Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives

European Journal of Medicinal Chemistry

Volumn 50, Issue , 2012, Pages 441-448

  Palumbo Piccionello, Antonio ^a   Musumeci, Rosario ^b   Cocuzza, Clementina ^b   Fortuna, Cosimo Gianluca ^c   Guarcello, Annalisa ^a,d   Pierro, Paola ^a,d   Pace, Andrea ^a,d  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c UNIVERSITY OF CATANIA   (Italy)

^d Istituto Euro Mediterraneo di Scienza e Tecnologia IEMEST   (Italy)

Author keywords

1,2,4 Oxadiazole; Antimicrobial activity; Fluorinated heterocycles; Linezolid; Oxazolidinone

Indexed keywords

1,2,4 OXADIAZOLE DERIVATIVE; 5 (2,3,5,6 TETRAFLUORO 4 MORPHOLINPHENYL) PHENYL] 1,2,4 OXADIAZOLE 3 CARBOXAMIDE; 5 [2',3',5' TRIFLUORO 4' (MORPHOLIN N YL) PHENYL] 1,2,4 OXADIAZOLE 3 CARBOXAMIDE; 5 [3' FLUORO 4' (MORPHOLIN N YL) PHENYL] 1,2,4 OXADIAZOLE 3 CARBOXAMIDE; 5 [3',5' DIFLUORO 4' (MORPHOLIN N YL) PHENYL] 1,2,4 OXADIAZOLE 3 CARBOXAMIDE; 5 [4' (MORPHOLIN N YL) PHENYL] 1,2,4 OXADIAZOLE 3 CARBOXAMIDE; ANTIINFECTIVE AGENT; CEFTRIAXONE; HETEROCYCLIC COMPOUND; LINEZOLID; N [5 [3' FLUORO (4' (MORPHOLIN N' YL) PHENYL) 1,2,4 OXADIAZOL 3 YL]METHYL] ACETAMIDE; N [[5 (2',3',5' TRIFLUORO 4' (MORPHOLIN N' YL) PHENYL) 1,2,4 OXADIAZOL 3 YL]METHYL] ACETAMIDE; N [[5 (2',3',5',6' TETRAFLUORO 4' (MORPHOLIN N' YL) PHENYL) 1,2,4 OXADIAZOL 3 YL]METHYL] ACETAMIDE; N [[5 (3',5' DIFLUORO 4' (MORPHOLIN N' YL) PHENYL) 1,2,4 OXADIAZOL 3 YL]METHYL] ACETAMIDE; N [[5 (4' (MORPHOLIN N' YL) PHENYL) 1,2,4 OXADIAZOL 3 YL]METHYL] ACETAMIDE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; DRUG SCREENING; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; NONHUMAN; SYNTHESIS;

ACETAMIDES; ANTI-BACTERIAL AGENTS; BACTERIA; CEFTRIAXONE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OXAZOLIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84858439331     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.02.002     Document Type: Article

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