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Volumn 20, Issue 7, 2012, Pages 2235-2251
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Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists
a
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Author keywords
EP2 receptor; EP4 receptor; Prostaglandin
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Indexed keywords
2 MERCAPTOTHIAZOLE 4 CARBOXYLIC ACID;
2 MERCAPTOTHIAZOLE 5 CARBOXYLIC ACID;
2 [3 [2 [3 HYDROXY 4 (3 METHYLPHENYL)BUT 1 ENYL] 5 OXOPYRROLIDIN 1 YL]PROPYL] 1,3 OXAZOLE 4 CARBOXYLIC ACID;
2 [3 [2 [3 HYDROXY 4 (3 METHYLPHENYL)BUT 1 ENYL] 5 OXOPYRROLIDIN 1 YL]PROPYL] 1,3 THIAZOLE 4 CARBOXYLIC ACID;
2 [[2 [2 (3 HYDROXY 4 PHENYLBUT 1 ENYL) 5 OXOPYRROLIDIN 1 YL]ETHYL]SULFANYL] 1,3 THIAZOLE 4 CARBOXYLIC ACID;
2 [[2 [2 (3 HYDROXYOCT 1 ENYL) 5 OXOPYRROLIDIN 1 YL]ETHYL]SULFANYL] 1,3 THIAZOLE 4 CARBOXYLIC ACID;
2 [[2 [2 [3 HYDROXY 4 (3 METHYLPHENYL)BUT 1 ENYL] 5 OXOPYRROLIDIN 1 YL]ETHYL]SULFANYL] 1,3 THIAZOLE 4 CARBOXYLIC ACID;
2 [[2 [2 [3 HYDROXY 4 [3 (2 NAPHTHYL)PHENYL]BUT 1 ENYL] 5 OXOPYRROLIDIN 1 YL]ETHYL]SULFANYL] 1,3 THIAZOLE 4 CARBOXYLIC ACID;
2 [[2 [2 [4 (1,1' BIPHENYL 3 YL) 3 HYDROXY BUT 1 ENYL] 5 OXOPYRROLIDIN 1 YL]ETHYL]SULFANYL] 1,3 THIAZOLE 4 CARBOXYLIC ACID;
2 [[2 [2 [4 (4' CHLORO 1,1' BIPHENYL 3 YL) 3 HYDROXYBUT 1 ENYL] 5 OXOPYRROLIDIN 1 YL]ETHYL]SULFANYL] 1,3 THIAZOLE 4 CARBOXYLIC ACID;
4 [2 [2 (3 HYDROXYOCT 1 ENYL) 5 OXOPYRROLIDIN 1 YL]ETHYL]BENZOIC ACID;
4 [2 [2 [3 HYDROXY 4 (3 METHYLPHENYL)BUT 1 ENYL] 5 OXOPYRROLIDIN 1 YL]ETHYL]BENZOIC ACID;
4 [[2 [2 (3 HYDROXYOCT 1 ENYL) 5 OXOPYRROLIDIN 1 YL]ETHYL]SULFANYL]BENZOIC ACID;
4 [[2 [2 [3 HYDROXY 4 (3 METHYLPHENYL)BUT 1 ENYL] 5 OXOPYRROLIDIN 1 YL]ETHYL]SULFANYL] 1,3 THIAZOLE 4 CARBOXYLIC ACID;
4 [[2 [2 [3 HYDROXY 4 (3 METHYLPHENYL)BUT 1 ENYL] 5 OXOPYRROLIDIN 1 YL]ETHYL]SULFANYL] 1,3 THIAZOLE 5 CARBOXYLIC ACID;
BENZOIC ACID;
BUTYL 2 [[2 [2 (HYDROXYMETHYL) 5 OXO 1 PYRROLIDINYL]ETHYL]THIO] 1,3 THIAZOLE 4 CARBOXYLATE;
ETHYL 2 [[2 (2 FORMYL 5 OXO 1 PYRROLIDINYL)ETHYL]THIO] 1,3 THIAZOLE 4 CARBOXYLATE;
ETHYL 2 [[2 [2 (3 HYDROXY 1 OCTEN 1 YL) 5 OXO 1 PYRROLIDINYL]ETHYL]THIO] 1,3 THIAZOLE 4 CARBOXYLATE;
ETHYL 2 [[2 [2 (3 HYDROXY 4 PHENYLBUT 1 ENYL) 5 OXO 1 PYRROLIDINYL]ETHYL]THIO] 1,3 THIAZOLE 4 CARBOXYLATE;
ETHYL 2 [[2 [2 (HYDROXYMETHYL) 5 OXO 1 PYRROLIDINYL]ETHYL]THIO] 1,3 THIAZOLE 4 CARBOXYLATE;
ETHYL 2 [[2 [2 (HYDROXYMETHYL) 5 OXO 1 PYRROLIDINYL]ETHYL]THIO] 1,3 THIAZOLE 5 CARBOXYLATE;
ETHYL 2 [[2 [2 [(TERT BUTYLDIMETHYLSILYLOXY)METHYL] 5 OXO 1 PYRROLIDINYL]ETHYL]THIO] 1,3 THIAZOLE 5 CARBOXYLATE;
ETHYL 2 [[2 [2 [3 HYDROXY 4 (3 METHYLPHENYL) 1 BUTEN 1 YL] 5 OXO 1 PYRROLIDINYL]ETHYL]THIO] 1,3 THIAZOLE 4 CARBOXYLATE;
ETHYL 2 [[2 [2 [3 HYDROXY 4 (3 METHYLPHENYL)BUT 1 ENYL] 5 OXOPYRROLIDIN 1 YL]ETHYL]SULFANYL] 1,3 THIAZOLE 5 CARBOXYLATE;
ETHYL 2 [[2 [2 [4 (3 METHYLPHENYL) 3 OXO 1 BUTEN 1 YL] 5 OXO 1 PYRROLIDINYL]ETHYL]THIO] 1,3 THIAZOLE 4 CARBOXYLATE;
PROSTAGLANDIN E2 AGONIST;
PROSTAGLANDIN E4 AGONIST;
PROSTAGLANDIN RECEPTOR STIMULATING AGENT;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
ANIMAL CELL;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ARTICLE;
BINDING AFFINITY;
CHEMICAL MODIFICATION;
CONTROLLED STUDY;
DRUG ACTIVITY;
DRUG POTENCY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
FRACTURE;
FRACTURE HEALING;
HYBRIDIZATION;
IN VITRO STUDY;
IN VIVO STUDY;
MALE;
NONHUMAN;
RAT;
RECEPTOR BINDING;
STRUCTURE ACTIVITY RELATION;
RATTUS;
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EID: 84858294299
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2012.02.018 Document Type: Article |
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Times cited : (19)
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References (18)
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