Favourable involvement of α 2A-adrenoreceptor antagonism in the I 2-imidazoline binding sites-mediated morphine analgesia enhancement

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 7, 2012, Pages 2259-2265

  Mammoli, Valerio ^a   Bonifazi, Alessandro ^a   Del Bello, Fabio ^a   Diamanti, Eleonora ^a   Giannella, Mario ^a   Hudson, Alan L ^b   Mattioli, Laura ^a   Perfumi, Marina ^a   Piergentili, Alessandro ^a   Quaglia, Wilma ^a   Titomanlio, Federica ^a   Pigini, Maria ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

2A Adrenoreceptor antagonists; 1,4 Dioxane nucleus; I 2 IBS morphine analgesia modulation; Morphine analgesia enhancement

Indexed keywords

(5 PHENYL 1,4 DIOXAN 2 YL)METHANOL; 1,4 DIOXANE DERIVATIVE; 2 (5 PHENYL 1,4 DIOXAN 2 YL) 4,5 DIHYDRO 1H IMIDAZOLE; 2 (5,5 DIPHENYL 1,4 DIOXAN 2 YL) 4,5 DIHYDRO 1H IMIDAZOLE; 2 (6 PHENYL 1,4 DIOXAN 2 YL) 4,5 DIHYDRO 1H IMIDAZOLE; 2 (6,6 DIPHENYL 1,4 DIOXAN 2 YL) 4,5 DIHYDRO 1H IMIDAZOLE; 2 (ALLOXY) 2 PHENYLETHANOL; 5 PHENYL 1,4 DIOXANE 2 CARBOXYLIC ACID; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR STIMULATING AGENT; IDAZOXAN; IMIDAZOLINE I2 RECEPTOR; METHYL 2 (ALLOXY) 2 PHENYLACETATE; METHYL 5 PHENYL 1,4 DIOXANE 2 CARBOXYLATE; METHYL 5,5 DIPHENYL 1,4 DIOXANE 2 CARBOXYLATE; METHYL 6 PHENYL 1,4 DIOXANE 2 CARBOXYLATE; METHYL 6,6 DIPHENYL 1,4 DIOXANE 2 CARBOXYLATE; MORPHINE; UNCLASSIFIED DRUG; YOHIMBINE;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SYNTHESIS; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; STEREOCHEMISTRY;

ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ANIMALS; BINDING SITES; HUMANS; IDAZOXAN; IMIDAZOLINES; MALE; MICE; MORPHINE; PAIN MEASUREMENT; RECEPTORS, ADRENERGIC, ALPHA-2; STEREOISOMERISM;

EID: 84858297639     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.016     Document Type: Article

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