Prenatal exposure to di-n-butyl phthalate induces anorectal malformations in male rat offspring

Toxicology

Volumn 290, Issue 2-3, 2011, Pages 322-326

  Jiang, Jun Tao ^a   Sun, Wen Lan ^a   Jing, Yi Feng ^a   Liu, Shi Bo ^a   Ma, Zheng ^b   Hong, Yan ^a   Ma, Long ^c   Qin, Chao ^d   Liu, Qiang ^e   Stratton, Harrison J ^f   Xia, Shu Jie ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b NANTONG UNIVERSITY   (China)

^c AFFILIATED HOSPITAL OF NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^d THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^e BARROW NEUROLOGICAL INSTITUTE   (United States)

^f ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Anorectal malformations; Di n butyl phthalate; Secondary megacolon; Terminal rectum; Testosterone

Indexed keywords

PHTHALIC ACID DIBUTYL ESTER; SONIC HEDGEHOG PROTEIN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANORECTAL MALFORMATION; ANTHROPOMETRY; ARTICLE; BODY WEIGHT DISORDER; BRAIN MALFORMATION; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DYSPLASIA; EPIDIDYMIS DISEASE; FEMALE; HISTOPATHOLOGY; LIVER DISEASE; MALE; MEGACOLON; NONHUMAN; ONCOGENITAL DISTANCE; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; RAT; SHORTENED BODY LENGTH; SPLEEN DISEASE; TESTIS DISEASE; TESTOSTERONE BLOOD LEVEL; UROGENITAL TRACT DISEASE; WEIGHT REDUCTION;

ERINACEIDAE; RATTUS;

EID: 84858614712     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2011.10.008     Document Type: Article

References (32)

1. Andersen A. Amended final report of the safety assessment of dibutyl adipate as used in cosmetics. Int. J. Toxicol. 2006, 25(Suppl. 1):129-134.
2. Baskin L.S., Himes K., Colborn T. Hypospadias and endocrine disruption: is there a connection. Environ. Health Perspect. 2001, 109(11):1175-1183.
3. Barlow N.J., Phillips S.L., Wallace D.G., et al. Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate. Toxicol. Sci. 2003, 73:431-441.
4. Ema M., Miyawaki E. Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy. Reprod. Toxicol. 2001, 15(2):189-194.
5. Falcone R.A., Levitt M.A., Pena A., et al. Increased heritability of certain types of anorectal malformations. J. Pediatr. Surg. 2007, 42(1):124-127. (discussion 127-128).
6. Fisher J.S., Macpherson S., Marchetti N., et al. Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate. Hum. Reprod. 2003, 18(7):1383-1394.
7. Foster P.M. Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int. J. Androl. 2006, 29(1):140-147. (discussion 181-185).
8. Grano C., Aminoff D., Lucidi F., et al. Disease-specific quality of life in children and adults with anorectal malformations. Pediatr. Surg. Int. 2010, 26(2):151-155.
9. Hartman E.E., Oort F.J., Aronson D.C., et al. Quality of life and disease-specific functioning of patients with anorectal malformations or Hirschsprung's disease: a review. Arch. Dis. Child. 2011, 96(4):398-406.
10. Hsieh M.H., Breyer B.N., Eisenberg M.L., et al. Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruption. Curr. Urol. Rep. 2008, 9(2):137-142.
11. Jiang J.T., Ma L., Yuan L., Wang X., et al. Study on developmental abnormalities in hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP). Toxicology 2007, 232(3):286-293.
12. Kalfa N., Philibert P., Sultan C. Is hypospadias a genetic, endocrine or environmental disease, or still an unexplained malformation. Int. J. Androl. 2009, 32(3):187-197.
13. Kavlock R., Boekelheide K., Chapin R., et al. NTP center for the evaluation of risks to human reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate. Reprod. Toxicol. 2002, 16(5):489-527.
14. Kim H.S., Kim T.S., Shin J.H., et al. Neonatal exposure to di(n-butyl) phthalate (DBP) alters male reproductive-tract development. J. Toxicol. Environ. Health A 2004, 67(23-24):2045-2060.
15. Le B.A.G., Carpentier E., Boscq M., et al. Imaging of anorectal malformations in the neonatal period. J. Radiol. 2010, 91(4):475-483.
16. Levitt M.A., Pena A. Anorectal malformations. Orphanet J. Rare Dis. 2007, 2:33.
17. Macedo M., Martins J.L., Freitas F.L.G. Sacral ratio and fecal continence in children with anorectal malformations. BJU Int. 2004, 94(6):893-894.
18. Mandhan P., Quan Q.B., Beasley S., et al. Sonic hedgehog, BMP4, and Hox genes in the development of anorectal malformations in Ethylenethiourea-exposed fetal rats. J. Pediatr. Surg. 2006, 41(12):2041-2045.
19. Mylchreest E., Wallace D.G., Cattley R.C., et al. Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl) phthalate during late gestation. Toxicol. Sci. 2000, 55(1):143-151.
20. Norgil D.I., Main K.M., Toppari J., et al. Impact of exposure to endocrine disrupters in utero and in childhood on adult reproduction. Best Pract. Res. Clin. Endocrinol. Metab. 2002, 16(2):289-309.
21. NTP-CERHR Monograph on the potential human reproductive and developmental effects of di-n-butyl phthalate (DBP). NTP CERHR MON 2003, 4:i-III90.
22. Oettling G., Franz H.B. Mapping of androgen, estrogen and progesterone receptors in the anal continence organ. Eur. J. Obstet. Gynecol. Reprod. Biol. 1998, 77(2):211-216.
23. Pan G., Hanaoka T., Yoshimura M., et al. Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China. Environ. Health Perspect. 2006, 114(11):1643-1648.
24. Patisaul H.B., Adewale H.B. Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior. Front. Behav. Neurosci. 2009, 3:10.
25. Sasaki Y., Iwai N., Tsuda T., et al. Sonic hedgehog and bone morphogenetic protein 4 expressions in the hindgut region of murine embryos with anorectal malformations. J. Pediatr. Surg. 2004, 39(2):170-173. (discussion).
26. Shultz V.D., Phillips S., Sar M., et al. Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate. Toxicol. Sci. 2001, 64:233-242.
27. Silva M.J., Barr D.B., Reidy J.A., et al. Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ. Health Perspect. 2004, 112(3):331-338.
28. Steinhardt G.F. Endocrine disruption and hypospadias. Adv. Exp. Med. Biol. 2004, 545:203-215.
29. Wang M.H., Baskin L.S. Endocrine disruptors, genital development, and hypospadias. J. Androl. 2008, 29(5):499-505.
30. Zhang J., Zhang Z.B., Gao H., et al. Down-regulation of SHH/BMP4 signalling in human anorectal malformations. J. Int. Med. Res. 2009, 37(6):1842-1850.
31. Zhang Y., Jiang X., Chen B. Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL. Reprod. Toxicol. 2004, 18(5):669-676.
32. Zhu Y.J., Jiang J.T., Ma L., et al. Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP). Toxicology 2009, 260(1-3):120-125.