Formulation and evaluations of ezetimibe nanoparticles prepared by controlled nanoprecipitation and transformation into solid dosage form

Acta Pharmaceutica Sciencia

Volumn 53, Issue 3, 2011, Pages 477-488

  Pandya, Vikram ^a   Patel, Jayvadan ^b  

^a BS Patel Pharmacy College   (India)

^b Nootan Pharmacy College   (India)

Author keywords

Controlled nanoprecipitation; Ezetimibe; Nanoparticles; Surfactant

Indexed keywords

ALCOHOL; EZETIMIBE; NANOPARTICLE; SOLVENT; WATER;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED NANOPRECIPITATION; DRUG DOSAGE FORM; DRUG FORMULATION; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRECIPITATION; SCANNING ELECTRON MICROSCOPY; SOLID DOSAGE FORM; TABLET; X RAY DIFFRACTION;

EID: 84858643014     PISSN: 13072080     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Kakran, M., Sahooa, N.G., Lia, L., Judeh, Z., Wang, Y., Chong, K., Loh, L. (2010). Fabrication of drug nanoparticles by evaporative precipitation of nanosuspension. Int. J. Pharm. 383: 285-292.
2. Kayser, O., Olbrich, C., Yardley, V., Kinderlen, A.F., Croft, S.L. (2003). Formulation of amphotericin B as nanosuspension for oral administration. Int. J. Pharm. 254: 73-75.
3. Keck, C.M., Muller, R.H. (2006). Drug nanocrystals of poorly soluble drugs produced by high pressure homogenization. Eur. J. Pharm. Biopharm. 62: 3-16.
4. Kesisoglou, F., Panmai, S., Wu, Y. (2007). Nanosizing-oral formulation development and biopharmaceutical evaluation. Adv. Drug Deliv. Rev. 59: 631-644.
5. Kocbek, P., Baumgartner, S., Kristl, J. (2006). Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs. Int. J. Pharm. 312: 179-186.
6. Lai, F., Sinico, C., Ennas, G., Marongiu, F., Marongiu, G., Fadda, A.M. (2009). Diclofenac nanosuspensions: Influence of preparation procedure and crystal form on drug dissolution behavior. Int. J. Pharm. 373: 124-130.
7. Lee, J. (2003). Drug nano and microparticles processed into solid dosage forms: physical properties. J. Pharm. Sci. 92 (10): 2057-2068.
8. Liversidge, G.G., Conzentino, P. (1995). Drug particle size reduction for decreasing gastric irritancy and enhancing absorption of naproxen in rats. Int. J. Pharm. 125: 309-313.
9. Patel, D.J., Patel, J.K., Pandya, V.M., Patel, R.D. (2010). Effect of formulation variables on nanosuspension containing famotidine prepared by solvent evaporation technique. Int. J. Pharm. Sci. Nano. 4(2): 707-713.
10. Patel, R., Bhimani, D., Patel, J., Patel, D. (2008). Solid-state characterization and dissolution properties of ezetimibe-cyclodextrins inclusion complexes J. Incl. Phenom. Macro. 60: 241-251.
11. Rabinow, B.E. (2004). Nanosuspensions in drug delivery, Nature Review, 3: 785-796.
12. Seedher, N., Bhatia, S. (2003). Solubility enhancement of Cox-2 inhibitors using various solvent systems. AAPS Pharm. Sci. Tech. 4(3): 1-8.
13. Serajuddin, A.T.M. (1999). Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. J. Pharm. Sci. 88(10): 1058-1066.
14. Sharma, P., Denny, W.A., Garg, S. (2009). Effect of wet milling process on the solid state of indomethacin and simvastatin. Int. J. Pharm. 380: 40-48.
15. Trotta, M., Gallarete, M., Pattarino, F., Morel, S. (2001). Emulsions containing partially watermiscible solvents for the preparation of drug nanosuspensions. J. Control. Release, 76: 119-128.
16. Verma, S., Gokhale, R., Burgessa, D.J. (2009). A comparative study of top-down and bottom-up approaches for the preparation of micro/nanosuspensions. Int. J. Pharm. 380: 216-222.