Apoptosis of human melanoma cells by a combination of lonidamine and radiation

Journal of Radiation Research

Volumn 45, Issue 2, 2004, Pages 189-194

  Miyato, Yasuyuki ^a,b   Ando, Koichi ^a,b  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Bad.; Bcl 2; C32TG cells; Caspase; Combination treatment; Human melanoma; Lonidamine; Mitochondria targeting; Radiation

Indexed keywords

CELL DEATH; DERMATOLOGY; DISEASES; MITOCHONDRIA; RADIOTHERAPY;

BAD; BCL-2; C32TG CELL; CASPASES; COMBINATION TREATMENTS; HUMAN MELANOMA; MALIGNANT MELANOMA; MELANOMA CELLS; MITOCHONDRIA-TARGETING; MITOCHONDRIAS;

ONCOLOGY;

CASPASE 3; CASPASE INHIBITOR; LONIDAMINE; PROTEIN BAD; PROTEIN BCL 2;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REPRESSION; GAMMA IRRADIATION; HUMAN; HUMAN CELL; MELANOMA CELL; PROTEIN PHOSPHORYLATION; RADIATION RESPONSE; RADIOSENSITIVITY; X IRRADIATION;

EID: 4544253492     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.45.189     Document Type: Article

References (25)

1. Soengas, M. S. and Lowe, S. W. (2003) Apoptosis and melanoma chemoresistance. Oncogene 22: 3138-3151.
2. Cooper, J. S. (2002) Radiation therapy of malignant melanoma. Dermatol. Clin. 20: 713-716.
3. Fadeel, B., Orrenius, S. and Zhivotovsky, B. (1999) Apoptosis in human disease: a new skin for the old ceremony? Biochem. Biophys. Res. Commun. 266: 699-717.
4. Strasberg, Rieber, M., Zangemeister-Wittke, U. and Rieber, M. (2001) p53-Independent induction of apoptosis in human melanoma cells by a bcl-2/bcl-xL bispecific antisense oligonucleotide. Clin. Cancer Res. 7: 1446-1451.
5. Kim, J. S., He, L. and Lemasters, J. J. (2003) Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem. Biophys. Res. Commun. 304: 463-470.
6. Ferri, K. F. and Kroemer, G. (2001) Organelle-specific initiation of cell death pathways. Nat. Cell Biol. 3: 255-263.
7. Hayakawa, J., Ohmichi, M., Kurachi, H., Kanda, Y., Hisamoto, K., Nishio, Y., Adachi, K., Tasaka, K., Kanzaki, T. and Murata, Y. (2000) Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin. Cancer Res. 60: 5988-5994.
8. Debatin, K. M., Poncet, D. and Kroemer, G. (2002) Chemotherapy: targeting the mitochondrial cell death pathway. Oncogene 21: 8786-8803.
9. Costantini, P., Jacotot, E., Decaudin, D. and Kroemer, G. (2000) Mitochondrion as a novel target of anticancer chemotherapy. J. Natl. Cancer Inst. 92: 1042-1053.
10. Ravagnan, L., Marzo, I., Costantini, P., Susin, S. A., Zamzami, N., Petit, P. X., Hirsch, F., Goulbern, M., Poupon, M. F., Miccoli, L., Xie, Z., Reed, J. C. and Kroemer, G. (1999) Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore. Oncogene 18: 2537-2546.
11. De, Cesare, M., Pratesi, G., Giusti, A., Polizzi, D. and Zunino, F. (1998) Stimulation of the apoptotic response as a basis for the therapeutic synergism of lonidamine and cisplatin in combination in human tumour xenografts. Br. J. Cancer 77: 434-439.
12. Orlandi, L., Zaffaroni, N., Bearzatto, A., Villa, R., De, Marco, C. and Silvestrini, R. (1998) Lonidamine as a modulator of taxol activity in human ovarian cancer cells: effects on cell cycle and induction of apoptosis. Int. J. Cancer 78: 377-384.
13. Gatzemeier, U., Cavalli, F., Haussinger, K., Kaukel, E., Koschel, G., Martinelli, G., Neuhauss, R. and von, Pawel, J. (1991) Phase III trial with and without lonidamine in non-small cell lung cancer. Semin. Oncol. 18: 42-48.
14. Choi, K. H., Hama-Inaba, H., Wang, B., Haginoya, K., Odaka, T., Yamada, T., Hayata, I. and Ohyama, H. (2000) UVC-induced apoptosis in human epithelial tumor A431 cells: sequence of apoptotic changes and involvement of caspase (-8 and -3) cascade. J. Radiat. Res. (Tokyo) 41: 243-258.
15. Shimizu, S., Eguchi, Y., Kamiike, W., Waguri, S., Uchiyama, Y., Matsuda, H. and Tsujimoto, Y. (1996) Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors. Oncogene. 13: 21-29.
16. Miyato, Y., Ibuki, Y., Ohyama, H., Yamada, T. and Goto, R. (2001) Phosphatidylserine induces apoptosis in CHO cells without mitochondrial dysfunction in a manner dependent on caspases other than caspases-1, - 3, -8 and -9. FEBS Lett. 504: 73-77.
17. Matsuura, H., Nishitoh, H., Takeda, K., Matsuzawa, A., Amagasa, T., Ito, M., Yoshioka, K. and Ichijo, H. (2002) Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. J. Biol. Chem. 277: 40703-40709.
18. Verheij, M. and Bartelink, H. (2000) Radiation-induced apoptosis. Cell Tissue Res. 301: 133-142.
19. Fei, P. and El-Deiry, W. S. (2003) p53 and radiation responses. Oncogene 22: 5774-5783.
20. Soengas, M. S., Capodieci, P., Polsky, D., Mora, J., Esteller, M., Opitz-Araya, X., McCombie, R., Herman, J. G., Gerald, W. L., Lazebnik, Y. A., Cordon-Cardo, C. and Lowe, S. W. (2001) Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 409: 207-211.
21. Del, Bello, B., Valentini, M. A., Zunino, F., Comporti, M. and Maellaro, E. (2001) Cleavage of Bcl-2 in oxidant- and cisplatin-induced apoptosis of human melanoma cells. Oncogene 20: 4591-4595.
22. Lu, Y. and Yagi, T. (1999) Apoptosis of human tumor cells by chemotherapeutic anthracyclines is enhanced by Bax overexpression. J. Radiat. Res. (Tokyo) 40: 263-272.
23. Scorrano, L. and Korsmeyer, S. J. (2003) Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun. 304: 437-444.
24. Degli, Esposti, M. and Dive, C. (2003) Mitochondrial membrane permeabilisation by Bax/Bak. Biochem. Biophys. Res. Commun. 304: 455-461.
25. Oudard, S., Poirson, F., Miccoli, L., Bourgeois, Y., Vassault, A., Poisson, M., Magdelenat, H., Dutrillaux, B. and Poupon, M. F. (1995) Mitochondria-bound hexokinase as target for therapy of malignant gliomas. Int. J. Cancer 62: 216-222.