Carcinosarcomas (malignant mullerian mixed tumors) of the uterus and ovary: A genetic study with special reference to histogenesis

International Journal of Gynecological Pathology

Volumn 22, Issue 4, 2003, Pages 368-373

  Jin, Zhe ^a   Ogata, Shinya ^a   Tamura, Gen ^a   Katayama, Yousei ^b   Fukase, Masayuki ^c   Yajima, Mihoko ^d   Motoyama, Teiichi ^a  

^a YAMAGATA UNIVERSITY   (Japan)

^b Hachinohe Municipal Hospital   (Japan)

^c Department of Pathology   (Japan)

^d Sakata Municipal Hospital   (Japan)

Author keywords

Carcinosarcoma; Histogenesis; Malignant mullerian mixed tumor; Ovary; Uterus

Indexed keywords

DNA; K RAS PROTEIN; PROTEIN P53; RAS PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CARCINOSARCOMA; CELL CLONE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC ANALYSIS; GYNECOLOGIC CANCER; HISTOGENESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROSATELLITE MARKER; MIXED MULLERIAN TUMOR; MOLECULAR BIOLOGY; ONCOGENE K RAS; OVARY CARCINOMA; PATHOLOGICAL ANATOMY; PRIORITY JOURNAL; PROTEIN ANALYSIS; UTERUS CARCINOMA; UTERUS SARCOMA; X CHROMOSOME INACTIVATION;

ADULT; AGED; CHROMOSOMES, HUMAN, X; DNA MUTATIONAL ANALYSIS; FEMALE; GENE SILENCING; GENES, P53; GENES, RAS; HUMANS; IMMUNOHISTOCHEMISTRY; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; MIDDLE AGED; MIXED TUMOR, MULLERIAN; MUTATION; OVARIAN NEOPLASMS; POLYMERASE CHAIN REACTION; UTERINE NEOPLASMS;

EID: 0141569560     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pgp.0000092134.88121.56     Document Type: Article

References (24)

1. Silverberg SG, Kurman RJ. Tumors of the Uterine Corpus and Gestational Trophoblastic Disease: Atlas of Tumor Pathology. 3rd Series, Fascicle 3, Washington DC: Armed Forces Institute of Pathology, 1992:166-77.
2. Gorstein F, Anderson TL. Malignant mixed mesodermal tumors: carcinoma, sarcoma, or both? Hum Pathol 1991;22:207-9.
3. Emoto M, Iwasaki H, Kikuchi M, et al. Characteristics of cloned cells of mixed mullerian tumor of the human uterus. Carcinoma cells showing myogenic differentiation in vitro. Cancer 1993;71: 3065-75.
4. Gorai I, Yanagibashi T, Taki A, et al. Uterine carcinosarcoma is derived from a single stem cell: an in vitro study. Int J Cancer 1997;72:821-7.
5. Ishikawa S, Kaneko H, Sumida T, et al. Ultrastructure of mesodermal mixed tumor of the uterus. Acta Pathol Jpn 1979;29:801-9.
6. George E, Manivel JC, Dehner LP, et al. Malignant mixed mullerian tumors: an immunohistochemical study of 47 cases, with histogenetic considerations and clinical correlation. Hum Pathol 1991;22:215-23.
7. Haba R, Kobayashi S, Miki H, et al. Mixed mesodermal tumor of the ovary: imunohistochemical study with histogenetic consideration. Acta Pathol Jpn 1993;43:696-701.
8. Silverberg SG, Major FJ, Blessing JA, et al. Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus. A gynecologic oncology group pathologic study of 203 cases. Int J Gynecol Pathol 1990;9:1-19.
9. De Brito PA, Silverberg SG, et al. Carcinosarcoma (malignant mixed mullerian [mesodermal] tumor) of the female genital tract: immunohistochemical and ultrastructural analysis of 28 cases. Hum Pathol 1993;24:132-42.
10. Matias-Guiu X, Lagarda H, Catasus L, et al. Clonality analysis in synchronous or metachronous tumors of the female genital tract. Int J Gynecol Pathol 2002;21:205-11.
11. Wada H, Enomoto T, Fujita M, et al. Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors. Cancer Res 1997;57:5379-85.
12. Kounelis S, Jones MW, Papadaki H, et al. Carcinosarcomas (malignant mixed mullerian tumors) of the female genital tract: comparative molecular analysis of epithelial and mesenchymal components. Hum Pathol 1998;29:82-7.
13. Gallardo A, Matias-Guiu X, Lagarda H, et al. Malignant mullerian mixed tumor arising from ovarian serous carcinoma: A clinicopathologic and molecular study of two cases. Int J Gynecol Pathol 2002;21:268-72.
14. Abeln ECA, Smit VT, Wessels JW, et al. Molecular genetic evidence for the conversion hypothesis of the origin of malignant mixed mullerian tumours. J Pathol 1997;183:424-31.
15. Fujii H, Yoshida M, Gong ZX, et al. Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity. Cancer Res 2000;60:114-20.
16. Goelz SE, Hamilton SR, Vogelstein B. Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. Biophys Res Commun 1985;130:118-26.
17. Allen RC, Zoghbi HY, Moseley AB, et al. Methylation of Hpa and Hha sites near the polymorphic CAG repeat in the human androgen receptor gene correlates with X chromosome inactivation. Am J Hum Genet 1992;51:1229-39.
18. Sakata K. Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma. J Oral Pathol Med 1996;25:302-7.
19. Suzuki Y, Tamura G, Maesawa C, et al. Analysis of genetic alterations in renal cell carcinoma using the polymerase chain reaction. Virchows Arch 1994;424:453-7.
20. Imamura T, Arima T, Kato H, et al. Chromosomal deletions and K-ras mutation in human endometrial carcinomas. Int J Cancer 1992;51:47-52.
21. Peiffer SL, Herzog TJ, Tribune DJ, et al. Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers. Cancer Res 1995;55:1922-6.
22. Kihana T, Yano N, Murao S, et al. Allelic loss of chromosome 16q in endometrial cancer: correlation with poor prognosis of patients and less differentiated histology. Jpn J Cancer Res 1996;87: 1184-90.
23. Ronnett BM, Burks RT, Cho KR, et al. DCC genetic alteration and expression in endometrial carcinoma. Mod Pathol 1997;10:38-46.
24. Nishizuka S, Tamura G, Terashima M, et al. Loss of heterozygosity during the development and progression of differentiated adenocarcinoma of the stomach. J Pathol 1998;185:38-43.