Circulating neuroactive C21- and C19-steroids in young men before and after ejaculation

Physiological Research

Volumn 55, Issue 4, 2006, Pages 429-436

  Starka L ^a   Hill, M ^a   Havlikova H ^a   Kancheva, L ^a   Sobotka, V ^b  

^a INSTITUTE OF ENDOCRINOLOGY   (Czech Republic)

^b Sanatorium Pronatal   (Czech Republic)

Author keywords

17 hydroxypregnenolone; Allopregnanolone; Ejaculation; Neuroactive steroids; Testosterone

Indexed keywords

17 HYDROXYPREGNENOLONE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 7ALPHA HYDROXY DIHYDROEPIANDROSTERONE; 7BETA HYDROXY DIHYDROEPIANDROSTERONE; ANDROGEN; ANDROSTANEDIOL; ANDROSTENEDIOL; ANDROSTENEDIONE; ANDROSTERONE; ETIOCHOLANOLONE; OXYTOCIN; PRASTERONE; PREGNENOLONE; STEROID; TESTOSTERONE; UNCLASSIFIED DRUG; ELTANOLONE;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DATA ANALYSIS; EJACULATION; ENDOCRINE FUNCTION; HORMONE ACTION; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; MALE; MASTURBATION; MEASUREMENT; ORGASM; PRECURSOR; BLOOD; MASS FRAGMENTOGRAPHY; PHYSIOLOGY;

17-ALPHA-HYDROXYPREGNENOLONE; ADULT; ANDROGENS; ANDROSTENEDIONE; DEHYDROEPIANDROSTERONE; EJACULATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; ORGASM; PREGNANOLONE; TESTOSTERONE;

EID: 33747879869     PISSN: 08628408     EISSN: 08628408     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. ARGIOLAS A, MELIS MR: The neurophysiology of the sexual cycle. J Endocrinol Invest 26: 20-22, 2003.
2. ARGIOLAS A, MELIS MR: The role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammals. Physiol Behav 83: 309-317, 2004.
3. A receptor function, and anxiety: a study in menopausal women. Psychoneuroendocrinology 25: 659-675, 2000.
4. 3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates. Steroids 69: 161-171, 2004.
5. EDINGER KL, FRYE CA: Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5α-reduced metabolites in the hippocampus. Behav Neurosci 118: 1352-1364, 2004.
6. EDINGER KL, LEE B, FRYE CA: Mnemonic effects of testosterone and its 5α-reduced metabolites in the conditioned fear and inhibitory avoidance tasks. Pharmacol Biochem Behav 78: 559-568, 2004.
7. FILIPPI S, VIGNOZZI L, VANNELLI GB, LEDDA F, FORTI G, MAGGI M: Role of oxytocin in the ejaculatory process. J Endocrinol Invest 26: 82-86, 2003.
8. FRYE CA, EDINGER KL: Testosterone's metabolism in the hippocampus may mediate its anti-anxiety effects in male rats. Pharmacol Biochem Behav 78: 473-481, 2004.
9. FRYE CA, VONGHER JM: Progesterone and 3α,5α-THP enhance sexual receptivity in mice. Behav Neurosci 115: 1118-1128, 2001.
10. FRYE CA, EDINGER KL, SELIGA AM, WAWRZYCKI JM: 5α-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats. Psychoneuroendocrinology 29: 1019-1027, 2004.
11. GEIGERSEDER C, DOEPNER R, THALHAMMER A, FRUNGIERI MB, GAMEL-DIDELON K, CALANDRA RS, KOHN FM, MAYERHOFER A: Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors. Neuroendocrinology 77: 314-323, 2003.
12. GENAZZANI AR, PETRAGLIA F, BERNARDI F, CASAROSA E, SALVESTRONI C, TONETTI A, NAPPI RE, LUISI S, PALUMBO M, PURDY RH, LUISI M: Circulating levels of allopregnanolone in humans: gender, age, and endocrine influences. J Clin Endocrinol Metab 83: 2099-2103, 1998.
13. HILL M, POPOV P, HAVLÍKOVÁ H, KANCHEVA L, VRBÍKOVÁ J, KANCHEVA R, POUZAR V, ČERNÝ I, STÁRKA L: Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction. Steroids 70: 515-524, 2005.
14. A receptor-mediated currents in the rat forebrain. J Neurophysiol 83: 3299-3309, 2000.
15. KLAK J, HILL M, PAŘÍZEK A, HAVLÍKOVÁ H, BIČÍKOVÁ M, HAMPL R, FAIT T, ŠULCOVÁ J, POUZAR V, KANCHEVA R, STÁRKA L: Pregnanolone isomers, pregnenolone and their polar conjugates around parturition. Physiol Res 52: 211-221. 2003.
16. KRUGER TH, HAAKE P, CHEREATH D, KNAPP W, JANSSEN OE, EXTON MS, SCHEDLOWSKI M, HARTMANN U.: Specificity of the neuroendocrine response to orgasm during sexual arousal in men. J Endocrinol 177: 57-64, 2003.
17. LENG G, RUSSELL JA: Coming to term with GABA. J Physiol Lond 516 (Pt 2): vi, 1999.
18. NISHIMORI K, YOUNG LJ, GUO Q, WANG Z, INSEL TR, MATZUK MM: Oxytocin is required for nursing but is not essential for parturition or reproductive behavior. Proc Natl Acad Sci USA 93: 11699-11704, 1996.
19. PERUSQUIA M, NAVARRETE E, JASSO-KAMEL J, MONTANO LM: Androgens induce relaxation of contractile activity in pregnant human myometrium at term: a nongenomic action on L-type calcium channels. Biol Reprod 73: 214-221, 2005.
20. REDDY DS: Pharmacology of endogenous neuroactive steroids. Crit Rev Neurobiol 15: 197-234, 2003.
21. REDDY DS: Anticonvulsant activity of the testosterone-derived neurosteroid 3α-androstanediol. Neuroreport 15: 515-518, 2004a.
22. REDDY DS: Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol. Neuroscience 129: 195-207, 2004b.
23. RUSSELL JA, LENG G, DOUGLAS AJ: The magnocellular oxytocin system, the fount of maternity: adaptations in pregnancy. Front Neuroendocrinol 24: 27-61, 2003.
24. A and opioid receptors reduce penile erection induced by hexarelin peptides. Pharmacol Biochem Behav 76: 563-570, 2003.
25. TURNER DM, RANSOM RW, YANG JS, OLSEN RW: Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates. J Pharmacol Exp Ther 248: 960-966, 1989.
26. A receptor complex by steroids in slices of rat cuneate nucleus. Br J Pharmacol 96: 409-417,1989.
27. A receptor single-channel kinetic properties of mouse spinal cord neurons in culture. J Physiol Lond 456: 2152-2145, 1992.
28. VIGNOZZI L, FILIPPI S, LUCONI M, MORELLI A, MANCINA R, MARINI M, VANNELLI GB, GRANCHI S, ORLANDO C, GELMINI S, LEDDA F, FORTI G, MAGGI M: Oxytocin receptor is expressed in the penis and mediates an estrogen-dependent smooth muscle contractility. Endocrinology 145: 1823-1834, 2004.