Carcinosarcoma of the ovary: A review of the literature

Gynecologic Oncology

Volumn 125, Issue 1, 2012, Pages 271-277

  Del Carmen, Marcela G ^a   Birrer, Michael ^a   Schorge, John O ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Chemotherapy; Debulking surgery; Ovarian carcinosarcoma; Targeted therapy

Indexed keywords

BEVACIZUMAB; CARBOPLATIN; CETUXIMAB; CISPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; IFOSFAMIDE; PACLITAXEL; PLATINUM; TAXANE DERIVATIVE; TRASTUZUMAB;

CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CANCER SURGERY; CARCINOSARCOMA; CYTOREDUCTIVE SURGERY; FEMALE; HUMAN; MEDLINE; NEUTROPENIA; OVARIAN CARCINOSARCOMA; OVARY CANCER; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; TREATMENT OUTCOME;

CARCINOSARCOMA; COMBINED MODALITY THERAPY; FEMALE; HUMANS; OVARIAN NEOPLASMS; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84858342785     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.12.418     Document Type: Review

References (64)

1. R. Siegel, E. Ward, O. Brawley, and A. Jemal Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths CA Cancer J Clin 61 2011 212 236
2. M.S. Mano, D.D. Rosa, E. Azambuja, G. Ismael, S. Braga, and V. D'Hondt Current management of ovarian carcinosarcoma Int J Gynecol Cancer 17 2007 316 324 (Pubitemid 46426755)
3. M.A. Harris, L.M. Delap, and P.S. Sengupta Carcinosarcoma of the ovary Br J Cancer 88 2003 654 657 (Pubitemid 36411438)
4. J. Barholtz-Sloan, C. Bryant, and R. Morris Survival of women diagnosed with malignant mixed mullerian tumors of the ovary (OMMMT) Gynecol Oncol 93 2004 506 512 (Pubitemid 38507626)
5. J. Chang, J.C. Sharpe, R.P. A'Hern, and C. Fisher Carcinosarcoma of the ovary: incidence, prognosis, treatment and survival of patients Ann Oncol 6 8 1995 755 758
6. E. Brown, M. Stewart, T. Rye, and A. Al-Nafussi Carcinosarcoma of the ovary: 19 years of prospective data from a single center Cancer 100 10 2004 2148 2153 15 (Pubitemid 38580333)
7. E. George, J.C. Marvivel, and L.P. Dehner Malignant mixed mullerian tumors: an immunohistochemical study of 47 cases with histogenic considerations and clinical correlation Hum Pathol 22 1991 215 223
8. R.E. Scully, R.H. Young, and P.B. Clement Tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament J. Rosai, Atlas of tumor pathology, 3rd series, fascicle 23 1998 Armed Forces Institute of Pathology Washington, DC 128 131
9. M. Dictor Malignant mixed mesodermal tumor of the ovary: a report of 22 cases Obstet Gynecol 65 1985 720 724 (Pubitemid 15123948)
10. A.K. Sood, J.I. Sorosky, M.S. Gelder, and R.E. Buller Primary ovarian sarcoma-analysis of prognostic variables and the role of surgical cytoreduction Cancer 82 1998 1731 1737 (Pubitemid 28208925)
11. C.P. Morrow, G. d'Ablaing, L.W. Brady, J.A. Blessing, and M.M. Hreshchyshin A clinical and pathologic study of 30 cases of malignant mixed mullerian epithelial and mesenchymal ovarian tumors: a Gynecologic Oncology Group study Gynecol Oncol 18 1984 278 292 (Pubitemid 14095027)
12. D. Boucher, and B. Tetu Morphologic prognostic factors of malignant mixed mullerian tumors of the ovary: a clinicopathologic study of 15 cases Int J Gynecol Pathol 13 1994 22 28 (Pubitemid 24006330)
13. K. Ariyoshi, S. Kawauchi, T. Kaku, H. Nakano, and M. Tsuneyoshi Prognostic factors in ovarian carcinosarcoma: a clinicopathological and immunohistochemical analysis of 23 cases Histopathology 37 2000 427 436
14. J.D. Seidman, P. Russell, and R.J. Kurman Surface epithelial tumors of the ovary R.J. Kurman, Blaustein's pathology of the female genital tract 5th ed. 2002 Springer-Verlag New York 885 886
15. J.M. Meis, and W.D. Lawrence The immunohistochemical profile of malignant mixed mullerian tumor. Overlap with endometrial adenocarcinoma Am J Clin Pathol 94 1990 1 7 (Pubitemid 20206887)
16. M.J. Costa, and D. Guinee Jr. CD34 immunohistochemistry in female genital tract carcinosarcoma (malignant mixed mullerian tumors) supports a dominant role of the carcinomatous component Appl Immunohistochem Mol Morphol 8 2000 293 299
17. L.E. Cantrell, and L. Van Le Carcinosarcoma of the ovary: a review Obstet Gynecol Surv 64 2009 673 680
18. P. Inthasorn, P. Beale, and C. Dairymple Malignant mixed mullerian tumour of the ovary: prognostic factor and response tof adjuvant platinum-based chemotherapy Aust N Z J Obstet Gynaecol 43 2003 61 64 (Pubitemid 36582531)
19. M. Guarino, F. Giordano, F. Palloti, G. Polizzotti, and P. Tricomi Malignant mixed mullerian tumor of the uterus. Features favoring its origin from a common clone and epithelial-to-mesenchymal transformation mechanism of histogenesis Tumori 84 1998 391 397 (Pubitemid 28313363)
20. Z. Jin, S. Ogata, and G. Tamura Carcinosarcomas (malignant mullerian mixed tumors) of the uterus and ovary: a genetic study with special reference to histogenesis Int J Gynecol Pathol 22 2003 368 373 (Pubitemid 37152987)
21. A. Schipf, D. Mayr, and T. Kichner Molecular genetic aberrations of ovarian and uterine carcinosarcomas-a CGH and FISH study Virchows Arch 452 2008 259 268
22. Y. Sonoda, P.E. Saigo, and M.G. Gederici Carcinosarcoma of the ovary in a patient with germline BRCA2 mutation: evidence for monoclonal origin Gynecol Oncol 76 2000 226 229 (Pubitemid 30067201)
23. W.G. McCluggage Malignant biphasic uterine tumors: carcinosarcomas or metaplastic carcinomas? J Clin Pathol 55 2002 321 325 (Pubitemid 34494168)
24. M. Emoto, H. Iwasaki, and M. Kikucki Two cell lines established from mixed mullerian tumors of the uterus. Morphologic, immunohistochemical and cytogenetic analyses Cancer 69 1992 1759 1768
25. J.S. Ng, A.C. Han, M.I. Edelson, and N.G. Rosenblum Oncoprotein profiles of primary peritoneal malignant mixed mullerian tumors Int J Gynecol Cancer 13 2003 870 874 (Pubitemid 38235234)
26. K.R. Geisinger, D.J. Dabbs, and R.B. Marshall Malignant mixed mullerian tumors: an ultrastructural and immunohistochemical analysis with histogenic consideration Cancer 59 1987 1781 1790 (Pubitemid 17075426)
27. P.A. deBrito, S.G. Silverberg, and J.M. Orenstein Carcinosarcomas (malignant mixed mullerian tumors) of the female genital tract: immunohistochemical and ultrastructural analysis of 28 cases Hum Pathol 24 1993 132 142 (Pubitemid 23066590)
28. H. Wada, T. Enomoto, and M. Fujita Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors Cancer Res 57 1997 1781 1790
29. W.B. Growden, B.N. Roussel, V.L. Scialabba, and R. Foster Tissue-specific signatures of activating PIK3CA and RAS mutations in carcinosarcomas of gynecologic origin Gynecol Oncol 121 2011 212 217
30. A. Gallardo, X. Matias-Guiu, and H. Lagarda Malignant mullerian mixed tumor arising from ovarian serous carcinoma: a clinicopathologic and molecular study of two cases Int J Gynecol Pathol 21 2002 268 272 (Pubitemid 34680344)
31. A.J. Rauh-Hain, W.B. Grodwon, N. Rodriguez, A.K. Goodman, and D. Boruta Carcinosarcoma of the ovary: a case-control study Gynecol Oncol 121 2011 477 481
32. J.F. Silverman, J. Gardner, and E.W. Larkin Ascitic fluid cytology in a case of metastatic malignant mixed mesodermal tumor of the ovary Acta Cytol 30 1986 173 176 (Pubitemid 16051008)
33. E. George, T.J. Lillimoe, and L.B. Twiggs Malignant mixed mullerian tumor versus high-grade endometrial carcinoma and aggressive variants of endometrial carcinoma: a comparative analysis of survival Int J Gynecol Pathol 14 1995 39 44
34. R. Althavale, N. Thomakos, and K. Godrey The effect of epithelial and stromal tumor components on FIGO stages III and IV ovarian carcinosarcomas treated with primary surgery and chemotherapy Int J Gynecol Cancer 17 2007 1025 1030 (Pubitemid 47414830)
35. V. Nayha, and F. Stenback Angiogenesis and expression of angiogenic agents in uterine and ovarian carcinosarcomas APMIS 116 2008 107 117 (Pubitemid 351347588)
36. F. Liu, M.F. Kohler, and J.R. Marks Mutation and overexpression of the p53 tujor suppressor gene frequently occurs in uterine and ovarian sarcomas Obstet Gynecol 83 1994 118 124 (Pubitemid 24027393)
37. T.L. Rutledge, M.A. Gold, and D.S. McMeekin Carcinosarcoma of the ovary-a case series Gynecol Oncol 100 2006 128 132
38. J. Barnholtz-Sloan, C. Bryant, and R. Morris Epidemiology and survival of women diagnosed with malignant mixed mullerian tumors of the ovary (OMMMT) [abstract] Proc Am Soc Clin Oncol 22 2003 467s Abstract 1875
39. R.R. Barakat, S.C. Rubin, and G. Wong Mixed mesodermal tumor of the ovary: analysis of prognostic factors in 31 cases Obstet Gynecol 80 1990 660 664
40. S.C. Plaxe, P.R. Dottline, and H.M. Goodman Clinical features of advanced ovarian mixed mesodermal tumors and treatment with doxorubicin and cisplatin-based chemotherapy Gynecol Oncol 37 1990 244 249 (Pubitemid 20182289)
41. K.Y. Terada, T.L. Johnson, and M. Hopkins Clinicopathologic features of ovarian mixed mesodermal tumors and carcinosarcomas Gynecol Oncol 32 1989 228 232 (Pubitemid 19041967)
42. A.L. Leiser, D.S. Chi, N.M. Ishill, and W.P. Tew Carcinosarcoma of the ovary treated with platinum and taxane: the Memorial-Sloan Kettering Cancer Center experience Gynecol Oncol 105 2007 657 661 (Pubitemid 46734188)
43. H.G. Muntz, M.A. Jones, and B.A. Goff Malignant mixed mullerian tumors of the ovary: experience with surgical cytoreduction and combination chemotherapy Cancer 76 1994 1209 1213
44. L.R. Duska, A. Garrett, and G.H. Eltabakh Paclitaxel and platinum chemotherapy for malignant mixed mullerian tumors of the ovary Gynecol Oncol 85 2002 459 463 (Pubitemid 34651885)
45. B. Anderson, D.A. Turner, and J. Benda Ovarian sarcoma Gynecol Oncol 26 1987 183 192 (Pubitemid 17026677)
46. D.A. Silasi, J.L. Illuzzi, and M.G. Kelly Carcinosarcoma of the ovary Int J Gynecol Cancer 18 2008 22 29
47. C.C. Earle, D. Schrag, and B.A. Neville Effect of surgeon specialty on processes of care and outcomes for ovarian cancer patients J Natl Cancer Inst 98 2006 172 180 (Pubitemid 43205479)
48. M.J. Engelen, H.E. Kos, and P.H. Willemse Surgery by consultant gynecologic oncologists improves survival in patients with ovarian carcinoma Cancer 106 2006 589 598 (Pubitemid 43157622)
49. C.P. Morrow, B.N. Bundy, J. Hoffman A Gynecologic Oncology Group Study Adriamycin chemotherapy for malignant mixed mesodermal tumor of the ovary Am J Clin Oncol 9 1986 24 26 (Pubitemid 16164707)
50. G.P. Sutton, J.A. Blessing, H.D. Homesley A Gynecologic Oncology Group study A phase II trial of ifosfamide and mesna in patients with advanced or recurrent mixed mesodermal tumors of the ovary previously treated with platinum-based chemotherapy Gynecol Oncol 53 1994 24 26
51. J.T. Thigpen, J.A. Blessing, K. DeGeest Gynecologic Oncology Group study Cisplatin as initial chemotherapy in ovarian carcinosarcoma Gynecol Oncol 93 2004 336 339
52. A.S. Sit, F.V. Price, and J.L. Kelley Chemotherapy for malignant mixed mullerian tumors of the ovary Gynecol Oncol 79 2000 196 200
53. D.R. Crotzer, J.K. Wolf, A.D. Jenkins, D.M. Gershenson, and C. Levenback A pilot study of cisplatin, ifosfamide and mesna in the treatment of malignant mixed mesodermal tumors of the ovary Gynecol Oncol 105 2 2007 399 403 (Pubitemid 46590332)
54. N.S. Piver, T.G. DeEulis, and S.B. Tele Cyclophosphamide, vincristine, adriamycin, and dimethyl-triazeno imidazole carboxamide (CYVADIC) for sarcomas of the female genital tract Gynecol Oncol 14 1982 319 323
55. M. Moore, S. Fine, and J. Sturgeon Malignant mixed mesodermal (MMM) tumors of the ovary: the Princess Margaret Hospital (PMH) experience Proc Am Soc Clin Oncol 5 1986 14 17
56. J. Prendiville, D. Murphy, and J. Renninson Carcinosarcoma of the ovary treated over a 10-year period at the Christie Hospital Int J Gynecol Cancer 4 1994 200 205
57. J.E. Mok, Y.M. Kim, and M.H. Jung Malignant mixed mullerina tumors of the ovary: experience with cytoreductive surgery and platinum-based combination chemotherapy Int J Gynecol Cancer 16 2006 101 105
58. I. Cecin, P. Sai, and Y. Eralp Ovarian carcinosarcomas: clinicopathological prognostic factors and evaluation of chemotherapy regimens containing platinum Gynecol Oncol 108 2008 136 140 (Pubitemid 350299436)
59. M. Sawada, H. Tsuda, and M. Kimura Different expression patterns of KIT, EGFR, and HER-2 (c-erb-b-2) oncoprotein between epithelial and mesenchymal components of uterine carcinosarcoma Cancer Sci 94 2003 986 991 (Pubitemid 37508982)
60. M.J. Costa, and J. Walls Epidermal growth factor receptor and c-erb-B-2 oncoprotein expression in female genital tract carcinosarcomas (malignant mixed mullerian tumors). Clinicopathologic study of 82 cases Cancer 77 1996 533 542
61. J.J. Caudell, M.T. Deavers, and B.M. Slomovitz Imatinib mesylate (gleevec)-targeted kinases are expressed in uterine sarcomas Appl Immunohistochem Mol Morphol 13 2005 167 170 (Pubitemid 40726854)
62. M.R. Raspollini, T. Susini, and G. Amunni COX-2, c-KIT, and HER2/neu expression in uterine carcinosarcomas: prognostic factors or potential markers for targeted therapies? Gynecol Oncol 96 2005 159 167 (Pubitemid 39612431)
63. M.P. Zorzou, S. Markaki, and A. Rodalakis Clinicopathological features of ovarian carcinosarcomas: a single institution experience Gynecol Oncol 96 2005 136 142 (Pubitemid 39612428)
64. S. Yamamoto, I. Konishi, and M. Manda Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival and analysis of serum VEGF levels Br J Cancer 76 1997 1221 1227 (Pubitemid 27448021)