Abnormal sleep/wake dynamics in orexin knockout mice

Sleep

Volumn 33, Issue 3, 2010, Pages 297-306

  Diniz Behn, Cecilia G ^a,b,c   Klerman, Elizabeth B ^b   Mochizuki, Takatoshi ^a   Lin, Shih Chieh ^d   Scammell, Thomas E ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cataplexy; EEG; Narcolepsy; Orexin hypocretin; Sleep

Indexed keywords

OREXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATAPLEXY; CONTROLLED STUDY; DELTA RHYTHM; ELECTROENCEPHALOGRAPHY; KNOCKOUT MOUSE; MALE; MOUSE; NARCOLEPSY; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REM SLEEP; SIGNAL TRANSDUCTION; SLEEP; SLEEP WAKING CYCLE; SPECTROSCOPY; THETA RHYTHM; WAKEFULNESS; WILD TYPE;

EID: 77649248943     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.1093/sleep/33.3.297     Document Type: Article

References (32)

1. Broughton R, Valley V, Aguirre M, Roberts J, Suwalski W, Dunham W. Excessive daytime sleepiness and the pathophysiology of narcolepsycataplexy: a laboratory perspective. Sleep 1986;9:205-15.
2. Peyron C, Tighe DK, van den Pol AN, et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998;18:9996-10015.
3. Thannickal TC, Moore RY, Nienhuis R, et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000;27:469-74.
4. Lin L, Faraco J, Li R, et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 1999;98:365-76.
5. Taheri S, Zeitzer JM, Mignot E. The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annu Rev Neurosci 2002;25:283-313.
6. Lee MG, Hassani OK, Jones BE. Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J Neurosci 2005;25:6716-20.
7. Mileykovskiy BY, Kiyashchenko LI, Siegel JM. Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 2005;46:787-98.
8. Takahashi K, Lin JS, Sakai K. Neuronal activity of orexin and non-orexin waking-active neurons during wake-sleep states in the mouse. Neuroscience 2008;153:860-70.
9. Adamantidis AR, Zhang F, Aravanis AM, Deisseroth K, de Lecea L. Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature 2007;450:420-4.
10. Mochizuki T, Crocker A, Mccormack S, Y anagisawa M, Sakurai T, Scammell TE. Behavioral state instability in orexin knock-out mice. J Neurosci 2004;24:6291-300.
11. Chemelli RM, Willie JT, Sinton CM, et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999;98:437-51.
12. Baker TL, Foutz AS, McNerney V, Mitler MM, Dement WC. canine model of narcolepsy: genetic and developmental determinants. Exp Neurol 1982;75:729-42.
13. Nishino S, Riehl J, Hong J, Kwan M, Reid M, Mignot E. Is narcolepsy a REM sleep disorder? analysis of sleep abnormalities in narcoleptic dobermans. neurosci res 2000;38:437-446.
14. Gervasoni D, Lin SC, Ribeiro S, Soares ES, Pantoja J, Nicolelis MA. global forebrain dynamics predict rat behavioral states and their transitions. J Neurosci 2004;24:11137-47.
15. Dzirasa K, Ribeiro S, Costa R, et al. Dopaminergic control of sleep-wake states. J Neurosci 2006;26:10577-10589.
16. Lin SC, Gervasoni D. Defining global brain states using multielectrode field potential recordings. In: Nicolelis MA, ed. Methods for neural ensemble recordings. 2nd ed. CRC Press; 2007.
17. Fujiki N, Cheng T, Yoshino F, Nishino S. Specificity of direct transition from wake to REM sleep in orexin/ataxin-3 transgenic narcoleptic mice. Exp Neurol 2009;217:46-54.
18. Scammell TE, Willie JT, Guilleminault C, Siegel JM. A consensus defi ni- definition of cataplexy in mouse models of narcolepsy. Sleep 2009;32:111-6.
19. Czurko A, Hirase H, Csicsvari J, Buzsaki G. Sustained activation of hippocampal pyramidal cells by 'space clamping' in a running wheel. Eur J Neurosci 1999;11:344-52.
20. Khatami R, Landolt HP, Achermann P, et al. Insufficient non-REM sleep intensity in narcolepsy-cataplexy. Sleep 2007;30:980-9.
21. Khatami R, Landolt HP, Achermann P, et al. Challenging sleep homeostasis in narcolepsy-cataplexy: implications for non-REM and REM sleep regulation. sleep 2008;31:859-67.
22. Anderson MP, Mochizuki T, Xie J, et al. Thalamic cav3.1 t-type ca2+ channel plays a crucial role in stabilizing sleep. Proc Nat Acad Sci U S A 2005;102:1743-8.
23. Joho RH, Ho CS, Marks GA. Increased gamma- and decreased deltaoscillations in a mouse deficient for a potassium channel expressed in fast-spiking interneurons. J Neurophysiol 1999;82:1855-64.
24. Wisor JP, Wurts SW, Hall FS, Lesch KP, Murphy DL, Uhl GR, Edgar dM. Altered rapid eye movement sleep timing in serotonin transporter knockout mice. Neuroreport 2003;14:233-8.
25. Willie JT, Chemelli RM, Sinton CM, et al. Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: molecular genetic dissection of non-REM and REM sleep regulatory processes. Neuron 2003;38:715-30.
26. Hu K, Van Someren EJ, Shea SA, Scheer FA. Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker. Proc Nat Acad Sci U S A 2009;106:2490-4.
27. Schwab K, Groh T, Schwab M, Witte H. Nonlinear analysis and modeling of cortical activation and deactivation patterns in the immature fetal electrocorticogram. chaos (Woodbury, NY 2009;19:015111.
28. Carvalho-Bos SS, Riemersma-van der Lek RF, Waterhouse J, Reilly T, Van Someren EJ. Strong association of the rest-activity rhythm with well-being in demented elderly women. Am J Geriatr Psychiatry 2007;15:92-100.
29. Diniz Behn CG, Kopell N, Brown EN, Mochizuki T, Scammell TE. Delayed orexin signaling consolidates wakefulness and sleep: physiology and modeling. J Neurophysiol 2008;99:3090-103.
30. Saper CB, Cano G, Scammell TE. Homeostatic, circadian, and emotional regulation of sleep. J Comp Neurol 2005;493:92-8.
31. Hara J, Beuckmann CT, Nambu T, et al. Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 2001;30:345-54.
32. Park DH, Kwon JS, Jeong DU. Changes of EEG coherence in narcolepsy measured with computerized EEG mapping technique. Sleep Med Psychophysiol 2001;8:121-8.