Oxytocin receptor is expressed in the penis and mediates an estrogen-dependent smooth muscle contractility

Endocrinology

Volumn 145, Issue 4, 2004, Pages 1823-1834

  Vignozzi, Linda ^b   Filippi, Sandra ^b   Luconi, Michaela ^b   Morelli, Annamaria ^b   Mancina, Rosa ^a   Marini, Mirca ^b   Vannelli, Gabriella Barbara ^a   Granchi, Simone ^a   Orlando, Claudio ^a   Gelmini, Stefania ^a   Ledda, Fabrizio ^a   Forti, Gianni ^b   Maggi, Mario ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; AROMATASE; AROMATASE INHIBITOR; ESTRADIOL VALERATE; ESTROGEN; ESTROGEN RECEPTOR; GONADORELIN AGONIST; LETROZOLE; OXYTOCIN RECEPTOR; SEX HORMONE; TAMOXIFEN; TESTOSTERONE ENANTATE; TRIPTORELIN PAMOATE; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; EJACULATION; GENE; HORMONAL REGULATION; HORMONE DEPENDENCE; HORMONE SENSITIVITY; HUMAN; HUMAN TISSUE; HYPOGONADOTROPIC HYPOGONADISM; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE RELAXATION; NEUROHYPOPHYSIS; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; ORGASM; OXYTOCIN RECEPTOR GENE; OXYTOCIN RELEASE; PENIS; PENIS DETUMESCENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RABBIT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE CONTRACTILITY; WESTERN BLOTTING;

ANIMALS; AROMATASE INHIBITORS; ENZYME INHIBITORS; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGENS; GONADOTROPIN-RELEASING HORMONE; HUMANS; HYPOGONADISM; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NITRILES; OSMOLAR CONCENTRATION; OXYTOCIN; PENIS; RABBITS; RECEPTORS, OXYTOCIN; TAMOXIFEN; TRIAZOLES; TRIPTORELIN;

EID: 12144288446     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0962     Document Type: Article

References (56)

1. Brackett NL, Bloch WE, Abae M 1994 Neurological anatomy and physiology of sexual function. In Singer C, Weiner WJ, eds. Sexual dysfunction: a neuromedical approach. New York: Futura; 1-43
2. Lue TF, Keel KL 2000 Pharmacotherapy for erectile dysfunction. Chin Med J 113:291-298
3. Maggi M, Filippi S, Ledda F, Magini A, Forti G 2000 Erectile dysfunction: from biochemical pharmacology to advances in medical therapy. Eur J Endocrinol 143:143-154
4. Andersson KE 2001 Pharmacology of penile erection. Pharmacol Rev 53:417-450
5. Kandeel FR, Koussa VK, Swerdloff RS 2001 Male sexual function and its disorders: physiology, pathophysiology, clinical investigation, and treatment. Endocr Rev 22:342-388
6. Thomas JA 2002 Pharmacological aspects of erectile dysfunction. Jpn J Pharmacol 89:101-112
7. Ishunina TA, Swaab DF 1999 Vasopressin and oxytocin neurons of the human supraoptic and paraventricular nucleus: size changes in relation to age and sex. J Clin Endocrinol Metab 84:4637-4644
8. Dale HH 1906 On some physiological action of ergot. J Physiol 34:163-206
9. Ott I, Scott JC 1910 The action of infundibulin upon the mammary secretion. Proc Soc Exp Biol 8:48-49
10. Debackere M, Peeters G, Tuyttens N 1961 Reflex release of an oxytocin hormone by stimulation of genital organs in male and female sheep studied by a cross circulation technique. J Endocrinol 22:321-334
11. Carmichael MS, Humbert R, Dixen J 1987 Plasma oxytocin increases in the human sexual response. J Clin Endocrinol Metab 64:27-31
12. Murphy MR, Seckl JR, Burton S, Checkley SA, Lightman SL 1987 Changes in oxytocin and vasopressin secretion during sexual activity in men. J Clin Endocrinol Metab 65:738-774
13. Murphy MR, Checkley SA, Seckl JR, Lightman SL 1990 Naloxone inhibits oxytocin release at orgasm in man. J Clin Endocrinol Metab 71:1056-1058
14. Carmichael MS, Warburton VL, Dixen J, Davidson JM 1994 Relationships among cardiovascular, muscular, and oxytocin responses during human sexual activity. Arch Sex Behav 23:59-79
15. Ogawa S, Kudo S, Kitsunai Y, Fukuchi S 1980 Increase in oxytocin secretion at ejaculation in male. Clin Endocrinol (Oxf) 13:95-97
16. Uckert S, Becker AJ, Ness BJ, Stief CJ, Scheller F, Knapp WJ, Jonas U 2003 Oxytocin plasma levels in the systemic and cavernous blood of healthy males during different penile conditions. World J Urol 20:323-326
17. Sharma SC, Fitzpatrick RJ, Ward WR 1972 Coital-induced release of oxytocin in the ram. J Reprod Fertil 31:488-489
18. Peeters G, Legros JJ, Piron-Bossuyt C, Reynaert R, Vanden Driessche R, Vannieuwenhuyse E 1983 Release of neurophysin 1 and oxytocin by stimulation of the genital organs in bulls. J Endocrinol 99:161-171
19. Stoneham MD, Everitt BJ, Hansen S, Lightman SL, Todd K 1985 Oxytocin and sexual behavior in the male rat and rabbit. J Endocrinol 107:97-106
20. Filippi S, Vignozzi L, Vannelli GB, Ledda F, Forti G, Maggi M 2003 Role of oxytocin in the ejaculatory process. J Endocrinol Invest 26:82-86
21. Filippi S, Vannelli GB, Granchi S, Luconi M, Crescioli C, Mancina R, Natali A, Brocchi S, Vignozzi L, Bencini E, Noci I, Ledda F, Forti G, Maggi M 2002 Identification, localization and functional activity of oxytocin receptors in epididymis. Mol Cell Endocrinol 193:89-100
22. Maggi M, Malozowski S, Kassis S, Guardabasso V, Rodbard D 1987 Identification and characterization of two classes of receptors for oxytocin and vasopressin in porcine tunica albuginea, epididymis, and vas deferens. Endocrinology 120:986-994
23. Einspanier A, Ivell R 1997 Oxytocin and oxytocin receptor expression in reproductive tissues of the male marmoset monkey. Biol Reprod 56:416-422
24. Frayne J, Nicholson HD 1998 Localization of oxytocin receptors in the human and macaque monkey male reproductive tracts: evidence for a physiological role of oxytocin in the male. Mol Hum Reprod 4:527-532
25. Whittington K, Assinder SJ, Parkinson T, Lapwood KR, Nicholson HD 2001 Function and localization of oxytocin receptors in the reproductive tissue of rams. Reproduction 122:317-325
26. Maggi M, Barni T, Orlando C, Fantoni G, Finetti G, Vannelli GB, Mancina R, Gloria L, Bonaccorsi L, Yanagisawa M, Forti G 1995 Endothelin-1 and its receptors in human testis. J Androl 16:213-224
27. Pinzani P, Orlando C, Raggi CC, Distante V, Valanzano R, Tricarico C, Maggi M, Serio M, Pazzagli M 2001 Type-2 somatostatin receptor mRNA levels in breast and colon cancer determined by a quantitative RT-PCR assay based on dual label fluorogenic probe and the TaqMan technology. Regul Pept 99:79-86
28. Casini Raggi C, Calabro A, Renzi D, Briganti V, Cianchi F, Messerini L, Valanzano R, Cameron Smith M, Cortesini C, Tonelli F, Serio M, Maggi M, Orlando C 2002 Quantitative evaluation of somatostatin receptor subtype 2 expression in sporadic colorectal tumor and in the corresponding normal mucosa. Clin Cancer Res 8:419-427
29. de Cremoux P, Tran-Perennou C, Elie C, Boudou E, Barbaroux C, Poupon MF, de Rycke Y, Asselain B, Magdelènat H 2002 Quantitation of estradiol receptors alpha and beta and progesterone receptors in human breast tumors by real-time reverse transcription-polymerase chain reaction. Correlation with protein assays. Biochem Pharmacol 64:507-515
30. Maggi M, Vannelli GB, Peri A, Brandi ML, Fantoni G, Giannini S, Torrisi C, Guardabasso V, Barni T, Toscano V, Massi G, Serio M 1991 Immunolocalization, binding and biological activity of endothelin in rabbit uterus: effects of ovarian steroids. Am J Physiol 260:E292-E305
31. Maggi M, Fantoni G, Baldi E, Cioni A, Rossi S, Vannelli GB, Melin P, Akerlund M, Serio M 1994 Antagonists for the human oxytocin receptor: an in vitro study. J Reprod Fertil 101:345-352
32. Peri A, Fantoni G, Granchi S, Vannelli GB, Barni T, Amerini S, Pupilli C, Barbagli G, Forti G, Serio M, Maggi M 1997 Gene expression of endothelin-1, endothelin-converting enzyme-1, and endothelin receptors in human epididymis. J Clin Endocrinol Metab 82:3797-3806
33. Peri A, Fantoni G, Granchi S, Vannelli GB, Barni T, Amerini S, Pupilli C, Barbagli G, Serio M, Maggi M, Forti G 1998 Endothelin-1 is synthesized and biologically active in human epididymis via a paracrine mode of action. Steroids 63:294-298
34. Munson PJ, Rodbard D 1980 LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107:220-239
35. Smith IE 1998 Pivotal trials of letrozole: a new aromatase inhibitor. Oncology 12:41-44
36. Filippi S, Luconi M, Granchi S, Vignozzi L, Bettuzzi S, Tozzi P, Forti G, Maggi M 2002 Estrogens, but not androgens, regulate expression and functional activity of oxytocin receptor in rabbit epididymis. Endocrinology 143:4271-4280
37. Filippi S, Luconi M, Granchi S, Natali A, Tozzi P, Forti G, Ledda F, Maggi M 2002 Endothelium-dependency of yohimbine-induced corpus cavernosum relaxation. Int J Impot Res 14:295-307
38. De Lean A, Munson PJ, Rodbard D 1978 Simultaneous analysis of families of sigmoidal curves: applications to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol 235:E97-E102
39. Takemura M, Kimura T, Nomura S, Makino Y, Inoue T, Kikuchi T, Kubota Y, Tokugawa Y, Nobunaga T, Kamiura S 1994 Expression and localization of human oxytocin receptor mRNA and its protein in chorion and decidua during parturition. J Clin Invest 93:2319-2323
40. Wathes DC, Borwick SC, Timmons PM, Leung ST, Thornton S 1999 Oxytocin receptor expression in human term and preterm gestational tissues prior to and following the onset of labour. J Endocrinol 161:143-151
41. McCann SM, Antunes-Rodrigues J, Jankowski M, Gutkowska J 2002 Oxytocin, vasopressin and atrial natriuretic peptide control body fluid homeostasis by action on their receptors in brain, cardiovascular system and kidney. Prog Brain Res 139:309-328
42. Gimpl G, Fahrenholz F 2001 The oxytocin receptor system: structure, function, and regulation. Physiol Rev 81:629-683
43. Crescioli C, Maggi M, Vannelli GB, Ferruzzi P, Granchi S, Mancina R, Muratori M, Forti G, Serio M, Luconi M 2003 Expression of functional estrogen receptors in human fetal male external genitalia. J Clin Endocrinol Metab 88:1815-1824
44. Bathgate RA, Sernia C 1994 Characterization and localization of oxytocin receptors in the rat testis. J Endocrinol 141:343-352
45. Weston GC, Haviv I, Rogers PA 2002 Microarray analysis of VEGF-responsive genes in myometrial endothelial cells. Mol Hum Reprod 8:855-863
46. Weston GC, Cann L, Rogers PA 2003 Myometrial microvascular endothelial cells express oxytocin receptor. Br J Obstet Gynaecol 110:149-156
47. Jankowski M, Wang D, Hajjar F, Mukaddam-Daher S, McCann SM, Gutkowska J 2000 Oxytocin and its receptors are synthesized in the rat vasculature. Proc Natl Acad Sci USA 97:6207-6211
48. Miller ME, Davidge ST, Mitchell BF 2002 Oxytocin does not directly affect vascular tone in vessels from nonpregnant and pregnant rats. Am J Physiol 282:H1223-H1228
49. Wang D, Gutkowska J, Marcinkiewicz M, Rachelska G, Jankowski M 2003 Genistein supplementation stimulates the oxytocin system in the aorta of ovariectomized rats. Cardiovasc Res 57:186-194
50. Orlando C, Brandi ML, Peri A, Giannini S, Fantoni G, Calabresi E, Serio M, Maggi M 1990 Neurohypophyseal hormone regulation of endothelin secretion from rabbit endometrial cells in primary culture. Endocrinology 126:1780-1782
51. Granchi S, Vannelli GB, Vignozzi L, Crescioli C, Ferruzzi P, Mancina R, Vinci MC, Forti G, Filippi S, Luconi M, Ledda F, Maggi M 2002 Expression and regulation of endothelin-1 and its receptors in human penile smooth muscle cells. Mol Hum Reprod 8:1053-1064
52. Hess RA, Bunick D, Bahr J 2001 Oestrogen, its receptors and function in the male reproductive tract: a review. Mol Cell Endocrinol 178:29-38
53. de Ronde W, Pols HA, van Leeuwen JP, de Jong FH 2003 The importance of oestrogens in males. Clin Endocrinol (Oxf) 58:529-542
54. Carreau S, Bourguiba S, Lambard S, Galeraud-Denis I, Genissel C, Levallet J 2002 Reproductive system: aromatase and estrogens. Mol Cell Endocrinol 193:137-143
55. Maggi M, Genazzani AD, Giannini S, Torrisi C, Baldi E, di Tomaso M, Munson PJ, Rodbard D, Serio M, di Tomasso M 1988 Vasopressin and oxytocin receptors in vagina, myometrium, and oviduct of rabbits. Endocrinology 122:2970-2980
56. Adaikan PG, Srilatha B 2003 Oestrogen-mediated hormonal imbalance precipitates erectile dysfunction. Int J Impot Res 15:38-43