Development of a novel LC-MS/MS method for the determination of letosteine in human plasma and its application on pharmacokinetic studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 25, 2011, Pages 2554-2560

  Liu, Xinxia ^a   Zheng, Heng ^a   Tang, Wei ^a   Qian, Zhenyu ^a   Zhu, Yinsong ^a   Wang, Jing ^a   Yuan, Shiying ^a   Wen, Xin ^a   Cao, Cuiling ^a   Chen, Hui ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Human plasma; Letosteine; Liquid chromatography tandem mass spectrometry; Pharmacokinetics

Indexed keywords

ANALYSIS TIME; CLINICAL PRACTICES; CLINICAL STUDY; CONCENTRATION RANGES; EXTRACTION RECOVERY; HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS/MS; LETOSTEINE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MULTIPLE-DOSE; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; PREPARATION PROCEDURES; PROTEIN PRECIPITATION; REVERSED PHASE; SAFETY RISKS; SENSITIVE METHOD; TANDEM MASS SPECTROMETRY;

COLUMN CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN);

PLASMAS;

LETOSTEINE; TINIDAZOLE;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHINESE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN EXPERIMENT; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRECIPITATION; PRIORITY JOURNAL; RADIOACTIVITY; SENSITIVITY ANALYSIS; SINGLE DRUG DOSE; STANDARD; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANALYSIS OF VARIANCE; CHROMATOGRAPHY, REVERSE-PHASE; DRUG STABILITY; FEMALE; HUMANS; LEAST-SQUARES ANALYSIS; MALE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; THIAZOLIDINES;

EID: 81155162489     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.07.011     Document Type: Article

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