메뉴 건너뛰기




Volumn 34, Issue 6, 2011, Pages

Anti-inflammatory and anti-fibrotic effects of sirolimus on bleomycininduced pulmonary fibrosis in rats

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; BLEOMYCIN; GAMMA INTERFERON; INTERLEUKIN 13; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR A; PLATELET-DERIVED GROWTH FACTOR A; RAPAMYCIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84858594806     PISSN: 0147958X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (33)

References (41)
  • 2
    • 0030893183 scopus 로고    scopus 로고
    • Diffuse lung disease: a view for the future
    • Mar
    • du Bois RM. Diffuse lung disease: a view for the future. Sarcoidosis Vasc Diffuse Lung Dis. 1997 Mar;14(1):23-30.
    • (1997) Sarcoidosis Vasc Diffuse Lung Dis , vol.14 , Issue.1 , pp. 23-30
    • du Bois, R.M.1
  • 3
    • 0032105481 scopus 로고    scopus 로고
    • Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression
    • Sehgal SN. Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression. Clin Biochem. 1998 Jul;31(5):335-40.
    • (1998) Clin Biochem , vol.31 , Issue.5 , pp. 335-40
    • Sehgal, S.N.1
  • 4
    • 0032738763 scopus 로고    scopus 로고
    • Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis
    • Nov
    • Zhu J, Wu J, Frizell E, Liu SL, Bashey R, Rubin R, et al. Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis. Gastroenterology. 1999 Nov;117(5):1198-204.
    • (1999) Gastroenterology , vol.117 , Issue.5 , pp. 1198-204
    • Zhu, J.1    Wu, J.2    Frizell, E.3    Liu, S.L.4    Bashey, R.5    Rubin, R.6
  • 5
    • 21844438523 scopus 로고    scopus 로고
    • Pulmonary fibrosis: searching for model answers
    • Jul
    • Chua F, Gauldie J, Laurent GJ. Pulmonary fibrosis: searching for model answers. Am J Respir Cell Mol Biol. 2005 Jul;33(1):9-13.
    • (2005) Am J Respir Cell Mol Biol , vol.33 , Issue.1 , pp. 9-13
    • Chua, F.1    Gauldie, J.2    Laurent, G.J.3
  • 6
    • 33645290774 scopus 로고    scopus 로고
    • Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model
    • Apr 1
    • Chaudhary NI, Schnapp A, Park JE. Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model. Am J Respir Crit Care Med. 2006 Apr 1;173(7):769-76.
    • (2006) Am J Respir Crit Care Med , vol.173 , Issue.7 , pp. 769-776
    • Chaudhary, N.I.1    Schnapp, A.2    Park, J.E.3
  • 7
    • 2342564524 scopus 로고    scopus 로고
    • IL-10 inhibits inflammation but does not affect fibrosis in the pulmonary response to bleomycin
    • Jun
    • Kradin RL, Sakamoto H, Jain F, Zhao LH, Hymowitz G, Preffer F. IL-10 inhibits inflammation but does not affect fibrosis in the pulmonary response to bleomycin. Exp Mol Pathol. 2004 Jun;76(3):205-11.
    • (2004) Exp Mol Pathol , vol.76 , Issue.3 , pp. 205-211
    • Kradin, R.L.1    Sakamoto, H.2    Jain, F.3    Zhao, L.H.4    Hymowitz, G.5    Preffer, F.6
  • 9
    • 39149103740 scopus 로고    scopus 로고
    • The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
    • Moeller A, Ask K, Warburton D, Gauldie J, Kolb M. The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol. 2008;40(3):362-82.
    • (2008) Int J Biochem Cell Biol , vol.40 , Issue.3 , pp. 362-82
    • Moeller, A.1    Ask, K.2    Warburton, D.3    Gauldie, J.4    Kolb, M.5
  • 10
    • 0034948521 scopus 로고    scopus 로고
    • Bleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis
    • Jun
    • Borzone G, Moreno R, Urrea R, Meneses M, Oyarzun M, Lisboa C. Bleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2001 Jun;163(7):1648-53.
    • (2001) Am J Respir Crit Care Med , vol.163 , Issue.7 , pp. 1648-53
    • Borzone, G.1    Moreno, R.2    Urrea, R.3    Meneses, M.4    Oyarzun, M.5    Lisboa, C.6
  • 11
    • 0036318611 scopus 로고    scopus 로고
    • P-selectin upregulation in bleomycin induced lung injury in rats: effect of N-acetyl-L-cysteine
    • Jul
    • Serrano-Mollar A, Closa D, Cortijo J, Morcillo EJ, Prats N, Gironella M, et al. P-selectin upregulation in bleomycin induced lung injury in rats: effect of N-acetyl-L-cysteine. Thorax. 2002 Jul;57(7):629-34.
    • (2002) Thorax , vol.57 , Issue.7 , pp. 629-634
    • Serrano-Mollar, A.1    Closa, D.2    Cortijo, J.3    Morcillo, E.J.4    Prats, N.5    Gironella, M.6
  • 13
    • 0023914820 scopus 로고
    • Simple method of estimating severity of pulmonary fibrosis on a numerical scale
    • Apr
    • Ashcroft T, Simpson JM, Timbrell V. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol. 1988 Apr;41(4):467-70.
    • (1988) J Clin Pathol , vol.41 , Issue.4 , pp. 467-470
    • Ashcroft, T.1    Simpson, J.M.2    Timbrell, V.3
  • 14
    • 33747756116 scopus 로고    scopus 로고
    • Promising pharmacologic innovations in treating pulmonary fibrosis
    • Jun
    • Bhatt N, Baran CP, Allen J, Magro C, Marsh CB. Promising pharmacologic innovations in treating pulmonary fibrosis. Curr Opin Pharmacol. 2006 Jun;6(3):284-92.
    • (2006) Curr Opin Pharmacol , vol.6 , Issue.3 , pp. 284-292
    • Bhatt, N.1    Baran, C.P.2    Allen, J.3    Magro, C.4    Marsh, C.B.5
  • 15
    • 33746530366 scopus 로고    scopus 로고
    • Efficacy of sirolimus compared with azathioprine for reduction of acute renal allogra? rejection: a randomised multicentre study
    • Jul 15
    • Kahan BD. Efficacy of sirolimus compared with azathioprine for reduction of acute renal allogra? rejection: a randomised multicentre study. The Rapamune US Study Group. Lancet. 2000 Jul 15;356(9225):194-202.
    • (2000) The Rapamune US Study Group. Lancet , vol.356 , Issue.9225 , pp. 194-202
    • Kahan, B.D.1
  • 16
    • 10744231651 scopus 로고    scopus 로고
    • Long-term improvement in renal function with sirolimus a?er early cyclosporine withdrawal in renal transplant recipients: 2-year results of the Rapamune Maintenance Regimen Study
    • Jul 27
    • Oberbauer R, Kreis H, Johnson RW, Mota A, Claesson K, Ruiz JC, et al. Long-term improvement in renal function with sirolimus a?er early cyclosporine withdrawal in renal transplant recipients: 2-year results of the Rapamune Maintenance Regimen Study. Transplantation. 2003 Jul 27;76(2):364-70.
    • (2003) Transplantation , vol.76 , Issue.2 , pp. 364-370
    • Oberbauer, R.1    Kreis, H.2    Johnson, R.W.3    Mota, A.4    Claesson, K.5    Ruiz, J.C.6
  • 17
    • 17144399488 scopus 로고    scopus 로고
    • [Successful treatment of a severe case of idiopathic pulmonary fibrosis with rapamycin]
    • Mar 15
    • Buschhausen L, Kamm M, Arns W, Schulze-Lohoff E, Weber M. [Successful treatment of a severe case of idiopathic pulmonary fibrosis with rapamycin]. Med Klin (Munich). 2005 Mar 15;100(3):161-4.
    • (2005) Med Klin (Munich) , vol.100 , Issue.3 , pp. 161-164
    • Buschhausen, L.1    Kamm, M.2    Arns, W.3    Schulze-Lohoff, E.4    Weber, M.5
  • 19
    • 44449122824 scopus 로고    scopus 로고
    • Standardized quantification of pulmonary fibrosis in histological samples
    • 2008 Apr, 14-7
    • Hubner RH, Gitter W, El Mokhtari NE, Mathiak M, Both M, Bolte H, et al. Standardized quantification of pulmonary fibrosis in histological samples. Biotechniques. 2008 Apr;44(4):507-11, 14-7.
    • Biotechniques , vol.44 , Issue.4 , pp. 507-511
    • Hubner, R.H.1    Gitter, W.2    El Mokhtari, N.E.3    Mathiak, M.4    Both, M.5    Bolte, H.6
  • 20
    • 0028109801 scopus 로고
    • Transforming growth factor beta in tissue fibrosis
    • Nov 10
    • Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med. 1994 Nov 10;331(19):1286-92.
    • (1994) N Engl J Med , vol.331 , Issue.19 , pp. 1286-1292
    • Border, W.A.1    Noble, N.A.2
  • 21
    • 35448988114 scopus 로고    scopus 로고
    • Molecular targets in pulmonary fibrosis: the myofibroblast in focus
    • Oct
    • Scotton CJ, Chambers RC. Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest. 2007 Oct;132(4):1311-21.
    • (2007) Chest , vol.132 , Issue.4 , pp. 1311-1321
    • Scotton, C.J.1    Chambers, R.C.2
  • 23
    • 33646496008 scopus 로고    scopus 로고
    • Inhibition of ALK5 as a new approach to treat liver fibrotic diseases
    • Mar
    • de Gouville AC, Huet S. Inhibition of ALK5 as a new approach to treat liver fibrotic diseases. Drug News Perspect. 2006 Mar;19(2):85-90.
    • (2006) Drug News Perspect , vol.19 , Issue.2 , pp. 85-90
    • de Gouville, A.C.1    Huet, S.2
  • 24
    • 2942682928 scopus 로고    scopus 로고
    • Regulation of PDGF and its receptors in fibrotic diseases
    • Aug
    • Bonner JC. Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth Factor Rev. 2004 Aug;15(4):255-73.
    • (2004) Cytokine Growth Factor Rev , vol.15 , Issue.4 , pp. 255-273
    • Bonner, J.C.1
  • 25
    • 20244364391 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis
    • Mar 21
    • Abdollahi A, Li M, Ping G, Plathow C, Domhan S, Kiessling F, et al. Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis. J Exp Med. 2005 Mar 21;201(6):925-35.
    • (2005) J Exp Med , vol.201 , Issue.6 , pp. 925-935
    • Abdollahi, A.1    Li, M.2    Ping, G.3    Plathow, C.4    Domhan, S.5    Kiessling, F.6
  • 27
    • 1642333177 scopus 로고    scopus 로고
    • Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts
    • Apr 1
    • Kolodsick JE, Toews GB, Jakubzick C, Hogaboam C, Moore TA, McKenzie A, et al. Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts. J Immunol. 2004 Apr 1;172(7):4068-76.
    • (2004) J Immunol , vol.172 , Issue.7 , pp. 4068-4076
    • Kolodsick, J.E.1    Toews, G.B.2    Jakubzick, C.3    Hogaboam, C.4    Moore, T.A.5    McKenzie, A.6
  • 28
    • 30044449492 scopus 로고    scopus 로고
    • IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis
    • Jan
    • Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med. 2006 Jan;12(1):99-106.
    • (2006) Nat Med , vol.12 , Issue.1 , pp. 99-106
    • Fichtner-Feigl, S.1    Strober, W.2    Kawakami, K.3    Puri, R.K.4    Kitani, A.5
  • 29
    • 0041427695 scopus 로고    scopus 로고
    • Therapeutic attenuation of pulmonary fibrosis via targeting of IL-4- and IL-13-responsive cells
    • Sep 1
    • Jakubzick C, Choi ES, Joshi BH, Keane MP, Kunkel SL, Puri RK, et al. Therapeutic attenuation of pulmonary fibrosis via targeting of IL-4- and IL-13-responsive cells. J Immunol. 2003 Sep 1;171(5):2684-93.
    • (2003) J Immunol , vol.171 , Issue.5 , pp. 2684-2693
    • Jakubzick, C.1    Choi, E.S.2    Joshi, B.H.3    Keane, M.P.4    Kunkel, S.L.5    Puri, R.K.6
  • 30
    • 0033592753 scopus 로고    scopus 로고
    • A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis
    • Oct 21
    • Ziesche R, Hofbauer E, Wittmann K, Petkov V, Block LH. A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis. N Engl J Med. 1999 Oct 21;341(17):1264-9.
    • (1999) N Engl J Med , vol.341 , Issue.17 , pp. 1264-1269
    • Ziesche, R.1    Hofbauer, E.2    Wittmann, K.3    Petkov, V.4    Block, L.H.5
  • 33
    • 20144381640 scopus 로고    scopus 로고
    • Physiology is a stronger predictor of survival than pathology in fibrotic interstitial pneumonia
    • Mar 15
    • Jegal Y, Kim DS, Shim TS, Lim CM, Do Lee S, Koh Y, et al. Physiology is a stronger predictor of survival than pathology in fibrotic interstitial pneumonia. Am J Respir Crit Care Med. 2005 Mar 15;171(6):639-44.
    • (2005) Am J Respir Crit Care Med , vol.171 , Issue.6 , pp. 639-644
    • Jegal, Y.1    Kim, D.S.2    Shim, T.S.3    Lim, C.M.4    Do Lee, S.5    Koh, Y.6
  • 34
    • 10744229010 scopus 로고    scopus 로고
    • Prognostic value of desaturation during a 6-minute walk test in idiopathic interstitial pneumonia
    • Nov 1
    • Lama VN, Flaherty KR, Toews GB, Colby TV, Travis WD, Long Q, et al. Prognostic value of desaturation during a 6-minute walk test in idiopathic interstitial pneumonia. Am J Respir Crit Care Med. 2003 Nov 1;168(9):1084-90.
    • (2003) Am J Respir Crit Care Med , vol.168 , Issue.9 , pp. 1084-1090
    • Lama, V.N.1    Flaherty, K.R.2    Toews, G.B.3    Colby, T.V.4    Travis, W.D.5    Long, Q.6
  • 35
  • 37
    • 4043055316 scopus 로고    scopus 로고
    • Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
    • Aug
    • Phillips RJ, Burdick MD, Hong K, Lutz MA, Murray LA, Xue YY, et al. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest. 2004 Aug;114(3):438-46.
    • (2004) J Clin Invest , vol.114 , Issue.3 , pp. 438-446
    • Phillips, R.J.1    Burdick, M.D.2    Hong, K.3    Lutz, M.A.4    Murray, L.A.5    Xue, Y.Y.6
  • 38
    • 67349261972 scopus 로고    scopus 로고
    • Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis
    • Aug-Sep
    • Mehrad B, Burdick MD, Strieter RM. Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis. Int J Biochem Cell Biol. 2009 Aug-Sep;41(8-9):1708-18.
    • (2009) Int J Biochem Cell Biol , vol.41 , Issue.8-9 , pp. 1708-1718
    • Mehrad, B.1    Burdick, M.D.2    Strieter, R.M.3
  • 41
    • 0034649707 scopus 로고    scopus 로고
    • Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients
    • Dec 14
    • Singer SJ, Tiernan R, Sullivan EJ. Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients. N Engl J Med. 2000 Dec 14;343(24):1815-6.
    • (2000) N Engl J Med , vol.343 , Issue.24 , pp. 1815-1816
    • Singer, S.J.1    Tiernan, R.2    Sullivan, E.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.