Interaction of regulatory T cells with antigen-presenting cells in health and disease

Chemical Immunology and Allergy

Volumn 94, Issue , 2008, Pages 29-39

  Mahnke, K ^a   Ring, S ^a   Bedke, T ^a   Karakhanova, S ^a   Enk, A ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGY; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CELL INTERACTION; CELL MATURATION; DENDRITIC CELL; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; INFLAMMATION; LYMPHOCYTE DIFFERENTIATION; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; THYMUS;

ANIMALS; ANTIGEN PRESENTATION; B-LYMPHOCYTES; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL MOVEMENT; DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; IMMUNOLOGICAL SYNAPSES; INTERLEUKIN-10; LYMPHOTOXIN-ALPHA; MACROPHAGES; T-LYMPHOCYTES, REGULATORY;

EID: 52249083923     PISSN: 16602242     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000154854     Document Type: Review

References (46)

1. Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature 1998;392:245-252.
2. Mahnke K, Knop J, Enk AH: Induction of tolerogenic DCs: 'you are what you eat'. Trends Immunol 2003;24:646-651.
3. Jonuleit H, Schmitt E, Schuler G, Knop J, Enk AH: Induction of interleukin-10-producing, nonproliferating CD4+ T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 2000;192:1213-1222.
4. Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH: Identification and functional characterization of human CD4+CD25+ T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001;193:1285-1294.
5. Sakaguchi S, Sakaguchi N: Regulatory T cells in immunologic self-tolerance and autoimmune disease. Int Rev Immunol 2005;24:211-226.
6. Mahnke K, Guo M, Lee S, Sepulveda H, Swain SL, Nussenzweig M, Steinman RM: The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J Cell Biol 2000;151:673-684.
7. Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM: Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med 2002;196:1627-1638.
8. Mahnke K, Qian Y, Knop J, Enk AH: Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells. Blood 2003;101:4862-4869.
9. Bruder D, Westendorf AM, Hansen W, Prettin S, Gruber AD, Qian Y, von Böhmer H, Mahnke K, Buer J: On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes. Diabetes 2005;54:3395-3401.
10. Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzweig MC, von Böhmer H: Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 2005;6:1219-1227.
11. Mahnke K, Johnson TS, Ring S, Enk AH: Tolerogenic dendritic cells and regulatory T cells: a two-way relationship. J Dermatol Sci 2007;46:159-167.
12. Min WP, Zhou D, Ichim TE, Strejan GH, Xia X, Yang J, Huang X, Garcia B, White D, Dutartre P, Jevnikar AM, Zhong R: Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J Immunol 2003;170:1304-1312.
13. Misra N, Bayry J, Lacroix-Desmazes S, Kazatchkine MD, Kaveri SV: Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells. J Immunol 2004;172:4676-4680.
14. Cederbom L, Hall H, Ivars F: CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol 2000;30:1538-1543.
15. Kryczek I, Wei S, Zou L, Zhu G, Mottram P, Xu H, Chen L, Zou W: Cutting edge: induction of B7-H4 on APCs through IL-10. Novel suppressive mode for regulatory T cells. J Immunol 2006;177:40-44.
16. Mahnke K, Ring S, Johnson TS, Schallenberg S, Schonfeld K, Storn V, Bedke T, Enk AH: Induction of immunosuppressive functions of dendritic cells in vivo by CD4+CD25+ regulatory T cells: role of B7-H3 expression and antigen presentation. Eur J Immunol 2007;37:2117-2126.
17. Suh WK, Gajewska BU, Okada H, Gronski MA, Bertram EM, Dawicki W, Duncan GS, Bukczynski J, Plyte S, Elia A, Wakeham A, Itie A, Chung S, Da CJ, Arya S, Horan T, Campbell P, Gaida K, Ohashi PS, Watts TH, Yoshinaga SK, Bray MR, Jordana M, Mak TW: The B7 family member B7-H3 preferentially down-regulates T-helper type 1-mediated immune responses. Nat Immunol 2003;4:899-906.
18. Schreiner B, Mitsdoerffer M, Kieseier BC, Chen L, Hartung HP, Weller M, Wiendl H: Interferon-β enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis. J Neuroimmunol 2004;155:172-182.
19. Selenko-Gebauer N, Majdic O, Szekeres A, Hofler G, Guthann E, Korthauer U, Zlabinger G, Steinberger P, Pickl WF, Stockinger H, Knapp W, Stockl J: B7-H1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy. J Immunol 2003;170:3637-3644.
20. Xu J, Huang B, Xiong P, Feng W, Xu Y, Fang M, Zheng F, Gong F: Soluble mouse B7-H3 down-regulates dendritic cell stimulatory capacity to allogenic T cell proliferation and production of IL-2 and IFN-γ. Cell Mol Immunol 2006;3:235-240.
21. Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, Brumlik M, Cheng P, Curiel T, Myers L, Lackner A, Alvarez X, Ochoa A, Chen L, Zou W: B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J Exp Med 2006;203:871-881.
22. Veldhoen M, Moncrieffe H, Hocking RJ, Atkins CJ, Stockinger B: Modulation of dendritic cell function by naive and regulatory CD4+ T cells. J Immunol 2006;176:6202-6210.
23. Hoves S, Krause SW, Schutz C, Halbritter D, Scholmerich J, Herfarth H, Fleck M: Monocyte-derived human macrophages mediate anergy in allogeneic T cells and induce regulatory t cells. J Immunol 2006;177:2691-2698.
24. Taams LS, van Amelsfort JM, Tiemessen MM, Jacobs KM, de Jong EC, Akbar AN, Bijlsma JW, Lafeber FP: Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells. Hum Immunol 2005;66:222-230.
25. Venet F, Pachot A, Debard AL, Bohe J, Bienvenu J, Lepape A, Powell WS, Monneret G: Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism. J Immunol 2006;177:6540-6547.
26. Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, Kerley M, Mucenski ML, Gordon S, Stein-Streilein J: The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J Exp Med 2005;201:1615-1625.
27. Balandina A, Lecart S, Dartevelle P, Saoudi A, Berrih-Aknin S: Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis. Blood 2005;105:735-741.
28. Boyer O, Saadoun D, Abriol J, Dodille M, Piette JC, Cacoub P, Klatzmann D: CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis. Blood 2004;103:3428-3430.
29. Fields ML, Hondowicz BD, Metzgar MH, Nish SA, Wharton GN, Picca CC, Caton AJ, Erikson J: CD4+CD25+ regulatory T cells inhibit the maturation but not the initiation of an autoantibody response. J Immunol 2005;175:4255-4264.
30. Lim HW, Hillsamer P, Kim CH: Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J Clin Invest 2004;114:1640-1649.
31. Lim HW, Hillsamer P, Banham AH, Kim CH: Cutting edge: direct suppression of B cells by CD4+CD25+ regulatory T cells. J Immunol 2005;175:4180-4183.
32. Janssens W, Carlier V, Wu B, VanderElst L, Jacquemin MG, Saint-Remy JM: CD4+ CD25+ T cells lyse antigen- presenting B cells by Fas-Fas ligand interaction in an epitope-specific manner. J Immunol 2003;171:4604-4612.
33. Zhao DM, Thornton AM, DiPaolo RJ, Shevach EM: Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood 2006;107:3925-3932.
34. Reichardt P, Dornbach B, Rong S, Beissert S, Gueler F, Loser K, Gunzer M: Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse. Blood 2007;110:1519-1529.
35. Yang ZZ, Novak AJ, Ziesmer SC, Witzig TE, Ansell SM: CD70+ non-Hodgkin lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25- T cells. Blood 2007;110:2537-2544.
36. Ring S, Schafer SC, Mahnke K, Lehr HA, Enk AH: CD4+ CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue. Eur J Immunol 2006;36:2981-2992.
37. Uhlig HH, Coombes J, Mottet C, Izcue A, Thompson C, Fanger A, Tannapfel A, Fontenot JD, Ramsdell F, Powrie F: Characterization of Foxp3+CD4+ CD25+ and IL-10-secreting CD4+ CD25+ T cells during cure of colitis. J Immunol 2006;177:5852-5860.
38. You S, Leforban B, Garcia C, Bach JF, Bluestone JA, Chatenoud L: Adaptive TGF-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc Natl Acad Sci USA 2007;104:6335-6340.
39. Joetham A, Takeda K, Taube C, Miyahara N, Matsubara S, Koya T, Rha YH, Dakhama A, Gelfand EW: Naturally occurring lung CD4+CD25+ T cell regulation of airway allergic responses depends on IL-10 induction of TGF-β-. J Immunol 2007;178:1433-1442.
40. Hara M, Kingsley CI, Niimi M, Read S, Turvey SE, Bushell AR, Morris PJ, Powrie F, Wood KJ: IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 2001;166:3789-3796.
41. Taylor A, Verhagen J, Blaser K, Akdis M, Akdis CA: Mechanisms of immune suppression by interleukin-10 and transforming growth factor-β: the role of T regulatory cells. Immunology 2006;117:433-442.
42. Read S, Greenwald R, Izcue A, Robinson N, Mandelbrot D, Francisco L, Sharpe AH, Powrie F: Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J Immunol 2006;177:4376-4383.
43. Oida T, Xu L, Weiner HL, Kitani A, Strober W: TGF-β-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling. J Immunol 2006;177:2331-2339.
44. Siegmund K, Feuerer M, Siewert C, Ghani S, Haubold U, Dankof A, Krenn V, Schon MP, Scheffold A, Lowe JB, Hamann A, Syrbe U, Huehn J: Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood 2005;106:3097-3104.
45. Lehmann J, Huehn J, de la Rosa M, Maszyna F, Kretschmer U, Krenn V, Brunner M, Scheffold A, Hamann A: Expression of the integrin αEβ-7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. Proc Natl Acad Sci USA 2002;99:13031-13036.
46. Schwarz A, Maeda A, Schwarz T: Alteration of the migratory behavior of UV-induced regulatory T cells by tissue-specific dendritic cells. J Immunol 2007;178:877-886.