SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2544-2549

Discovery of nor-seco himbacine analogs as thrombin receptor antagonists

(12) Chelliah, Mariappan V a Chackalamannil, Samuel a Xia, Yan a Eagen, Keith a Greenlee, William J a Ahn, Ho Sam a Agans Fantuzzi, Jacqueline a Boykow, George a Hsieh, Yunsheng a Bryant, Matthew a Chan, Tze Ming a Chintala, Madhu a

a MERCK RESEARCH LABORATORIES (United States)

Author keywords

Himbacine; PAR 1; Platelet aggregation; SCH 530348; Thrombin receptor antagonist; Vorapaxar

Indexed keywords

HIMBACINE; THROMBIN RECEPTOR ANTAGONIST; VORAPAXAR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG EFFICACY; HAPLORHINI; NONHUMAN; PHASE 2 CLINICAL TRIAL (TOPIC); RAT; THROMBOCYTE AGGREGATION;

ADMINISTRATION, ORAL; ALKALOIDS; ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD PLATELETS; DRUG DISCOVERY; FURANS; HUMANS; MACACA FASCICULARIS; NAPHTHALENES; PIPERIDINES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN BINDING; RATS; RECEPTOR, PAR-1; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 84858699261 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.01.138 Document Type: Article

Times cited : (10)

References (22)

1
- 0242300217
- S.P. Jackson, and S.M. Schoenwaelder Nat. Rev. Drug Disc. 2 2003 775
- (2003) Nat. Rev. Drug Disc. , vol.2 , pp. 775
- Jackson, S.P.¹ Schoenwaelder, S.M.²

2
- 0037271306
- D.L. Bhatt, and E.J. Topol Nat. Rev. Drug Disc. 2 2003 15
- (2003) Nat. Rev. Drug Disc. , vol.2 , pp. 15
- Bhatt, D.L.¹ Topol, E.J.²

3
- 0033549388
- V. Fuster, Z.A. Fayad, and J.J. Badimon Lancet 353 1999 5
- (1999) Lancet , vol.353 , pp. 5
- Fuster, V.¹ Fayad, Z.A.² Badimon, J.J.³

4
- 77951295830
- E.B. Hanna, D.L. Glancy, and J.F. Saucedo Cardiovasc. Drugs Ther. 24 2010 61
- (2010) Cardiovasc. Drugs Ther. , vol.24 , pp. 61
- Hanna, E.B.¹ Glancy, D.L.² Saucedo, J.F.³

5
- 44949114152
- S. Chackalamannil, Y. Wang, W.J. Greenlee, Z. Hu, Y. Xia, H. Ahn, G. Boykow, Y. Hsieh, J. Palamanda, J. Agans-Fantuzzi, S. Kurowski, M. Graziano, and M. Chintala J. Med. Chem. 51 2008 3061
- (2008) J. Med. Chem. , vol.51 , pp. 3061
- Chackalamannil, S.¹ Wang, Y.² Greenlee, W.J.³ Hu, Z.⁴ Xia, Y.⁵ Ahn, H.⁶ Boykow, G.⁷ Hsieh, Y.⁸ Palamanda, J.⁹ Agans-Fantuzzi, J.¹⁰ Kurowski, S.¹¹ Graziano, M.¹² Chintala, M.¹³

6
- 79952283375
- Donald J. Abraham, David P. Rotella, 7th ed.
- S. Chackalamannil Donald J. Abraham, David P. Rotella, Burger's Medicinal Chemistry, Drug Discovery, and Development 7th ed. 2010 409 476
- (2010) Burger's Medicinal Chemistry, Drug Discovery, and Development , pp. 409-476
- Chackalamannil, S.¹

7
- 24944439301
- Protease-Activated Receptors
- R.A. Bradshaw, E.A. Dennis, Elsevier San Diego, USA
- S.R. Coughlin Protease-Activated Receptors R.A. Bradshaw, E.A. Dennis, Handbook of Cell Signaling Vol. 1 2004 Elsevier San Diego, USA 167 171
- (2004) Handbook of Cell Signaling , vol.1 , pp. 167-171
- Coughlin, S.R.¹

8
- 0037786684
- Protease-Activated Receptors in the Cardiovascular System
- S.R. Coughlin Protease-Activated Receptors in the Cardiovascular System Cold Spring Harb. Symp. Quant. Biol. 67 2002 197
- (2002) Cold Spring Harb. Symp. Quant. Biol. , vol.67 , pp. 197
- Coughlin, S.R.¹

9
- 0034921205
- S.R. Coughlin Thromb. Haemost. 86 2001 298
- (2001) Thromb. Haemost. , vol.86 , pp. 298
- Coughlin, S.R.¹

10
- 33748523149
- S. Chackalamannil J. Med. Chem. 49 2006 5389
- (2006) J. Med. Chem. , vol.49 , pp. 5389
- Chackalamannil, S.¹

11
- 0030032791
- R.J.A. Grand, A.S. Turnell, and P.W. Grabham Biochem. J. 313 1996 353
- (1996) Biochem. J. , vol.313 , pp. 353
- Grand, R.J.A.¹ Turnell, A.S.² Grabham, P.W.³

12
- 28344436780
- S.R. Coughlin J. Thromb. Haemost. 3 2005 1800
- (2005) J. Thromb. Haemost. , vol.3 , pp. 1800
- Coughlin, S.R.¹

13
- 58149143160
- M. Chintala, K. Shimizu, M. Ogawa, H. Yamaguchi, M. Doi, and P. Jensen J. Pharmacol. Sci. 108 2008 433
- (2008) J. Pharmacol. Sci. , vol.108 , pp. 433
- Chintala, M.¹ Shimizu, K.² Ogawa, M.³ Yamaguchi, H.⁴ Doi, M.⁵ Jensen, P.⁶

14
- 84858704207
- C.B. Richard, J.M. David, K.J. Lisa, S.P. Karen, P. Jinglan, N. Alan, M.Z. Khaled, B. Gail, S. John, J. Diane, W.M. Kenneth, V.W. Frans, V. Enrico, and A.H. Robert Lancet 373 2009 919
- (2009) Lancet , vol.373 , pp. 919
- Richard, C.B.¹ David, J.M.² Lisa, K.J.³ Karen, S.P.⁴ Jinglan, P.⁵ Alan, N.⁶ Khaled, M.Z.⁷ Gail, B.⁸ John, S.⁹ Diane, J.¹⁰ Kenneth, W.M.¹¹ Frans, V.W.¹² Enrico, V.¹³ Robert, A.H.¹⁴

15
- 85058720552
- The Thrombin Receptor Antagonist for Clinical Event. Reduction in Acute Coronary Syndrome (TRA·CER) trial: Study design and rationale
- The TRA·CER Executive and Steering Committees
- The TRA·CER Executive and Steering Committees. The Thrombin Receptor Antagonist for Clinical Event. Reduction in Acute Coronary Syndrome (TRA·CER) trial: study design and rationale. Am. Heart J. 2009, 158, 327.
- (2009) Am. Heart J. , vol.158 , pp. 327

16
- 68949156886
- D.A. Morrow, B.M. Scirica, K.A.A. Fox, G. Berman, J. Strony, E. Veltri, M.P. Bonaca, P. Fish, C.H. McCabe, and E. Braunwald Am. Heart J. 158 2009 335
- (2009) Am. Heart J. , vol.158 , pp. 335
- Morrow, D.A.¹ Scirica, B.M.² Fox, K.A.A.³ Berman, G.⁴ Strony, J.⁵ Veltri, E.⁶ Bonaca, M.P.⁷ Fish, P.⁸ McCabe, C.H.⁹ Braunwald, E.¹⁰

17
- 24944580749
- S. Chackalamannil, Y. Xia, W.J. Greenlee, M. Clasby, D. Doller, H. Tsai, T. Asberom, M. Czarniecki, H.-S. Ahn, G. Boykow, C. Foster, J. Agans-Fantuzzi, M. Bryant, J. Lau, and M. Chintala J. Med. Chem. 48 2005 5884
- (2005) J. Med. Chem. , vol.48 , pp. 5884
- Chackalamannil, S.¹ Xia, Y.² Greenlee, W.J.³ Clasby, M.⁴ Doller, D.⁵ Tsai, H.⁶ Asberom, T.⁷ Czarniecki, M.⁸ Ahn, H.-S.⁹ Boykow, G.¹⁰ Foster, C.¹¹ Agans-Fantuzzi, J.¹² Bryant, M.¹³ Lau, J.¹⁴ Chintala, M.¹⁵

18
- 33846260165
- M.C. Clasby, S. Chackalamannil, M. Czarniecki, D. Doller, K. Eagen, W. Greenlee, G. Kao, Y. Lin, H. Tsai, Y. Xia, H.-S. Ahn, J. Agans-Fantuzzi, G. Boykow, M. Chintala, C. Foster, A. Smith-Torhan, K. Alton, M. Bryant, Y. Hsieh, J. Lau, and J. Palamanda J. Med. Chem. 50 2007 129
- (2007) J. Med. Chem. , vol.50 , pp. 129
- Clasby, M.C.¹ Chackalamannil, S.² Czarniecki, M.³ Doller, D.⁴ Eagen, K.⁵ Greenlee, W.⁶ Kao, G.⁷ Lin, Y.⁸ Tsai, H.⁹ Xia, Y.¹⁰ Ahn, H.-S.¹¹ Agans-Fantuzzi, J.¹² Boykow, G.¹³ Chintala, M.¹⁴ Foster, C.¹⁵ Smith-Torhan, A.¹⁶ Alton, K.¹⁷ Bryant, M.¹⁸ Hsieh, Y.¹⁹ Lau, J.²⁰ Palamanda, J.²¹ more..

19
- 35348867494
- M.V. Chelliah, S. Chackalamannil, Y. Xia, K. Eagen, M.C. Clasby, X. Gao, W.J. Greenlee, H.-S. Ahn, J. Agans-Fantuzzi, G. Boykow, Y. Hsieh, M. Bryant, J. Palamanda, T.-M. Chan, D. Hesk, and M. Chintala J. Med. Chem. 50 2007 5147
- (2007) J. Med. Chem. , vol.50 , pp. 5147
- Chelliah, M.V.¹ Chackalamannil, S.² Xia, Y.³ Eagen, K.⁴ Clasby, M.C.⁵ Gao, X.⁶ Greenlee, W.J.⁷ Ahn, H.-S.⁸ Agans-Fantuzzi, J.⁹ Boykow, G.¹⁰ Hsieh, Y.¹¹ Bryant, M.¹² Palamanda, J.¹³ Chan, T.-M.¹⁴ Hesk, D.¹⁵ Chintala, M.¹⁶

20
- 34250185768
- M.C. Clasby, S. Chackalamannil, M. Czarniecki, D. Doller, K. Eagen, W.J. Greenlee, Y. Lin, J.R. Tagat, H. Tsai, Y. Xia, H. Ahn, J. Agans-Fantuzzi, G. Boykow, M. Chintala, Y. Hsieh, and A.T. McPhail Bioorg. Med. Chem. Lett. 17 2007 3647
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 3647
- Clasby, M.C.¹ Chackalamannil, S.² Czarniecki, M.³ Doller, D.⁴ Eagen, K.⁵ Greenlee, W.J.⁶ Lin, Y.⁷ Tagat, J.R.⁸ Tsai, H.⁹ Xia, Y.¹⁰ Ahn, H.¹¹ Agans-Fantuzzi, J.¹² Boykow, G.¹³ Chintala, M.¹⁴ Hsieh, Y.¹⁵ McPhail, A.T.¹⁶

21
- 0031017203
- H.-S. Ahn, C. Foster, G. Boykow, L. Arik, A. Smith-Torhan, D. Hesk, and M. Chatterjee Mol. Pharm. 51 1997 350
- (1997) Mol. Pharm. , vol.51 , pp. 350
- Ahn, H.-S.¹ Foster, C.² Boykow, G.³ Arik, L.⁴ Smith-Torhan, A.⁵ Hesk, D.⁶ Chatterjee, M.⁷

22
- 0037533957
- Han-Cheng Zhang, Kimberly B. White, David F. McComsey, Michael F. Addo, Patricia Andrade-Gordon, Claudia K. Derian, Donna Oksenberg, and Bruce E. Maryanoff Bioorg. Med. Chem. Lett. 13 2003 2199
- (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 2199
- Zhang, H.-C.¹ White, K.B.² McComsey, D.F.³ Addo, M.F.⁴ Andrade-Gordon, P.⁵ Derian, C.K.⁶ Oksenberg, D.⁷ Maryanoff, B.E.⁸

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.