Rapid accumulation of CD14 +CD11c + dendritic cells in gut mucosa of celiac disease after in vivo gluten challenge

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Beitnes, Ann Christin Røberg ^a   Ráki, Melinda ^a   Brottveit, Margit ^b   Lundin, Knut Erik Aslaksen ^a   Jahnsen, Frode Lars ^a   Sollid, Ludvig Magne ^a,c  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; CD14 ANTIGEN; CD163 ANTIGEN; CD1C ANTIGEN; CHEMOKINE RECEPTOR CCR2; GLUTEN; GLYCOPROTEIN P 15095; HLA DQ ANTIGEN; HLA DQ2 ANTIGEN; GLIADIN; PEPTIDE FRAGMENT;

ADULT; AGED; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELIAC DISEASE; CELL DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DUODENUM BIOPSY; FEMALE; FLOW CYTOMETRY; GLUTEN FREE DIET; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOLOGY; IN VIVO STUDY; INTESTINE MUCOSA; LYMPHOCYTE; MACROPHAGE; MALE; MONOCYTE; NEUTROPHIL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STAINING; CASE CONTROL STUDY; CELL COUNT; CLASSIFICATION; DIET THERAPY; DUODENUM; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; ANTIGENS, CD11C; ANTIGENS, CD14; CASE-CONTROL STUDIES; CELIAC DISEASE; CELL COUNT; DENDRITIC CELLS; DIET, GLUTEN-FREE; DUODENUM; FEMALE; GLIADIN; GLUTENS; HLA-DQ ANTIGENS; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; MONOCYTES; PEPTIDE FRAGMENTS;

EID: 84858414938     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033556     Document Type: Article

References (33)

1. Sollid LM, (2002) Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2: 647-655.
2. Jabri B, Sollid LM, (2009) Tissue-mediated control of immunopathology in coeliac disease. Nat Rev Immunol 9: 858-870.
3. Walker MM, Murray JA, (2011) An update in the diagnosis of coeliac disease. Histopathology 59: 166-179.
4. Raki M, Tollefsen S, Molberg O, Lundin KE, Sollid LM, et al. (2006) A unique dendritic cell subset accumulates in the celiac lesion and efficiently activates gluten-reactive T cells. Gastroenterology 131: 428-438.
5. Beitnes AC, Raki M, Lundin KE, Jahnsen J, Sollid LM, et al. (2011) Density of CD163(+) CD11c(+) dendritic cells increases and CD103(+) dendritic cells decreases in the coeliac lesion. Scand J Immunol 74: 186-194.
6. Brottveit M, Raki M, Bergseng E, Fallang LE, Simonsen B, et al. (2011) Assessing possible celiac disease by an HLA-DQ2-gliadin Tetramer Test. Am J Gastroenterol 106: 1318-1324.
7. Oberhuber G, Granditsch G, Vogelsang H, (1999) The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 11: 1185-1194.
8. Spits H, Borst J, Giphart M, Coligan J, Terhorst C, et al. (1984) HLA-DC antigens can serve as recognition elements for human cytotoxic T lymphocytes. Eur J Immunol 14: 299-304.
9. Micklem KJ, Dong Y, Willis A, Pulford KA, Visser L, et al. (1991) HML-1 antigen on mucosa-associated T cells, activated cells, and hairy leukemic cells is a new integrin containing the beta 7 subunit. Am J Pathol 139: 1297-1301.
10. Wang JE, Warris A, Ellingsen EA, Jorgensen PF, Flo TH, et al. (2001) Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae. Infect Immun 69: 2402-2406.
11. Huitfeldt HS, Brandtzaeg P, (1985) Various keratin antibodies produce immunohistochemical staining of human myocardium and myometrium. Histochemistry 83: 381-389.
12. Jahnsen FL, Haraldsen G, Rugtveit J, Halstensen TS, Brandtzaeg P, (1994) Differential interference contrast microscopy combined with immunofluorescence: a new method to phenotype eosinophils in situ. J Immunol Methods 173: 77-91.
13. Arentz-Hansen H, Korner R, Molberg O, Quarsten H, Vader W, et al. (2000) The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase. J Exp Med 191: 603-612.
14. Shan L, Molberg O, Parrot I, Hausch F, Filiz F, et al. (2002) Structural basis for gluten intolerance in celiac sprue. Science 297: 2275-2279.
15. Molberg O, McAdam SN, Lundin KE, Sollid LM, (2000) Studies of gliadin-specific T-cells in celiac disease. Methods Mol Med 41: 105-124.
16. Wong KL, Tai JJ, Wong WC, Han H, Sem X, et al. (2011) Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets. Blood 118: e16-e31.
17. Tallone T, Turconi G, Soldati G, Pedrazzini G, Moccetti T, et al. (2011) Heterogeneity of human monocytes: an optimized four-color flow cytometry protocol for analysis of monocyte subsets. J Cardiovasc Transl Res 4: 211-219.
18. Shantsila E, Wrigley B, Tapp L, Apostolakis S, Montoro-Garcia S, et al. (2011) Immunophenotypic characterisation of human monocyte subsets: Possible implications for cardiovascular disease pathophysiology. J Thromb Haemost 9: 1056-1066.
19. Leigh RJ, Marsh MN, Crowe P, Kelly C, Garner V, et al. (1985) Studies of intestinal lymphoid tissue. IX. Dose-dependent, gluten-induced lymphoid infiltration of coeliac jejunal epithelium. Scand J Gastroenterol 20: 715-719.
20. Marsh MN, (1992) Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 102: 330-354.
21. Dhesi I, Marsh MN, Kelly C, Crowe P, (1984) Morphometric analysis of small intestinal mucosa. II. Determination of lamina propria volumes; plasma cell and neutrophil populations within control and coeliac disease mucosae. Virchows Arch A Pathol Anat Histopathol 403: 173-180.
22. Marsh MN, Hinde J, (1985) Inflammatory component of celiac sprue mucosa. I. Mast cells, basophils, and eosinophils. Gastroenterology 89: 92-101.
23. Schwartzkopff F, Petersen F, Grimm TA, Brandt E, (2010) CXC chemokine ligand 4 (CXCL4) down-regulates CC chemokine receptor expression on human monocytes. Innate Immun.
24. Cheong C, Matos I, Choi JH, Dandamudi DB, Shrestha E, et al. (2010) Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell 143: 416-429.
25. Schuppan D, Junker Y, Barisani D, (2009) Celiac disease: from pathogenesis to novel therapies. Gastroenterology 137: 1912-1933.
26. Troncone R, Jabri B, (2011) Coeliac disease and gluten sensitivity. J Intern Med 269: 582-590.
27. Rakhimova M, Esslinger B, Schulze-Krebs A, Hahn EG, Schuppan D, et al. (2009) In vitro differentiation of human monocytes into dendritic cells by peptic-tryptic digest of gliadin is independent of genetic predisposition and the presence of celiac disease. J Clin Immunol 29: 29-37.
28. Palova-Jelinkova L, Rozkova D, Pecharova B, Bartova J, Sediva A, et al. (2005) Gliadin fragments induce phenotypic and functional maturation of human dendritic cells. J Immunol 175: 7038-7045.
29. Maiuri L, Ciacci C, Ricciardelli I, Vacca L, Raia V, et al. (2003) Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet 362: 30-37.
30. Diosdado B, van BH, Strengman E, Franke L, van OE, et al. (2007) Neutrophil recruitment and barrier impairment in celiac disease: a genomic study. Clin Gastroenterol Hepatol 5: 574-581.
31. Halstensen TS, Scott H, Fausa O, Brandtzaeg P, (1993) Gluten stimulation of coeliac mucosa in vitro induces activation (CD25) of lamina propria CD4+ T cells and macrophages but no crypt-cell hyperplasia. Scand J Immunol 38: 581-590.
32. Raki M, Molberg O, Tollefsen S, Lundin KE, Sollid LM, (2005) The effects of atorvastatin on gluten-induced intestinal T cell responses in coeliac disease. Clin Exp Immunol 142: 333-340.
33. Bodd M, Raki M, Tollefsen S, Fallang LE, Bergseng E, et al. (2010) HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22. Mucosal Immunol 3: 594-601.