Dual pathways of p53 mediated glucolipotoxicity-induced apoptosis of rat cardiomyoblast cell: Activation of p53 proapoptosis and inhibition of Nrf2-NQO1 antiapoptosis

Metabolism: Clinical and Experimental

Volumn 61, Issue 4, 2012, Pages 496-503

  Wang, Hye Jin ^a   Lee, Eun Young ^b   Han, Seung Jin ^c   Kim, Soo Hyun ^b   Lee, Byung Wan ^b   Ahn, Chul Woo ^a,b   Cha, Bong Soo ^a,b   Lee, Hyun Chul ^a,b  

^a Yonsei University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Ajou University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; GLUCOSE; NAD(P)H:QUINONE OXIDOREDUCTASE 1; PALMITIC ACID; PIFITHRIN ALPHA; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE EXPRESSION; GLUCOLIPOTOXICITY; HEART MUSCLE CELL; IN VITRO STUDY; LIPOTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; BENZOTHIAZOLES; CELL LINE; FREE RADICAL SCAVENGERS; GLUCOSE; MYOCYTES, CARDIAC; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; PALMITIC ACID; RATS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TOLUENE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84858448312     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2011.09.005     Document Type: Article

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