Alteration of TH1 and TH2 cells by intracellular cytokine detection in patients with unexplained recurrent abortion before and after immunotherapy with the husband's mononuclear cells

Fertility and Sterility

Volumn 85, Issue 5, 2006, Pages 1452-1458

  Yokoo, Tomokazu ^a   Takakuwa, Koichi ^a   Ooki, Izumi ^a   Kikuchi, Akira ^a   Tamura, Masaki ^a   Tanaka, Kenichi ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

immunotherapy; mechanisms; TH1; TH2; Unexplained recurrent abortion

Indexed keywords

CYTOKINE;

ADOPTIVE IMMUNOTHERAPY; ADULT; ARTICLE; BLOOD; CD4+ T LYMPHOCYTE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; LABOR INDUCTION; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; PREGNANT WOMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECURRENT ABORTION; TH1 CELL; TH2 CELL;

ABORTION, HABITUAL; CYTOKINES; FEMALE; HUMANS; IMMUNOTHERAPY; LYMPHOCYTE TRANSFUSION; LYMPHOCYTES; MALE; SPOUSES; TH1 CELLS; TH2 CELLS; TREATMENT OUTCOME;

EID: 33646079873     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2005.10.058     Document Type: Article

References (29)

1. Medawar P.B. Some immunological and endocrinological problems raised by evolution of viviparity in vertebrates. Symp Soc Exp Biol 7 (1953) 320-338
2. Wegmann T.G. Placental immunotrophism. maternal T cell enhance placental growth and function. Am J Reprod Immunol Microbiol 156 (1987) 67-69
3. Wegmann T.G., Lin H., Guilbert L., and Mosmann T.R. Bidirectional cytokine interactions in the maternal-fetal relationship. is successful pregnancy a TH2 phenomenon?. Immunol Today 14 (1993) 353-356
4. Lin H., Mosmann T.R., Guilbert L., Tuntipopipat S., and Wegmann T.G. Synthesis of T helper 2-type cytokines at the maternal-fetal interface. J Immunol 151 (1993) 4562-4573
5. Marzi M., Vigano A., Trabattoni D., Villa M.L., Salvaggio A., Clerici E., et al. Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin Exp Immunol 106 (1996) 127-133
6. Raghupathy R. Th1-type immunity is incompatible with successful pregnancy. Immunol Today 18 (1997) 478-2
7. Guilbert L. There is a bias against type 1 (inflammatory) cytokine expression and function in pregnancy. J Reprod Immunol 32 (1996) 105-110
8. Raghupathy R., Makhseed M., Azizieh F., Hassan N., Al-Azemi M., and Al-Shamali E. Maternal Th1- and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions. Cell Immunol 196 (1999) 122-130
9. Chaouat G., Zourbas S., Ostogic S., Lappree-Delage G., Dubanchet S., Ledee N., et al. A brief review of recent data on some cytokine expression at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy. J Reprod Immunol 53 (2002) 241-256
10. Hill J.A. T helper 1 immunity to trophoblast. evidence for a new immunological mechanism for recurrent abortion in women. Hum Reprod 10 suppl 2 (1995) 114-120
11. Lim K.J.H., Odukoya O.A., Ajjan R.A., Li T., Weetman A.P., and Cooke I.D. The role of T-helper cytokines in human reproduction. Fertil Steril 73 (2000) 136-142
12. Mowbray J.F., Gibbings C., Liddell H., Reginald P.W., Underwood J.L., and Beard R.W. Controlled trial of treatment of recurrent spontaneous abortion by immunisation with paternal cells. Lancet i (1985) 941-943
13. Gatenby P.A., Cameron K., Simes R.J., Adelstein S., Bennett M.J., Jansen R.P.S., et al. Treatment of recurrent spontaneous abortion by immunization with paternal lymphocytes. results of a controlled trial. Am J Reprod Immunol 29 (1993) 88-94
14. Unander A.M., and Lindholm A. Transfusion of leucocyte-rich erythrocyte concentrates. a successful treatment in selected cases of habitual abortion. Am J Obstet Gynecol 154 (1986) 516-520
15. Takakuwa K., Goto S., Hasegawa I., Ueda H., Kanazawa K., Takeuchi S., et al. Result of immunotherapy on patients with unexplained recurrent abortion. a beneficial treatment for patients with negative blocking antibodies. Am J Reprod Immunol 23 (1990) 37-41
16. Takakuwa K., Higashino M., Yasuda M., Ishii S., Ueda H., Asano K., et al. Is an additional vaccination necessary for a successful second pregnancy in unexplained recurrent aborters who were successfully immunized with their husband's lymphocytes before the first pregnancy?. Am J Reprod Immunol 29 (1993) 39-44
17. Park M.I., Edwin S.S., Scott J.R., and Branch D.W. Interpretation of blocking activity in maternal serum depends on the equation used for calculation of mixed lymphocyte culture results. Clin Exp Immunol 82 (1990) 363-368
18. Adachi H., Takakuwa K., Mitsui T., Ishii K., Tamura M., and Tanaka K. Results of immunotherapy for patients with unexplained secondary recurrent abortions. Clin Immunol 106 (2003) 175-180
19. Pandey M.K., and Agrawal S. Induction of MLR-Bf and protection of fetal loss. a current double blind randomized trial of paternal lymphocyte immunization for women with recurrent spontaneous abortion. Int Immunopharmacol 4 (2004) 289-298
20. Takakuwa K., Kanazawa K., and Takeuchi S. Production of blocking antibodies by vaccination with husband's lymphocytes in unexplained recurrent aborters. the role in successful pregnancies. AM J Reprod Immunol Microbiol 10 (1986) 1-9
21. Jung T., Shauer U., Heussern C., Neumann C., and Rieger C. Detection of intracellular cytokines by flow cytometry. J Immunol Methods 159 (1993) 179-207
22. Picker L.J., Singh M.K., Zdraveski Z., Treer J.R., Waldrop S.L., and Bergstresser P.R. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood 86 (1995) 1408-1419
23. Aoki Y., Tsuneki I., Sasaki M., Watanabe M., Sato T., Aida H., et al. Analysis of TH1 and TH2 cells by intracellular cytokine detection with flow cytometry in patients with ovarian cancer. Gynecol Obstet Invest 50 (2000) 207-211
24. Ober C., Karrison T., Odem R.R., Barnes R.B., Branch D.W., Stephenson M.D., et al. Mononuclear-cell immunization in prevention of recurrent miscarriages. A randomised trial. Lancet 354 (1999) 365-369
25. Recurrent Miscarriage Immunotherapy Trialists Group. Worldwide collaborative observational study and meta-analysis on allogeneic leucocyte immunotherapy for recurrent spontaneous abortions. Am J Reprod Immunol 32 (1994) 55-72
26. Takakuwa K., Ueda H., Goto S., Hasegawa I., Yamada K., Kazama Y., et al. Influence of immunotherapy on the cellular immunity of unexplained recurrent aborters. J Reprod Immunol 20 (1991) 153-163
27. Miki A., Fujii T., Ishikawa Y., Hamai Y., Yamashita T., Tadokoro K., et al. Immunotherapy prevents recurrent abortion without influencing natural killer receptor status. Am J Reprod Immunol 43 (2000) 98-106
28. Seder R.A., and Mosmann T.M. Differentiation of effector phenotypes of CD4+ and CD8+ T cells. In: Paul W.E. (Ed). Fundamental Immunology. 4th ed. (1999), Lippincott-Raven Publishers, Philadelphia 879-908
29. Hayakawa S., Karasaki-Suzuki M., Itoh T., Ishii M., Kanaeda T., Nagai N., et al. Effects of paternal lymphocyte immunization on peripheral Th1/Th2 balance and TCR Vβ and Vγ repertoire usage of patients with recurrent spontaneous abortions. Am J Reprod Immunol 43 (2000) 107-115