Transforming growth factor-β 1 promotes nasal mucosal mast cell chemotaxis in murine experimental allergic rhinitis

ORL

Volumn 74, Issue 3, 2012, Pages 117-123

  Ouyang, Yuhui ^a   Nakao, Atsuhito ^c   Han, Demin ^a,b   Zhang, Luo ^a,b  

^a BEIJING INSTITUTE OF OTOLARYNGOLOGY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Allergic rhinitis; Mast cells; RhoA; Transforming growth factor 1

Indexed keywords

1 (5 IODO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; HTS 466284; MYOSIN LIGHT CHAIN KINASE INHIBITOR; OVALBUMIN; PROTEIN KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ALLERGIC RHINITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; EXPERIMENTAL MODEL; FEMALE; IMMUNOHISTOCHEMISTRY; MAST CELL; MOUSE; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENSITIZATION; WESTERN BLOTTING;

ADP RIBOSE TRANSFERASES; ANIMALS; AZEPINES; BOTULINUM TOXINS; CHEMOTAXIS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENZYME INHIBITORS; FEMALE; MAST CELLS; MICE; MICE, INBRED BALB C; NAPHTHALENES; NASAL MUCOSA; OVALBUMIN; RHINITIS, ALLERGIC, PERENNIAL; RHOA GTP-BINDING PROTEIN; SMAD2 PROTEIN; SPECIFIC PATHOGEN-FREE ORGANISMS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84858303934     PISSN: 03011569     EISSN: 14230275     Source Type: Journal    
DOI: 10.1159/000328587     Document Type: Article

References (19)

1. Attisano L, Wrana JL: Signal transduction by the TGF-β superfamily. Science 2002;296:1646-1647.
2. Gleizes PE, Rifkin DB: Activation of latent TGF-betaA required mechanism for vascular integrity. Pathol Biol 1999;47:322-329.
3. Nakao A, Röijer E, Imamura T, Souchelnytskyi S, Stenman G, Heldin CH, et al: Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway. J Biol Chem 1997;272:2896-2900.
4. Blobe GC, Schiemann WP, Lodish HF: Role of transforming growth factor-β in human disease. N Engl J Med 2000;342: 1350-1385.
5. Sagara H, Okada T, Okumura K, Ogawa H, Ra C, Fukuda T, et al: Activation of TGF-β / Smad2 signaling is associated with airway remodeling in asthma. J Allergy Clin Immunol 2002;110:249-254.
6. Ouyang Y, Miyata M, Hatsushika K, Ohnuma Y, Katoh R, Ogawa H, et al: TGF-beta signaling may play a role in the development of goblet cell hyperplasia in a mouse model of allergic rhinitis. Allergol Int 2010;59:313-319.
7. Bousquet J, Van Cauwenberge P, Khaltaev N: Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001;108:147-334.
8. Ogasawara H, Asakura K, Saito H, Kataura A: Role of CD4-positive T cells in the pathogenesis of nasal allergy in the murine model. Int Arch Allergy Immunol 1999;118:37-43.
9. Karnoub AE, Symons M, Campbell SL: Molecular basis for Rho GTPase signaling specificity. Breast Cancer Res Treat 2004;84:61-71.
10. Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA: Transforming growth factor-βregulation in immune responses. Ann Rev Immunol 2006;25:455-471.
11. Letterio JJ, Roberts AB: Regulation of immune responses by TGF-beta. Ann Rev Immunol 1998;16:137-161.
12. Reibman J, Meixler S, Lee TC, Gold LI, Cronstein BN, Haines KA, et al: Transforming growth factor beta 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways. Proc Natl Acad Sci USA 1991;88:6805-6809.
13. Olsson N, Piek E, ten Dijke P, Nilsson G: Human mast cell migration in response to members of the transforming growth factor-β family. J Leukoc Biol 2000;67:350-356.
14. Luster AD, Alon R, Von Andrian UH: Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol 2005;6:1182-1190.
15. Etienne-Manneville S, Hall A: Rho GTPases in cell biology. Nature 2002;420:629-635.
16. Edlund S, Landstrom M, Heldin CH, Aspenstrom P: Transforming growth factor-β-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell 2002;13:902-914.
17. Meriane M, Charrasse S, Comunale F, Gauthier-Rouviere C: Transforming growth factor β activates Rac1 and Cdc42Hs GTPases and the JNK pathway in skeletal muscle cells. Biol Cell 2002;94:535-543.
18. Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, et al: Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 2001;12:27-36.
19. Kim JS, Kim JG, Moon MY, Jeon CY, Won HY, Kim HJ, et al: Transforming growth factor-beta1 regulates macrophage migration via RhoA. Blood 2006;108:1821-1829.