Synthesis and evaluation of a γ-lactam as a highly selective EP2 and EP4 receptor agonist

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 2, 2008, Pages 821-824

  Xiao, Yufang ^a   Araldi, Gian Luca ^a   Zhao, Zhong ^a   Reddy, Adulla ^a   Karra, Srinivasa ^a   Brugger, Nadia ^a   Fischer, David ^a   Palmer, Elizabeth ^a   Bao, Bagna ^a   Mckenna, Sean D ^a  

^a EMD SERONO INC   (United States)

Author keywords

EP2 receptor; EP4 receptor; Prostaglandin

Indexed keywords

BUTAPROST; GAMMA LACTAM DERIVATIVE; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR STIMULATING AGENT;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BRONCHOSPASM; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; MOUSE; NONHUMAN; OVULATION INDUCTION; RAT;

ANIMALS; FEMALE; GUINEA PIGS; HUMANS; LACTAMS; MALE; MICE; OVULATION INDUCTION; RECEPTORS, PROSTAGLANDIN E; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 38149041705     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.020     Document Type: Article

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