Structure of aminopeptidase N from Escherichia coli complexed with the transition-state analogue aminophosphinic inhibitor PL250

Acta Crystallographica Section D: Biological Crystallography

Volumn 65, Issue 8, 2009, Pages 814-822

  Fournié Zaluski, Marie Claude ^a   Poras, Hervé ^a   Roques, Bernard P ^a   Nakajima, Yoshitaka ^b   Ito, Kiyoshi ^b   Yoshimoto, Tadashi ^b  

^a Pharmaleads ^*  (France)

^b NAGASAKI UNIVERSITY   (Japan)

Author keywords

Active site recognition; Aminophosphinic inhibitors; Complex structure; Escherichia coli APN; Side chain flexibility

Indexed keywords

DRUG DERIVATIVE; ENZYME INHIBITOR; ESCHERICHIA COLI PROTEIN; MICROSOMAL AMINOPEPTIDASE; PHENYLALANINE; PHOSPHINIC ACID DERIVATIVE; ZINC;

ANIMAL; ARTICLE; BINDING SITE; CHEMISTRY; CRYSTALLIZATION; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYMOLOGY; ESCHERICHIA COLI; HUMAN; HYDROGEN BOND; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIGENS, CD13; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HUMANS; HYDROGEN BONDING; PHENYLALANINE; PHOSPHINIC ACIDS; PROTEIN BINDING; PROTEIN CONFORMATION; ZINC;

ESCHERICHIA COLI; MAMMALIA;

EID: 68349147918     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S090744490901779X     Document Type: Article

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