메뉴 건너뛰기




Volumn 131, Issue 3, 2003, Pages 490-497

Monocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: An intracellular flow cytometric analysis of peripheral blood mononuclear cells

Author keywords

Human pregnancy; Interleukin 12; Monocytes; Th1 Th2

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4;

EID: 0037339109     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2003.02082.x     Document Type: Article
Times cited : (143)

References (40)
  • 1
    • 0000516920 scopus 로고
    • Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates
    • Medawar PB. Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp Soc Exp Biol 1953; 7:320-38.
    • (1953) Symp Soc Exp Biol , vol.7 , pp. 320-338
    • Medawar, P.B.1
  • 2
    • 0027214206 scopus 로고
    • Maternal and fetal immune responses during pregnancy
    • Sargent IL. Maternal and fetal immune responses during pregnancy. Exp Clin Immunogenet 1993; 10:85-102.
    • (1993) Exp Clin Immunogenet , vol.10 , pp. 85-102
    • Sargent, I.L.1
  • 3
    • 0027207375 scopus 로고
    • Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon?
    • Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 1993; 14:353-6.
    • (1993) Immunol Today , vol.14 , pp. 353-356
    • Wegmann, T.G.1    Lin, H.2    Guilbert, L.3    Mosmann, T.R.4
  • 4
    • 0034922459 scopus 로고    scopus 로고
    • Pregnancy: Success and failure within the Th1/Th2/Th3 paradigm
    • Raghupathy R. Pregnancy: success and failure within the Th1/Th2/Th3 paradigm. Semin Immunol 2001; 13:219-27.
    • (2001) Semin Immunol , vol.13 , pp. 219-227
    • Raghupathy, R.1
  • 5
    • 0029759714 scopus 로고    scopus 로고
    • Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy
    • Marzi M, Vigano A, Trabattoni D et al. Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin Exp Immunol 1996; 106:127-33.
    • (1996) Clin Exp Immunol , vol.106 , pp. 127-133
    • Marzi, M.1    Vigano, A.2    Trabattoni, D.3
  • 6
    • 0032783274 scopus 로고    scopus 로고
    • Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia
    • Saito S, Sakai M, Sasaki Y, Tanebe K, Tsuda H, Michimata T. Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia. Clin Exp Immunol 1999; 117:550-5.
    • (1999) Clin Exp Immunol , vol.117 , pp. 550-555
    • Saito, S.1    Sakai, M.2    Sasaki, Y.3    Tanebe, K.4    Tsuda, H.5    Michimata, T.6
  • 7
    • 0031825025 scopus 로고    scopus 로고
    • Normal pregnancy and pre-eclampsia both produce inflammatory changes in peripheral blood leucocytes akin to sepsis
    • Sacks GP, Studena K, Sargent IL, Redman CWG. Normal pregnancy and pre-eclampsia both produce inflammatory changes in peripheral blood leucocytes akin to sepsis. Am J Obstet Gynecol 1998; 179:80-6.
    • (1998) Am J Obstet Gynecol , vol.179 , pp. 80-86
    • Sacks, G.P.1    Studena, K.2    Sargent, I.L.3    Redman, C.W.G.4
  • 9
    • 0023484464 scopus 로고
    • Study on nonspecific immunity in pregnant women: Increased chemiluminescence response of peripheral blood phagocytes
    • Shibuya T, Izuchi K, Kuroiwa A, Okabe N, Shirakawa K. Study on nonspecific immunity in pregnant women: increased chemiluminescence response of peripheral blood phagocytes. Am J Reprod Immunol Microbiol 1987; 15:19-23.
    • (1987) Am J Reprod Immunol Microbiol , vol.15 , pp. 19-23
    • Shibuya, T.1    Izuchi, K.2    Kuroiwa, A.3    Okabe, N.4    Shirakawa, K.5
  • 10
    • 0036583327 scopus 로고    scopus 로고
    • Signaling from cytokine receptors that affect Th1 responses
    • Hanlon AM, Jang S, Salgame P. Signaling from cytokine receptors that affect Th1 responses. Front Biosci 2002; 7:1247-54.
    • (2002) Front Biosci , vol.7 , pp. 1247-1254
    • Hanlon, A.M.1    Jang, S.2    Salgame, P.3
  • 11
    • 0031058331 scopus 로고    scopus 로고
    • Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-gamma)
    • Trinchieri G. Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-gamma). Curr Opin Immunol 1997; 9:17-23.
    • (1997) Curr Opin Immunol , vol.9 , pp. 17-23
    • Trinchieri, G.1
  • 12
    • 0030220888 scopus 로고    scopus 로고
    • Elevations of serum interleukin-12 concentrations in women with severe pre-eclampsia and HELLP syndrome
    • Dudley DJ, Hunter C, Mitchell MD, Varner MW, Gately M. Elevations of serum interleukin-12 concentrations in women with severe pre-eclampsia and HELLP syndrome. J Reprod Immunol 1996; 31:97-107.
    • (1996) J Reprod Immunol , vol.31 , pp. 97-107
    • Dudley, D.J.1    Hunter, C.2    Mitchell, M.D.3    Varner, M.W.4    Gately, M.5
  • 13
    • 0028061457 scopus 로고
    • Immunoreactive tumor necrosis factor-alpha is elevated in maternal plasma but undetected in amniotic fluid in the second trimester
    • Kupferminc MJ, Peaceman AM, Wigton TR, Tamura RK, Rehnberg KA, Socol ML. Immunoreactive tumor necrosis factor-alpha is elevated in maternal plasma but undetected in amniotic fluid in the second trimester. Am J Obstet Gynecol 1994; 171:976-9.
    • (1994) Am J Obstet Gynecol , vol.171 , pp. 976-979
    • Kupferminc, M.J.1    Peaceman, A.M.2    Wigton, T.R.3    Tamura, R.K.4    Rehnberg, K.A.5    Socol, M.L.6
  • 14
    • 0029586280 scopus 로고
    • Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies
    • Prussin C, Metcalfe DD. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. J Immunol Meth 1995; 188:117-28.
    • (1995) J Immunol Meth , vol.188 , pp. 117-128
    • Prussin, C.1    Metcalfe, D.D.2
  • 16
    • 0028877056 scopus 로고
    • Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations
    • Openshaw P, Murphy EE, Hosken NA et al. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med 1995; 182:1357-67.
    • (1995) J Exp Med , vol.182 , pp. 1357-1367
    • Openshaw, P.1    Murphy, E.E.2    Hosken, N.A.3
  • 17
    • 0026779198 scopus 로고
    • The detection of intracytoplasmic interleukin-1 alpha, interleukin-1 beta and tumour necrosis factor alpha expression in human monocytes using two colour immunofluorescence flow cytometry
    • De Caestecker MP, Telfer BA, Hutchinson IV, Ballardie FW. The detection of intracytoplasmic interleukin-1 alpha, interleukin-1 beta and tumour necrosis factor alpha expression in human monocytes using two colour immunofluorescence flow cytometry. J Immunol Meth 1992; 154:11-20.
    • (1992) J Immunol Meth , vol.154 , pp. 11-20
    • De Caestecker, M.P.1    Telfer, B.A.2    Hutchinson, I.V.3    Ballardie, F.W.4
  • 18
    • 9444249329 scopus 로고    scopus 로고
    • Cell-associated IL-8 in human blood monocytes: Analysis by flow cytometry
    • Fujishima S, Nakamura H, Waki Y et al. Cell-associated IL-8 in human blood monocytes: analysis by flow cytometry. Cytometry 1996; 24:382-9.
    • (1996) Cytometry , vol.24 , pp. 382-389
    • Fujishima, S.1    Nakamura, H.2    Waki, Y.3
  • 19
    • 0034922174 scopus 로고    scopus 로고
    • Flow cytometric measurement of intracellular Th1 and Th2 cytokine production by human villous and extravillous cytotrophoblast
    • Sacks GP, Clover LM, Bainbridge DR, Redman CW, Sargent IL. Flow cytometric measurement of intracellular Th1 and Th2 cytokine production by human villous and extravillous cytotrophoblast. Placenta 2001; 22:550-9.
    • (2001) Placenta , vol.22 , pp. 550-559
    • Sacks, G.P.1    Clover, L.M.2    Bainbridge, D.R.3    Redman, C.W.4    Sargent, I.L.5
  • 20
    • 0029843656 scopus 로고    scopus 로고
    • + T cells from normal and immunodeficient donors using directly conjugated anti-cytokine antibodies and three-colour flow cytometry
    • + T cells from normal and immunodeficient donors using directly conjugated anti-cytokine antibodies and three-colour flow cytometry. Clin Exp Immunol 1996; 105:517-22.
    • (1996) Clin Exp Immunol , vol.105 , pp. 517-522
    • North, M.E.1    Ivory, K.2    Funauchi, M.3    Webster, A.D.4    Lane, A.C.5    Farrant, J.6
  • 22
    • 0033970868 scopus 로고    scopus 로고
    • Upregulation of IL-12 in monocytes: A fundamental defect in common variable immunodeficiency
    • Cambronero R, Sewell WA, North ME, Webster AD, Farrant J. Upregulation of IL-12 in monocytes: a fundamental defect in common variable immunodeficiency. J Immunol 2000; 164:488-94.
    • (2000) J Immunol , vol.164 , pp. 488-494
    • Cambronero, R.1    Sewell, W.A.2    North, M.E.3    Webster, A.D.4    Farrant, J.5
  • 23
    • 0033198660 scopus 로고    scopus 로고
    • Suppression of interleukin-12 production by human monocytes after preincubation with lipopolysaccharide
    • Wittmann M, Larsson VA, Schmidt P, Begemann G, Kapp A, Werfel T. Suppression of interleukin-12 production by human monocytes after preincubation with lipopolysaccharide. Blood 1999; 94:1717-26.
    • (1999) Blood , vol.94 , pp. 1717-1726
    • Wittmann, M.1    Larsson, V.A.2    Schmidt, P.3    Begemann, G.4    Kapp, A.5    Werfel, T.6
  • 24
    • 0029949205 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha (TNF-alpha) gene polymorphism and expression in pre-eclampsia
    • Chen GR, Wilson Wang SH, Zheng HZ, Walker JJ, McKillop JH. Tumour necrosis factor-alpha (TNF-alpha) gene polymorphism and expression in pre-eclampsia. Clin Exp Immunol 1996; 104:154-9.
    • (1996) Clin Exp Immunol , vol.104 , pp. 154-159
    • Chen, G.R.1    Wilson Wang, S.H.2    Zheng, H.Z.3    Walker, J.J.4    McKillop, J.H.5
  • 25
    • 0036094438 scopus 로고    scopus 로고
    • Interleukin-12 secretion by peripheral blood mononuclear cells is decreased in normal pregnant subjects and increased in preeclamptic patients
    • Sakai M, Tsuda H, Tanebe K, Sasaki Y, Saito S. Interleukin-12 secretion by peripheral blood mononuclear cells is decreased in normal pregnant subjects and increased in preeclamptic patients. Am J Reprod Immunol 2002; 47:91-7.
    • (2002) Am J Reprod Immunol , vol.47 , pp. 91-97
    • Sakai, M.1    Tsuda, H.2    Tanebe, K.3    Sasaki, Y.4    Saito, S.5
  • 26
    • 0030046989 scopus 로고    scopus 로고
    • Lymphocyte subsets and mitogen stimulation of blood lymphocytes in normal pregnancy
    • Matthiesen L, Berg G, Ernerudh J, Hakansson L. Lymphocyte subsets and mitogen stimulation of blood lymphocytes in normal pregnancy. Am J Reprod Immunol 1996; 35:70-9.
    • (1996) Am J Reprod Immunol , vol.35 , pp. 70-79
    • Matthiesen, L.1    Berg, G.2    Ernerudh, J.3    Hakansson, L.4
  • 27
    • 0023638069 scopus 로고
    • Cytotoxic activity and phenotypic analysis of natural killer cells in early normal human pregnancy
    • Lee H, Gregory CD, Rees GB, Scott IV, Golding PR. Cytotoxic activity and phenotypic analysis of natural killer cells in early normal human pregnancy. J Reprod Immunol 1987; 12:35-47.
    • (1987) J Reprod Immunol , vol.12 , pp. 35-47
    • Lee, H.1    Gregory, C.D.2    Rees, G.B.3    Scott, I.V.4    Golding, P.R.5
  • 29
    • 0028911482 scopus 로고
    • Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor alpha production
    • D'Andrea A, Ma X, Aste Amezaga M, Paganin C, Trinchieri G. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. J Exp Med 1995; 181:537-46.
    • (1995) J Exp Med , vol.181 , pp. 537-546
    • D'Andrea, A.1    Ma, X.2    Aste Amezaga, M.3    Paganin, C.4    Trinchieri, G.5
  • 30
    • 0031799092 scopus 로고    scopus 로고
    • Syncytiotrophoblast microvilli are shed into the maternal circulation in increased amounts in pre-eclamptic pregnancy
    • Knight M, Redman CWG, Linton EA, Sargent IL. Syncytiotrophoblast microvilli are shed into the maternal circulation in increased amounts in pre-eclamptic pregnancy. Br J Obstet Gynaecol 1998; 105:632-40.
    • (1998) Br J Obstet Gynaecol , vol.105 , pp. 632-640
    • Knight, M.1    Redman, C.W.G.2    Linton, E.A.3    Sargent, I.L.4
  • 31
    • 0033832416 scopus 로고    scopus 로고
    • Placental debris, oxidative stress and pre-eclampsia
    • Redman CWG, Sargent IL. Placental debris, oxidative stress and pre-eclampsia. Placenta 2000; 21:597-602.
    • (2000) Placenta , vol.21 , pp. 597-602
    • Redman, C.W.G.1    Sargent, I.L.2
  • 32
    • 0036230102 scopus 로고    scopus 로고
    • Deficiency of decidual IL-10 in first trimester missed abortion: A lack of correlation with the decidual immune cell profile
    • Plevyak M, Hanna N, Mayer S et al. Deficiency of decidual IL-10 in first trimester missed abortion: a lack of correlation with the decidual immune cell profile. Am J Reprod Immunol 2002; 47:242-50.
    • (2002) Am J Reprod Immunol , vol.47 , pp. 242-250
    • Plevyak, M.1    Hanna, N.2    Mayer, S.3
  • 33
    • 0036224419 scopus 로고    scopus 로고
    • Distributions of endometrial NK cells, B cells, T cells an Th1/Th2 cells fail to predict pregnancy outcome following recurrent abortion
    • Michimata T, Ogasawara MS, Tsuda H et al. Distributions of endometrial NK cells, B cells, T cells an Th1/Th2 cells fail to predict pregnancy outcome following recurrent abortion. Am J Reprod Immunol 2002; 47:196-202.
    • (2002) Am J Reprod Immunol , vol.47 , pp. 196-202
    • Michimata, T.1    Ogasawara, M.S.2    Tsuda, H.3
  • 34
    • 0022120398 scopus 로고
    • Epidemiology of infection in pregnancy
    • Brabin BJ. Epidemiology of infection in pregnancy. Rev Infect Dis 1985; 7:579-603.
    • (1985) Rev Infect Dis , vol.7 , pp. 579-603
    • Brabin, B.J.1
  • 35
    • 0019406529 scopus 로고
    • The Shwartzman reaction: A review including clinical manifestations and proposal for a univisceral or single organ third type
    • Mori W. The Shwartzman reaction: a review including clinical manifestations and proposal for a univisceral or single organ third type. Histopathology 1981; 5:113-26.
    • (1981) Histopathology , vol.5 , pp. 113-126
    • Mori, W.1
  • 36
    • 0027982098 scopus 로고
    • Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction
    • Ozmen L, Pericin M, Hakimi J et al. Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction. J Exp Med 1994; 180:907-15.
    • (1994) J Exp Med , vol.180 , pp. 907-915
    • Ozmen, L.1    Pericin, M.2    Hakimi, J.3
  • 37
    • 0032957844 scopus 로고    scopus 로고
    • Pre-eclampsia: An excessive maternal inflammatory response to pregnancy
    • Redman CWG, Sacks GP, Sargent IL. Pre-eclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999; 180:499-506.
    • (1999) Am J Obstet Gynecol , vol.180 , pp. 499-506
    • Redman, C.W.G.1    Sacks, G.P.2    Sargent, I.L.3
  • 38
    • 0030308048 scopus 로고    scopus 로고
    • Murine experimental abortion by IL-12 administration is caused by activation of cytotoxic T lymphocytes and placental apoptosis
    • Shiraishi H, Hayakawa S, Satoh K. Murine experimental abortion by IL-12 administration is caused by activation of cytotoxic T lymphocytes and placental apoptosis. Clin Laboratory Immunol 1996; 48:93-108.
    • (1996) Clin Laboratory Immunol , vol.48 , pp. 93-108
    • Shiraishi, H.1    Hayakawa, S.2    Satoh, K.3
  • 39
    • 0034814317 scopus 로고    scopus 로고
    • Evaluation of interleukin concentrations in amniotic fluid in preterm and term parturution and in oligohydramnios
    • Lemancewicz A, Urban R, Skotnicki M, Kretowska M, Sierakowski S. Evaluation of interleukin concentrations in amniotic fluid in preterm and term parturution and in oligohydramnios. Med Sci Monit 1997; 7:924-7.
    • (1997) Med Sci Monit , vol.7 , pp. 924-927
    • Lemancewicz, A.1    Urban, R.2    Skotnicki, M.3    Kretowska, M.4    Sierakowski, S.5
  • 40
    • 0034882184 scopus 로고    scopus 로고
    • Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma
    • Wong CK, Ho CY, Ko FW et al. Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol 2001; 125:177-83.
    • (2001) Clin Exp Immunol , vol.125 , pp. 177-183
    • Wong, C.K.1    Ho, C.Y.2    Ko, F.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.