Synthesis and biological evaluation of 3-aryltyramines as fragments binding to BACE-1 and BACE-2

Tetrahedron Letters

Volumn 53, Issue 17, 2012, Pages 2189-2194

  Fehler, Stefanie K ^a   Pratsch, Gerald ^a   Huber, Walter ^b   Gast, Alain ^b   Hochstrasser, Remo ^b   Hennig, Michael ^a,b   Heinrich, Markus R ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Arylation; BACE; Biaryl; Radical reactions; Tyramine

Indexed keywords

3 ARYLTYRAMINE DERIVATIVE; AMYLOID PRECURSOR PROTEIN; BETA SITE AMYLOID PRECURSOR PROTEIN CLEAVAGE ENZYME 1; BETA SITE AMYLOID PRECURSOR PROTEIN CLEAVAGE ENZYME 2; TYRAMINE; UNCLASSIFIED DRUG;

ARTICLE; ARYLATION; ENZYME INHIBITION; RADICAL REACTION; SYNTHESIS;

EID: 84858706435     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2012.02.070     Document Type: Article

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