; REGRESSION ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STELLATE CELL; UNIVARIATE ANALYSIS; VIRUS HEPATITIS;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; BIOPSY; CASE-CONTROL STUDIES; CHEMOKINE CXCL1; DISEASE PROGRESSION; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEK293 CELLS; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LIGANDS; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TOLL-LIKE RECEPTOR 2;

EID: 84858707446     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.10.019     Document Type: Article

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