The effect of epithelial and stromal tumor components on FIGO stages III and IV ovarian carcinosarcomas treated with primary surgery and chemotherapy

International Journal of Gynecological Cancer

Volumn 17, Issue 5, 2007, Pages 1025-1030

  Athavale, R ^a   Thomakos, N ^a   Godfrey, K ^a   Kew, F ^a   Cross, P ^a   De Barros Lopes, A ^a   Hatem, M H ^a   Naik, R ^a  

^a QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

Carcinosarcoma; Chemotherapy; Mixed m llerian tumor; Ovary

Indexed keywords

CARBOPLATIN; DOXORUBICIN; IFOSFAMIDE; PACLITAXEL;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CANCER CENTER; CANCER CHEMOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CARCINOSARCOMA; CLINICAL ARTICLE; CYTOREDUCTIVE SURGERY; DATA BASE; ENDOMETRIOID CARCINOMA; EPITHELIUM; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MIXED MULLERIAN TUMOR; MONOTHERAPY; OVARY CARCINOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; STROMA; SURVIVAL TIME; TREATMENT OUTCOME; UNIVARIATE ANALYSIS;

AGED; AGED, 80 AND OVER; CARCINOSARCOMA; CHEMOTHERAPY, ADJUVANT; EPITHELIAL CELLS; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM STAGING; OVARIAN NEOPLASMS; STROMAL CELLS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 34548675592     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1111/j.1525-1438.2007.00919.x     Document Type: Article

References (28)

1. Dehner LP, Norris HJ, Taylor HB. Carcinosarcomas and mixed mesodermal tumors of the ovary. Cancer 1971 27 : 207 16.
2. Brown E, Stewart M, Rye T et al. Carcinosarcoma of the ovary: 19 years of prospective data from a single center. Cancer 2004 100 : 2148 53.
3. Amant F, Vloeberghs V, Woestenborghs H, Moerman P, Vergote I. Transition of epithelial toward mesenchymal differentiation during ovarian carcinosarcoma tumorigenesis. Gynecol Oncol 2003 90 : 372 7.
4. Sreenan JJ, Hart WR. Carcinosarcomas of the female genital tract. A pathologic study of 29 metastatic tumors: further evidence for the dominant role of the epithelial component and the conversion theory of histogenesis. Am J Surg Pathol 1995 19 : 666 74.
5. Barakat RR, Rubin SC, Wong G, Saigo PE, Markman M, Hoskins WJ. Mixed mesodermal tumor of the ovary: analysis of prognostic factors in 31 cases. Obstet Gynecol 1992 80 : 660 4.
6. Ariyoshi K, Kawauchi S, Kaku T, Nakano H, Tsuneyoshi M. Prognostic factors in ovarian carcinosarcoma: a clinicopathological and immunohistochemical analysis of 23 cases. Histopathology 2000 37 : 427 36.
7. Chang J, Sharpe JC, A'Hern RP et al. Carcinosarcoma of the ovary: incidence, prognosis, treatment and survival of patients. Ann Oncol 1995 6 : 755 8.
8. Muntz HG, Jones MA, Goff BA et al. Malignant mixed mullerian tumors of the ovary: experience with surgical cytoreduction and combination chemotherapy. Cancer 1995 76 : 1209 13.
9. Morrow CP, d'Ablaing G, Brady LW, Blessing JA, Hreshchyshyn MM. A clinical and pathologic study of 30 cases of malignant mixed mullerian epithelial and mesenchymal ovarian tumors: a Gynecologic Oncology Group study. Gynecol Oncol 1984 18 : 278 92.
10. Barnholtz-Sloan JS, Morris R, Malone JM Jr., Munkarah AR. Survival of women diagnosed with malignant, mixed mullerian tumors of the ovary (OMMMT). Gynecol Oncol 2004 93 : 506 12.
11. Mok JE, Kim YM, Jung MH et al. Malignant mixed mullerian tumors of the ovary: experience with cytoreductive surgery and platinum-based combination chemotherapy. Int J Gynecol Cancer 2006 16 : 101 5.
12. Rutledge TL, Gold MA, McMeekin DS et al. Carcinosarcoma of the ovary- - a case series. Gynecol Oncol 2006 100 : 128 32.
13. Kounelis S, Jones MW, Papadaki H, Bakker A, Swalsky P, Finkelstein SD. Carcinosarcomas (malignant mixed mullerian tumors) of the female genital tract: comparative molecular analysis of epithelial and mesenchymal components. Hum Pathol 1998 29 : 82 7.
14. Czernobilsky B, LaBarre GC. Carcinosarcoma and mixed mesodermal tumor of the ovary. A clinicopathologic analysis of 9 cases. Obstet Gynecol 1968 31 : 21 32.
15. Plaxe SC, Dottino PR, Goodman HM, Deligdisch L, Idelson M, Cohen CJ. Clinical features of advanced ovarian mixed mesodermal tumors and treatment with doxorubicin- and cis-platinum-based chemotherapy. Gynecol Oncol 1990 37 : 244 9.
16. Dinh TV, Slavin RE, Bhagavan BS, Hannigan EV, Tiamson EM, Yandell RB. Mixed mesodermal tumors of the ovary: a clinicopathologic study of 14 cases. Obstet Gynecol 1988 72 (3 Pt 1 409 12.
17. Suggs CL III., Lee JL Jr., Choi H, Lewis GC. Malignant mixed mesodermal tumors of the ovary. A report of 13 cases. Am J Clin Oncol 1988 11 : 12 5.
18. Tate Thigpen J, Blessing JA, DeGeest K, Look KY, Homesley HD. Cisplatin as initial chemotherapy in ovarian carcinosarcomas: a Gynecologic Oncology Group study. Gynecol Oncol 2004 93 : 336 9.
19. Pfeiffer P, Hardt-Madsen M, Rex S, Holund B, Bertelsen K. Malignant mixed mullerian tumors of the ovary. Report of 13 cases. Acta Obstet Gynecol Scand 1991 70 : 79 83.
20. Duska LR, Garrett A, Eltabbakh GH, Oliva E, Penson R, Fuller AF. Paclitaxel and platinum chemotherapy for malignant mixed mullerian tumors of the ovary. Gynecol Oncol 2002 85 : 459 63.
21. Naik R, Nordin A, Cross PA, Hemming D, de Barros Lopes A, Monaghan JM. Optimal cytoreductive surgery is an independent prognostic indicator in stage IV epithelial ovarian cancer with hepatic metastases. Gynecol Oncol 2000 78 : 171 5.
22. Harris MA, Delap LM, Sengupta PS et al. Carcinosarcoma of the ovary. Br J Cancer 2003 88 : 654 7.
23. Gourley C, Al-Nafussi A, Abdulkader M, Smyth JF, Gabra H. Malignant mixed mesodermal tumours: biology and clinical aspects. Eur J Cancer 2002 38 : 1437 46.
24. Morrow CP, Bundy BN, Hoffman J, Sutton G, Homesley H. Adriamycin chemotherapy for malignant mixed mesodermal tumor of the ovary. A Gynecologic Oncology Group Study. Am J Clin Oncol 1986 9 : 24 6.
25. Andersen WA, Young DE, Peters WA III., Smith EB, Bagley CM, Taylor PT Jr. Platinum-based combination chemotherapy for malignant mixed mesodermal tumors of the ovary. Gynecol Oncol 1989 32 : 319 22.
26. Bicher A, Levenback C, Silva EG, Burke TW, Morris M, Gershenson DM. Ovarian malignant mixed mullerian tumors treated with platinum-based chemotherapy. Obstet Gynecol 1995 85 (5 Pt 1 735 9.
27. Hellstrom AC, Tegerstedt G, Silfversward C, Pettersson F. Malignant mixed mullerian tumors of the ovary: histopathologic and clinical review of 36 cases. Int J Gynecol Cancer 1999 9 : 312 6.
28. Le T, Krepart GV, Lotocki RJ, Heywood MS. Malignant mixed mesodermal ovarian tumor treatment and prognosis: a 20-year experience. Gynecol Oncol 1997 65 : 237 40.