High resolution SPECT imaging for visualization of intratumoral heterogeneity using a SPECT/CT scanner dedicated for small animal imaging

Annals of Nuclear Medicine

Volumn 26, Issue 1, 2012, Pages 67-76

  Umeda, Izumi O ^a   Tani, Kotaro ^a   Tsuda, Keisuke ^a   Kobayashi, Masamitsu ^a,b   Ogata, Mayumi ^a,c   Kimura, Sadaaki ^a   Yoshimoto, Mitsuyoshi ^d   Kojima, Shuji ^b   Moribe, Kunikazu ^c   Yamamoto, Keiji ^c   Moriyama, Noriyuki ^d   Fujii, Hirofumi ^a  

^a NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c CHIBA UNIVERSITY   (Japan)

^d NATIONAL CANCER CENTER   (Japan)

Author keywords

111In; Liposome; Small animal; SPECT; Tumor heterogeneity

Indexed keywords

INDIUM CHLORIDE IN 111; LIPOSOME IN 111;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; CANCER DIAGNOSIS; COMPUTER ASSISTED TOMOGRAPHY; COMPUTER PROGRAM; DEVICES; IMAGE ANALYSIS; IMAGE QUALITY; IMAGE RECONSTRUCTION; MALE; MOUSE; NONHUMAN; PHANTOM; PRIORITY JOURNAL; SARCOMA; SARCOMA 180; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; MALE; MICE; PHANTOMS, IMAGING; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY; SARCOMA, EXPERIMENTAL; TIME FACTORS;

EID: 84858701990     PISSN: 09147187     EISSN: 18646433     Source Type: Journal    
DOI: 10.1007/s12149-011-0542-7     Document Type: Article

References (29)

1. Saga T, Koizumi M, Furukawa T, Yoshikawa K, Fujibayashi Y. Molecular imaging of cancer: evaluating characters of individual cancer by PET/SPECT imaging. Cancer Sci. 2009;100(3):375-81.
2. Beekman FJ, van der Have F, Vastenhouw B, van der Linden AJ, van Rijk PP, Burbach JP, et al. U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in mice. J Nucl Med. 2005;46(7):1194-200. (Pubitemid 43741082)
3. Rowland DJ, Cherry SR. Small-animal preclinical nuclear medicine instrumentation and methodology. Semin Nucl Med. 2008;38(3):209-22. (Pubitemid 351466917)
4. Franc BL, Acton PD, Mari C, Hasegawa BH. Small-animal SPECT and SPECT/CT: important tools for preclinical investigation. J Nucl Med. 2008;49(10):1651-63.
5. Branderhorst W, Vastenhouw B, van der Have F, Blezer EL, Bleeker WK, Beekman FJ. Targeted multi-pinhole SPECT. Eur J Nucl Med Mol Imaging. 2011;38(3):552-61.
6. Hwang AB, Franc BL, Gullberg GT, Hasegawa BH. Assessment of the sources of error affecting the quantitative accuracy of SPECT imaging in small animals. Phys Med Biol. 2008;53(9): 2233-52. (Pubitemid 351570908)
7. Nuyts J, Vunckx K, Defrise M, Vanhove C. Small animal imaging with multi-pinhole SPECT. Methods. 2009;48(2):83-91.
8. Magota K, Kubo N, Kuge Y, Nishijima K, Zhao S, Tamaki N. Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging. Eur J Nucl Med Mol Imaging. 2011;38(4):742-52.
9. Acton PD, Kung HF. Small animal imaging with high resolution single photon emission tomography. Nucl Med Biol. 2003;30(8):889-95. (Pubitemid 38040998)
10. Funk T, Sun M, Hasegawa BH. Radiation dose estimate in small animal SPECT and PET. Med Phys. 2004;31(9):2680-6. (Pubitemid 39287885)
11. Muller C, Forrer F, Schibli R, Krenning EP, de Jong M. SPECT study of folate receptor-positive malignant and normal tissues in mice using a novel 99mTc-radiofolate. J Nucl Med. 2008;49(2):310-7. (Pubitemid 351225671)
12. Phillips WT, Goins BA, Bao A. Radioactive liposomes. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009;1(1):69-83.
13. Chisholm EJ, Vassaux G, Martin-Duque P, Chevre R, Lambert O, Pitard B, et al. Cancer-specific transgene expression mediated by systemic injection of nanoparticles. Cancer Res. 2009;69(6): 2655-62.
14. 99mTc SPECT imaging in phantoms and in tumored mice. Bioconjug Chem. 2010;21(8): 1565-70.
15. Ogihara-Umeda I, Sasaki T, Kojima S, Nishigori H. Optimal radiolabeled liposomes for tumor imaging. J Nucl Med. 1996; 37(2):326-32. (Pubitemid 26150911)
16. Ogihara-Umeda I, Nishigori H. Radiolabeled liposomes for diagnostic imaging. In: Arshady R, editor. Radiolabeled and magnetic particulates in medicine and biology. London: Citus; 2001. p. 123-48.
17. Ogihara-Umeda I, Kojima S. Increased delivery of gallium-67 to tumors using serum-stable liposomes. J Nucl Med. 1988;29(4): 516-23.
18. Ogihara-Umeda I, Kojima S. Cholesterol enhances the delivery of liposome-encapsulated gallium-67 to tumors. Eur J Nucl Med. 1989;15(9):612-7. (Pubitemid 19236005)
19. Ogihara-Umeda I, Sasaki T, Nishigori H. Development of a liposome-encapsulated radionuclide with preferential tumor accumulation - the choice of radionuclide and chelating ligand. Int J Radiat Appl Instrum B. 1992;19(7):753-7.
20. Mok GS, Tsui BM, Beekman FJ. The effects of object activity distribution on multiplexing multi-pinhole SPECT. Phys Med Biol. 2011;56(8):2635-50.
21. 123I-labelled probes. Eur J Nucl Med Mol Imaging. 2009;36(9):1495-509.
22. Forrer F, Valkema R, Bernard B, Schramm NU, Hoppin JW, Rolleman E, et al. In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals. Eur J Nucl Med Mol Imaging. 2006;33(10):1214-7. (Pubitemid 44484478)
23. Kung MP, Kung HF. Mass effect of injected dose in small rodent imaging by SPECT and PET. Nucl Med Biol. 2005;32(7):673-8. (Pubitemid 41502971)
24. Gindy ME, Prud'homme RK. Multifunctional nanoparticles for imaging, delivery and targeting in cancer therapy. Expert Opin Drug Deliv. 2009;6(8):865-78.
25. Sajja HK, East MP, Mao H, Wang YA, Nie S, Yang L. Development of multifunctional nanoparticles for targeted drug delivery and noninvasive imaging of therapeutic effect. Curr Drug Discov Technol. 2009;6(1):43-51.
26. 18F-FDG distribution with regional expression of glucose transporters and hexokinase-II in experimental tumor. J Nucl Med. 2005;46(4):675-82.
27. 125I-Gluco-RGD autoradiography. J Nucl Med. 2008;49(4):597-605.
28. 2-polarography, and fluorescence microscopy. Int J Radiat Oncol Biol Phys. 2008;70(4):1202-12.
29. 125I]IPOS as a molecular imaging probe for hypoxia-inducible factor-1-active regions in a tumor: comparison among SPECT/CT imaging, autoradiography, and immunohistochemistry. Cancer Sci. 2011. doi:10.1111/j.1349-7006.2011.02057.x.