Hardness, function, emotional well-being, satisfaction and the overall sexual experience in men using 100-mg fixed-dose or flexible-dose sildenafil citrate

International Journal of Impotence Research

Volumn 22, Issue 4, 2010, Pages 284-289

  Stroberg P ^a   Kaminetsky, J C ^b   Park, N C ^c   Goldfischer, E R ^d   Creanga, D L ^e   Stecher, V J ^e  

^a Urohålsan/ED kliniken ^*  (Sweden)

^b University Urology Associates   (United States)

^c Pusan National University School of Medicine   (South Korea)

^d Hudson Valley Urology   (United States)

^e PFIZER INC   (United States)

Author keywords

erectile dysfunction; quality of life; sildenafil

Indexed keywords

PLACEBO; SILDENAFIL; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; SULFONE;

ADULT; AGED; ARTICLE; DIZZINESS; DRUG DOSE COMPARISON; DRUG DOSE REGIMEN; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPEPSIA; ERECTILE DYSFUNCTION; FLUSHING; FUNCTIONAL STATUS; HUMAN; INTERNATIONAL INDEX OF ERECTILE FUNCTION; MAJOR CLINICAL STUDY; MALE; NOSE CONGESTION; PATIENT SATISFACTION; PENIS ERECTION; PRESCRIPTION; PRIORITY JOURNAL; PSYCHOLOGICAL WELL BEING; QUESTIONNAIRE; SELF REPORT; SEXUAL SATISFACTION; SIDE EFFECT; TREATMENT OUTCOME; COITUS; COMPARATIVE STUDY; DOUBLE BLIND PROCEDURE; EMOTION; MIDDLE AGED; ORGASM; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ADULT; COITUS; DOUBLE-BLIND METHOD; EMOTIONS; ERECTILE DYSFUNCTION; HUMANS; MALE; MIDDLE AGED; ORGASM; PATIENT SATISFACTION; PENILE ERECTION; PIPERAZINES; PLACEBOS; PURINES; QUESTIONNAIRES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SULFONES;

EID: 77954816723     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/ijir.2010.17     Document Type: Article

References (24)

1. VIAGRA. Full Prescribing Information, Sildenafil Citrate. Pfizer, Inc.: New York, NY, 2008.
2. King R, Juenemann KP, Levinson IP, Stecher VJ, Creanga DL. Correlations between increased erection hardness and improvements in emotional well-being and satisfaction outcomes in men treated with sildenafil citrate for erectile dysfunction. Int J ImpotRes 2007; 19: 398-406.
3. Steidle C, McCullough A, Kaminetsky J, Crowley A, Siegel R, Deriesthal H et al. Early sildenafil dose optimization and personalized instruction improves the frequency, flexibility, and success of sexual intercourse in men with erectile dysfunction. Int J Impot Res 2007; 19: 154-160.
4. Jiann BP, Yu CC, Su CC, Huang JK. Rechallenge prior sildenafil nonresponders. Int J Impot Res 2004; 16: 64-68.
5. Lowy M, Collins S, Bloch MT, Gillman M, Lording DW, Sutherland P et al. Quality of erection questionnaire correlates: change in erection quality with erectile function, hardness, and psychosocial measures in men treated with sildenafil for erectile dysfunction. J Sex Med 2007; 4: 83-92.
6. McCullough AR, Carson C, Hatzichristou D. A prospective study of the beneficial effects of dose optimization and customized instructions on patient satisfaction with sildenafil citrate (VIAGRA) for erectile dysfunction. Urology 2006; 68: 38-46.
7. Loran OB, Stroberg P, Lee SW, Park NC, Kim SW, Tseng LJ et al. Sildenafil citrate 100 mg starting dose in men with erectile dysfunction in an international, double-blind, placebo-controlled study: effect on the sexual experience and reducing feelings of anxiety about the next intercourse attempt. J Sex Med 2009; 6: 2826-2835.
8. Jones LA, Klimberg IW, McMurray JG, Padula R, Tseng L-J, Stecher VJ et al. Effect of sildenafil citrate on the male sexual experience assessed with the Sexual Experience Questionnaire; a multicenter, double-blind, placebo-controlled trial with open-label extension. J Sex Med 2008; 5: 1955-1964.
9. Mulhall JP, Goldstein I, Bushmakin AG, Cappelleri JC, Hvidsten K. Validation of the Erection Hardness Score (EHS). J Sex Med 2007; 4: 1626-1634.
10. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: 822-830.
11. Cappelleri JC, Althof SE, Siegel RL, Shpilsky A, Bell SS, Duttagupta S. Development and validation of the Self-Esteem And Relationship (SEAR) questionnaire in erectile dysfunction. Int J Impot Res 2004; 16: 30-38.
12. Cappelleri JC, Bell SS, Althof SE, Siegel RS, Stecher VJ. Comparison between sildenafil-treated subjects with erectile dysfunction and control subjects on the Self-Esteem And Relationship Questionnaire. J Sex Med 2006; 3: 274-282.
13. Althof SE, O'Leary MP, Cappelleri JC, Hvidsten K, Stecher VJ, Glina S et al. Sildenafil citrate improves self-esteem, confidence, and relationships in men with erectile dysfunction: results from an international, multi-center, double-blind, placebo-controlled trial. J Sex Med 2006; 3: 521-529.
14. Mulhall JP, King R, Kirby M, Hvidsten K, Symonds T, Bushmakin AG et al. Evaluating the sexual experience in men: validation of the Sexual Experience Questionnaire. J Sex Med 2008; 5: 365-376.
15. Porst H, Gilbert C, Collins S, Huang X, Symonds T, Stecher V et al. Development and validation of the Quality of Erection Questionnaire. J Sex Med 2007; 4: 372-381.
16. Althof SE, Corty EW, Levine SB, Levine F, Burnett AL, McVary K et al. EDITS: development of questionnaires for evaluating satisfaction with treatments for erectile dysfunction. Urology 1999; 53: 793-799.
17. O'Leary MP, Althof SE, Cappelleri JC, Crowley A, Sherman N, Duttagupta S. Self-esteem, confidence and relationship satisfaction of men with erectile dysfunction treated with sildenafil citrate: a multicenter, randomized, parallel group, double-blind, placebo controlled study in the United States. J Urol 2006; 175: 1058-1062.
18. Jiann BP, Yu CC, Tsai JY, Wu TT, Lee YH, Huang JK. What to learn about sildenafil in the treatment of erectile dysfunction from 3-year clinical experience. Int J Impot Res 2003; 15: 412-417.
19. McCullough AR, Barada JH, Fawzy A, Guay AT, Hatzichristou D. Achieving treatment optimization with sildenafil citrate (Viagra) in patients with erectile dysfunction. Urology 2002; 60: 28-38.
20. Harrold LR, Gurwitz JH, Field TS, Andrade SE, Fish LS, Jarry PD et al. The diffusion of a novel therapy into clinical practice: the case of sildenafil. Arch Intern Med 2000; 160: 3401-3405.
21. Muirhead GJ, Wilner K, Colburn W, Haug-Pihale G, Rouvieux B. The effects of age and renal and hepatic impairment on the pharmacokinetics of sildenafil citrate. Br J Clin Pharmacol 2002; 53: 21S-30S.
22. Muirhead GJ, Faulkner S, Harness JA, Taubel J. The effects of steady-state erythromycin and azithromycin on the pharma- cokinetics of sildenafil in healthy volunteers. Br J Clin Pharmacol 2002; 53: 37S-43S.
23. Muirhead GJ, Wulff MB, Fielding A, Kleinermans D, Buss N. Pharmacokinetic interactions between sildenafil and saquina- vir/ritonavir. Br J Clin Pharmacol 2000; 50: 99-107.
24. Kloner RA. Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions. Am J Cardiol 2005; 96: 42M-46M.