Factors associated with ejaculatory and orgasmic dysfunction in men with erectile dysfunction: Analysis of clinical trials involving the phosphodiesterase type 5 inhibitor tadalafil

BJU International

Volumn 109, Issue 7, 2012, Pages 1060-1067

  Paduch, Darius A ^a   Bolyakov, Alexander ^a   Beardsworth, Anthony ^b   Watts, Steven D ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

epidemiology; erectile dysfunction; human; male; orgasm; phosphodiesterases

Indexed keywords

NEUROLEPTIC AGENT; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; SEROTONIN UPTAKE INHIBITOR; TADALAFIL; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; AGE DISTRIBUTION; ARTICLE; ASIAN; CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG USE; EJACULATION DISORDER; ERECTILE DYSFUNCTION; HEART FAILURE; HUMAN; INTERNATIONAL INDEX OF ERECTILE FUNCTION; MAJOR CLINICAL STUDY; MALE; ORGASM DISORDER; POST HOC ANALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; SELF REPORT; SEXUAL SATISFACTION;

CARBOLINES; EJACULATION; ERECTILE DYSFUNCTION; HUMANS; MALE; MIDDLE AGED; PHOSPHODIESTERASE 5 INHIBITORS; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL;

EID: 84858440087     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2011.10504.x     Document Type: Article

References (59)

1. Hatzichristou D, Gambla M, Rubio-Aurioles E, et al,. Efficacy of tadalafil once daily in men with diabetes mellitus and erectile dysfunction. Diabet Med 2008; 25: 138-46 (Pubitemid 351297651)
2. Lue TF, Giuliano F, Montorsi F, et al,. Summary of the recommendations on sexual dysfunctions in men. J Sex Med 2004; 1: 6-23 (Pubitemid 40424662)
3. Wespes E, Amar E, Hatzichristou D, et al,. EAU Guidelines on erectile dysfunction: an update. Eur Urol 2006; 49: 806-15
4. Brock GB, McMahon CG, Chen KK, et al,. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. J Urol 2002; 168: 1332-6 (Pubitemid 35034115)
5. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA,. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. N Engl J Med 1998; 338: 1397-404 (Pubitemid 28221980)
6. Hellstrom WJ, Gittelman M, Karlin G, et al,. Vardenafil for treatment of men with erectile dysfunction: efficacy and safety in a randomized, double-blind, placebo-controlled trial. J Androl 2002; 23: 763-71 (Pubitemid 36300965)
7. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A,. The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: 822-30 (Pubitemid 27246947)
8. Edwards D, Hackett G, Collins O, Curram J,. Vardenafil improves sexual function and treatment satisfaction in couples affected by erectile dysfunction (ED): a randomized, double-blind, placebo-controlled trial in PDE5 inhibitor-naive men with ED and their partners. J Sex Med 2006; 3: 1028-36 (Pubitemid 44644715)
9. Fisher WA, Rosen RC, Mollen M, et al,. Improving the sexual quality of life of couples affected by erectile dysfunction: a double-blind, randomized, placebo-controlled trial of vardenafil. J Sex Med 2005; 2: 699-708 (Pubitemid 41742930)
10. Martin-Morales A, Haro JM, Beardsworth A, Bertsch J, Kontodimas S, EDOS Group. Therapeutic effectiveness and patient satisfaction after 6 months of treatment with tadalafil, sildenafil, and vardenafil: results from the Erectile Dysfunction Observational Study (EDOS). Eur Urol 2007; 51: 541-50 (Pubitemid 44937813)
11. O'Leary MP, Althof SE, Cappelleri JC, et al,. Self-esteem, confidence and relationship satisfaction of men with erectile dysfunction treated with sildenafil citrate: a multicenter, randomized, parallel group, double-blind, placebo controlled study in the United States. J Urol 2006; 175: 1058-62 (Pubitemid 43200088)
12. Perimenis P, Roumeguere T, Heidler H, Roos E, Belger M, Schmitt H,. Evaluation of patient expectations and treatment satisfaction after 1-year tadalafil therapy for erectile dysfunction: the DETECT study. J Sex Med 2009; 6: 257-67
13. Seftel AD, Buvat J, Althof SE, et al,. Improvements in confidence, sexual relationship and satisfaction measures: results of a randomized trial of tadalafil 5 mg taken once daily. Int J Impot Res 2009; 21: 240-8
14. Ströberg P, Kaminetsky JC, Park NC, Goldfischer ER, Creanga DL, Stecher VJ,. Hardness, function, emotional well-being, satisfaction and the overall sexual experience in men using 100-mg fixed-dose or flexible-dose sildenafil citrate. Int J Impot Res 2010; 22: 284-9
15. Haning RV, O'Keefe SL, Randall EJ, Kommor MJ, Baker E, Wilson R,. Intimacy, orgasm likelihood, and conflict predict sexual satisfaction in heterosexual male and female respondents. J Sex Marital Ther 2007; 33: 93-113
16. Mah K, Binik YM,. Are orgasms in the mind or the body? Psychosocial versus physiological correlates of orgasmic pleasure and satisfaction. J Sex Marital Ther 2005; 31: 187-200 (Pubitemid 40594091)
17. Rowland D, Perelman M, Althof S, et al,. Self-reported premature ejaculation and aspects of sexual functioning and satisfaction. J Sex Med 2004; 1: 225-32 (Pubitemid 40424658)
18. Rust J, Golombok S, Collier J,. Marital problems and sexual dysfunction: how are they related? Br J Psychiatry 1988; 152: 629-31
19. Colpi G, Weidner W, Jungwirth A, et al,. EAU guidelines on ejaculatory dysfunction. Eur Urol 2004; 46: 555-8 (Pubitemid 39345721)
20. Rosen RC, Lane RM, Menza M,. Effects of SSRIs on sexual function: a critical review. J Clin Psychopharmacol 1999; 19: 67-85 (Pubitemid 29047334)
21. Jannini EA, Lombardo F, Lenzi A,. Correlation between ejaculatory and erectile dysfunction. Int J Androl 2005; 28 (Suppl. 2): 40-5 (Pubitemid 41719772)
22. Moreira ED Jr, Brock G, Glasser DB, et al,. Help-seeking behaviour for sexual problems: the global study of sexual attitudes and behaviors. Int J Clin Pract 2005; 59: 6-16 (Pubitemid 40260106)
23. Nazareth I, Boynton P, King M,. Problems with sexual function in people attending London general practitioners: cross sectional study. BMJ 2003; 327: 423
24. el-Sakka AI,. Severity of erectile dysfunction at presentation: effect of premature ejaculation and low desire. Urology 2008; 71: 94-8 (Pubitemid 351173272)
25. Malavige LS, Jayaratne SD, Kathriarachchi ST, Sivayogan S, Fernando DJ, Levy JC,. Erectile dysfunction among men with diabetes is strongly associated with premature ejaculation and reduced libido. J Sex Med 2008; 5: 2125-34
26. Montague DK, Jarow J, Broderick GA, et al,. AUA guideline on the pharmacologic management of premature ejaculation. J Urol 2004; 172: 290-4
27. Donatucci C, Taylor T, Thibonnier M, et al,. Vardenafil improves patient satisfaction with erection hardness, orgasmic function, and overall sexual experience, while improving quality of life in men with erectile dysfunction. J Sex Med 2004; 1: 185-92 (Pubitemid 40424652)
28. Giuliano F, Rubio-Aurioles E, Kennelly M, et al,. Vardenafil improves ejaculation success rates and self-confidence in men with erectile dysfunction due to spinal cord injury. Spine (Phila Pa 1976) 2008; 33: 709-15 (Pubitemid 351489406)
29. Mattos RM, Marmo Lucon A, Srougi M,. Tadalafil and fluoxetine in premature ejaculation: prospective, randomized, double-blind, placebo-controlled study. Urol Int 2008; 80: 162-5 (Pubitemid 351440510)
30. Sáenz de Tejada I, Anglin G, Knight JR, Emmick JT,. Effects of tadalafil on erectile dysfunction in men with diabetes. Diabetes Care 2002; 25: 2159-64 (Pubitemid 41071021)
31. Rajfer J, Aliotta PJ, Steidle CP, Fitch WP III, Zhao Y, Yu A,. Tadalafil dosed once a day in men with erectile dysfunction: a randomized, double-blind, placebo-controlled study in the US. Int J Impot Res 2007; 19: 95-103 (Pubitemid 46067355)
32. Thomas DG,. Exact confidence limits for the odds ratio in a 2 x 2 table. Appl Statist 1971; 20: 105-10
33. Cheng JY, Ng EM, Chen RY, Ko JS,. Prevalence of erectile dysfunction in Asian populations: a meta-analysis. Int J Impot Res 2007; 19: 229-44 (Pubitemid 46701450)
34. Laumann EO, Paik A, Glasser DB, et al,. A cross-national study of subjective sexual well-being among older women and men: findings from the Global Study of Sexual Attitudes and Behaviors. Arch Sex Behav 2006; 35: 145-61 (Pubitemid 43873222)
35. Jern P, Santtila P, Johansson A, et al,. Subjectively measured ejaculation latency time and its association with different sexual activities while controlling for age and relationship length. J Sex Med 2009; 6: 2568-78
36. Corona G, Petrone L, Mannucci E, et al,. Psycho-biological correlates of rapid ejaculation in patients attending an andrologic unit for sexual dysfunctions. Eur Urol 2004; 46: 615-22 (Pubitemid 39345733)
37. Jern P, Santtila P, Witting K, et al,. Premature and delayed ejaculation: genetic and environmental effects in a population-based sample of Finnish twins. J Sex Med 2007; 4: 1739-49 (Pubitemid 47616867)
38. Waldinger MD, Rietschel M, Nöthen MM, Hengeveld MW, Olivier B,. Familial occurrence of primary premature ejaculation. Psychiatr Genet 1998; 8: 37-40 (Pubitemid 28181559)
39. Basson R, Rees P, Wang R, Montejo AL, Incrocci L,. Sexual function in chronic illness. J Sex Med 2010; 7: 374-88
40. McMahon CG, Abdo C, Incrocci L, et al,. Disorders of orgasm and ejaculation in men. J Sex Med 2004; 1: 58-65 (Pubitemid 40424667)
41. van Anders SM, Dunn EJ,. Are gonadal steroids linked with orgasm perceptions and sexual assertiveness in women and men? Horm Behav 2009; 56: 206-13
42. Argiolas A, Melis MR,. The role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammals. Physiol Behav 2004; 83: 309-17 (Pubitemid 39361572)
43. Filippi S, Vignozzi L, Vannelli GB, Ledda F, Forti G, Maggi M,. Role of oxytocin in the ejaculatory process. J Endocrinol Invest 2003; 26 (Suppl.): 82-6
44. Stárka L, Hill M, Havliková H, Kancheva L, Sobotka V,. Circulating neuroactive C21- and C19-steroids in young men before and after ejaculation. Physiol Res 2006; 55: 429-36 (Pubitemid 44291100)
45. Vignozzi L, Filippi S, Luconi M, et al,. Oxytocin receptor is expressed in the penis and mediates an estrogen-dependent smooth muscle contractility. Endocrinology 2004; 145: 1823-34 (Pubitemid 38402391)
46. Sadovsky R, Brock GB, Gutkin SW, Sorsaburu S,. Toward a new 'EPOCH': optimising treatment outcomes with phosphodiesterase type 5 inhibitors for erectile dysfunction. Int J Clin Pract 2009; 63: 1214-30
47. Exton MS, Krüger TH, Koch M, et al,. Coitus-induced orgasm stimulates prolactin secretion in healthy subjects. Psychoneuroendocrinology 2001; 26: 287-94 (Pubitemid 32144732)
48. Haake P, Exton MS, Haverkamp J, et al,. Absence of orgasm-induced prolactin secretion in a healthy multi-orgasmic male subject. Int J Impot Res 2002; 14: 133-5 (Pubitemid 34450462)
49. Turrone P, Kapur S, Seeman MV, Flint AJ,. Elevation of prolactin levels by atypical antipsychotics. Am J Psychiatry 2002; 159: 133-5
50. Vaucher L, Bolyakov A, Paduch DA,. Evolving techniques to evaluate ejaculatory function. Curr Opin Urol 2009; 19: 606-14
51. Baldwin D, Mayers A,. Sexual side-effects of antidepressant and antipsychotic drugs. Advs Psychiatric Treatment 2003; 9: 202-10 (Pubitemid 36575967)
52. Giuliano F, Bernabe J, Droupy S, Alexandre L, Allard J,. A comparison of the effects of tamsulosin and alfuzosin on neurally evoked increases in bladder neck and seminal vesicle pressure in rats. BJU Int 2004; 93: 605-8
53. Giuliano FA, Clément P, Denys P, Alexandre L, Bernabé J,. Comparison between tamsulosin and alfuzosin on the expulsion phase of ejaculation in rats. BJU Int 2006; 98: 876-9 (Pubitemid 44368043)
54. Hellstrom WJ, Sikka SC,. Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers. J Urol 2006; 176: 1529-33 (Pubitemid 44307193)
55. Hisasue S, Furuya R, Itoh N, Kobayashi K, Furuya S, Tsukamoto T,. Ejaculatory disorder caused by alpha-1 adrenoceptor antagonists is not retrograde ejaculation but a loss of seminal emission. Int J Urol 2006; 13: 1311-6 (Pubitemid 44453698)
56. 1-blocker silodosin: a preliminary study to analyze human ejaculation using color Doppler ultrasonography. Int J Urol 2008; 15: 915-8
57. Giuliano F, Hellstrom WJ,. The pharmacological treatment of premature ejaculation. BJU Int 2008; 102: 668-75
58. McMahon CG, Stuckey BG, Andersen M, et al,. Efficacy of sildenafil citrate (Viagra) in men with premature ejaculation. J Sex Med 2005; 2: 368-75 (Pubitemid 40744377)
59. Papaharitou S, Athanasiadis L, Nakopoulou E, et al,. Erectile dysfunction and premature ejaculation are the most frequently self-reported sexual concerns: profiles of 9,536 men calling a helpline. Eur Urol 2006; 49: 557-63 (Pubitemid 43259569)