Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 7, 2006, Pages 1799-1802

  Cameron, Kimberly O ^a   Lefker, Bruce A ^a   Chu Moyer, Margaret Y ^a   Crawford, David T ^a   Jardine, Paul DaSilva ^a   DeNinno, Shari L ^a   Gilbert, Sandra ^a   Grasser, William A ^a   Ke, HuaZhu ^a   Lu, Bihong ^a   Owen, Thomas A ^a   Paralkar, Vishwas M ^a   Qi, Hong ^a   Scott, Dennis O ^a   Thompson, David D ^a   Tjoa, Christina M ^a   Zawistoski, Michael P ^a  

^a PFIZER INC   (United States)

Author keywords

Bone anabolic agent; EP2; EP4; Lactam; Osteoporosis; Prostaglandin

Indexed keywords

HEPTANOIC ACID DERIVATIVE; LACTAM DERIVATIVE; PROSTAGLANDIN EP4 RECEPTOR AGONIST; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL MODEL; ARTICLE; BONE MASS; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OSSIFICATION; OSTEOPOROSIS; OVARIECTOMY; RAT; REDUCTION; SAPONIFICATION;

ANIMALS; BONE AND BONES; BONE DENSITY; BONE DEVELOPMENT; FEMALE; ORGAN SIZE; OSTEOPOROSIS; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN E;

ANIMALIA;

EID: 33144478325     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.018     Document Type: Article

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