Different expression patterns of KIT, EGFR, and HER-2 (c-erbB-2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma

Cancer Science

Volumn 94, Issue 11, 2003, Pages 986-991

  Sawada, Morio ^a,b   Tsuda, Hitoshi ^b   Kimura, Mikihiko ^b   Okamoto, Sanshiro ^b   Kita, Tsunekazu ^b   Kasamatsu, Takahiro ^a   Yamada, Takuro ^a   Kikuchi, Yoshihiro ^b   Honjo, Hideo ^c   Matsubara, Osamu ^b  

^a NATIONAL CANCER CENTER HOSPITAL   (Japan)

^b NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ONCOPROTEIN; TYROSINE KINASE RECEPTOR;

ALLELE; ARTICLE; CANCER INCIDENCE; CHROMOSOME 7; CHROMOSOME STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOMETRIUM; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MESENCHYME; METAPLASIA; ONCOGENE NEU; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTO ONCOGENE; UTERUS CARCINOMA;

CARCINOSARCOMA; CHONDROSARCOMA, MESENCHYMAL; FEMALE; GENE AMPLIFICATION; HUMANS; HYSTERECTOMY; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION, FLUORESCENCE; NEOPLASMS, GLANDULAR AND EPITHELIAL; POLYPLOIDY; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; UTERINE NEOPLASMS;

EID: 0344668685     PISSN: 13479032     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2003.tb01389.x     Document Type: Article

References (43)

1. Ali S, Wells M. Mixed müllerian tumors of the uterine corpus: a review. Int J Gynecol Cancer 1993; 3: 1-11.
2. Silverberg SG, Major FJ, Blessing JA, Fetter B, Askin FB, Liao SY, Miller A. Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus. A Gynecologic Oncology Group pathologic study of 203 cases. Int J Gynecol Pathol 1990; 9: 1-19.
3. de Brito PA, Silverberg SG, Orenstein JM. Carcinosarcoma (malignant mixed müllerian (mesodermal) tumor) of the female genital tract: immunohistochemical and ultrastructural analysis of 28 cases. Hum Pathol 1993; 24: 32-42.
4. Wada H, Enomoto T, Fujita M, Yoshino K, Nakashima R, Kurachi H, Haba T, Wakasa K, Shroyer KR, Tsujimoto M, Hongyo T, Nomura T, Murata Y. Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors. Cancer Res 1997; 57: 5379-85.
5. Gorai I, Yanagibashi T, Taki A, Udagawa K, Miyagi E, Nakazawa T, Hirahara F, Nagashima Y, Minaguchi H. Uterine carcinosarcoma is derived from a single stem cell: an in vitro study. Int J Cancer 1997; 72: 821-7.
6. Fujii H, Yoshida M, Gong ZX, Matsumoto T, Hamano Y, Fukunaga M, Hruban RH, Gabrielson E, Shirai T. Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity. Cancer Res 2000; 60: 4-20.
7. McCluggage WG. Malignant biphasic uterine tumours: carcinosarcomas or metaplastic carcinomas? J Clin Pathol 2002; 55: 321-5.
8. Dinh TV, Slavin RE, Bhagavan BS, Hannigan EV, Tiamson EM, Yandell RB. Mixed müllerian tumors of the uterus: a clinicopathologic study. Obstet Gynecol 1989; 74: 388-92.
9. Nielsen SN, Podratz KC, Scheithauer BW, O'Brien PC. Clinicopathologic analysis of uterine malignant mixed müllerian tumors. Gynecol Oncol 1989; 34: 372-8.
10. Podczaski ES, Woomert CA, Stevens CW Jr, Manetta A, Larson JE, Zaino RJ, Mortel R. Management of malignant, mixed mesodermal tumors of the uterus. Gynecol Oncol 1989; 32: 240-4.
11. Peters WA 3rd, Kumar NB, Fleming WP, Morley GW. Prognostic features of sarcomas and mixed tumors of the endometrium. Obstet Gynecol 1984; 63: 550-6.
12. Nicholson RI, Gee JM, Harper ME. EGFR and cancer prognosis. Eur J Cancer 2001; 37 Suppl 4: S9-15.
13. Ebert AD, Wechselberger C, Martinez-Lacaci I, Bianco C, Weitzel HK, Salomon DS. Expression and function of EGF-related peptides and their receptors in gynecological cancer-from basic science to therapy. J Recept Signal Transduct Res 2000; 20: 1-46.
14. Battifora H, Gaffey M, Esteban J, Mehta P, Bailey A, Faucett C, Niland J. Immunohistochemical assay of neu/c-erbB-2 oncogene product in paraffin-embedded tissues in early breast cancer: retrospective follow-up study of 245 stage I and II cases. Mod Pathol 1991; 4: 466-74.
15. Lupu R, Dickson RB, Lippman ME. The role of erbB-2 and its ligands in growth control of malignant breast epithelium. J Steroid Biochem Mol Biol 1992; 43: 229-36.
16. Ross JS, McKenna BJ. The HER-2/neu oncogene in tumors of the gastrointestinal tract. Cancer Invest 2001; 19: 554-68.
17. Hynes NE. Amplification and overexpression of the erbB-2 gene in human tumors: its involvement in tumor development, significance as a prognostic factor, and potential as a target for cancer therapy. Semin Cancer Biol 1993; 4: 19-26.
18. Berchuck A. Biomarkers in the ovary. J Cell Biochem Suppl 1995; 23: 223-6.
19. Tokunaga A, Onda M, Okuda T, Teramoto T, Fujita I, Mizutani T, Kiyama T, Yoshiyuki T, Nishi K, Matsukura N. Clinical significance of epidermal growth factor (EGF), EGF receptor, and c-erbB-2 in human gastric cancer. Cancer 1995; 75: 1418-25.
20. Besmer P, Murphy JE, George PC, Qiu FH, Bergold PJ, Lederman L, Snyder HW Jr, Brodeur D, Zuckerman EE, Hardy WD. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 1986; 320: 415-21.
21. Williams DE, Eisenman J, Baird A, Rauch C, Van Ness K, March CJ, Park LS, Martin U, Mochizuki DY, Boswell HS, Burgess GS, Cosman D, Lyman SD. Identification of a ligand for the c-kit proto-oncogene. Cell 1990; 63: 67-74.
22. Flanagan JG, Leder P. The kit ligand: a cell surface molecule altered in steel mutant fibroblasts. Cell 1990; 63: 85-94.
23. Zsebo KM, Williams DA, Geissler EN, Broudy VC, Martin FH, Atkins HL, Hsu RY, Birkett NC, Okino KH, Murdock DC, Jacobsen FW, Langley KE, Smith KA, Takeishi T, Cattanach BM, Galli SJ, Suggs SV. Stem cell factor is encoded at the S1 locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 1990; 63: 213-24.
24. Russel ES, Thompson MW, McFarland E. Analysis of effects of W and f genic substitutions on fetal mouse hematology. Genetics 1968; 58: 259-70.
25. Kitamura Y, Go S. Decreased production of mast cells in S1/S1d anemic mice. Blood 1979; 53: 492-7.
26. Besmer P, Manova K, Duttlinger R, Huang EJ, Packer A, Gyssler C, Bachvarova RF. The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis. Dev Suppl; 1993: 125-37.
27. Huizinga JD, Thuneberg L, Kluppel M, Malysz J, Mikkelsen HB, Bernstein A. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 1995; 373: 347-9.
28. Miettinen M, Lasota J. Gastrointestinal stromal tumors-definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 2001; 438: 1-12.
29. Cheuk W, Lee KC, Chan JK. c-kit immunocytochemical staining in the cytologic diagnosis of metastatic gastrointestinal stromal tumor. A report of two cases. Acta Cytol 2000; 44: 679-85.
30. Goselink HM, Williams DE, Fibbe WE, Wessels HW, Beverstock GC, Willemze R, Falkenburg JH. Effect of mast cell growth factor (c-kit ligand) on clonogenic leukemic precursor cells. Blood 1992; 80: 750-7.
31. Cohen PS, Chan JP, Lipkunskaya M, Biedler JL, Seeger RC. Expression of stem cell factor and c-kit in human neuroblastoma. The Children' s Cancer Group. Blood 1994; 84: 3465-72.
32. Tsuura Y, Hiraki H, Watanabe K, Igarashi S, Shimamura K, Fukuda T, Suzuki T, Seito T. Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues. Virchows Arch 1994; 424: 135-41.
33. Natali PG, Nicotra MR, Sures I, Mottolese M, Botti C, Ullrich A. Breast cancer is associated with loss of the c-kit oncogene product. Int J Cancer 1992; 52: 713-7.
34. Toyota M, Hinoda Y, Takaoka A, Makiguchi Y, Takahashi T, Itoh F, Imai K, Yachi A. Expression of c-kit and kit ligand in human colon carcinoma cells. Tumour Biol 1993; 14: 295 -302.
35. Inoue M, Kyo S, Fujita M, Enomoto T, Kondoh G. Coexpression of the c-kit receptor and the stem cell factor in gynecological tumors. Cancer Res 1994; 54: 3049-53.
36. Sekido Y, Obata Y, Ueda R, Hida T, Suyama M, Shimokata K, Ariyoshi Y, Takahashi T. Preferential expression of c-kit protooncogene transcripts in small cell lung cancer. Cancer Res 1991; 51: 2416-9.
37. Tsuda H, Kitada S, Hasegawa T, Tani Y, Murata T, Tamai S, Hirohashi S, Matsubara O, Natori T. Frequent concurrence of expression the KIT oncoprotein and epidermal growth factor receptor overexpression in special histologic subtypes of human breast cancer. Proc Am Assoc Cancer Res 2003; 44 (2nd ed): 4449.
38. Scobie JV, Acs G, Bandera CA, Blank SV, Wheeler JE, Pasha TL, Salscheider M, Zhang PJ. C-kit immunoreactivity in endometrial adenocarcinomas and its clinicopathologic significance. Int J Gynecol Pathol 2003; 22: 149-55.
39. Klein WM, Kurman RJ. Lack of expression of c-kit protein (CD 117) in mesenchymal tumors of the uterus and ovary. Int J Gynecol Pathol 2003; 22: 181-4.
40. Berchuck A, Soisson AP, Olt GJ, Soper JT, Clarke-Pearson DL, Bast RC Jr, McCarty KS Jr. Epidermal growth factor receptor expression in normal and malignant endometrium. Am J Obstet Gynecol 1989; 161: 1247-52.
41. Khakifa MA, Abdoh AA, Mannel RS, Haraway SD, Walker JL, Min KW. Prognostic utility of epidermal growth factor receptor overexpression in endometrial adenocarcinoma. Cancer 1994; 73: 370-6.
42. Reinartz JJ, George E, Lindgren BR, Niehans GA. Expression of p53, transforming growth factor alpha, epidermal growth factor receptor, and cerbB-2 in endometrial carcinoma and correlation with survival and known predictors of survival. Hum Pathol 1994; 25: 1075-83.
43. Swisher EM, Gown AM, Skelly M, Ek M, Tamimi HK, Cain JM, Greer BE, Muntz HG, Goff BA. The expression of epidermal growth factor receptor, HER-2/Neu, p53, and Ki-67 antigen in uterine malignant mixed mesodermal tumors and adenosarcoma. Gynecol Oncol 1996; 60: 81-88.