Development and validation of an open screening method for diuretics, stimulants and selected compounds in human urine by UHPLC-HRMS for doping control

Analytica Chimica Acta

Volumn 721, Issue , 2012, Pages 137-146

  Jimenez Giron A ^a   Deventer, K ^b   Roels, K ^b   Van Eenoo, P ^b  

^a UNIVERSITY OF EXTREMADURA   (Spain)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Doping; High resolution mass spectrometry; Liquid chromatography; Polarity switching; Screening; Urine

Indexed keywords

DETECTION LIMITS; DOPING CONTROL; HIGH RESOLUTION MASS SPECTROMETRY; HUMAN URINE; INTERNAL STANDARDS; ORBITRAP; POLARITY SWITCHING; RUNTIMES; SAMPLE PREPARATION; SCREENING METHODS; TARGET ANALYTES; ULTRAHIGH PRESSURE; URINE;

BODY FLUIDS; CHROMATOGRAPHY; DOPING (ADDITIVES); HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SCREENING;

DIAGNOSIS;

4' METHYLMETHCATHINONE; ACETAZOLAMIDE; AMFEPRAMONE; AMILORIDE; AMPHETAMINE; CANRENONE; CENTRAL STIMULANT AGENT; CHLORTALIDONE; CLOPAMIDE; CYCLOPENTHIAZIDE; DICLOFENAMIDE; DIURETIC AGENT; EFAPROXIRAL; EPITIZIDE; ETACRYNIC ACID; ETILEFRINE; FENPROPOREX; FUROSEMIDE; HYDROCHLOROTHIAZIDE; HYDROFLUMETHIAZIDE; INDAPAMIDE; ISOMETHEPTENE; MEBUTIZIDE; MEFRUSIDE; OXILOFRINE; PENTETRAZOLE; PROLINTANE; SELEGILINE; SYDNOCARB; UNINDEXED DRUG;

ACCURACY; ARTICLE; CHLORINATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOPING; DRUG DETERMINATION; DRUG SCREENING; HUMAN; LIMIT OF DETECTION; MASS SPECTROMETRY; METABOLITE; PREDICTION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; SENSITIVITY AND SPECIFICITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; VALIDATION PROCESS;

CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIURETICS; DOPING IN SPORTS; HUMANS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; URINALYSIS;

EID: 84858289135     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2012.02.002     Document Type: Article

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