Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2

Blood

Volumn 119, Issue 11, 2012, Pages 2510-2522

  Ting, Stephen B ^a,b,g   Deneault, Eric ^a   Hope, Kristin ^a,h   Cellot, Sonia ^a,c   Chagraoui, Jalila ^a   Mayotte, Nadine ^a   Dorn, Jonas F ^a   Laverdure, Jean Philippe ^a   Harvey, Michael ^b   Hawkins, Edwin D ^b   Russell, Sarah M ^b,d   Maddox, Paul S ^a   Iscove, Norman N ^e   Sauvageau, Guy ^a,f  

^a INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

^c UNIVERSITY OF MONTREAL   (Canada)

^d SWINBURNE UNIVERSITY OF TECHNOLOGY   (Australia)

^e UNIVERSITY OF TORONTO   (Canada)

^f MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^g MONASH UNIVERSITY   (Australia)

^h MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PROTEIN AP2A2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AP2A2 GENE; ARTICLE; ASYMMETRIC CELL DIVISION; CANCER STEM CELL; CCNB1 GENE; CELL EXPANSION; CELL FUNCTION; CELL POLARITY; EMBRYO; GENE; GENE EXPRESSION; GPSM2 GENE; HEMATOPOIETIC STEM CELL; KIF3A GENE; LEUKEMIA STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RACGAP1 GENE; STEM CELL; TMOD1 GENE;

EID: 84858696013     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-11-393272     Document Type: Article

References (49)

1. Jan YN, Jan LY. Asymmetric cell division. Nature. 1998;392(6678):775-778. (Pubitemid 28225310)
2. Betschinger J, Knoblich JA. Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. Curr Biol. 2004;14(16):R674-R685. (Pubitemid 39123738)
3. Knoblich JA. Mechanisms of asymmetric stem cell division. Cell. 2008;132(4):583-597. (Pubitemid 351253698)
4. Zhou Y, Atkins JB, Rompani SB, et al. The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis. Cell. 2007;129(1):163-178. (Pubitemid 46507585)
5. Coumailleau F, Furthauer M, Knoblich JA, Gonzalez-Gaitan M. Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division. Nature. 2009;458(7241):1051-1055.
6. Chia W, Somers WG, Wang H. Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesis. J Cell Biol. 2008;180(2):267-272. (Pubitemid 351185913)
7. Zhong W. Timing cell-fate determination during asymmetric cell divisions. Curr Opin Neurobiol. 2008;18(5):472-478.
8. Bowman SK, Neumuller RA, Novatchkova M, Du Q, Knoblich JA. The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division. Dev Cell. 2006;10(6):731-742. (Pubitemid 43779107)
9. Izumi Y, Ohta N, Hisata K, Raabe T, Matsuzaki F. Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization. Nat Cell Biol. 2006;8(6):586-593. (Pubitemid 43827351)
10. Siller KH, Cabernard C, Doe CQ. The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts. Nat Cell Biol. 2006;8(6):594-600. (Pubitemid 43827352)
11. Suda J, Suda T, Ogawa M. Analysis of differentiation of mouse hemopoietic stem cells in culture by sequential replating of paired progenitors. Blood. 1984;64(2):393-399. (Pubitemid 14051325)
12. Giebel B, Zhang T, Beckmann J, et al. Primitive human hematopoietic cells give rise to differentially specified daughter cells upon their initial cell division. Blood. 2006;107(5):2146-2152. (Pubitemid 43289400)
13. Benveniste P, Cantin C, Hyam D, Iscove NN. Hematopoietic stem cells engraft in mice with absolute efficiency. Nat Immunol. 2003;4(7):708-713. (Pubitemid 36874449)
14. Ema H, Sudo K, Seita J, et al. Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. Dev Cell. 2005;8(6):907-914. (Pubitemid 40754061)
15. Dykstra B, Kent D, Bowie M, et al. Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell. 2007;1(2):218-229. (Pubitemid 47215588)
16. Beckmann J, Scheitza S, Wernet P, Fischer JC, Giebel B. Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteins. Blood. 2007;109(12):5494-5501. (Pubitemid 46890575)
17. Chang JT, Palanivel VR, Kinjyo I, et al. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science. 2007; 315(5819):1687-1691. (Pubitemid 46515618)
18. Wu M, Kwon HY, Rattis F, et al. Imaging hematopoietic precursor division in real time. Cell Stem Cell. 2007;1(5):541-554. (Pubitemid 350056405)
19. Dykstra B, Ramunas J, Kent D, et al. High-resolution video monitoring of hematopoietic stem cells cultured in single-cell arrays identifies new features of self-renewal. Proc Natl Acad Sci U SA. 2006;103(21):8185-8190. (Pubitemid 43801073)
20. Deneault E, Cellot S, Faubert A, et al. A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell. 2009;137(2):369-379.
21. Faubert A, Lessard J, Sauvageau G. Are genetic determinants of asymmetric stem cell division active in hematopoietic stem cells? Oncogene. 2004;23(43):7247-7255. (Pubitemid 39382158)
22. Sauvageau G, Thorsteinsdottir U, Eaves CJ, et al. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev. 1995;9(14):1753-1765.
23. Ohta H, Sekulovic S, Bakovic S, et al. Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions. Exp Hematol. 2007;35(5):817-830. (Pubitemid 46601757)
24. Antonchuk J, Sauvageau G, Humphries RK. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell. 2002;109(1):39-45. (Pubitemid 34327515)
25. Cellot S, Krosl J, Chagraoui J, Meloche S, Humphries RK, Sauvageau G. Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells. Exp Hematol. 2007;35(5):802-816.
26. Wilson A, Laurenti E, Oser G, et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell. 2008;135(6):1118-1129.
27. Foudi A, Hochedlinger K, Van Buren D, et al. Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol. 2009;27(1):84-90.
28. Benveniste P, Frelin C, Janmohamed S, et al. Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential. Cell Stem Cell. 2010;6(1):48-58.
29. Boehm M, Bonifacino JS. Adaptins: the final recount. Mol Biol Cell. 2001;12(10):2907-2920. (Pubitemid 33062950)
30. Rappoport JZ. Focusing on clathrin-mediated endocytosis. Biochem J. 2008;412(3):415-423. (Pubitemid 351846407)
31. Santolini E, Puri C, Salcini AE, et al. Numb is an endocytic protein. J Cell Biol. 2000;151(6):1345-1352.
32. Berdnik D, Torok T, Gonzalez-Gaitan M, Knoblich JA. The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev Cell. 2002;3(2):221-231.
33. Hawkins ED, Russell SM. Upsides and downsides to polarity and asymmetric cell division in leukemia. Oncogene. 2008;27(55):7003-7017.
34. Cicalese A, Bonizzi G, Pasi CE, et al. The Tumor Suppressor p53 Regulates Polarity of Self- Renewing Divisions in Mammary Stem Cells. Cell. 2009;138(6):1083-1095.
35. Hope KJ, Cellot S, Ting SB, et al. An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity. Cell Stem Cell. 2010;7(1):101-113.
36. Ueno H, Sakita-Ishikawa M, Morikawa Y, Nakano T, Kitamura T, Saito M. A stromal cell-derived membrane protein that supports hematopoietic stem cells. Nat Immunol. 2003;4(5):457-463. (Pubitemid 36592438)
37. McKenzie JL, Gan OI, Doedens M, Wang JC, Dick JE. Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment. Nat Immunol. 2006;7(11):1225-1233. (Pubitemid 44594319)
38. Hitchcock IS, Chen MM, King JR, Kaushansky K. YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation. Blood. 2008;112(6): 2222-2231.
39. Qian H, Buza-Vidas N, Hyland CD, et al. Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell. 2007;1(6):671-684. (Pubitemid 350215331)
40. Yoshihara H, Arai F, Hosokawa K, et al. Thrombopoietin/ MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell. 2007;1(6):685-697. (Pubitemid 350215333)
41. Sorkin A, von Zastrow M. Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol. 2009;10(9):609-622.
42. Gould GW, Lippincott-Schwartz J. New roles for endosomes: from vesicular carriers to multipurpose platforms. Nat Rev Mol Cell Biol. 2009; 10(4):287-292.
43. Lee YS, Pressman S, Andress AP, et al. Silencing by small RNAs is linked to endosomal trafficking. Nat Cell Biol. 2009;11(9):1150-1156.
44. Wilson A, Ardiet DL, Saner C, et al. Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike. J Immunol. 2007;178(11):6746- 6751. (Pubitemid 46847398)
45. Mancini SJ, Mantei N, Dumortier A, Suter U, MacDonald HR, Radtke F. Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood. 2005;105(6):2340-2342. (Pubitemid 40387028)
46. Maillard I, Koch U, Dumortier A, et al. Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell. 2008;2(4):356-366. (Pubitemid 351455243)
47. Sengupta ADA, Ishikawa E, Florian MC, et al. Atypical protein kinase C (aPKCzeta and aPKCdelta) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proc Natl Acad Sci USA. 2011;108(24):9957-9962.
48. Lanzetti L, Di Fiore PP. Endocytosis and cancer: an 'insider' network with dangerous liaisons. Traffic. 2008;9(12):2011-2021.
49. Coumailleau F, Gonzalez-Gaitan M. From endocytosis to tumors through asymmetric cell division of stem cells. Curr Opin Cell Biol. 2008;20(4):462-469.