A local effect of CYP24 inhibition on lung tumor xenograft exposure to 1,25-dihydroxyvitamin D 3 is revealed using a novel LC-MS/MS assay

Steroids

Volumn 77, Issue 5, 2012, Pages 477-483

  Beumer, Jan H ^a,b   Parise, Robert A ^a,b   Kanterewicz, Beatriz ^a   Petkovich, Martin ^c,d   D'Argenio, David Z ^e   Hershberger, Pamela A ^a,f,g  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c Cytochroma   (Canada)

^d QUEEN S UNIVERSITY   (Canada)

^e University of Southern California   (United States)

^f UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^g ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

1,25 Dihydroxyvitamin D 3; CTA091; CYP24; Lung cancer; Pharmacokinetics

Indexed keywords

25 HYDROXYCOLECALCIFEROL 24 HYDROXYLASE; CALCIFEDIOL; CTA 091; CYTOCHROME P450 INHIBITOR; CYTOCHROME P450 ISOENZYME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DISPOSITION; DRUG TISSUE LEVEL; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LUNG TUMOR; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TANDEM MASS SPECTROMETRY; TUMOR XENOGRAFT; VITAMIN BLOOD LEVEL;

ANIMALS; AREA UNDER CURVE; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; ENZYME INHIBITORS; FEASIBILITY STUDIES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LUNG NEOPLASMS; MASS SPECTROMETRY; MICE; MICE, NUDE; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEROID HYDROXYLASES; VITAMIN D; VITAMINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS;

EID: 84858339084     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.01.007     Document Type: Article

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