Liquid chromatography/electrospray ionization tandem mass spectrometric screening and confirmation methods for β2-agonists in human or equine urine

Journal of Mass Spectrometry

Volumn 38, Issue 11, 2003, Pages 1197-1206

  Thevis, Mario ^a   Opfermann, Georg ^a   Schänzer, Wilhelm ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

Author keywords

Anabolic agents; Doping; Horse; Mass spectrometry; Sports; Stimulants; Urine

Indexed keywords

CONFORMATIONS; DEGRADATION; DISSOCIATION; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

CHARGE-REMOTE FRAGMENTATION; EQUINE URINE;

DOPING (ADDITIVES);

BAMBUTEROL; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BROMBUTEROL; CIMATEROL; CIMBUTEROL; CLENBUTEROL; CLENPENTEROL; FENOTEROL; FORMOTEROL FUMARATE; ION; ISOXSUPRINE; MABUTEROL; MAPENTEROL; PROCATEROL; RACTOPAMINE; REPROTEROL; RITODRINE; SALBUTAMOL; SALMETEROL XINAFOATE; TELOBUTEROL; TERBUTALINE SULFATE; THEOBROMINE; THEOPHYLLINE DERIVATIVE; TULOBUTEROL; UNCLASSIFIED DRUG;

ACIDITY; ADULT; ALKALINITY; ANALYTIC METHOD; ARTICLE; CONTROL STRATEGY; CONTROLLED STUDY; DISSOCIATION; DOPING; DRUG DETERMINATION; DRUG HYDROLYSIS; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; FEMALE; FRAGMENTATION REACTION; HORSE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; SAMPLING; TANDEM MASS SPECTROMETRY; URINALYSIS;

ADRENERGIC BETA-AGONISTS; ANIMALS; ARTIFACTS; CHROMATOGRAPHY, LIQUID; CLENBUTEROL; DOPING IN SPORTS; ETHANOLAMINES; HORSES; HUMANS; MASS SCREENING; MOLECULAR STRUCTURE; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EQUIDAE; EQUUS CABALLUS;

EID: 0345547402     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/jms.542     Document Type: Article

References (26)

1. Morgan DJ. Clinical pharmacokinetics of beta-agonists. Clin. Pharmacokinet. 1990; 18: 274.
2. Höher J, Troidl H. Doping in Sport. Dtsch. Z. Sportmed. 1995; 46: 270.
3. Reeds PJ, Hay SM, Dorward PM, Palmer RM. The effect of beta-agonists and antagonists on muscle growth and body composition of young rats (rattus sp.). Comp. Biochem. Physiol. C 1988; 89: 337.
4. Stallion A, Zhang FS, Chance WT, Foley-Nelson T, Fischer JE. Reversal of cancer cachexia in rats by cimaterol and supplemental nutrition. Surgery 1991; 110: 678.
5. Wagner JC. Abuse of drugs used to enhance athletic performance. Am. J. Hosp. Pharm. 1989; 46: 2059.
6. International Olympic Committee Medical Commission and World Anti-Doping Agency. List of prohibited classes of substances and prohibited methods. http://www.wada-ama.org. 2003.
7. Bocca B, Fiori M, Cartoni C, Brambilla G. Simultaneous determination of zilpaterol and other beta agonists in calf eye by gas chromatography/tandem mass spectrometry. J. AOAC Int. 2003; 86: 8.
8. Amendola L, Colamonici C, Rossi F, Botre F. Determination of clenbuterol in human urine by GC-MS-MS-MS: Confirmation analysis in antidoping control. J. Chromatogr. B 2002; 773: 7.
9. Henze MK, Opfermann G, Spahn-Langguth H, Schänzer W. Screening of beta-2 agonists and confirmation of fenoterol, orciprenaline, reproterol and terbutaline with gas chromatography-mass spectrometry as tetrahydroisoquinoline derivatives. J. Chromatogr. B 2001; 751: 93.
10. Damasceno L, Ventura R, Ortuño J, Segura J. Derivatization procedures for the detection of beta(2)-agonists by gas chromatographic/mass spectrometric analysis. J. Mass Spectrom. 2000; 35: 1285.
11. Biancotto G, Angeletti R, Traldi P, Guidugli F. Positive chemical ionization and tandem mass spectrometric fragmentation for the gas chromatographic analysis of beta-agonists using the ion trap technique. J. Mass Spectrom. 1999; 34: 1346.
12. Machnik M, Geyer H, Horning S, Breidbach A, Delahaut P, Schänzer W. Long-term detection of clenbuterol in human scalp hair by gas chromatography-high-resolution mass spectrometry. J. Chromatogr. B 1999; 723: 147.
13. Thieme D, Grosse J, Lang R, Mueller RK, Wahl A. Screening, confirmation and quantification of diuretics in urine for doping control analysis by high-performance liquid chromatography-atmospheric pressure ionisation tandem mass spectrometry. J. Chromatogr. 2001; 757: 49.
14. Thevis M, Opfermann G, Schänzer W. High speed determination of beta-receptor blocking agents in human urine by liquid chromatography/tandem mass spectrometry. Biomed. Chromatogr. 2001; 15: 393.
15. Van Eenoo P, Deventer K, Delbeke FT. Quantitative detection of salmeterol after inhalation in equine urine by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2002; 16: 1755.
16. Guan F, Uboh CE, Soma LR, Luo Y, Li R, Birks EK, Teleis D, Rudy JA, Tsang DS. Quantification of clenbuterol in equine plasma, urine and tissue by liquid chromatography coupled on-line with quadrupole time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2002; 16: 1642.
17. Antignac JP, Marchand P, Le Bizec B, Andre F. Identification of ractopamine residues in tissue and urine samples at ultra-trace level using liquid chromatography-positive electrospray tandem mass spectrometry. J Chromatogr. B 2002; 774: 59.
18. De Wasch K, De Brabander H, Courtheyn D. LC-MS-MS to detect and identify four beta-agonists and quantify clenbuterol in liver. Analyst 1998; 123: 2701.
19. Biancotto G, Angeletti R, Piro RDM, Favretto D, Traldi P. Ion trap high-performance liquid chromatography/multiple mass spectrometry in the determination of beta-agonists in bovine urines. J. Mass Spectrom. 1997; 32: 781.
20. Doerge DR, Churchwell MI, Holder CL, Rowe L, Bajic S. Detection and confirmation of beta-agonists in bovine retina using LC/APCI-MS. Anal. Chem. 1996; 68: 1918.
21. Kromidas S. Validierung in der Analytik. Wiley-VCH: Weinheim, 1999; 176.
22. Pictet A, Spengler T. Über die Bildung von Isochinolin-derivaten durch Einwirkung von Methylal auf Phenyl-äthylamin, Phenyl-alanin und Tyrosin. Chem. Ber. 1911; 44: 2030.
23. Rousseau JF, Dodd RH. Synthesis of 3-deaza-beta-hydroxyhistidine derivatives and their use for the preparation of substituted pyrrolo[2,3-c]pyridine-5-carboxylates via the Pictet-Spengler reaction. J. Org. Chem. 1998; 63: 2731.
24. Sourgens H, Köster FE. Reproterol and competitive sports-a literature review. Focus Clinical Drug Development GmbH: Neuss, Germany.
25. Gross ML. Charge-remote fragmentation: method, mechanism and applications. Int. J. Mass Spectrom. Ion Processes 1992; 118/119: 137.
26. Cai J, Henion J. Quantitative multi-residue determination of beta-agonists in bovine urine using on-line immunoaffinity extraction-coupled column packed capillary liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 1997; 691: 357.