Chemical mechanism of UDP-galactopyranose mutase from trypanosoma cruzi: A potential drug target against chagas' disease

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Oppenheimer, Michelle ^a   Valenciano, Ana Lisa ^a,b   Kizjakina, Karina ^a   Qi, Jun ^a   Sobrado, Pablo ^a,b,c  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b INSTITUTO TECNOLÓGICO DE COSTA RICA   (Costa Rica)

^c Fralin Life Science Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE DERIVATIVE; FLAVIN IMINIUM ION; FLAVOPROTEIN; ION; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SEMIQUINONE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GALACTOPYRANOSE; URIDINE DIPHOSPHATE GALACTOPYRANOSE MUTASE; DRUG DERIVATIVE; GALACTOSE; MUTASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBOFLAVIN DERIVATIVE; UDP GALACTOPYRANOSE MUTASE; UDP-GALACTOPYRANOSE MUTASE; URIDINE DIPHOSPHATE; URIDINE DIPHOSPHATE GALACTOFURANOSE;

ANISOTROPY; ARTICLE; CHAGAS DISEASE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG TARGETING; EMISSION ANISOTROPY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME SUBSTRATE COMPLEX; MOLECULAR CLONING; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; STEADY STATE; TRYPANOSOMA CRUZI; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; HUMAN; KINETICS; METABOLISM; PROTEIN CONFORMATION;

TRYPANOSOMA CRUZI;

CHAGAS DISEASE; FLAVINS; GALACTOSE; HUMANS; INTRAMOLECULAR TRANSFERASES; KINETICS; MOLECULAR STRUCTURE; NADP; OXIDATION-REDUCTION; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; TRYPANOSOMA CRUZI; URIDINE DIPHOSPHATE;

EID: 84858635325     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032918     Document Type: Article

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