Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2

Biochemical Journal

Volumn 443, Issue 1, 2012, Pages 85-94

  Boo, Irene ^a   Tewierik, Kevin ^a   Douam, Florian ^b,c,d   Lavillette, Dimitri ^b,c,d   Poumbourios, Pantelis ^a,e   Drummer, Heidi E ^a,e,f  

^a MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH   (Australia)

^b UNIVERSITÉ LYON 1   (France)

^c CENTRE INTERNATIONAL DE RECHERCHE EN INFECTIOLOGIE   (France)

^d UNIVERSITÉ DE LYON   (France)

^e MONASH UNIVERSITY   (Australia)

^f UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

CD81; Glycoprotein; Hepatitis C virus (HCV); Heterodimerization; Protonation; Virus entry

Indexed keywords

ALANINE; ARGININE; BAFILOMYCIN A1; CD81 ANTIGEN; GLYCOPROTEIN E1; GLYCOPROTEIN E2; HISTIDINE;

ARTICLE; BINDING SITE; CELL FUSION; CELL STRAIN HEK293; DIMERIZATION; ENDOSOME; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN SYNTHESIS; PROTON TRANSPORT; RECEPTOR BINDING; VIRUS ENTRY; VIRUS MUTATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGENS, CD81; CONSERVED SEQUENCE; HEK293 CELLS; HEPACIVIRUS; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; VIRAL ENVELOPE PROTEINS; VIRION; VIRUS INTERNALIZATION;

HEPATITIS C VIRUS;

EID: 84858324994     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110868     Document Type: Article

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